A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells당뇨병 환경은 인간 신장 오르가노이드 및 환자 세포에서 SARS-CoV-2 감염에 대한 ACE2 발현 및 세포 감수성을 증가시킵니다Article Published on 2022-06-072022-09-11 Journal: Cell Metabolism [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 ACE2 expression aerobic aerobic glycolysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biopsy Cell cells cellular condition COVID-19 COVID-19 pathogenesis Critical develop diabete diabetes diabetes 2 Diabetic diabetic kidney diabetic patient diabetic patients dichloroacetate door energy metabolism enzyme exhibited Glycolysis hallmark human kidney human kidney organoids. increase individual inhibitor Intervention kidney Kidney disease kidney organoid kidney organoids metabolism mitochondrial Organoid organoids Patient prevented programming reduced resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe COVID-19 susceptibility Viral detection Viral load [DOI] 10.1016/j.cmet.2022.04.009 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Whole-Genome Sequencing by Ion S5 Technology-Challenges, Protocol Optimization and Success Rates for Different StrainsIon S5 기술에 의한 SARS-CoV-2 전체 게놈 시퀀싱 - 다양한 균주에 대한 과제, 프로토콜 최적화 및 성공률Article Published on 2022-06-062022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Amplicon arise assigned cDNA Concentration construction COVID-19 COVID-19 pandemic demonstrated diagnostics Effectiveness Emergency genomic data idea immunization Ion less library library preparation lineages Modification molecular Molecular epidemiology mRNA mRNA or viral vector vaccines Mutation Next-generation sequencing NGS optimization Panel Patient Poland produced protocol Public public health emergency Rate Real-time PCR required RT-PCR SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 lineage SARS-CoV-2 sequencing Scientific community Sequencing strain Support Surveillance Thermo Fisher Scientific variant variants variants of concern Viral Viral load Viral RNA Viral vector vaccines whole-genome whole-genome sequencing [DOI] 10.3390/v14061230 PMC 바로가기 [Article Type] Article
National Scale Real-Time Surveillance of SARS-CoV-2 Variants Dynamics by Wastewater Monitoring in Israel이스라엘의 폐수 모니터링을 통한 SARS-CoV-2 변종 역학의 국가 규모 실시간 감시Article Published on 2022-06-062022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha approach average B.1.1.7 circulation Combination Complete differential PCR Dynamics examined identify monitoring National normalized NVL omicron other variants PCR test plants progression qPCR quantitative PCR reached real-time dynamics replaced RT-qPCR SARS-CoV-2 scale selective Sequencing Surveillance tested the SARS-CoV-2 Treatment vaccination variant variant B.1.1.7 (Alpha) variants Viral load viral RNA load wastewater wastewater surveillance [DOI] 10.3390/v14061229 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infection Is Associated with Uncontrolled HIV Viral Load in Non-Hospitalized HIV-Infected Patients from Gugulethu, South AfricaSARS-CoV-2 감염은 남아프리카 구굴레투에서 입원하지 않은 HIV 감염 환자의 통제되지 않은 HIV 바이러스 부하와 관련이 있습니다Observational Study Published on 2022-06-032022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] adjusted age Antiretroviral therapy ART association CD4 clinical parameter Co-infection Cohort conducted COVID-19 cross-sectional higher risk HIV HIV patients HIV-infected patient Human load male median median age occur Patient patients with HIV PLWH prevalent recruited SARS-CoV-2 SARS-CoV-2 seroprevalence SARS-CoV-2 susceptibility seropositive Sex significantly higher South South Africa stratified Study design uncontrolled viral control Viral load Viremia [DOI] 10.3390/v14061222 PMC 바로가기 [Article Type] Observational Study
Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine재조합 식물 기반 면역증강제 코로나19 백신의 효능 및 안전성Clinical Trial Published on 2022-06-022022-09-11 Journal: The New England Journal of Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] 1:1 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant adverse event age Analysis AS03 assigned baseline candidate vaccine caused conducted coronavirus coronavirus disease Coronavirus disease 2019 CoVLP CoVLP+AS03 determine disease dose effective Efficacy Factor FIVE incidence injection intention-to-treat intention-to-treat population Intramuscular injection Local median age Median viral load Medicago Mild moderate occurred participant Participants participated Particle performed Phase 3 Placebo placebo group placebo-controlled trial plant plants polymerase post-hoc analysis prefusion produced Randomized receive recombinant respiratory Safety SARS-CoV-2 sequenced Sequencing seronegative severe acute respiratory syndrome Coronavirus Severe case Spectrum spike glycoprotein symptomatic symptomatic COVID-19 symptomatic infection System systemic adverse event systemic adverse events the median the placebo group the vaccine Trial two group two groups Vaccine vaccine efficacy vaccine group variant variants Viral Viral load viral sample Volunteer [DOI] 10.1056/NEJMoa2201300 PMC 바로가기 [Article Type] Clinical Trial
Photodynamic disinfection of SARS-CoV-2 clinical samples using a methylene blue formulationArticle Published on 2022-06-012022-10-04 Journal: Photochemical & photobiological sciences : Official journal of the European [Category] COVID19(2023년), SARS, 신약개발, [키워드] amplification amplitude antimicrobial Antimicrobial photodynamic disinfection approved clinical sample Clinical use collected Concentration condition coronavirus disease COVID-19 COVID-19 patients cytotoxicity early stage exhibiting form global effort HEK293T cells infect Infection lentiviral luciferase reporter gene medical need Medicines Methylene Methylene blue nasal pandemic PDI photodisinfection photodynamic inactivation prevented pseudotyped Pseudotyped lentiviral vector reduce SARS-CoV-2 severity the disease the S protein Transmission Treatment urgency Viral load [DOI] 10.1007/s43630-022-00202-6 PMC 바로가기 [Article Type] Article
SARS-CoV-2 transmitters have more than three times higher viral loads than non-transmitters – Practical use of viral load for disease controlArticle Published on 2022-06-012023-07-08 Journal: Journal of Clinical Virology [Category] COVID19(2023년), [키워드] COVID-19 SARS-CoV-2 Test delay Transmission Viral load [DOI] 10.1016/j.jcv.2022.105131 PMC 바로가기
SARS-CoV-2 infections in mRNA vaccinated individuals are biased for viruses encoding spike E484K and associated with reduced infectious virus loads that correlate with respiratory antiviral IgG levelsmRNA 백신을 접종한 개인의 SARS-CoV-2 감염은 스파이크 E484K를 인코딩하는 바이러스에 대해 편향되어 있으며 호흡기 항바이러스성 IgG 수준과 상관관계가 있는 감소된 감염성 바이러스 부하와 관련이 있습니다.Article Published on 2022-06-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] A significant reduction accompanied Alpha Alpha variant Amino acid Analysis Anti-viral Antiviral association B.1.1.7 B.1.526 BNT162b2 Breakthrough infection breakthrough infections caused Cell culture change Cohort collected COVID-19 cycle threshold dose E484K early phase ELISA examined Genome ICU admission IgG IgG level IgG levels immunization increase in Infectious virus investigated Lineage Moderna molecular Mortality mRNA mRNA-1273 PCR Pfizer-BioNTech positive positive sample Positive test predominant Protein reduce reduced required respiratory respiratory sample Respiratory samples Sample SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-COV-2 infection SARS-CoV-2 positive patient sequenced Sequencing specimen specimens spike Spike protein symptomatic infection symptomatic infections upper respiratory tract vaccinated individual vaccinated individuals vaccination Vaccines variant Viral Viral load viral loads viral variant virus were used whole genome [DOI] 10.1016/j.jcv.2022.105151 PMC 바로가기 [Article Type] Article
Comparison of reverse-transcription qPCR and droplet digital PCR for the detection of SARS-CoV-2 in clinical specimens of hospitalized patients입원환자 임상검체에서 SARS-CoV-2 검출을 위한 역전사 qPCR과 droplet digital PCR 비교Article Published on 2022-06-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alternative caused Chain Reaction China clinical Clinical performance coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 Critical ddPCR demonstrated detect Diagnosis Digital digital PCR discharged evidenced Hospitalized hospitalized patient Huoshenshan Hospital N gene negative ORF ORF gene oropharyngeal swab Patient patients patients hospitalized PCR polymerase chain polymerase chain reaction qPCR Quantitative Quantitative detection recovered patients Result reverse transcription risk RT-qPCR SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly specimen target gene Target genes the patient Treatment viral gene viral genes Viral load viral shedding Wuhan [DOI] 10.1016/j.diagmicrobio.2022.115677 PMC 바로가기 [Article Type] Article
Proficiency testing for SARS-CoV-2 in assuring the quality and overall performance in viral RNA detection in clinical and public health laboratories임상 및 공중 보건 실험실에서 바이러스 RNA 검출의 품질 및 전반적인 성능을 보장하기 위한 SARS-CoV-2에 대한 숙련도 테스트Article Published on 2022-06-012022-09-11 Journal: Pathology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus assays assist Australasia change choice college Concordance confidence coronavirus demonstrated diagnostic testing early stage early stages FIVE Genes house improvement in viral Inconclusive increase in initial Laboratory medium New nucleic acid offered pandemic participant Pathologists positive produced proficiency testing Program progressed protocol protocols provided public health Quality Quality assurance Result RNA SARS-CoV-2 selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown specimen specimens Viral detection Viral load viral loads [DOI] 10.1016/j.pathol.2022.01.006 PMC 바로가기 [Article Type] Article