Variable recombination dynamics during the emergence, transmission and ‘disarming’ of a multidrug-resistant pneumococcal clone다제내성 폐렴구균 클론의 출현, 전파 및 '무력화' 동안의 변이 재조합 역학Research Article Published on 2014-06-232024-07-28 Journal: BMC Biology [Category] 폐렴구균 감염증, [키워드] Antibiotic resistance Bacterial evolution Coalescent analysis Mobile genetic elements phylogeography Recombination [DOI] 10.1186/1741-7007-12-49 PMC 바로가기 [Article Type] Research Article
Sequence of a Complete Chicken BG Haplotype Shows Dynamic Expansion and Contraction of Two Gene Lineages with Particular Expression Patterns완전한 치킨 BG 일배체형의 시퀀스는 특정 발현 패턴을 가진 두 유전자 계통의 동적 확장 및 수축을 보여줍니다Research Article Published on 2014-06-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Actin allelic Antigen presentation appear association Autoimmune disease Autoimmune diseases B12 brush border Cell cells change chicken chromosome chromosome 2 CNV complex contraction copy number Deletion domain dynamic Evolution expansion expressed expression family fixed Genes genetic association genetic associations Haplotype haplotypes homolog homologue homologues Human humans identify immune immune gene immune genes Immunity implicated Interaction intestinal involved major histocompatibility complex mammal mammals MHC multigene families multigene family myosin Particular pathogen Pathogens pattern polymorphism promoter promoters Recombination Region scrutiny sequence show single gene species tandem repeats the major histocompatibility tissue tissue expression tissues undergo untranslated regions Variation Viral diseases whole genome [DOI] 10.1371/journal.pgen.1004417 PMC 바로가기 [Article Type] Research Article
Heterogeneity in the Frequency and Characteristics of Homologous Recombination in Pneumococcal Evolution폐렴구균 진화에서 상동 재조합의 빈도와 특성의 이질성Research Article Published on 2014-05-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 폐렴구균 감염증, [키워드] a major acquisition adaptive Antibiotic resistance Bacteria bacterial cell Bacterial pathogens bacterium best carried Cell changes children described disease DNA epidemiological evade evaluate events Evolution Genome genomic data greater heterogeneous Homologous recombination Lineage lineages macro mathematical Mathematical models mechanism Meningitis morbidity morbidity and mortality pathogen Pathogens phenotypic pneumococcal pneumococcus Pneumonia pneumoniae Population dynamics populations Recombination respond S. pneumoniae serotype shown species Streptococcus pneumoniae transformation undergo Vaccines [DOI] 10.1371/journal.pgen.1004300 PMC 바로가기 [Article Type] Research Article
A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness관련성 전체 스펙트럼에 걸친 일배체형 단계에 대한 일반적인 접근 방식Research Article Published on 2014-04-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accuracy allele alleles approach association can be used chance chromosome Cohort cohorts correction detect disease downstream analyses error rate explicit Genetic Genetic studies genetics Genotype genotyped individuals genotypes genotyping Haplotype haplotypes IBD individual individuals information investigated isolates Merlin much lower parents Phenotypes Population populations provide Recombination recombination event researcher sequence Spectrum [DOI] 10.1371/journal.pgen.1004234 PMC 바로가기 [Article Type] Research Article
Temperate Phages Acquire DNA from Defective Prophages by Relaxed Homologous Recombination: The Role of Rad52-Like Recombinases온대 파지는 이완된 상동 재조합에 의해 결함 있는 프로파지로부터 DNA를 획득한다: Rad52-유사 재조합효소의 역할Research Article Published on 2014-03-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition addressed Bacteria Bacterial bacterial virus bacterial viruses bacteriophage bacteriophages Bioinformatics analysis biosphere catalyzed comparison complementary contribute defective prophages dependent on Divergence DNA dormant dormant state E. coli Efficiency element Escherichia coli Evidence evidence of Evolution exchange functions gene exchange gene exchanges gene transfer Genetic genetic determinant genetic determinants genetic diversity genetic exchanges Genome genomes genomic Homologous recombination homologous recombination enzymes horizontal gene Horizontal gene transfer Hypothesis in vivo Infection lambdoid phage lambdoid phages majority mechanism molecular mechanisms mosaicism no evidence of phage phage encoded recombinase phage encoded recombinases phage gene phage genome phage λ phages phenotype promote prophage prophages Rad52 RecA REcombinase recombinases Recombination replicate role sequence sequence homology sequences subject Temperate bacteriophage Temperate bacteriophages temperate phage temperate phages transfer virulence virulent virulent phages viruses vivo assays [DOI] 10.1371/journal.pgen.1004181 PMC 바로가기 [Article Type] Research Article
Analysis of Meiosis in SUN1 Deficient Mice Reveals a Distinct Role of SUN2 in Mammalian Meiotic LINC Complex Formation and FunctionSUN1 결핍 마우스의 감수분열 분석은 포유류 감수분열 LINC 복합체 형성 및 기능에서 SUN2의 뚜렷한 역할을 보여줍니다Research Article Published on 2014-02-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence appear attachment cause chromosome Clusters complexes component composed conserved Critical Deficient demonstrated described detect determine domain driving error event expressed Formation function functional functions Genome homolog indicate infertility interfere KASH5 lead meiosis meiotic meiotic recombination membrane mice nuclear nuclear envelope prophase Protein protein complex protein complexes Proteins provoke recent Recombination regulated retained role shown subsequent SUN1 SUN2 telomere telomeres while [DOI] 10.1371/journal.pgen.1004099 PMC 바로가기 [Article Type] Research Article
Extreme Population Differences in the Human Zinc Transporter ZIP4 (SLC39A4) Are Explained by Positive Selection in Sub-Saharan Africa인간 아연 수송체 ZIP4(SLC39A4)의 극단적인 인구 차이는 사하라 사막 이남의 아프리카에서 양성 선택으로 설명됩니다Research Article Published on 2014-02-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accompanied acrodermatitis acrodermatitis enteropathica African allele allele frequencies allele frequency Amino acid Author biological function Cell characterized classical computer simulations Concentration deficiency derived allele difference different directional disease phenotype disease risk DNA Evidence explained expression extreme finding fixation found functional Genetic Health HeLa cells homeostasis hotspot Human human population human populations implication intestinal investigated isoform leucine Local locus membrane Mutation natural selection Neanderthal Non-synonymous overexpression pathogen Pathogens polymorphism Population positive Positive selection Protein Recombination reduced reducing regulated Regulation Research Selection selective sweep significantly SLC39A4 sub-Saharan Africa surface protein Trace element transporter valine variant West Zinc zinc deficiency [DOI] 10.1371/journal.pgen.1004128 PMC 바로가기 [Article Type] Research Article
Molecular Characterization of Major Structural Protein Genes of Avian Coronavirus Infectious Bronchitis Virus Isolates in Southern ChinaArticle Published on 2013-12-042022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] addition amino acid sequence Amino acid sequences Analysis avian coronavirus characterization China circulating conducted detected different driven by Entropy Evolution exhibited FIVE genetic diversity genetic information Genetic variation Genotype IBV indicate Infectious Bronchitis Virus isolate less M gene Major N gene Phylogenetic analysis Phylogenetic tree Positive selection predominant Proteins recombinant Recombination Result strain Topology Vaccine vaccine strain Variation [DOI] 10.3390/v5123007 PMC 바로가기 [Article Type] Article
Evolution of Foamy Viruses: The Most Ancient of All Retroviruses †Review Published on 2013-09-252023-08-29 Journal: Viruses [Category] E형 간염, [키워드] Evolution foamy viruses Genetic conservation hepadnaviruses Recombination retroviruses [DOI] 10.3390/v5102349 PMC 바로가기 [Article Type] Review
Molecular and phylogenetic analysis of the porcine kobuvirus VP1 region using infected pigs from Sichuan Province, ChinaResearch Published on 2013-09-112023-08-29 Journal: Virology Journal [Category] E형 간염, [키워드] Co-infection diarrhea Phylogenetic analysis Porcine kobuvirus Recombination VP1 protein [DOI] 10.1186/1743-422X-10-281 PMC 바로가기 [Article Type] Research