A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectivenessResearch Article Published on 2020-12-212022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, MERS, SARS, [키워드] acute viral infection Administered antiviral drug Cell Cellular immune response cellular mechanism clearance clinical effectiveness Combination component COVID-19 decrease disease Disease progression dosage drug Effect effective Effectiveness epithelial epithelial cell exhibit faster Hepatitis High dose immune immune response immune-cell Infection infection mechanism Interaction interfere less low dose mechanisms multicellular multiple groups outcome outcomes platform Potential treatment primary viral infection progression promote prophylactically recruitment reduce reduced Remdesivir Replication rate Repository Side effect Simulation spatiotemporal Support susceptibility Therapies therapy tissue tissue damage tissues Treatment viral infection Viral RNA virus virus replication viruses widespread [DOI] 10.1371/journal.pcbi.1008451 PMC 바로가기 [Article Type] Research Article
Identification of SARS-CoV-2 Nucleocapsid and Spike T-Cell Epitopes for Assessing T-Cell ImmunityCellular Response to Infection Published on 2020-12-212022-10-30 Journal: Journal of Virology [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Analysis assays Assessing binding candidate CD8 Cellular immune response cellular response circulating conserved contribute Convalescent patients coronavirus coronavirus immunity Coverage COVID-19 vaccines Critical cross-reactivity Developing diagnostic tools disease effective Efficacy effort elicit elicited epitope exhibited highly networked/conserved T-cell epitope derived peptides HLA allele homology human coronavirus human coronaviruses identification identify Immunity immunogen immunogenic peptide immunoinformatics in silico novel coronavirus disease nucleocapsid nucleocapsid and spike proteins peptide Protein protein network Region response resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific immune response SARS-CoV-2-specific T-cell responses spike Spike proteins survivor T cell T-cell T-cell effector/polyfunctionality T-cell epitope T-cell immunity T-cell Response the SARS-CoV-2 to define Vaccine vaccine candidates variant Viral proteins viral variant [DOI] 10.1128/JVI.02002-20 PMC 바로가기 [Article Type] Cellular Response to Infection
Harnessing Cellular Immunity for Vaccination against Respiratory VirusesReview Published on 2020-12-212022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activate acute respiratory disease acute respiratory syndrome approach Aside B cell response candidate CD4+ CD8+ T cell Cellular immune response cellular immunity Clinical sign Coronavirus-2 Coronaviruses Critical detrimental Efficacy and safety examined group Health humoral immune response illness immunocompromised individuals immunopathology Infants Infection Influenza long-lasting métapneumovirus Mild morbidity Mortality Nanoparticles neutralizing antibody Patient Pneumonia Protein Research respiratory Respiratory illness respiratory syncytial virus respiratory viral respiratory viral infections respiratory viruses response rhinovirus RNA RNA vaccines robust RSV SARS-CoV-2 severe disease subunits tested These viruses upper respiratory vaccination Vaccine vaccine candidate vaccine candidates viral infection virus Virus-like particle virus-like particles viruses VLPs [DOI] 10.3390/vaccines8040783 PMC 바로가기 [Article Type] Review
Failure of CD4 T Cell-Deficient Hosts To Control Chronic Nontyphoidal Salmonella Infection Leads to Exacerbated Inflammation, Chronic Anemia, and Altered MyelopoiesisCD4 T 세포 결핍 숙주가 만성 비타이푸스 살모넬라 감염을 조절하지 못하면 염증 악화, 만성 빈혈 및 골수 생성 변화가 발생한다.Article Published on 2020-12-152024-08-21 Journal: Infection and Immunity [Category] 살모넬라증, [키워드] Anemia Bone marrow CD4 deficiency CD4 T cell Cellular immune response Inflammation Salmonella
Establishing a Multicolor Flow Cytometry to Characterize Cellular Immune Response in Chickens Following H7N9 Avian Influenza Virus InfectionArticle Published on 2020-12-062023-05-31 Journal: Viruses [Category] Fulltext, [키워드] Avian influenza virus Cellular immune response chicken flow cytometry H7N9 [DOI] 10.3390/v12121396 PMC 바로가기 [Article Type] Article
A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate Research Published on 2020-12-012022-10-05 Journal: Nature [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome animal models Antigen candidate vaccine Cellular immune response coronavirus coronavirus disease COVID-19 cynomolgus macaque Efficacy Express Fever hamster immune response Immunity induce infection with SARS-CoV-2 Lung disease macaques Mesocricetus mice Mus pandemic prefusion Prevent protective immunity Safe safety profile SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 vaccine single dose T helper the SARS-CoV-2 triggered Vaccine vaccine platform Vaccines virus [DOI] 10.1038/s41586-020-3035-9 [Article Type] Research
Convalescent plasma anti-SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization회복기 혈장 항-SARS-CoV-2 스파이크 단백질 엑토도메인 및 수용체 결합 도메인 IgG는 바이러스 중화와 상관관계가 있습니다Clinical Trial Published on 2020-12-012022-09-11 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 비임상, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immunity anti-RBD anti-receptor-binding domain anti-SARS-CoV-2 Anti-spike Asymptomatic breath Cellular immune response convalescent plasma convalescent plasma samples coronavirus COVID-19 COVID-19 disease COVID-19 treatment Critical decrease detect disease severity domain donors Dyspnea ectodomain highlight Hospitalization identify IgG IgG titer IgG titers immune immunology in vitro In vitro assay individual Infectious disease information Molecular pathology neutralization Neutralizing antibodies pathology patients with COVID-19 plasma positive correlation Probability Protective respiratory SARS-CoV-2 SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus significantly Spike protein surrogate titers Treatment Virus neutralization [DOI] 10.1172/JCI141206 PMC 바로가기 [Article Type] Clinical Trial
Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primatesSARS-CoV-2에 감염된 비인간 영장류에서 급성, 해결 또는 진행성 COVID-19의 세포 사건Article Published on 2020-11-272022-09-10 Journal: Nature Communications [Category] SARS, 진단, 치료기술, [키워드] accumulation acute phase animals anti-inflammatory response anti-inflammatory responses association CCL17 CD11b CD11c CD16 Cell cell population Cellular immune response cellular mechanism cellular mechanisms COVID-19 detectable develop disease event expressing heterogeneous HLA-DR identify IL-10 IL-6 IL-6 level IL-6 levels immune Infection infiltration Innate immunity interstitial Kynurenine less long-lasting lung Lungs Macrophage macrophages Migration Mild monocyte Monocytes Neutrophils NHP non-human primate non-human primates outcome pathology plasma progressive COVID-19 Pulmonary pathology robust SARS-CoV-2 SARS-COV-2 infection subset subtype Therapies Tryptophan understanding Vaccine Viral Viral load viral replication [DOI] 10.1038/s41467-020-19967-4 PMC 바로가기 [Article Type] Article
Immunological imprint of COVID‐19 on human peripheral blood leukocyte populations인간 말초 혈액 백혈구 개체군에 대한 COVID-19의 면역학적 각인Original Article Published on 2020-11-222022-09-01 Journal: Allergy [Category] SARS, 진단, 치료법, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive addition antibody antibody levels B cells CD25 CD3 CD31 CD38 CD4 CD45 CD45RA CD8 Cell cells cellular Cellular immune response cellular immune responses central memory clinical immunology Cohort convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID‐19 COVID‐19 patient COVID‐19 patients determined by disease domain effector memory elevated ELISA expression flow cytometry FOXP3 healthy control HLA‐DR immune responses immune system immunological immunological change immunological changes immunosorbent Infection infections innate immune system investigated leukocyte population Lymphocytes Mild Mild disease multiparametric flow cytometry neutrophil Neutrophils nucleocapsid pandemic parameters Patient patients Peripheral blood qPCR Quantitative quantitative PCR RBD receptor receptor‐binding domain Recombination reduction reflected regression analysis respiratory responses Result SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‑CoV2 SARS‐CoV‐2 sense sense of taste severe acute respiratory syndrome Coronavirus significantly Spike protein subject T cell T cells T regulatory cell T regulatory cells T‐cell Taste thymic emigrant thymic emigrants transitional B cell transitional B cells triggered Viral [DOI] 10.1111/all.14647 PMC 바로가기 [Article Type] Original Article
Neutralizing antibody against SARS-CoV-2 spike in COVID-19 patients, health care workers, and convalescent plasma donorsCOVID-19 환자, 의료 종사자 및 회복기 혈장 기증자의 SARS-CoV-2 급증에 대한 중화 항체Technical Advance Published on 2020-11-192022-09-12 Journal: JCI Insight [Category] SARS, 진단, [키워드] antibody Antibody testing Cellular immune response cohorts convalescent plasma COVID-19 COVID-19 pathogenesis COVID-19 patients COVID-19 symptoms Donor donors Efficacy evaluate followed by glycoprotein HCWs Health care Health care worker health care workers highest highlight HIV-1 hospitalized patients human antibody response ICU ICU Patients individual individuals intensive care intensive care unit intron lentiviral lentivirus Neutralization assay neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Patient phenotypic phenotypic variation pseudotype pseudotyped Rapid reporter SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 spike SARS-CoV-2 strain secreted serological survey Serological surveys serum the SARS-CoV-2 Treatment Variation Virus neutralization was used [DOI] 10.1172/jci.insight.143213 PMC 바로가기 [Article Type] Technical Advance