Prediction of potential inhibitors for RNA-dependent RNA polymerase of SARS-CoV-2 using comprehensive drug repurposing and molecular docking approachResearch article Published on 2020-11-012022-10-05 Journal: International journal of biological macromolecules [Category] SARS, 신약개발, [키워드] addition ADME Amino acid Analysis approach Comparative complexes Compound compounds computational approach COVID-19 drug drug candidate drug target drug-likeness effective effective drug effective inhibitor enzyme feature fidaxomicin Health hotspot inhibitor inhibitory Interaction molecular docking pandemic predict prediction prevalence of COVID-19 RdRP rifabutin Rifapentine RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 replication scientist Structural analysis Toxicity Virtual screening ZINC database [DOI] 10.1016/j.ijbiomac.2020.09.098 [Article Type] Research article
Rapid Serological Assays and SARS-CoV-2 Real-Time Polymerase Chain Reaction Assays for the Detection of SARS-CoV-2: Comparative StudyOriginal Paper Published on 2020-10-302022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, SARS, [키워드] age analyzed chain Comparative COVID-19 detection diagnosing diagnosis of SARS-CoV-2 expression Factor IgM/IgG Immunoglobulin independent Infection information Laboratory limit molecular molecular test Multivariate analysis objective performed polymerase chain positive Predictive proportion provided Rapid reaction Result RT-PCR RT-PCR assay RT-PCR testing SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 nucleic acid sensitivity serological serological test specificity subject subjects Symptom symptom onset Symptomatic patients tested viral nucleic acid [DOI] 10.2196/19152 PMC 바로가기 [Article Type] Original Paper
Comparative Study of the Restorative Effects of Forest and Urban Videos during COVID-19 Lockdown: Intrinsic and Benchmark ValuesCOVID-19 잠금 기간 동안 산림 및 도시 비디오의 복원 효과에 대한 비교 연구: 본질적 및 벤치마크 가치Article Published on 2020-10-302022-08-13 Journal: International Journal of Environmental Research an [Category] MERS, SARS, 임상, [키워드] Anxiety anxiety levels assigned audio-visual stimulation baseline collected Comparative Compound Contact contact with COVID-19 COVID-19 pandemic Deprivation determinant determinants direct contact Effect effective Effectiveness environmental deprivation environmental enrichment example exposure to fill out forest forest environments forest therapy form Health highlighting inventory investigated limitation lockdown mental health morning organic compounds Part participant prevented Psychological well-being quarantine questionnaire Questionnaires raising reduce reported restorative scale selected short term STAI Stress urban value Virus Disease worsening [DOI] 10.3390/ijerph17218011 PMC 바로가기 [Article Type] Article
Comparative Performance of Private Equity–Owned US Nursing Homes During the COVID-19 PandemicResearch Published on 2020-10-282022-10-29 Journal: JAMA Network Open [Category] COVID-19, MERS, SARS, [키워드] 95% CI adjusted analyses Characteristics Comparative coronavirus disease COVID-19 COVID-19 case cross-sectional death deaths equity evaluate exposure File finding home Importance less measure N95 mask Nurse Nursing nursing home objective outcome outcomes pandemic participant performance performed Personal protective equipment Point PPE Private Public Relevance Result setting statistically statistically significant difference [DOI] 10.1001/jamanetworkopen.2020.26702 PMC 바로가기 [Article Type] Research
Comparative ACE2 variation and primate COVID-19 riskArticle Published on 2020-10-272022-10-04 Journal: Communications Biology [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 gene ACE2 gene sequence ACE2 variation African Americas amino acid residue Asian binding affinity caused coded Comparative Contact COVID-19 Critical death develop effort Evolutionary genetics greatly reduce host cell receptor human ACE2 humans Infection limit modulate Monkey Other predict predicted Protein protein-protein interaction reduced residue residues risk SARS-CoV-2 shown susceptibility susceptible Variation viral infection virus recognition [DOI] 10.1038/s42003-020-01370-w PMC 바로가기 [Article Type] Article
A Machine Learning Explanation of the Pathogen-Immune Relationship of SARS-CoV-2 (COVID-19), and a Model to Predict Immunity and Therapeutic Opportunity: A Comparative Effectiveness Research StudyOriginal Paper Published on 2020-10-192022-10-29 Journal: Jmirx Med [Category] COVID-19, [키워드] 95% CI Accuracy age Algorithm association Asymptomatic asymptomatic patient AUROC build carrier Cell characteristic China Chinese Clinical data Comorbidities Comparative Contact COVID-19 COVID-19 immunity COVID-19 symptom diagnosed differentiator District Effectiveness excluded explanation extreme Factor female growth hospital identify immune immune factor immune factors Immunity immunological individual infect infected with COVID-19 Infectious disease M-CSF machine machine learning machine learning analysis Macrophage male mass vaccinations median age Model objective observation Outbreaks outcome Patient patients patients with COVID-19 point of care positive predict predicted primary care Primary outcome programming public health relationship Research Result RT-PCR SARS-CoV-2 SCGF-β selected Sex single-center statistical statistically significant stem-cell growth factor-beta Symptom symptomatic symptomatic case Testing Therapeutics therapy Treatment treatment for COVID-19 understanding Vaccine were measured were recorded with COVID-19 [DOI] 10.2196/23582 PMC 바로가기 [Article Type] Original Paper
Mortality of Patients With Severe COVID-19 in the Intensive Care Unit: An Observational Study From a Major COVID-19 Receiving HospitalInternal Medicine Published on 2020-10-122022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 24 hour 24 hours 95% CI 95%CI Administered age analyzed chi-square test chronic obstructive co-morbid conditions co-morbidities co-morbidity Comorbidities Comparative COVID-19 cross-sectional determine diabete Diabetes Mellitus Frequency Gender hypertension IBM ICU IMV independent risk factor independent t-test intensive care Invasive mechanical ventilation less likelihood LOS Major Mortality mortality rate multivariable multivariate regression analysis NIV not affected objective overall mortality Patient patients predict pulmonary disease Result retrieved severe COVID-19 SPSS survival survivor the mean variable variables Ventilation ventilatory was used were used [DOI] 10.7759/cureus.10906 PMC 바로가기 [Article Type] Internal Medicine
Comparative docking studies to understand the binding affinity of nicotine with soluble ACE2 (sACE2)-SARS-CoV-2 complex over sACE2Regular Article Published on 2020-10-082022-10-29 Journal: Toxicology Reports [Category] COVID-19, [키워드] absence Abstract ACE2 Amino acid Angiotensin-converting enzyme angiotensin-converting enzyme 2 bind binding binding affinity clinical trial Comparative complex conserved Contact COVID19 docked docking study dosage Infection inhibitory Interaction Lower neuronal Neuronal nicotinic acetylcholine receptor Nicotine patients Protein protein complex RBD domain receptor recorded reduced reducing required sACE2 sACE2 protein sACE2-INS1 complex SARS-CoV-2 SARS-CoV-2 protein sequence identity Smokers soluble ACE2 the binding affinity the healthy the SARS-CoV-2 therapeutic efficacy turn virulence [DOI] 10.1016/j.toxrep.2020.10.002 PMC 바로가기 [Article Type] Regular Article
Comparative Analysis of 95 Patients with Different Severity in the Early Outbreak of COVID-19 in Wuhan, ChinaResearch Article Published on 2020-10-052022-10-31 Journal: The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien des Maladies Infectieuses et de la Microbiologie Médicale [Category] COVID-19, [키워드] abnormality Admission analyzed C-reactive protein Chest computed tomography China clinical Clinical characteristics Clinical data Clinical diagnosis Cluster Clusters common Comorbidities Comparative cough COVID-19 COVID-19 patient Critical Critical case cured D-dimer discharged elevated epidemiological fatigue females Fever Ground-glass opacities hospital investigated Laboratory Local lymphopenia male measure objective Older outbreak patchy pathogenicity Patient patients died prognosis of patient Questionnaires Red Result Severe patient severity Shortness of breath significantly Symptom the disease Transmission Treatment Wuhan Wuhan, China [DOI] 10.1155/2020/4783062 PMC 바로가기 [Article Type] Research Article
Potential therapeutic target identification in the novel 2019 coronavirus: insight from homology modeling and blind docking studyResearch Published on 2020-10-022022-11-01 Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19, [키워드] 2019-nCoV 3CLpro 3D structure activities administration Amino acid binding site blind carried co-crystallized coding sequence Comparative coronavirus coronavirus epidemic Coronaviruses docked docking study elicited Genome HIV protease inhibitor homology Human inhibitors International Ligand mapped Novel coronavirus outbreak polyprotein polyproteins positive-sense single-stranded RNA Potential protease Protein proteinase Proteolytic processing public health reduced Replication Result selected sequence shown target protein The 2019-nCoV therapeutic agent therapeutic target translated Treatment viral infection viral replication virus [DOI] 10.1186/s43042-020-00081-5 PMC 바로가기 [Article Type] Research