Senolytics reduce coronavirus-related mortality in old mice
Article
[키워드] accumulate
acute respiratory syndrome
adverse outcome
age
amplify
amplifying
antibody
Antibody Response
Antiviral
antiviral antibodies
antiviral gene
Apoptosis
approach
asked
biopsies
blunt
caused
Cell
cell fate
cells
cellular
cellular senescence
changes in
chronic disease
Chronic diseases
chronic inflammation
Complete
contribute
coronavirus
COVID-19
COVID-19 pandemic
Cytokine storm
Dasatinib
decrease
Defense
drug
dysfunction
Effect
elicited
eliminated
endothelial
ENhance
event
expression
Factors
Gene Expression
Genetic
Human
human cell
human lung
hyperinflammation
Hyperinflammatory
Hypothesis
IFITM
immune response
IMPROVE
in vivo
increase
increase in
increased expression
increased risk
individual
Infection
Inflammation
Inflammatory marker
inflammatory protein
LPS
Lung epithelial cells
mechanism
metabolism
MHV
mice
microbial
morbidity and mortality
morphology
Mortality
mouse hepatitis virus
multi-organ failure
obesity
occur
organ
organism
outcome
PAMP
PAMPs
paracrine
pathogen
pathogen-associated molecular
pathogen-associated molecular pattern
pathogenic
phenotype
pro-inflammatory
pro-inflammatory factors
PROTECT
Protein
protein expression
reduce
reduce mortality
reduced
reducing
regimen
Resilience
response
resulting
SARS-CoV-2
SARS-CoV-2 S1
SARS-CoV-2 spike
SARS-CoV-2 spike protein
SASP
secrete
Secretome
senescence
senescent
senescent cell
serum
significantly
significantly increased
SPF
Stress
Support
susceptibility
targeting
tissue
transferred
treat
treated
treating
viral entry
viral infection
viral pathogen
β-coronavirus
[DOI] 10.1126/science.abe4832 PMC 바로가기 [Article Type] Article
[DOI] 10.1126/science.abe4832 PMC 바로가기 [Article Type] Article