Coronaviruses Lacking Exoribonuclease Activity Are Susceptible to Lethal Mutagenesis: Evidence for Proofreading and Potential Therapeutics
Research Article
[키워드] 5-FU
activity
antiviral activity
antiviral drug
Author
biochemical
Combination
compared
conserved
coronavirus
CoV
CoV replication
CoVs
Critical
decrease
demonstrated
determine
Epidemic
Evidence
Exoribonuclease
Express
Genetic
high mutation rate
human coronavirus
human disease
Hypothesis
identify
increase in
inhibitor
inhibitory activity
lethal
MERS-CoV
Middle East
Mutagenesis
Mutation
Next-generation sequencing
NO
nonstructural protein 14
nsp14-ExoN
nucleotides
Population
Potential
Prevent
Probability
Proofreading
provide
RdRP
Replication
required
respiratory
responsible
ribavirin
RNA
RNA synthesis
RNA virus
SARS-CoV
selective
sensitivity
severe
Support
susceptible
target
Therapeutics
to define
treated
Vaccine
viral adaptation
Viral protein
viral RNA synthesis
virus
virus replication
while
wild-type
zoonotic
[DOI] 10.1371/journal.ppat.1003565 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1003565 PMC 바로가기 [Article Type] Research Article