High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cellsSARS-CoV-2에 대한 고친화성 중화 항체는 T 여포 보조 세포 없이 만들 수 있습니다.Article Published on 2022-02-042022-09-11 Journal: Science Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Beta absence Alternative pathway antibody antibody production Antiviral B cell B cell response B cell responses B.1.351 Cell cell interaction cell interactions cells complement damaged driver effective epitope epitope mapping Epitopes Evidence evidence of follicular Germinal center high affinity homologous Immunoglobulin immunoglobulin class immunoglobulin class switching Infection Inflammation Influenza influenza A influenza A virus influenza A virus infection Neutralizing neutralizing antibody occur operative pathway Patient patients Protective reactive receptor reduced responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination Sequencing severe COVID-19 Support switching T cell These data variant Viral viral infection virus infection [DOI] 10.1126/sciimmunol.abl5652 PMC 바로가기 [Article Type] Article
Design of a multi-epitope-based peptide vaccine against the S and N proteins of SARS-COV-2 using immunoinformatics approachResearch Published on 2022-02-042022-11-01 Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19, [키워드] acquisition adjuvant adjuvants antigenic antigenic epitope antigenicity approach B cell B cell epitope C terminal cloned COVID-19 virus CTL develop E. coli epitope evaluated expression HTL identify immune response immunoinformatics Infection linker Mortality Multi-epitope Multi-epitope vaccine N protein non-allergenic non-toxic pandemic peptide predicted reduce Result SARS Coronavirus SARS-CoV-2 SARS-CoV-2 S protein selected supplementary material the vaccine three-dimensional structure Toxicity Vaccine vaccine construct were used [DOI] 10.1186/s43042-022-00224-w PMC 바로가기 [Article Type] Research
Homologous or heterologous booster of inactivated vaccine reduces SARS-CoV-2 Omicron variant escape from neutralizing antibodies불활성화 백신의 동종 또는 이종 부스터는 중화 항체로부터 SARS-CoV-2 오미크론 변이체 탈출을 감소시킵니다.Coronaviruses Published on 2022-02-042022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] accumulated addition antibodies Antibody titer B.1.1.529 BBIBP-CorV booster booster vaccination convalescent dose eight epitope Epitopes Heterologous homologous homologous or heterologous identified variant inactivated Inactivated vaccine individual less mAb mAbs monoclonal antibodies monoclonal antibody neutralization neutralization titer neutralization titers Neutralizing neutralizing antibody Neutralizing antibody titer NTD omicron Omicron variant protein subunit vaccine pseudovirus raising RBD reduce reduction SARS-CoV-2 SARS-CoV-2 variants sera Seven significantly increased spike mutations Subunit vaccine tested the vaccine therapeutic therapeutic antibodies transmission of SARS-CoV-2 urgency Vaccine variant Viral viral variant VOCs ZF2001 [DOI] 10.1080/22221751.2022.2030200 PMC 바로가기 [Article Type] Coronaviruses
Unravelling the molecular interactions between the SARS-CoV-2 RBD spike protein and various specific monoclonal antibodiesSARS-CoV-2 RBD 스파이크 단백질과 다양한 특정 단일클론항체 간의 분자 상호작용 규명Article Published on 2022-02-012022-09-12 Journal: Biochimie [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accelerated Accelerated molecular dynamics ACE2 ACE2 receptor approach cell receptor conformation Conformational study conformations COVID-19 disease CR3022 determine drugs epitope identify increase Interaction knowledge mAb mAbs molecular molecular interaction monoclonal antibody physiological conditions predominant protein-protein interaction RBD Result S protein S309 Salt Bridge SARS-CoV-2 spike glycoprotein Spike protein the RBD the receptor-binding domain the SARS-CoV-2 therapeutic therapeutic option treat Vaccine virus [DOI] 10.1016/j.biochi.2021.10.013 PMC 바로가기 [Article Type] Article
Screening and identification of B cell epitope of the nucleocapsid protein in SARS-CoV-2 using the monoclonal antibodies단일클론항체를 이용한 SARS-CoV-2의 뉴클레오캡시드 단백질 B 세포 에피토프의 스크리닝 및 동정Article Published on 2022-02-012022-09-11 Journal: Applied Microbiology and Biotechnology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Amino acid amino acids antibody antibody affinity Antibody titer Antibody titers Antigen B cell B-cell B-cell epitope cause cells Characteristics codon coronavirus coronavirus disease COVID-19 ELISA epitope expressed expression Guidance high affinity Host immune response insect cell insect cells linear mAb mAbs modulation monoclonal antibodies monoclonal antibody N gene N protein nucleocapsid nucleocapsid protein overlapped peptide peptides Protein reactivity Replication respiratory RNA SARS-CoV-2 SARS-CoV-2 N protein Screening sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown strain targets the N protein the SARS-CoV-2 Transcription variants variants of concern variants of interest Viral viral pathogenesis virus virus detection VOCs VOIs were used [DOI] 10.1007/s00253-022-11769-6 PMC 바로가기 [Article Type] Article
Characterization of the antibody response to SARS-CoV-2 in a mildly affected pediatric population경미한 영향을 받는 소아 집단에서 SARS-CoV-2에 대한 항체 반응의 특성화Article Published on 2022-02-012022-09-12 Journal: Pediatric allergy and immunology : official public [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2-RBD Adults affected age Analysis anti-S antibodies antibody Antibody Response Antigen Asymptomatic Asymptomatic disease binding characterization children comparable conformational control group convalescent Course COVID-19 develop ELISA epitope Features Gender humoral Humoral immunity IgG IgG antibody inhibit Interaction Microarray Mild neutralize Patient patients pediatric Pediatric patient pediatric population peptide performed RBD RBD-ACE2 RBD-specific IgG reactivity response Result SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2-specific IgG seropositive severe disease Specificities subjects Symptom the antibody response the spike protein virus Virus neutralization was performed were assessed while [DOI] 10.1111/pai.13737 PMC 바로가기 [Article Type] Article
Computational Analysis of Mutations in the Receptor-Binding Domain of SARS-CoV-2 Spike and Their Effects on Antibody BindingArticle Published on 2022-01-302022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 ACE2 binding ACE2 receptor administration amino acid replacement Analysis analyzed antibody antigenic antigenic escape approaches binding binding affinity binding free energy bioinformatics Cluster complexes computational analysis computational mutagenesis coronavirus disease Coronaviruses COVID-19 Deleterious Effect epitope Epitopes feature hACE2 human ACE2 receptor human cell identify impairment indicate Infection Interaction monoclonal multiple mutation multiple mutations Mutation Neutralizing neutralizing antibody Pandemics performed produced Protein RBD RBD mutation RBD variant reduce resolved responsible S-protein SAR-CoV-2 SARS-CoV-2 sequence spike Strains Structure the RBD the receptor-binding domain the SARS-CoV-2 the vaccine Trigger Vaccines variants of SARS-CoV-2 virus–host interactions [DOI] 10.3390/v14020295 PMC 바로가기 [Article Type] Article
Cytotoxic T-Cell-Based Vaccine against SARS-CoV-2: A Hybrid Immunoinformatic ApproachArticle Published on 2022-01-302022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 3D structure acquired immunity administration Antigen Antigen presentation binding Cancer immunotherapy canonical cellular cellular immunity characterized Coverage COVID-19 convalescent patient cytotoxic cytotoxic T lymphocytes dendritic cells epithelia epitope Epitopes highest HLA HLA class I hybrid IEDB immune protection immune response immune stimulation immunization immunogenic immunoinformatics in silico In silico methods intranasal long term immunity molecular docking Molecular docking study NetMHCpan non-allergenic non-toxic parameter peptide platform Population positive Probability protein folding provide provided robust SARS-CoV-2 T-Cell vaccine screened stimulate Structure synthetic long peptide T-cells Toll-like receptor Toxicity vaccination VaxiJen 2.0 Viral mutations virus clearance [DOI] 10.3390/vaccines10020218 PMC 바로가기 [Article Type] Article
Three Specific Potential Epitopes That Could Be Recognized by T Cells of Convalescent COVID-19 Patients Were Identified From Spike Protein회복기 COVID-19 환자의 T 세포가 인식할 수 있는 3개의 특정 잠재적 에피토프가 스파이크 단백질에서 확인되었습니다Immunology Published on 2022-01-282022-09-11 Journal: Frontiers in Immunology [Category] 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Amino acid amino acids antibody Antigen Chinese convalescent Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 Coverage COVID-19 COVID-19 convalescent patient COVID-19 convalescent patients COVID-19 patient COVID-19 vaccine COVID-19 vaccines cross-reaction detect disease disease susceptibility Efficacy epitope Epitopes flow cytometry Frequency frequency of occurrence Genotype HLA HLA allele HLA alleles Identified IFN-γ Infection information mononuclear cell neutralizing antibody nonspecific Occurrence peptide peptides Peripheral blood positive Potential Prevent provide provided reaction rate Reactions Research respiratory SARS-CoV-2 SARS-CoV-2 S protein screened Seven severe acute respiratory syndrome Coronavirus severity of COVID-19 Specific spike Spike protein subsequent susceptibility T cell T cells T-cell T-cell epitope T-cell epitopes T-cell immunity Vaccine Viral viral infection [DOI] 10.3389/fimmu.2022.752622 PMC 바로가기 [Article Type] Immunology
Predicted HLA Class I and Class II Epitopes From Licensed Vaccines Are Largely Conserved in New SARS-CoV-2 Omicron Variant of Concern허가된 백신에서 예측된 HLA 클래스 I 및 클래스 II 에피토프는 우려의 새로운 SARS-CoV-2 오미크론 변이체에서 크게 보존됩니다Immunology Published on 2022-01-282022-09-11 Journal: Frontiers in Immunology [Category] 변종, [키워드] alleles analyzed cellular Cellular immune response class concern contagious Critical cytotoxic Efficacy elicited epitope Epitopes escape mutant escape mutation facilitate HLA HLA class 1 HLA class 2 HLA class I HLA class I and II alleles human population immune protection immune responses issue Mutation New new SARS-CoV-2 omicron SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants These data Vaccine vaccine efficacy variant virus [DOI] 10.3389/fimmu.2022.832889 PMC 바로가기 [Article Type] Immunology