Next-Generation “-omics” Approaches Reveal a Massive Alteration of Host RNA Metabolism during Bacteriophage Infection of Pseudomonas aeruginosa차세대 "-omics" 접근 방식으로 녹농균(Pseudomonas aeruginosa)의 박테리오파지 감염 동안 숙주 RNA 대사의 대규모 변경이 밝혀짐Research Article Published on 2016-07-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] alteration Analysis approaches Bacteria Bacterial bacterial strains bacteriophage bacteriophages block changes in characterized coding Complete Course Degradation demonstrated drastic early stage Escherichia coli expressed family Gene Expression generate highlight Host infecting Infection infection cycle infection cycles Interaction interfere involved knowledge lifecycle massive metabolic pathway metabolic pathways metabolism metabolomics molecular molecular mechanism molecular mechanisms multidrug resistant nucleotide opportunistic pathogen pathogen produced promote proportion Pseudomonas aeruginosa pyrimidine Regulation required RNA RNA-sequencing RNAs shown stimulate strain suggested therapeutic therapeutic potential therapy transcript transcriptomics treat Trigger triggers Viral viral replication Viral RNA viral RNAs virulent virulent phage virus viruses [DOI] 10.1371/journal.pgen.1006134 PMC 바로가기 [Article Type] Research Article
Exploiting Genetic Interference for Antiviral Therapy항바이러스 치료를 위한 유전자 간섭 활용Review Published on 2016-05-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 신종인플루엔자, [키워드] Antiviral strategies Cell circumvent competing de novo dominant drug resistance Ebola virus Evolution generate Genetic genetic diversity Genome genome replication Health heterogeneity heterogeneous highly pathogenic HIV Influenza Influenza virus inherent interfere Interference Particles Population power replicate therapeutic therapeutic intervention therapy Treatment Viral viral fitness viral variant virus viruses [DOI] 10.1371/journal.pgen.1005986 PMC 바로가기 [Article Type] Review
Analysis of Meiosis in SUN1 Deficient Mice Reveals a Distinct Role of SUN2 in Mammalian Meiotic LINC Complex Formation and FunctionSUN1 결핍 마우스의 감수분열 분석은 포유류 감수분열 LINC 복합체 형성 및 기능에서 SUN2의 뚜렷한 역할을 보여줍니다Research Article Published on 2014-02-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence appear attachment cause chromosome Clusters complexes component composed conserved Critical Deficient demonstrated described detect determine domain driving error event expressed Formation function functional functions Genome homolog indicate infertility interfere KASH5 lead meiosis meiotic meiotic recombination membrane mice nuclear nuclear envelope prophase Protein protein complex protein complexes Proteins provoke recent Recombination regulated retained role shown subsequent SUN1 SUN2 telomere telomeres while [DOI] 10.1371/journal.pgen.1004099 PMC 바로가기 [Article Type] Research Article
Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan연령, 성별 및 암은 아니지만 신경퇴행성 및 심혈관 질환은 수명에 대한 아포지단백 E4 대립유전자의 전신 효과를 강력하게 조절합니다Research Article Published on 2014-01-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adverse effect age allele Analysis ApoE APOE gene ApoE4 allele ApoE4 carrier APOE4 carriers Apolipoprotein Apolipoprotein e association Author Cancer cardiovascular cardiovascular and neurodegenerative diseases cardiovascular disease carriers Cohort cohorts compared CVD death deaths disease Diseases e4 allele e4 allele carrier e4 allele carriers e4 carrier e4 carriers Effect Enduring ENhance explain extreme family Family Study genetic origin genetic origins genotyped ApoE polymorphism Geriatrics Gerontology healthy heart Human human disease human diseases increase interfere large sample lead life Life expectancy lifespan Long Longitudinal studies Major mechanism mechanisms men moderate Mortality neurodegenerative neurodegenerative disorder neurodegenerative disorders Non-skin cancer offspring old ages participant polymorphism Population populations Relative risk resulting risk risk of death sensitivity skin cancer survival systemic women [DOI] 10.1371/journal.pgen.1004141 PMC 바로가기 [Article Type] Research Article
Post-Transcriptional Control of Type I Interferon Induction by Porcine Reproductive and Respiratory Syndrome Virus in Its Natural Host CellsReview Published on 2012-05-022022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Control defined dsRNA molecules gastroenteritis host cell inducer induction inhibit interfere less natural post-transcriptional regulation PRRSV Regulation reproductive respiratory syndrome TGEV translational translational control Type type I interferon virus [DOI] 10.3390/v4050725 PMC 바로가기 [Article Type] Review
Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A VirusResearch Article Published on 2011-01-062022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] Acidic Author bypasse bypassed cathepsin L Cell cellular cellular tropism circumvent compared Control cytoplasm described did not reduce Ebola Ebola virus Endocytic pathway ENhance example Express expression Factors Filovirus glycoprotein highly pathogenic IAV IFITM IFITM1 IFITM3 indicate Infection infectious influenza A virus inhibit inhibited innate immune system interfere late stage less limit lysosomal modulate murine observation pathogenic viruses pattern plasma membrane Protein Proteins pseudovirions receptor Replication restrict restriction restriction factor SARS Coronavirus SARS-CoV transmembrane transmembrane protein Treatment viral replication virion virus viruses [DOI] 10.1371/journal.ppat.1001258 PMC 바로가기 [Article Type] Research Article
Mouse Hepatitis Coronavirus RNA Replication Depends on GBF1-Mediated ARF1 ActivationResearch Article Published on 2008-06-132022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] Activation ADP-ribosylation Analysis ARF ARF1 association Author cells cellular cellular pathway characteristic complex connection coronavirus Coronavirus replication Critical demonstrated dominant-negative downstream Endoplasmic reticulum Express expression Factors GBF1 GTPase GTPases guanine Host Human induce infected cell Infection inhibited inhibiting interfere involved knockdown MDCK cells membrane MHV Microscopy mouse mouse hepatitis mutant nucleotide observation provide Quantitative reduced Replication replication complex required RNA RNA virus secretory pathway significantly siRNA siRNAs structures target vesicles viruses [DOI] 10.1371/journal.ppat.1000088 PMC 바로가기 [Article Type] Research Article
Improved microarray gene expression profiling of virus-infected cells after removal of viral RNAMethodology Article Published on 2008-05-142022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] Accuracy acquisition alteration analyses conditions coronavirus detect different False-positive Gene Expression Gene expression profiling host cell IMPROVE Improved infected cell Infection interfere investigated mean Microarray microarray analysis Microarrays reduced reliability Result RNA RNAs sensitivity significantly tested total RNA Viral RNA virus-infected cell vRNA [DOI] 10.1186/1471-2164-9-221 PMC 바로가기 [Article Type] Methodology Article
Coronavirus Non-Structural Protein 1 Is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus VaccinesResearch Article Published on 2007-08-102022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] acute respiratory syndrome analyzed antigen-presenting cell Author Cell culture Cell-mediated immunity cellular Cellular immune response coding sequence coronavirus Coronavirus infection coronavirus vaccine Coronavirus vaccines Coronaviruses Culture deleting dendritic cell disease elicited Factors Gene Expression genetics Heterologous homolog homologous IFN immune responses implication in vitro in vivo interfere long-lasting low dose macrophages Major MHV mice mouse hepatitis virus murine model mutant mutant virus non-structural protein pathogenicity plasmacytoid dendritic cells prevention Protective protective immune response Protein provide recombinant vaccine reduced replicate Replication replication-competent virus restored retained SARS-coronavirus sequence Spread T cell response tissue Type I IFN type I interferon vaccination Vaccine viral disease viral pathogenicity viral pathogens virus wild-type [DOI] 10.1371/journal.ppat.0030109 PMC 바로가기 [Article Type] Research Article
Chloroquine is a potent inhibitor of SARS coronavirus infection and spreadResearch Published on 2005-08-222022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] abrogate acute respiratory syndrome addition angiotensin-converting enzyme 2 Antiviral compounds Antiviral effect appear binding caused Cell Cell culture cellular receptor Chloroquine clinically concentrations coronavirus described effective Elevation endosomal pH function immunofluorescence assay Infection inhibition inhibitor inhibitory effect interfere NO primate cells Prophylactic Result resulting SARS Coronavirus SARS CoV SARS-CoV SARS-CoV infection severe severe acute respiratory syndrome Coronavirus Spread terminal glycosylation therapeutic therapy treated virus virus spread [DOI] 10.1186/1743-422X-2-69 PMC 바로가기 [Article Type] Research