Randomized controlled trials for alcohol use disorder during the COVID-19 pandemicCOVID-19 전염병 동안 알코올 사용 장애에 대한 무작위 대조 시험Editorial Published on 2021-05-012022-09-11 Journal: Alcohol (Fayetteville, N.Y.) [Category] 임상, [키워드] activities acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alcohol assessment complexity Controlled trial coronavirus COVID-19 COVID-19 pandemic disorder Efficacy limitation logistics medication medications mental health mental health professional pandemic Randomized controlled trial RCT RCTs reduce required Research SARS-CoV-2 [DOI] 10.1016/j.alcohol.2021.01.001 PMC 바로가기 [Article Type] Editorial
Mortality, viral clearance, and other clinical outcomes of hydroxychloroquine in COVID-19 patients: A systematic review and meta-analysis of randomized controlled trials코로나19 환자에서 하이드록시클로로퀸의 사망률, 바이러스 제거 및 기타 임상 결과: 무작위 대조 시험의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-05-012022-09-11 Journal: Clinical and translational science [Category] SARS, 임상, [키워드] 95% CI 95% confidence interval adverse events certainty certainty of evidence Clinical outcome clinical outcomes coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection database effective Efficacy evaluated Evidence HCQ Hydroxychloroquine IMPROVE increased risk Lower Meta-analysis Mortality MOST no effect no significant effect not effective observational studies Patient patients with COVID-19 Prevent prevention of COVID-19 Prophylaxis Randomized controlled trial Randomized controlled trials RCT RCTs reducing mortality risk risk difference risk ratio safety profile screened searched systematic review Treatment Trial viral clearance [DOI] 10.1111/cts.13001 PMC 바로가기 [Article Type] Meta-Analysis
Instructional interventions for improving COVID-19 knowledge, attitudes, behaviors: Evidence from a large-scale RCT in IndiaRandomized Controlled Trial Published on 2021-05-012022-10-05 Journal: Social science & medicine (1982) [Category] SARS, 임상, [키워드] affecting appear assigned Attitudes Behavioral interventions Compliance Controlled trial COVID-19 knowledge Health Health beliefs health economics Health Education hypothese improvement India Intervention knowledge pandemic Pandemics provided Randomized controlled trials (RCT). Randomly RCT reducing relative sustained Treatment [DOI] 10.1016/j.socscimed.2021.113846 PMC 바로가기 [Article Type] Randomized Controlled Trial
Comprehensive evaluation of the efficacy and safety of LPV/r drugs in the treatment of SARS and MERS to provide potential treatment options for COVID-19COVID-19에 대한 잠재적인 치료 옵션을 제공하기 위해 SARS 및 MERS 치료에서 LPV/r 약물의 효능 및 안전성에 대한 종합 평가Meta-Analysis Published on 2021-04-302022-09-10 Journal: Aging (Albany NY) [Category] MERS, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome addition adverse event adverse events age and sex analyzed Antiviral treatment applied ARDS assessment tool benefit bias risk case-control studies CBM Chest CT China CNKI Cochrane Library Cohort studies Combination comprehensive evaluation conducted control group conversion rate coronavirus disease Coronavirus disease 2019 Coronavirus infections COVID-19 COVID-19 treatment database drug effective Effectiveness Efficacy Efficacy and safety eligible evaluate exhibited Factor incidence Infrastructure literature Lopinavir Lopinavir/ritonavir lower mortality LPV/r MERS Meta-analysis Middle East Middle East respiratory syndrome molecular Newcastle-Ottawa Scale NOS nucleic acid outbreak outcome patients patients with COVID-19 patients with SARS performed potential treatment option prognostic Randomized controlled studies RCT reduced Registration respiratory respiratory distress retrieved Risk assessment Ritonavir SARS Severe acute respiratory syndrome significantly similarities similarity statistically significant Structure syndrome systematic review the Newcastle-Ottawa Scale these viruses Treatment treatment of COVID-19 Trial two group two groups virus clearance viruses was used were used [DOI] 10.18632/aging.202860 PMC 바로가기 [Article Type] Meta-Analysis
Hypoalbuminemia as Surrogate and Culprit of InfectionsReview Published on 2021-04-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] acquisition acute lung injury Adaptive immune response Affect albumin albumin level albumins/pharmacology Antimicrobial therapy Antimicrobials Bacteremia Bacterial bioactive lipid mediators causal link changes in chronic conditions cirrhosis Clinical practice Clostridium difficile community-acquired pneumonia Complication coronavirus disease Defense Diseases Effect evidence of fungal infections Healthcare-associated infection Hypoalbuminemia hypothese in viral increased risk Infection infections infectious complication Infectious complications infusion Innate immunity Interaction lipid mediator liver management organ dysfunction Patient predict Prognostic value Prospective Randomized controlled trial RCT RCTs risk secondary infections Sepsis serum albumin severity supported surrogate Treatment Viral load [DOI] 10.3390/ijms22094496 PMC 바로가기 [Article Type] Review
Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art ReviewCOVID-19 환자를 위한 항혈전 요법의 최근 무작위 시험: JACC State-of-the-Art ReviewReview Published on 2021-04-202022-09-11 Journal: Journal of the American College of Cardiology [Category] 임상, [키워드] Anticoagulant antiplatelet Antithrombotic clinical trial coronavirus coronavirus disease coronavirus disease-2019 COVID-19 Critically ill doses endothelial injury hospitalized patient hospitalized patients Illness severity Injury knowledge outpatients pathophysiological feature Patient Perspective provide Randomized controlled trial RCT RCTs recent regimen review Spectrum therapy thrombosis variety with COVID-19 [DOI] 10.1016/j.jacc.2021.02.035 PMC 바로가기 [Article Type] Review
Hydroxychloroquine and COVID-19: can we learn from the use of rituximab in systemic lupus erythematosus?하이드록시클로로퀸과 코로나19: 전신성 홍반성 루푸스에서 리툭시맙을 사용하여 배울 수 있습니까?Commentary Published on 2021-04-152022-09-01 Journal: The Pan African Medical Journal [Category] 진단, [키워드] anti-CD20 antibody Arthritis asymptomatic patient asymptomatic patients B-cell lymphoma CD20 chimeric COVID-19 debate determine disorders dose duration of treatment effective Effectiveness Efficacy Efficacy and safety evaluate HCQ hematological Hydroxychloroquine lupus erythematosus monoclonal multicentre Neuropsychiatric open Patient profile Randomized controlled trials RCT renal rheumatoid arthritis rituximab RTX Safe SAGA shown SLE SSA Standard therapy systemic lupus erythematosus the disease Treatment understanding [DOI] 10.11604/pamj.2021.38.372.29087 PMC 바로가기 [Article Type] Commentary
Remdesivir for treatment of COVID-19; an updated systematic review and meta-analysisCOVID-19 치료를 위한 렘데시비르; 업데이트된 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-04-152022-09-11 Journal: European journal of pharmacology [Category] 임상, 치료법, 치료제, [키워드] 95%CI administration ADR ADRS Adverse drug reaction Adverse drug reactions approval approved benefit bioRxiv Clinical improvement Cochrane Library controlled trials coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patients COVID-19 treatment Direct Drug administration Efficacy and safety evaluate Evidence extracorporeal membrane oxygenation FDA FIVE follow-up time Google Scholar Health Health crisis Intervention Invasive mechanical ventilation median medRxiv Meta-analysis non-randomized study oxygen oxygen support pandemic performed Performing provided Randomized controlled trial RCT RCTs regimen Remdesivir risk SARS-CoV-2 Science Science Direct scientific evidence sensitivity analysis significantly lower systematic literature search systematic review Treatment was done Web of Science [DOI] 10.1016/j.ejphar.2021.173926 PMC 바로가기 [Article Type] Meta-Analysis
Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials무작위 시험의 국제 협력 메타 분석에서 COVID-19에서 히드록시클로로퀸과 클로로퀸의 사망률 결과Meta-Analysis Published on 2021-04-152022-09-10 Journal: Nature Communications [Category] MERS, SARS, 바이오마커, 임상, 치료법, [키워드] 95% CI 95% confidence interval all-cause mortality Analysis benefit bioRxiv children Chloroquine CIs clinical clinical trials Comorbidities COVID-19 COVID-19 patient COVID-19 patients COVID-19 research diagnostic Effect Effects eligible Epidemiology Evidence finding Generalizability High dose Hydroxychloroquine hydroxychloroquine/chloroquine include increased mortality International investigated investigator investigators medRxiv Meta-analysis Mortality Odds ratio Odds ratios outcome outpatients Patient patients Potential treatment Pragmatic pregnant women random-effects meta-analyses randomized clinical trial randomized trial RCT RCTs recovery recruitment registry Result survival total sample size Treatment Trial trials viral infection WHO WHO International Clinical Trials Registry Platform [DOI] 10.1038/s41467-021-22446-z PMC 바로가기 [Article Type] Meta-Analysis
Monitoring advances including consent: learning from COVID-19 trials and other trials running in UKCRC registered clinical trials units during the pandemic동의를 포함한 모니터링 발전: 대유행 기간 동안 UKCRC에 등록된 임상 시험 단위에서 실행되는 COVID-19 시험 및 기타 시험에서 학습Research Published on 2021-04-142022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] affected best caused Central monitoring change clinical Clinical research clinical trial clinical trials collaboration Combination conducted Consent COVID-19 COVID-19 pandemic Critical dataset datasets defined group home Home working identify infection risk Informed consent integrity Isolation leads Minimising monitoring National On-site monitoring pandemic Pandemics PROTECT protocol RCT reduce reduced Registered remote monitoring required Research resource responsible site monitoring Sponsor the patient Trial trials unit United Kingdom workload [DOI] 10.1186/s13063-021-05225-5 PMC 바로가기 [Article Type] Research