Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing StrategyArticle Published on 2020-11-122023-06-19 Journal: Cell [Category] Fulltext, SARS, [키워드] antibody cocktail COVID-19 cryo-EM epitope hamster Mutation neutralizing antibody RBD SARS-CoV-2 spike [DOI] 10.1016/j.cell.2020.09.035 PMC 바로가기
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity530 Published on 2020-10-272022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome animal model Antiviral antiviral activity antiviral drug Antiviral effect antiviral efficacy antiviral therapy Antiviral treatment baseline candidate Candidates clinical clinical trial Consensus Contact coronavirus COVID-19 COVID-19 patient COVID-19 patients dose drug effective Efficacy evaluate Evidence exhibit Favipiravir ferrets globe hamster hamsters High dose Human Hydroxychloroquine identify in vivo Infection infectious virus titer lack low dose lung Lung histopathology macaque Mild nontoxic preclinical model Prophylactic Prophylaxis protective effect reduced reduction in Repurposed drug required SARS-CoV-2 Significance significantly small molecule Spread suggested therapeutic toxic effects Transmission Treatment use of hydroxychloroquine viral disease virus virus levels virus transmission Wuhan [DOI] 10.1073/pnas.2014441117 PMC 바로가기 [Article Type] 530
Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters Research Published on 2020-10-072022-10-05 Journal: Nature Microbiology [Category] SARS, 신약개발, 치료제, [키워드] activity anti-SARS-CoV-2 antimicrobial agents antiviral activity ATPase Compound compounds COVID-19 cytotoxicity drug enzyme exhibited hamster Helicase Helicobacter pylori highlight identify in vitro in vivo Infection Ion ions pandemic of COVID-19 Pneumonia Ranitidine bismuth citrate respiratory tracts SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2-infected cell suppresse suppressed the SARS-CoV-2 therapeutic option Treatment Viral load [DOI] 10.1038/s41564-020-00802-x [Article Type] Research
Evidence of a wide gap between COVID-19 in humans and animal models: a systematic reviewResearch Published on 2020-10-062022-11-01 Journal: Critical Care [Category] COVID-19, MERS, [키워드] animal animal model animal models bioRxiv clinical manifestations Coagulopathy COVID-19 criteria Cytokine storm death elicited Endpoint English evidence of ferret ferrets full recovery hamster hamsters high viral replication Human hypoxemic inclusion criteria Lower respiratory tract Lung pathology macaques medRxiv mice Mild Mortality MOST multiple organ dysfunction non-human primate Other pandemic peer-reviewed study phenotype Prophylaxis Protective reported Research Respiratory failure Result review rodent SARS-CoV-2 searched specific IgG antibody Spike proteins supported systematic review systemic inflammation the MEDLINE Therapies Transient Vaccines [DOI] 10.1186/s13054-020-03304-8 PMC 바로가기 [Article Type] Research
Oral SARS-CoV-2 Inoculation Establishes Subclinical Respiratory Infection with Virus Shedding in Golden Syrian HamstersArticle Published on 2020-09-222023-06-15 Journal: Cell Reports Medicine [Category] MERS, SARS, [키워드] coronavirus COVID-19 feces Gastrointestinal hamster oral SARS-CoV-2 Subclinical [DOI] 10.1016/j.xcrm.2020.100121 PMC 바로가기 [Article Type] Article
Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamstersAd26 백신은 햄스터의 SARS-CoV-2 중증 임상 질환으로부터 보호합니다Letter Published on 2020-09-032022-09-12 Journal: Nature Medicine [Category] Fulltext, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Ad26 Adenovirus animals binding clinical disease clinically coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death demonstrated develop elicited expressing hamster hamsters High-dose Human immunization individual induce Infection intranasal Lower respiratory tract Mild mild illness Mortality Neutralizing antibody response neutralizing antibody responses Pathogenesis Pneumonia preclinical studies preclinical study PROTECT reduction reported respiratory Respiratory failure SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2 vaccines serotype severe acute respiratory syndrome Coronavirus severe pneumonia Spike protein subset Therapeutics These data tissues upper and lower respiratory tracts Vaccine Vaccines Viral viral replication virus replication weight loss [DOI] 10.1038/s41591-020-1070-6 PMC 바로가기 [Article Type] Letter
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal modelResearch Article Published on 2020-08-212022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 binding site acute respiratory syndrome angiotensin-converting enzyme 2 animal model antibodies antibody binding Cohort convalescent coronavirus coronavirus disease countermeasure COVID-19 develop disease donors enrolled epitope facilitate hamster hamsters Health High-dose host cell indicated lung viral titer monoclonal antibody MOST NAb Neutralization assay Neutralizing Neutralizing antibodies neutralizing antibody overlap Participants passive transfer Prevent produced Prophylaxis proportion Protective Protein provide provided RBD RBD-binding antibody receptor Receptor binding domain Region responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibody Science selected survivor tested Therapies therapy transfer treat treated Vaccine design viral spike protein [DOI] 10.1126/science.abc7520 PMC 바로가기 [Article Type] Research Article
Age-Dependent Progression of SARS-CoV-2 Infection in Syrian HamstersCommunication Published on 2020-07-202022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] age age-related disease alveolar alveolar epithelial cell animal model animal models antivirals appear Bronchial epithelium caused cellular tropism coronavirus Course COVID-19 disease edema exhibited hamster hamsters Histopathology humans Immune cell In situ hybridization independent Infection information Lower respiratory tract lung macrophages Mesocricetus auratus morbidity and mortality Older outbreak patients perivascular Pneumonia SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine serology severe respiratory disease Treatment type I Vaccine vascular leakage Viral RNA virus replication weight loss [DOI] 10.3390/v12070779 PMC 바로가기 [Article Type] Communication
Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development530 Published on 2020-07-142022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] acute respiratory syndrome addition animal model antiviral drugs Characteristics China consequence consolidation convalescent serum coronavirus coronavirus disease countermeasure COVID-19 patient disease feature Ground glass opacity hamster hamsters Health human lung immunotherapies Infection inhibited intranasal isolate lesion lung lung lesion Lungs mounted naïve Neutralizing antibody response Novel coronavirus pathogenesis of SARS-CoV-2 Pneumonia Postinfection Region replicate replicated Replication replicative reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolate SARS-CoV-2 pathogenesis serum severe lung injury Significance Spread subsequent suppressed Syrian hamsters transfer Vaccine Vaccines virus virus replication Wuhan, China [DOI] 10.1073/pnas.2009799117 PMC 바로가기 [Article Type] 530
Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junctionArticle Published on 2020-05-042022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] acquisition adaptive Amino acid Asymptomatic Body weight loss cleavage coronavirus COVID-19 Cross-species transmission Deletion detect evaluated examination hamster Human infected cases Infection Laboratory lung motif pandemic pathological change Point mutation positive Prevalence promoted purification Replication S1/S2 junction SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant selective specimen specimens Spike mutant Spike S1/S2 mutant the spike protein unique Vaccine variant variants VERO-E6 Vero-E6 cell virus infection wild type [DOI] 10.1080/22221751.2020.1756700 PMC 바로가기 [Article Type] Article