Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera회복기 및 백신 혈청에 의한 SARS-CoV-2 B.1.1.7 변이체의 중화 감소Article Published on 2021-04-152022-09-11 Journal: Cell [Category] MERS, SARS, 변종, 진단, [키워드] Abstract ACE2 ACE2 binding Amino acid amino acid change Analysis antibody Antibody Response Antibody responses appearance B.1.1.7 B.1.1.7 variant binding affinity can not caused Contact convalescent death dominant elicited ENhance escape evade generate IGHV3-53 Kent monoclonal antibodies monoclonal antibody mutant virus mutant viruses N501Y natural antibody natural infection neutralization neutralize neutralized original original form pandemic parental reduced residue responses responses against SARS-CoV-2 SARS-CoV-2 B.1.1.7 SARS-COV-2 infection sera Transmission vaccination Vaccine Vaccines variant virus virus replication Virus spike viruses widespread [DOI] 10.1016/j.cell.2021.02.033 PMC 바로가기 [Article Type] Article
mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variantsSARS-CoV-2 및 순환 변이체에 대한 mRNA 백신 유도 항체Article Published on 2021-04-012022-09-11 Journal: Nature [Category] MERS, SARS, 변종, 진단, [키워드] anti-SARS-CoV-2 antibody arising binding BNT162b2 Cell circulating variant Clinical efficacy Clinical use Cohort Donor E484K elicited epitope Epitopes expressing IgM and IgG individual injection K417N memory B memory B cell memory B cells Moderna monoclonal antibodies monoclonal antibody mRNA mRNA vaccine mRNA vaccines mRNA-1273 Mutation N501Y N501Y mutation natural infection neutralization neutralize Neutralizing activity Pfizer-BioNTech plasma RBD RBD-specific memory B cells receptor response SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 variant SARS-CoV-2 variants selected Spike protein stomatitis tested the vaccine the vaccines titre Vaccine Vaccines variants vesicular stomatitis vesicular stomatitis virus Volunteer volunteers was reduced [DOI] 10.1038/s41586-021-03324-6 PMC 바로가기 [Article Type] Article
SARS-CoV-2 re-infection risk in AustriaObservational Study Published on 2021-04-012022-10-05 Journal: European Journal of Clinical Investigation [Category] SARS, 임상, [키워드] 95% confidence interval acute respiratory syndrome both group comparable concerning coronavirus coronavirus disease COVID-19 disease effective epidemiological Epidemiology estimate evaluate excluded False positive First wave General population highest Immunity individual Infection National natural infection Odds ratio PCR polymerase chain positive PCR Primary outcome protection public health measure question Re-infection recorded Research retrospective risk SARS-CoV-2 SARS-COV-2 infection second wave survivor Vaccination strategies Vaccine [DOI] 10.1111/eci.13520 PMC 바로가기 [Article Type] Observational Study
Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies Research Published on 2021-03-262022-10-05 Journal: Nature Medicine [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome antibody B.1.1.7 B.1.351 B.1.351 variant B1.351 circulating collected convalescent convalescent individual convalescent sera coronavirus D614G examined gene encoding GFP immune evasion immunized individual individuals infected individuals Infection less Mutation nasal swab natural infection Neutralization assay neutralized neutralizing antibody neutralizing titers Pfizer positive raise reduction in remained reporter cell risk of infection SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 B.1.1.7 SARS-CoV-2 variant sensitivity sera Serological assay South Africa Spike protein spread to strain Symptoms tested the spike protein United Kingdom vaccinated individual vaccination vaccine dose vaccinees variant virus [DOI] 10.1038/s41591-021-01318-5 [Article Type] Research
Endogenously Produced SARS-CoV-2 Specific IgG Antibodies May Have a Limited Impact on Clearing Nasal Shedding of Virus during Primary Infection in Humans내인적으로 생성된 SARS-CoV-2 특이적 IgG 항체는 인간의 1차 감염 동안 바이러스의 비강 배출 제거에 제한적인 영향을 미칠 수 있음Article Published on 2021-03-202022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] antibody antibody kinetics antigenic antigenic stimulation binding characterized Clearing Clinical severity ENhance Human IgG IgG and IgM IgG antibodies IgG level IgG levels IgM antibodies Immunity Impact Infection isotype Limited mathematical mathematical model Mathematical models Mitigation nasal passage nasal passages natural infection neutralization no effect occur Primary infection production rate resulting SARS-CoV-2 SARS-CoV-2 viral severe disease severity shedding Specific specific IgG antibodies specific IgG antibody specific neutralizing antibodies specific neutralizing antibody symptom onset therapeutic purposes Trigger triggers vaccination Viral viral clearance viral dynamics virus while [DOI] 10.3390/v13030516 PMC 바로가기 [Article Type] Article
Detection of Pintomyia fischeri (Diptera: Psychodidae) With Leishmania infantum (Trypanosomatida: Trypanosomatidae) Promastigotes in a Focus of Visceral Leishmaniasis in BrazilArticle Published on 2021-03-122023-06-22 Journal: Journal of medical entomology [Category] 조류인플루엔자, [키워드] Leishmania infantum natural infection Pintomyia fischeri Sand fly visceral leishmaniasis [DOI] 10.1093/jme/tjaa199
Persistence of SARS-CoV-2-specific B and T cell responses in convalescent COVID-19 patients 6-8 months after the infection감염 후 6~8개월 후 회복 중인 COVID-19 환자에서 SARS-CoV-2 특이적 B 및 T 세포 반응의 지속성Article Published on 2021-03-122022-09-11 Journal: Med (New York, N.Y.) [Category] MERS, SARS, 변종, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptive Adaptive immune response adaptive immune responses addition anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG Anti-spike antibody B cell binding domain center collected convalescent convalescent COVID-19 patient coronavirus disease Coronavirus disease 2019 Coronavirus-2 Council Course COVID-19 COVID-19 patients COVID-19 research Critical disease declined development Diagnosis disease severity Donor elevated European Horizon IgG immune immune response immune responses Immunity Immunoglobulin immunoglobulin M immunological Immunological memory Infection information Italian Level Longevity longevity of immune response Medicine medium memory B Mild Ministry of Health monitoring National natural infection Neutralizing Neutralizing activity neutralizing antibody onset of symptom patients plasma Protective protective immunity provide remained Research respiratory SARS-CoV-2 serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly lower subset supported Swedish symptom onset T cell T cell response T cell responses tested the patient union vaccination Vaccination strategies Vaccination strategy variants virus [DOI] 10.1016/j.medj.2021.02.001 PMC 바로가기 [Article Type] Article
Antibody Response to the BNT162b2 mRNA COVID-19 Vaccine in Subjects with Prior SARS-CoV-2 InfectionSARS-CoV-2 감염 이전에 BNT162b2 mRNA COVID-19 백신에 대한 항체 반응Clinical Trial Published on 2021-03-052022-08-13 Journal: Viruses [Category] SARS, 임상, 진단, [키워드] all subject all subjects analyzed Anti-spike anti-spike RBD IgG antibody antibody antibody levels Antibody Response Antibody titers BNT162b2 BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine booster both groups control subject COVID-19 COVID-19 vaccine COVID-19 vaccines decrease develop domain effective response expected first dose Frequency healthcare worker IgG antibodies IgG antibody immune memory immune memory persist immune response immunogenicity individual induce infected individuals Infection local pain naïve individuals naïve subject naïve subjects natural infection Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers nine no significant difference not significantly different pre-existing immunity rapid increase RBD reactogenicity response SARS-CoV-2 SARS-COV-2 infection Side effects single dose subjects sustained the antibody response the vaccine titers vaccination Vaccine vaccine dose vaccine doses vaccine-associated side effects [DOI] 10.3390/v13030422 PMC 바로가기 [Article Type] Clinical Trial
A household case evidences shorter shedding of SARS-CoV-2 in naturally infected cats compared to their human owners가정 사례는 인간 소유자에 비해 자연적으로 감염된 고양이에서 SARS-CoV-2가 더 짧게 배출된다는 증거를 보여줍니다.Coronaviruses Published on 2021-03-052022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis antibody coronavirus detectable determine disease disease spread domestic cats ELISA test Evidence female females household Households Human Infection male mild respiratory symptom mild respiratory symptoms natural infection occurred positive respiratory respiratory symptoms RT–PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 tested the SARS-CoV-2 Transmission Viral viral infection viral infections viral sequence viral shedding virus isolation [DOI] 10.1080/22221751.2020.1863132 PMC 바로가기 [Article Type] Coronaviruses
Comparative Assessment of Sera from Individuals after S-Gene RNA-Based SARS-CoV-2 Vaccination with Spike-Protein-Based and Nucleocapsid-Based Serological AssaysCommunication Published on 2021-03-032022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Anti-spike antibody assessment Breakthrough infection Comparative COVID-19 detectable different time point Effect epitope Euroimmun expected first dose humoral IgA IgG IgM individual natural infection nucleocapsid positive Protein RNA vaccine SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein second dose serological serological response serology serum sample specificity Spike protein Surveillance the vaccine vaccination vaccination against COVID-19 vaccinee while [DOI] 10.3390/diagnostics11030426 PMC 바로가기 [Article Type] Communication