Identifying SARS-CoV Membrane Protein Amino Acid Residues Linked to Virus-Like Particle AssemblyResearch Article Published on 2013-05-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acid acute respiratory syndrome addition affected Amino acid amino acid residue analyses Analysis assembly codon coexpressed Combined conserved coronavirus Critical cysteine residue ectodomain endodomain identify identifying Interaction involved membrane motif mutant Mutation nucleocapsid Particle Protein reduced reduction in regions required residue Result SARS-CoV SARS-CoV virus secretion sequence Serine severe significantly Substitution transmembrane vesicles virus Virus-like particle VLP VLPs [DOI] 10.1371/journal.pone.0064013 PMC 바로가기 [Article Type] Research Article
The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve the HLA Class I Antigen Recognition GrooveHLA 클래스 I 항원 인식 그루브와 관련된 중국 비인두암의 주요 유전적 결정인자Research Article Published on 2012-11-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele allele frequencies alleles Amino acid Analysis analyzed antigens association associations Author binding Cancer carcinoma carried China Chinese chromosome chromosome 6 class Cohort concert dependent on detect detected determinant disease driven by EBV epithelial Epstein-Barr virus examined facilitated GABBR1 Gene gene region genetic influence Genome-wide association study Groove Guangdong Guangxi GWAS HCG9 help High-resolution HLA HLA alleles HLA class I HLA class I gene HLA region HLA-A HLA-A and -B HLA-B HLA-F incidence independent Infection influences influences on Interaction involved large cohort Linkage disequilibrium malignancy molecular motif multivariate Nasopharyngeal carcinoma NPC nucleotide operative OR2H1 over peptide performed physically principal Recognition recognize Region regression analysis replicate Replication resolved risk second sequence SNP SNPs statistical study participant the major histocompatibility the strongest variant variants virus infection [DOI] 10.1371/journal.pgen.1003103 PMC 바로가기 [Article Type] Research Article
Identification of a conserved linear B-cell epitope in the M protein of porcine epidemic diarrhea virusResearch Published on 2012-10-012022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Amino acid Analysis Antigen antigenic B-cell epitope C-terminus cell line conserved Coronaviruses demonstrated diagnostic different elicit ELISA enzyme-linked immunosorbent epidemic diarrhea epitope epitope-based vaccines fusion protein gastroenteritis GST identification information linear M protein membrane monoclonal antibody motif overlapping PEDV protective antibodies Protein provide reactivity Result secreting sequence serum shown Strains virus was obtained were expressed western blot [DOI] 10.1186/1743-422X-9-225 PMC 바로가기 [Article Type] Research
Interferon Regulatory Factor 8 Regulates Pathways for Antigen Presentation in Myeloid Cells and during Tuberculosis인터페론 조절 인자 8은 골수 세포 및 결핵 기간 동안 항원 제시 경로를 조절합니다Research Article Published on 2011-06-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (major histocompatibility complex activate Activation allele Analysis Antigen presentation antigen processing Author binding binding site cellular pathway cellular pathways chromatin chromatin immunoprecipitation class Combination component Critical cytokine Defense dendritic cell dendritic cells differentiation early response endomembrane eQTLs expressed expression F2 Factor fixed functional Gene gene transcription GTPase GTPases histocompatibility complex Host–pathogen interaction identify IFNγ IL-12 IL12 immune response Infected Infection interferon gamma interferon regulatory factor interleukin intracellular pathogens intrinsic investigated IRF8 lipopolysaccharide LPS lung tissue lung tissues Lungs Macrophage macrophages major histocompatibility complex maturation member MHC mice Microarray Microarrays microbial motif mutant Mycobacterium tuberculosis myeloid myeloid cell myeloid cells ontogeny Pathogens pathway Pathways presentation priming progenitor cells promoter promoters Proteins pulmonary tuberculosis regulated Regulation represse required resistance to infection resistance to infections significantly Stimulation susceptible target transcript Transcription transcriptional treated Tuberculosis wild-type [DOI] 10.1371/journal.pgen.1002097 PMC 바로가기 [Article Type] Research Article
Coronavirus Gene 7 Counteracts Host Defenses and Modulates Virus VirulenceResearch Article Published on 2011-06-092022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence accelerated accessory gene acquisition Activation Analysis Antiviral antiviral response Apoptosis assay association Author benefit binding caspase catalytic caused Cell cellular RNA clinical disease compared conserved coronavirus CoV cultures Cytopathic effect Defense Degradation Deleterious demonstrated eIF2α ENCODE eukaryotic translation evade Evolution expression Genome growth Host host antiviral response host cell hydrophobic immune response indicated Infected infected cells Infection Innate inoculation Interaction led to mechanism modify modulation molecular mechanism motif mutant mutant virus Newborn observation parental pathology Pathways persistence Phosphorylation promoted Protein protein phosphatase 1 provided pull-down reducing required RNA degradation RNA viruses RNase selective sequence subunit suggested survival TGEV tissue translational transmissible gastroenteritis virus Viral RNA virulence virus virus infection [DOI] 10.1371/journal.ppat.1002090 PMC 바로가기 [Article Type] Research Article
Development of loop-mediated isothermal amplification assay for detection of human coronavirus-NL63Article Published on 2011-04-272022-11-01 Journal: Journal of virological methods [Category] Coronavirus, [키워드] Analysis cell culture supernatant conserved coronavirus cross-react Detection limit develop development diagnostic distribution found Genome HCoV-NL63 Human isothermal amplification Laboratory LAMP Loop-mediated isothermal amplification motif Netherlands NL63 nucleic acid Other respiratory viruses pathogen PCR Prevalence Real-time PCR RNA specimens technique [DOI] 10.1016/j.jviromet.2011.04.024 PMC 바로가기 [Article Type] Article
Mutagenesis of the transmembrane domain of the SARS coronavirus spike glycoprotein: refinement of the requirements for SARS coronavirus cell entryResearch Published on 2009-12-242022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] assays cell entry cell-cell fusion cells characteristic Critical cysteine cysteines described domain glycine hydrophobic investigated lysine membrane fusion motif Particle pseudotyped Receptor binding residue Result SARS Coronavirus SARS CoV SARS-CoV Spike protein target cells the S protein transmembrane domain viral membrane virus [DOI] 10.1186/1743-422X-6-230 PMC 바로가기 [Article Type] Research
Prevention of Cytotoxic T Cell Escape Using a Heteroclitic Subdominant Viral T Cell DeterminantResearch Article Published on 2008-10-242022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] alteration amino acid substitution Analysis antigen-specific T cell association Author CD8+ T cell changes in clinical disease complex Complex molecule conformation Consensus Critical CTL cytotoxic determinant Disease progression Diseases elicit Enhancing epitope escape expressed functional Hepatitis histocompatibility HIV immune response immune responses immunodominant Infected Local Major memory MHC class I mice molecular basis motif mouse hepatitis mutated Mutation natural infection occur pathogen peptide performed prevention PROTECT Protective recombinant residue response significantly higher stability Subdominant T cell T cell epitope T cell response tumor immunity Vaccine development viral infection virus wildtype [DOI] 10.1371/journal.ppat.1000186 PMC 바로가기 [Article Type] Research Article
Molecular Epidemiology of SARS-associated Coronavirus, BeijingResearch Published on 2005-09-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] amplified amplified products Beijing Characteristics clinical sample Cluster collected coronavirus different dominant Epidemics geographic location Guangdong Host immune pressure isolate loci molecular Molecular epidemiology motif Mutation nucleotide Patient patients reported RT-PCR RT-PCR, research SARS-CoV selective sequence Sequencing Severe acute respiratory syndrome single nucleotide variation SNV SNVs to define Variation viral adaptation were used [DOI] 10.3201/eid1109.040773 PMC 바로가기 [Article Type] Research
A Three-Stemmed mRNA Pseudoknot in the SARS Coronavirus Frameshift SignalResearch Article Published on 2005-06-172022-10-28 Journal: PLoS Biology [Category] Coronavirus, [키워드] Affect Analysis antiviral drugs antiviral therapeutics assay conserved coronavirus Coronaviruses double-stranded RNA Efficiency frameshift fusion protein GenBank database Gene Expression Genetic Genome in vivo Inspection Interaction Local motif mRNA Mutation nuclear ORF1a ORF1b other coronavirus overlap predicted promote Proteins pseudoknot Region RNA RNA virus SARS virus SARS-CoV sequence signal Structure supported two-dimensional virus yeast [DOI] 10.1371/journal.pbio.0030172 PMC 바로가기 [Article Type] Research Article