Antiviral agents – Page 29 – Communicable Diseases Research

SARS-CoV-2 Rapidly Adapts in Aged BALB/c Mice and Induces Typical Pneumonia

Pathogenesis and Immunity

Published on 2021-03-102022-10-30
Journal: Journal of Virology [Category] COVID-19,

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

Pharmacology

Published on 2021-03-022022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] activity acute respiratory distress Against Antiviral Antiviral agents ARDS AYUSH medicine caused chemokine China Clinical research clinical study clinical testing clinical trial COVID-19 drug effector cells Fatality rate Formulation global scientific community Health immune immunomodulator immunomodulators immunomodulatory India indian medicinal plants Indian people indian traditional medicine information investigated less Medicine National Occurrence Patient plant plants platform Potential pro-inflammatory cytokine public health reaction reported Research S proteins SARS-CoV infection SARS-CoV-2 SARS-COV-2 infection severe disease suggested syndrome systemic inflammatory tested Wuhan
[DOI] 10.3389/fphar.2020.578970 PMC 바로가기 [Article Type] Pharmacology

A computational drug repurposing approach in identifying the cephalosporin antibiotic and anti-hepatitis C drug derivatives for COVID-19 treatment

COVID-19 치료를 위한 세팔로스포린 항생제 및 항 C형 간염 약물 유도체 식별을 위한 컴퓨터 약물 용도 변경 접근법

Article

Published on 2021-03-012022-08-31
Journal: Computers in biology and medicine [Category] MERS, SARS, 신약개발, 치료제,

[키워드] active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amalgam Analysis antibiotic antiviral agent Antiviral agents approach backbone atom Bacterial bacterial pneumonia Bank binding binding free energy caused Ceftaroline Ceftaroline fosamil Chemical complex Computational drug coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical Cys145 database death derivative drug Drug repurposing free energy Free energy calculations Glu166 Gly143 HCV hepatitis C hepatitis C virus His41 hydrogen Hydrogen bond hydrogen bonds identify indicated indication information inhibitor inhibitors Interaction investigated M pro MD simulations molecular molecular dynamics offer pharmacokinetic Pneumonia potential energy Preclinical Testing profiles Protease inhibitor Protein repurposing residue respiratory RMSD SARS-CoV-2 SARS-CoV-2 main protease Seven severe acute respiratory syndrome Coronavirus Side effects suggested supported telaprevir Treatment Virtual screening
[DOI] 10.1016/j.compbiomed.2020.104186 PMC 바로가기 [Article Type] Article

Glucose-6-phosphate dehydrogenase deficiency and hydroxychloroquine in the COVID-19 era: a mini review

COVID-19 시대의 포도당-6-인산 탈수소효소 결핍과 하이드록시클로로퀸: 미니 리뷰

Review

Published on 2021-03-012022-09-11
Journal: Molecular biology reports [Category] MERS, 신약개발, 진단, 치료제,

[키워드] activities addition antiviral agent Antiviral agents association caused Cellular immune response Chloroquine coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID-19 patients cytokine deficiency effective effective drug effective drugs effort Final G6PD G6PD deficiency glucose-6-phosphate dehydrogenase deficiency HCQ health emergency hemoglobin Hemolysis hemolytic hemolytic anemia Hemolytic crisis Hydroxychloroquine immune responses in vitro inflammasome activation Innocent Intensive involved limelight modulating occur oxygen Patient patients performed Prevent pro-inflammatory cytokine question raised reactive oxygen species reactive oxygen specy Safe searched shown today treat
[DOI] 10.1007/s11033-021-06234-y PMC 바로가기 [Article Type] Review

Lowering the transmission and spread of human coronavirus

Article

Published on 2021-03-012023-07-05
Journal: Journal of medical virology [Category] SARS,

[키워드] Antiviral agents coronavirus dissemination Epidemiology horizontal transmission Pathogenesis shedding virus classification
[DOI] 10.1002/jmv.26514

Interrogation of the cellular immunome of cancer patients with regard to the COVID-19 pandemic

코로나19 팬데믹에 대한 암 환자의 세포 면역 체계 조사

Review

Published on 2021-03-012022-09-11
Journal: Journal for immunotherapy of cancer [Category] SARS, 바이오마커,

Closing the serological gap in the diagnostic testing for COVID-19: The value of anti-SARS-CoV-2 IgA antibodies

Article

Published on 2021-03-012023-06-19
Journal: Journal of medical virology [Category] MERS, SARS,

[키워드] Antiviral agents immune globulin immune responses Immunoglobulin SARS Coronavirus virus classification
[DOI] 10.1002/jmv.26422 PMC 바로가기

In Silico , In Vitro and In Cellulo Models for Monitoring SARS-CoV-2 Spike/Human ACE2 Complex, Viral Entry and Cell Fusion

SARS-CoV-2 스파이크/인간 ACE2 복합체, 바이러스 진입 및 세포 융합 모니터링을 위한 In Silico, In Vitro 및 In Cellulo 모델

Article

Published on 2021-02-252022-09-10
Journal: Viruses [Category] MERS, 변종, 치료기술, 치료제,

[키워드] ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral agent Antiviral agents approach approaches assays association binding biochemical BLI Cell Cell fusion cell line cell surface cellular cellular processe cellular processes Clinical research complex Contact coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 detect determine etiologic agent expressing flow cytometry fusion help house in silico in vitro Infection Interaction kinetic Lentiviral vector Model modulation MONITOR monitoring pandemic parameter pseudotyped Replication Research respiratory responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein Spike Protein S Spike/ACE2 complex the cell the SARS-CoV-2 therapeutic target transduction assay variant Viral viral entry viral spike protein viral spike protein S virus virus entry
[DOI] 10.3390/v13030365 PMC 바로가기 [Article Type] Article

Effect of a genetically engineered interferon-alpha versus traditional interferon-alpha in the treatment of moderate-to-severe COVID-19: a randomised clinical trial

중등도에서 중증의 COVID-19 치료에서 유전적으로 조작된 인터페론-알파 대 전통적인 인터페론-알파의 효과: 무작위 임상 시험

Randomized Controlled Trial

Published on 2021-02-232022-08-09
Journal: Annals of Medicine [Category] 임상, 치료제,

[키워드] 1:1 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus adaptive immune responses added Adverse adverse events Alpha antiviral agent Antiviral agents antiviral therapy ARMS assigned baseline antiviral agent baseline antiviral agents Clinical efficacy Clinical improvement clinical trial coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death Effect effective therapy Effectiveness Endpoint event groups head immune responses interferon Interferon alpha interferon-alpha interferon-alpha group interferon-alpha nebulization Lopinavir Lopinavir–ritonavir lopinavir–ritonavir or umifenovir Middle East Middle East respiratory syndrome Coronavirus moderate-to-severe COVID-19 multicenter Negative conversion nucleic acid outbreak pandemic participant Patient patients hospitalized primary endpoint radiological improvement randomised Randomized recombinant super-compound interferon respiratory respiratory syndrome coronavirus Result Ritonavir rSIFN-co rSIFN-co group rSIFN-co nebulization rSIFN-co therapy SARS CoV-2 secondary Secondary endpoints severe acute respiratory syndrome Coronavirus shown traditional interferon-alpha Treatment Trial umifenovir virus nucleic acid
[DOI] 10.1080/07853890.2021.1890329 PMC 바로가기 [Article Type] Randomized Controlled Trial

Clinical features and prognostic factors of critically ill patients with COVID-19 in Daegu, South Korea A multi-center retrospective study

3900

Published on 2021-02-192022-10-30
Journal: Medicine [Category] COVID-19, MERS,

[키워드] acute respiratory distress Admission antibiotic Antiviral agents antiviral medication APACHE II score ARDS clinical cohort study COVID-19 Critically ill Critically ill patient death demographic characteristics died ECMO feature Final Follow-up hospital Hydroxychloroquine ICU In-hospital death in-hospital mortality in-hospital mortality rate independent risk factor injection interquartile range Invasive mechanical ventilation Lopinavir-ritonavir median age medical record multivariable logistic regression neuromuscular blockade Odds ratio Patient patients Prognostic factor Retrospective study risk factor SARS-COV-2 infection South Korea study period syndrome Treatment with COVID-19
[DOI] 10.1097/MD.0000000000024437 PMC 바로가기 [Article Type] 3900