Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis짧은 사슬 지방산 아세테이트는 호흡기 세포융합 바이러스 세기관지염이 있는 유아의 세포에서 RIG-I에 의해 매개되는 항바이러스 반응을 유발합니다Article Published on 2022-03-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 치료제, [키워드] A549 A549 cell A549 cells Acetate Admission animal animals antiviral response Bronchiolitis Cell clinical clinical isolates code COVID-19 demonstrated disease severity duration of fever Effect epithelial cell epithelial cells examined expression faster fatty fecal gut microbiota Hospitalized IFNB1 Impact in vitro Increased increased expression Infant Infants Infection interferon interferon-stimulated gene interferon-stimulated genes intranasally ISG ISG15 ISGs isolate isolates lung MAVS mice microbial modulation mouse model OAS1 oxygen oxygen saturation Patient PROTECT receptor reduce reduced reduction in respiratory respiratory cell respiratory epithelial cell respiratory epithelial cells respiratory syncytial virus RIG-I RSV SARS-CoV-2 infected patient SARS-CoV-2 infected patients severity significantly Stool strain Strains treated Treatment Trigger Viral load virus virus recognition [DOI] 10.1016/j.ebiom.2022.103891 PMC 바로가기 [Article Type] Article
Lack of association between pandemic chilblains and SARS-CoV-2 infection유행성 아동과 SARS-CoV-2 감염 사이의 연관성 부족420 Published on 2022-02-252022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibodies antibody Antibody Response Antibody responses antiviral immune response assays association biopsy causative agent chilblain chilblains Cohort Connecticut coronavirus covid toe diagnose diagnosed Direct Endpoint enrolled enzyme-linked immunosorbent enzyme-linked immunosorbent assay epitope Evidence evidence of First wave immune profiling immunohistochemical staining incidence infections interferon Microarray molecular Most patients pandemic Patient PCR peptide performed pernio positive robust SARS-CoV-2 SARS-COV-2 infection Sequencing seronegative serum severe acute respiratory syndrome Coronavirus Significance staining subsequent Support T cell T cell receptor T cell response T cell responses tissue tissues viral infection were assessed [DOI] 10.1073/pnas.2122090119 PMC 바로가기 [Article Type] 420
Type I Interferons in Systemic Lupus Erythematosus: A Journey from Bench to BedsideReview Published on 2022-02-242024-09-02 Journal: International Journal of Molecular Sciences [Category] 대상포진, [키워드] anifrolumab biologics IFN interferon precision medicine SLE systemic lupus erythematosus [DOI] 10.3390/ijms23052505 PMC 바로가기 [Article Type] Review
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infectionArticle Published on 2022-02-232022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 임상, 치료기술, [키워드] airway antiviral immune response approach characterized circulating COVID-19 immune Immune cell immune response immune signature Immunological response Immunomodulatory therapies implication Infection Inflammatory diseases interferon ISG limit Local monocyte natural Patient phenotype Prevent Prognosis progressive disease Protective protective immunity reduced resolved SARS-CoV-2 SARS-CoV-2 infected patient SARS-COV-2 infection SARS-CoV2 infection stimulated subset systemic inflammatory T cells trajectory upper airway upper respiratory upregulation viral infection viral spread [DOI] 10.1038/s41467-022-28508-0 PMC 바로가기 [Article Type] Article
Durable T-cellular and humoral responses in SARS-CoV-2 hospitalized and community patientsSARS-COV-2 입원 및 지역 사회 환자의 내구성 T- 세포 및 체액 반응Clinical Trial Published on 2022-02-222022-09-10 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, [키워드] age analyzed antibody Antibody Response Antibody responses assays Blood blood sample Blood samples boost Clinical data clinical observations collected Community Comorbidity determine diagnosed ELISA Gender Hospitalized Humoral response IFN-γ IgA IgG IgM IL-2 immune response Immunity immunosorbent impacted infected patients Infection interferon interferon-γ interleukin investigated long-term memory memory response microneutralization mononuclear cell mononuclear cells neutralization Neutralizing antibodies neutralizing antibody pandemic Patient patients peripheral Peripheral blood Peripheral blood mononuclear cells prospective cohort Protein pseudotype Re-infection recruited response Result risk RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 virus secreting serum sample serum samples severity severity of illness specific antibodies specific antibody T-cell Response T-cell responses vaccination variant variants of concern virus-specific T-cell response virus-specific T-cell responses viruses [DOI] 10.1371/journal.pone.0261979 PMC 바로가기 [Article Type] Clinical Trial
Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 InfectionImmunology Published on 2022-02-212022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] Activation adaptive addition antigen-presentation Cell complex interplay concerning COVID-19 DCs dendritic dendritic cells Depletion disorder immune systems Immunity Immunopathogenesis Immunotherapy Infection innate immune Innate immunity intercellular interferon overcome potential mechanism reduced Research SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 severe SARS-CoV-2 uncontrolled understanding vaccination [DOI] 10.3389/fimmu.2022.843342 PMC 바로가기 [Article Type] Immunology
An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicityArticle Published on 2022-02-172023-06-20 Journal: Cell [Category] Fulltext, MERS, [키워드] coronavirus Dectin Inflammation influenza A virus Innate immunity interferon PAMP pathogen-associated molecular pattern pattern recognition receptor PRR SARS-CoV-2 viral glycoprotein [DOI] 10.1016/j.cell.2022.01.009 PMC 바로가기
SARS-CoV-2 variants of concern display enhanced intrinsic pathogenic properties and expanded organ tropism in mouse models우려되는 SARS-CoV-2 변이체는 마우스 모델에서 향상된 고유 병원성 특성 및 확장된 기관 친화성을 나타냅니다.Article Published on 2022-02-152022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] accelerated ACE2 receptor Alpha Alpha variant Antibody neutralization Beta Beta variant cellular cellular immunity curtail cytokine cytokine production Depletion disease Disease progression elicit expand Gamma Gamma variant gastrointestinal tract hACE2 host range human ACE2 immune activation immune responses induce Infection Inflammation innate immune response interferon intrinsic ISG ISG expression K18-hACE2 lung Lungs management mice mouse model murine Natural killer cells neutralization organ pandemic pathogenic pathogenicity reduced replicate responses reveal SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spread Symptoms systemic infection tissue transgenic Transmissibility Trigger variants variants of concern VoC VOCs wild-type zoonotic transmission [DOI] 10.1016/j.celrep.2022.110387 PMC 바로가기 [Article Type] Article
Adipose tissue in COVID-19: detection of SARS-CoV-2 in adipocytes and activation of the interferon-alpha responseCOVID-19의 지방 조직: 지방 세포에서 SARS-CoV-2 감지 및 인터페론-알파 반응 활성화Original Article Published on 2022-02-152022-09-10 Journal: Journal of Endocrinological Investigation [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] ACE2 gene activate Activation adipocyte adipocytes adipose Adipose tissue Adults age and sex Alpha alteration appear association Autopsy BMI cardiac death cause causes Cell characterization Control controls COVID-19 COVID-19 case COVID-19 cases COVID-19 cohort cytoplasm death Deceased fat Features form Genome IFN IFN-alpha Immune transcriptome immune-related genes infect infiltrating Inflammatory mediators interferon interferon-alpha investigation leukocyte leukocytes lung parenchyma mechanism mediators moderate moderate to severe nucleocapsid antigen obesity objective parenchymal Pathogenesis pathway PCR progression proportion Result risk factor RT-PCR SARS-CoV-2 SARS-CoV-2 genome severe disease severe forms of COVID-19 specimen Subcutaneous subcutaneous fat subject sudden cardiac death the SARS-CoV-2 the SARS-CoV-2 genome tissue Transcription trauma upregulation virus virus antigen virus antigens [DOI] 10.1007/s40618-022-01742-5 PMC 바로가기 [Article Type] Original Article
Cell specific peripheral immune responses predict survival in critical COVID-19 patients세포 특이적 말초 면역 반응은 중요한 COVID-19 환자의 생존을 예측합니다Article Published on 2022-02-152022-09-10 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, [키워드] Accuracy Activation antibody Antigen presentation Applied immunology Blood CD14 CD16 Cell cell cycle cell type cell types cells circulating Clinical management complex COVID-19 COVID-19 patients Critical critical COVID-19 patient critical COVID-19 patients Critically ill critically ill COVID-19 patients dataset Differential gene expression framework identify identifying Immune cell immune cell type independent Infection interferon interferon signaling machine mechanism monocyte Monocytes mononuclear cells Mortality NK-cell Pathogens pathway Peripheral blood peripheral immune response predict predictor prognostic indicator promote Regulation risk stratification SARS-CoV-2 sequence Single Cell single cell sequencing Single-cell RNA sequencing survival systemic immune response transcriptional transcriptomes transcriptomics Trigger triggers viral infection [DOI] 10.1038/s41467-022-28505-3 PMC 바로가기 [Article Type] Article