Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross-reactivity풍토성 코로나바이러스 교차 반응성을 평가하기 위해 MultiCoV-Ab를 사용하여 임상 일상적인 SARS-CoV-2 혈청학 이상의 탐색Comparative Study Published on 2021-02-192022-09-10 Journal: Nature Communications [Category] MERS, 진단, 치료법, [키워드] Analysis antibodies antibody response against antigens coronavirus Coronaviruses COVID-19 cross-reactive cross-reactivity develop Diagnostic markers diagnostic tests Endemic endemic human coronavirus endemic human coronaviruses evaluate General population humoral immune response Humoral immunity IgG response immune response Immunity immunoassay in vitro individuals majority manifestation MONITOR multiplex Multiplex assay nucleocapsid protein Nucleocapsid proteins overcome pandemic progression required robust SARS-CoV-2 SARS-COV-2 infection Screening sensitivity Sensitivity and specificity Seroconversion Serological assay serology specificity spike and nucleocapsid proteins Support the SARS-CoV-2 uninfected vaccination Vaccine development viral infection [DOI] 10.1038/s41467-021-20973-3 PMC 바로가기 [Article Type] Comparative Study
Neutralizing Human Antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 Isolated from a Human Synthetic Fab Phage Display Library인간 합성 Fab 파지 디스플레이 라이브러리에서 분리된 중증 급성 호흡기 증후군 코로나바이러스 2에 대한 인간 항체 중화Article Published on 2021-02-152022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, 진단, [키워드] absence ACE2 activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinities angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 Antibody therapeutics apparent affinity avidity caused Cell coronavirus coronavirus 2 COVID-19 cross-reactivity D12 develop diagnostics display domain drug target Effect Fab Fabs FIVE Human human monoclonal antibodies Human monoclonal antibody IgGs Immunoglobulin In vitro assay Interaction Isolated library mAb mAbs MERS MERS-CoV moderate monoclonal antibody neutralize neutralizing activities Neutralizing activity outbreak pandemic phage phage display Prophylactic RBD reagent receptor protein Receptor-binding domain reported Research respiratory resulting SARS-CoV spike protein SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus significantly Spike protein Spread synthetic the RBD the SARS-CoV-2 therapeutic drug thermal stability treat unique Vaccine Viral viral entry virus Wuhan Wuhan, China yielding [DOI] 10.3390/ijms22041913 PMC 바로가기 [Article Type] Article
Immunoreactive peptide maps of SARS-CoV-2SARS-CoV-2의 면역반응성 펩타이드 지도Article Published on 2021-02-122022-09-12 Journal: Communications Biology [Category] MERS, 진단, [키워드] 229E Asymptomatic collected cross-reactivity determine healthy high-density HKU1 human coronavirus human coronaviruses humoral immune response identify IgG antibody immunological individual Infection infections Infectious-disease diagnostics linear Linear regression MERS-CoV Mild multidimensional NL63 OC43 peptide peptide microarray plasma plasma sample qPCR required SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 epitope SARS-COV-2 infection SARS-CoV-2 peptide severe SARS-CoV-2 statistical subject subjects viral infection [DOI] 10.1038/s42003-021-01743-9 PMC 바로가기 [Article Type] Article
In silico analysis suggests less effective MHC-II presentation of SARS-CoV-2 RBM peptides: Implication for neutralizing antibody responsesIn silico 분석은 SARS-CoV-2 RBM 펩타이드의 덜 효과적인 MHC-II 제시를 시사합니다: 항체 반응 중화에 대한 의미Research Article Published on 2021-02-112022-09-12 Journal: PLoS ONE [Category] MERS, 진단, [키워드] Analysis Antibody Response Antibody responses B cell cross-reactivity develop effective epitope Epitopes evaluated Examining General population Infection lack less MHC-II MHC-II alleles microbial neutralizing antibody Neutralizing antibody response peptide peptides Post-infection predicted processing raising RBM receptor binding motif SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody Spike protein subject Support T cell T cell epitope T cell memory the spike protein [DOI] 10.1371/journal.pone.0246731 PMC 바로가기 [Article Type] Research Article
Sensitive mass spectrometric determination of kinin-kallikrein system peptides in light of COVID-19Article Published on 2021-02-042022-10-04 Journal: Scientific Reports [Category] MERS, 치료기술, [키워드] activate Adsorption alteration assays Biomarkers blockade cough COVID-19 cross-reactivity Degradation determine drug effort European food impede increasingly limit Medicine nasal non-specific other diseases outbreak pathophysiology peptide promote inflammation quantification raised receptor Regulatory Respiratory tract diseases sensitive sensitivity Support [DOI] 10.1038/s41598-021-82191-7 PMC 바로가기 [Article Type] Article
Clinical performance evaluation of a SARS-CoV-2 Rapid Antibody Test for determining past exposure to SARS-CoV-2SARS-CoV-2에 대한 과거 노출을 결정하기 위한 SARS-CoV-2 신속 항체 검사의 임상 성능 평가Article Published on 2021-02-012022-09-11 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% CI Analytical specificity anti-SARS-CoV-2 antibodies antibody Antibody test antibody tests asymptomatic infection asymptomatic infections automated clinical collected common cold common cold symptoms conducted CoV cross-reactivity demonstrated EDTA Elecsy Elecsys failure rate IgG antibodies IgM/IgG immunoassay Past exposure Patient plasma point-of-care positive Prevalence Rapid rapid antibody test SARS-CoV-2 SARS-COV-2 infection Seropositivity specificity Test was tested was used Whole blood [DOI] 10.1016/j.ijid.2020.11.164 PMC 바로가기 [Article Type] Article
Cross-reactivity of SARS-CoV structural protein antibodies against SARS-CoV-2Article Published on 2021-01-262023-06-15 Journal: Cell Reports [Category] MERS, [키워드] antibody COVID-19 cross-reactivity CSARS-CoV-2 envelope membrane nucleocapsid spike [DOI] 10.1016/j.celrep.2021.108737 PMC 바로가기 [Article Type] Article
Diagnostic Efficiency of Three Fully Automated Serology Assays and Their Correlation with a Novel Surrogate Virus Neutralization Test in Symptomatic and Asymptomatic SARS-COV-2 IndividualsArticle Published on 2021-01-252022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] addition assays asymptomatic patient automated bioMérieux collected control sample correlation COVID-19 COVID-19 pandemic cross-reactivity demonstrated diagnostic domain help highest individual investigated Laboratory LIAISON Mindray Neutralizing antibodies novel nucleocapsid Population screening positive sample provide RT-PCR S1 and S2 SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 RT-PCR sensitivity serology serology assay specificity subunits Support surrogate surrogate virus neutralization test (sVNT) sVNT symptom onset symptomatic patient Test viral antibody virus-neutralizing [DOI] 10.3390/microorganisms9020245 PMC 바로가기 [Article Type] Article
Systematic evaluation of IgG responses to SARS-CoV-2 spike protein-derived peptides for monitoring COVID-19 patients코로나19 환자 모니터링을 위한 SARS-CoV-2 스파이크 단백질 유래 펩타이드에 대한 IgG 반응의 체계적인 평가Clinical Trial Published on 2021-01-222022-08-13 Journal: Cellular and Molecular Immunology [Category] SARS, 임상, 진단, 치료기술, [키워드] 12-mer peptide 95% CI a peptide microarray aa 1148–1159 aa 553–564 aa 577–588 aa 601–612 aa 625–636 Adaptive immunity analyzed antibody asymptomatic patient clinical centers Cohort collected combating Combination comparable Control Coverage COVID-19 cases COVID-19 diagnosis COVID-19 pandemic COVID-19 patient COVID-19 patients cross-reactivity Diagnosis diagnostic Diagnostic markers ELISA exhibited human coronavirus IgG IgG response independent other coronavirus other coronaviruses Patient peptide peptide microarray peptides reagent recombinant Recombinant spike protein S protein S1 protein S1–101 S1–105 S1–93 S1–97 S2–78 SARS-CoV-2 SARS-CoV-2 spike sensitivity sera serological serological test Serological tests several S protein-derived 12-mer peptides specificity spike Spike protein symptomatic and asymptomatic the S1 protein [DOI] 10.1038/s41423-020-00612-5 PMC 바로가기 [Article Type] Clinical Trial
Screening and development of monoclonal antibodies for identification of ferret T follicular helper cellsArticle Published on 2021-01-212022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] animal model antibodies antibody assist Bcl6 Cell clone Critical cross-reactivity CXCR5 effective ferret ferrets follicular Follicular T-helper cells humans Humoral response identify immune system Infection Influenza Lymph node marker mice monoclonal antibodies monoclonal antibody murine pathogenicity PCR-based method reagents response SARS-CoV2 Screening single B cell Tfh Tfh cell Transmissibility Vaccine Vaccines viruses [DOI] 10.1038/s41598-021-81389-z PMC 바로가기 [Article Type] Article