Phytochemicals present in Indian ginseng possess potential to inhibit SARS-CoV-2 virulence: A molecular docking and MD simulation study인도 인삼에 존재하는 파이토케미컬은 SARS-CoV-2 독성을 억제할 수 있는 잠재력을 가지고 있습니다: 분자 도킹 및 MD 시뮬레이션 연구Article Published on 2021-08-012022-09-11 Journal: Microbial pathogenesis [Category] SARS, 치료제, [키워드] active site Affect anti-SARS-CoV-2 Antiviral antiviral agent Antiviral agents binding characteristic complex Compound contagious coronavirus drug target effective effort exhibited glucoside In silico studies in vitro in vivo inhibit SARS-CoV-2 inhibitor inhibitory Lopinavir M pro M(pro) MD simulation molecular docking molecular docking studies Molecular docking study molecular dynamics nelfinavir pathogen Pathogens phytochemical phytochemicals protease Protein protein-ligand quercetin rutin rutinoside SARS-CoV-2 silico studies simulation studies Simulation study trajectory Withania somnifera withanolide [DOI] 10.1016/j.micpath.2021.104954 PMC 바로가기 [Article Type] Article
Adverse Events Following COVISHIELD Vaccination Among Adult Population in BangladeshCovid-19 Published on 2021-07-312022-10-29 Journal: Sn Comprehensive Clinical Medicine [Category] COVID-19, [키워드] Adverse adverse event adverse events asked Blood Comorbidity conducted contagious COVID 19 Covishield cross-sectional determine diagnosed with COVID-19 dose FIVE help inclusion criteria injection life-threatening Mild occur Oxford AstraZeneca Population questionnaire reduce significantly statistically significant Symptom Transmission vaccination Vaccine virus [DOI] 10.1007/s42399-021-01021-z PMC 바로가기 [Article Type] Covid-19
Network pharmacology and molecular docking analysis on mechanisms of Tibetan Hongjingtian ( Rhodiola crenulata ) in the treatment of COVID-19Covid-19의 처리에서 티베트 홍지 (Rhodiola crenulata)의 메커니즘에 대한 네트워크 약리학 및 분자 도킹 분석Prevention, Therapy and Therapeutics Published on 2021-07-272022-08-31 Journal: Journal of Medical Microbiology [Category] SARS, 유전자 메커니즘, 치료제, [키워드] (quercetin Analysis Anti-inflammatory applied AutoDock component contagious contagious disease coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine Cytokine storm Cytoscape Discovery Studio disease docking Effect enrichment analyses Genes genomes GO analysis GO annotation Hongjingtian (R. crenulata) hub genes IL-17 IL-1B IL-1β IL-6 immune regulation immune response Inflammatory response inhibiting kaempferol KEGG Kyoto mechanism molecular docking molecular docking analysis network network pharmacology overcome pathway pathway enrichment Pathways potential molecular PPI PPI network Protein–protein interaction quercetin Result retrieved Rhodiola target target gene Target genes targets TCMSP database the cytokine storm TNF TNF-α Treatment [DOI] 10.1099/jmm.0.001374 PMC 바로가기 [Article Type] Prevention, Therapy and Therapeutics
Minute-scale detection of SARS-CoV-2 using a low-cost biosensor composed of pencil graphite electrodes연필 흑연 전극으로 구성된 저비용 바이오 센서를 사용한 SARS-CoV-2의 미세 검출410 Published on 2021-07-272022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 진단, 치료기술, [키워드] Accuracy ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin B.1.1.7 comparable composed condition contagious coronavirus COVID-19 COVID-19 testing cross-reactivity death detect Device diagnosed diagnostic diagnostic test diagnostic tests facilitate graphite help High human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 Influenza lead limit of detection opens Outbreaks phosphate phosphate-buffered saline point of care Prevent reproducibility Saliva SARS-CoV-2 SARS-CoV-2 B.1.1.7 SARS-CoV-2 spike protein sensitivity sensor severe acute respiratory syndrome Coronavirus Significance specificity Spike protein spread of COVID-19 Strains tested unit variant viral spike protein virus viruses [DOI] 10.1073/pnas.2106724118 PMC 바로가기 [Article Type] 410
Pathophysiology of SARS-CoV-2 Infection in the Upper Respiratory Tract and Its Relation to Breath Volatile Organic CompoundsOpinion/Hypothesis Published on 2021-07-272022-10-29 Journal: mSystems [Category] COVID-19, [키워드] acute respiratory syndrome airway airways Alter alteration Analysis arising changes in Clinical diagnosis Compound contagious coronavirus COVID-19 diagnosing disease Evidence function Gut Health Infection metabolic processe metabolite microbial Microbiome nasal noninvasive organic presenting public health recent relation respiratory respiratory tract SARS-CoV-2 Screening screening test severe acute respiratory syndrome coronavirus 2 the disease tract upper upper respiratory tract upper respiratory tract infections URTI URTIs VoC VOCs Volatile organic compounds [DOI] 10.1128/mSystems.00104-21 PMC 바로가기 [Article Type] Opinion/Hypothesis
Self-supervised deep learning model for COVID-19 lung CT image segmentation highlighting putative causal relationship among age, underlying disease and COVID-19연령, 기저 질환 및 COVID-19 간의 추정 인과 관계를 강조하는 COVID-19 폐 CT 이미지 분할을 위한 자체 지도 딥 러닝 모델Research Published on 2021-07-262022-09-10 Journal: Journal of Translational Medicine [Category] SARS, 유전자 메커니즘, [키워드] Accuracy age Analysis approach Automatic automatically auxiliary baseline best causal relationship chain Chain Reaction Chest CT image Chest CT images computer vision Computerized tomography consolidation contagious contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis COVID-19 severity COVID-19 testing dataset deep deep learning Diagnosis diagnostic Efficiency evaluate faster feature ground-glass opacity highlighting Image analysis Image segmentation introduced lesion lung Lung CT Lung CT images lung lesions mechanism Mediation analysis Mediation effect phenotype polymerase chain reaction predicted problems provide reaction Result Self-supervised learning severity supplementary material Support underlying disease underlying diseases were used with COVID-19 [DOI] 10.1186/s12967-021-02992-2 PMC 바로가기 [Article Type] Research
CAR-NK Cells Effectively Target SARS-CoV-2-Spike-Expressing Cell Lines In VitroCAR-NK 세포, 시험관 내에서 SARS-CoV-2-스파이크 발현 세포주를 효과적으로 표적화Immunology Published on 2021-07-232022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome coronavirus addition adverse effect Anticoagulants antigen receptor antivirals approach Cancer CAR CAR (chimeric antigen receptor) Cell cells chimeric antigen receptor conserved conserved region contagious convalescent plasma coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 CR3022 current cytokine cytokine production D614G domain E484K E484K variant effective Emergency use escape mutant escape mutants Evidence expressing glycoprotein hematologic immune pressure immune response Immunity immunocompromised condition immunodeficient patients immunomodulators Immunotherapy IMPROVE in vitro include individual isolates kill killing LINE Moderna monoclonal antibody monoclonal antibody therapies mutants N501Y N501Y variant NAbs natural killer neutralizing antibody NK cells off-the-shelf Patient Pfizer Population pseudotyped SARS-CoV-2 virus public health recognize reported respiratory S protein S309 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolates SARS-CoV-2 neutralizing antibody SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 virus scFv Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown Side effect target target cell target cells the vaccines Therapies therapy treat treating COVID-19 Treatment Vaccine Vaccines variants of SARS-CoV-2 [DOI] 10.3389/fimmu.2021.652223 PMC 바로가기 [Article Type] Immunology
Next-Generation Bioinformatics Approaches and Resources for Coronavirus Vaccine Discovery and Development—A Perspective ReviewReview Published on 2021-07-222022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 3D structure acute respiratory syndrome antigenic epitope bioinformatics bioinformatics resources caused computational tool contagious coronavirus coronavirus strain coronavirus vaccine COVID-19 database death disease effective effort epitope experimental validation function Genome sequencing genomic globe immune response immunoinformatics in viral pandemic pathogen platform Protein researcher resource resources review SARS-CoV-2 Stage target the vaccine Vaccine vaccine construct valuable resource [DOI] 10.3390/vaccines9080812 PMC 바로가기 [Article Type] Review
The Characteristics of Spike Glycoprotein Gene of Swine Acute Diarrhea Syndrome Coronavirus Strain CH/FJWT/2018 Isolated in ChinaVeterinary Science Published on 2021-07-222022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] acute diarrhea affected Amino acid Analysis analyzed B cell epitope cell tropism cellular receptor characterized China contagious coronavirus country Critical determine diarrhea epitope family Coronaviridae full-length genome genetic diversity Guangdong host range Infectious disease Interaction Isolated isolates linear Neonatal Neutralizing antibodies Phylogenetic analysis predicted Region similarity spike spike glycoprotein spike glycoprotein gene strain Surveillance swine acute diarrhea syndrome coronavirus (SADS-CoV) syndrome tissue tropism Variation viral isolate virus virus genome virus infection vomiting watery [DOI] 10.3389/fvets.2021.687079 PMC 바로가기 [Article Type] Veterinary Science
Monocytes and Macrophages in COVID-19COVID-19의 단핵구 및 대식세포Review Published on 2021-07-212022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] affected alarmin alveolar macrophage Blood caused cellular characterized clinical manifestation clinical manifestations common cold complex Consequences contagious cough COVID-19 Critical defend Defense detrimental developmental disease dominant dysfunction dysregulated effector cell exacerbating expression Fever Health heterogeneous group HLA-DR homeostasis homeostatic Host host defense hyperinflammation Infection infiltrating Inflammation Inflammatory inflammatory monocyte interferon-stimulated gene invading pathogen invading pathogens knowledge Macrophage macrophage phenotype macrophage phenotypes macrophages mammalian mechanisms mild common cold Moderate COVID-19 monocyte Monocytes mononuclear phagocyte multi-organ failure organism organs pandemic pathogen Pathogens pathological condition pathological conditions patients with moderate phagocytes phenotype plasticity pro-inflammatory cytokine pro-inflammatory cytokine release pulmonary recruited recruitment repair respiratory respiratory distress responsible resulting SARS-CoV-2 scRNA-seq severe disease Severe respiratory distress Symptoms tissue tissue damage Viral viral disease viral infection viral infections while [DOI] 10.3389/fimmu.2021.720109 PMC 바로가기 [Article Type] Review