Oxidative Stress and Inflammatory Biomarkers for the Prediction of Severity and ICU Admission in Unselected Patients Hospitalized with COVID-19COVID-19로 입원 한 선택되지 않은 환자의 중증도 및 ICU 입원 예측을위한 산화 스트레스 및 염증 바이오 마커Article Published on 2021-07-122022-08-31 Journal: International Journal of Molecular Sciences [Category] SARS, 바이오마커, [키워드] Admission albumin AUC best Biomarker Biomarkers calprotectin cell activation cellular activation Concentration COVID-19 COVID-19 patient COVID-19 patients Critical disease severity Dyspnoea hospital ICU ICU admission IL-6 indicated Inflammation Inflammatory interleukin interleukin-6 Ischemia Logistic regression measurement Mild Mortality Negative predictive value outcome overweight oxidative stress Patient plasma Positive predictive value predict prediction Predictive Predictive value predictive value) prognostic Protein retrospective risk SARS-CoV-2 SARS-COV-2 infection scored sensitivity severity significantly increased specificity survival curve Survival curves thiol threshold with COVID-19 [DOI] 10.3390/ijms22147462 PMC 바로가기 [Article Type] Article
Predictive Modeling of Morbidity and Mortality in Patients Hospitalized With COVID-19 and its Clinical Implications: Algorithm Development and InterpretationOriginal Paper Published on 2021-07-092022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, SARS, [키워드] 24 hour 24 hours age assist AUC Blood urea nitrogen C-reactive protein canonical markers clinical clinical activity Clinical data clinical decision clinical marker coronavirus COVID-19 COVID-19 pandemic Deceased Decision making development Diabetic Disease progression disease severity effort elevated Endpoint Factor feature Final Glucose Gradient Health care system highest hospital Hospital stay Hospitalization ICU identify intensive care lab value lactate dehydrogenase LDH machine learning marker Model modeling morbidity morbidity and mortality Mortality New York New York City objective offered outcome outcomes Patient patient data performance peripheral oxygen saturation positive predict prediction Predictive Predictive modeling respiration rate Result Retrospective study risk SARS-CoV-2 severity strain Symptom temperature tested treated university Ventilated was obtained with COVID-19 [DOI] 10.2196/29514 PMC 바로가기 [Article Type] Original Paper
Validation of a Prospective Urinalysis-Based Prediction Model for ICU Resources and Outcome of COVID-19 Disease: A Multicenter Cohort StudyArticle Published on 2021-07-092022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] abnormality Acute kidney injury Admission Algorithm categories clinical outcomes Course COVID-19 death disease disease severity elevated eligible Enrollment Extra-corporeal membrane oxygenation hospital Hospital admission Hypothesis ICU ICU admission ICU resources mechanical ventilation Model Mortality outcome patients pilot study Post-mortem predict prediction preventive measures Prospective renal renal replacement therapy resource risk risk stratification SARS-CoV-2 screened serum albumin significantly the primary endpoint time Urinalysis Urine validation [DOI] 10.3390/jcm10143049 PMC 바로가기 [Article Type] Article
The Prognostic Accuracy of National Early Warning Score 2 on Predicting Clinical Deterioration for Patients With COVID-19: A Systematic Review and Meta-AnalysisMedicine Published on 2021-07-092022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Accuracy addition Admission Analysis AUC clinical Clinical deterioration Cochrane Library conditions coronavirus disease COVID-19 COVID-19 patient COVID-19 patients defined detect Deterioration FIVE Hospital admission In-hospital death indicated Intensive intensive care likelihood ratio Meta-analysis moderate NEWS2 pandemic participant Patient patients with COVID-19 performed prediction prognostic random-effects model Respiratory failure Respiratory Support review risk stratification score searched sensitivity Sensitivity and specificity severe cases specificity Support systematic review [DOI] 10.3389/fmed.2021.699880 PMC 바로가기 [Article Type] Medicine
Prediction of individual COVID-19 diagnosis using baseline demographics and lab data기준 인구 통계 및 실험실 데이터를 사용한 개별 COVID-19 진단 예측Article Published on 2021-07-062022-09-01 Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, 진단, [키워드] age an area Analysis aspartate Aspartate aminotransferase baseline calcium Cohort Comorbidities complement COVID-19 COVID-19 case COVID-19 diagnosis current Decision tree demographics Diagnosis diagnostic test diagnostic tests ENhance health system hemoglobin Infectious diseases lab lab values lymphocyte Lymphocyte count machine learning machine learning models operable oxygen oxygen saturation pandemic Patient positive prediction predictors Programming language provide provided resulting serum calcium serum calcium levels smoking temperature tested [DOI] 10.1038/s41598-021-93126-7 PMC 바로가기 [Article Type] Article
Endothelium Activation Markers in Severe Hospitalized COVID-19 Patients: Role in Mortality Risk PredictionOriginal Article Published on 2021-07-042022-10-29 Journal: TH Open: Companion Journal to Thrombosis and Haemostasis [Category] COVID-19, [키워드] abnormality Activation analyzed Bergamo C reactive protein characterized Coagulation Cohort COVID-19 COVID-19 patient COVID-19 patients CRP cumulative D-dimer death elevated endothelial Endothelium enrolled Evidence exacerbated Factor fibrinogen fibrinolytic FVIII group highest hospital Hospitalized hypercoagulability Hypercoagulation ICU identify in-hospital mortality incidence Increased Infection Inflammation Inflammatory biomarker inflammatory status intensive care Italy linear median age median time multivariable analysis neutrophil non-ICU nucleosomes occurred paO2/fiO2 Patient patients plasma prediction Predictive procalcitonin Prospective Study Protein provide provided Result role SARS-COV-2 infection SARSCoV-2 severity significantly the disease variables von Willebrand factor were assessed were measured [DOI] 10.1055/s-0041-1731711 PMC 바로가기 [Article Type] Original Article
Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning기계 학습을 사용하여 디코딩된 COVID-19 심각도 및 만성의 면역 기반 예측Immunology Published on 2021-06-282022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] activated T cells Activation activities analyzed approach B-cell bioinformatics CCL3 CCL4 CCR5 CD14+ CD16+ CD4 CD8 characterized chemokines Classifier continuum COVID COVID-19 COVID-19 disease COVID-19 pathogenesis COVID-19 patient cytokine Cytokines dataset defined disease dysregulated effective effector T cell elevated excessive inflammation expressing generate GM-CSF healthy control healthy controls identify IFN-γ IL-10 IL-2 IL-4 IL-6 IL-8 immune response implicated individual individuals induce investigated Ligand machine learning Model mononuclear cell PASC Patient PBMCs Peripheral blood plasma positive predict prediction pro-inflammatory random recruitment second significantly significantly lower subset Symptoms T cell activation T-cell T-regulatory cell treatment strategy VEGF virus while [DOI] 10.3389/fimmu.2021.700782 PMC 바로가기 [Article Type] Immunology
Direct Measurement of B Lymphocyte Gene Expression Biomarkers in Peripheral Blood Transcriptomics Enables Early Prediction of Vaccine SeroconversionArticle Published on 2021-06-252022-10-31 Journal: Genes [Category] COVID-19, [키워드] 95% CI applied approach AUC B cell B lymphocyte B lymphocytes Biomarker blood transcriptome Cell clinical setting collected correlated COVID-19 COVID-19 vaccines datasets determine develop Direct expressed expression FCRLA Gene Expression gene expression dataset Genes greater immunology Influenza leukocyte log measurement mononuclear cells pathway PBMC peripheral Peripheral blood Precision predict predicted prediction Predictive proportion purified reference gene Responder sensitivity Seroconversion SMD subpopulation subpopulations target gene TNFRSF13C TNFRSF17 transcript transcript abundance Transcriptome Trial TXNDC5 vaccination was used [DOI] 10.3390/genes12070971 PMC 바로가기 [Article Type] Article
EASIX for Prediction of Outcome in Hospitalized SARS-CoV-2 Infected Patients입원한 SARS-CoV-2 감염 환자의 결과 예측을 위한 EASIXImmunology Published on 2021-06-232022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] 95%CI Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Admission age allocation Allogeneic angiopoietin angiopoietin-2 (Ang-2) Biomarkers caused Cell Cohort Comorbidities Comorbidity Complication coronavirus disease Coronavirus disease 2019 Coronavirus-2 correlated Course COVID-19 COVID19 CXCL8 CXCL9 death disease dysfunction EASIX endothelial endothelial activation and stress index Endothelial cell Endpoint enrolled Gender hazard ratio health-care system help Hospital admission hospitalized patient hospitalized patients independent Intensive interferon-alpha interleukin Interleukin-18 life-threatening mechanical ventilation multivariable analysis Odds ratio outcome pandemic pathophysiology Patient patients treated patients with COVID-19 predict prediction prediction of outcome primary endpoint resources respiratory Result retained SARS-CoV-2 SARS-CoV2 (COVID- 19) Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus soluble thrombomodulin stem cell Stem cell transplantation Stress suppressor of tumorigenicity 2 (ST2) Surveillance survival the disease thrombomodulin were assessed [DOI] 10.3389/fimmu.2021.634416 PMC 바로가기 [Article Type] Immunology
Deep Learning-Based Stroke Disease Prediction System Using Real-Time Bio Signals실시간 생체 신호를 이용한 딥 러닝 기반 뇌졸중 질환 예측 시스템Article Published on 2021-06-222022-09-10 Journal: Sensors (Basel, Switzerland) [Category] MERS, SARS, 치료기술, [키워드] Accuracy advance Algorithm approach attribute bidirectional Birth rate brain wave Certain disease change collected convolutional neural network (CNN) COVID-19 decrease decreases deep deep learning discomfort disease EEG electroencephalography (EEG) Ensemble equipment expected experimental results feasibility FPR Frequency Health services healthcare healthcare service improvement Improvements increases in lead life Life expectancy long short-term memory (LSTM) medical observation methodology MONITOR mortality rate MOST MRI Non-invasive non-invasive method Non-invasive methods observation predict prediction raw data real time reduced separated signal social changes stroke stroke disease analysis stroke prediction System time-consuming [DOI] 10.3390/s21134269 PMC 바로가기 [Article Type] Article