Virtual screening of approved clinic drugs with main protease (3CL pro) reveals potential inhibitory effects on SARS-CoV-2주요 프로테아제 (3CL PRO)가있는 승인 된 클리닉 약물의 가상 스크리닝Article Published on 2022-02-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] [DOI] 10.1080/07391102.2020.1817786 PMC 바로가기 [Article Type] Article
Pro108Ser mutation of SARS-CoV-2 3CL pro reduces the enzyme activity and ameliorates the clinical severity of COVID-19SARS-COV-2 3CL PRO의 PRO108SER 돌연변이는 효소 활성을 감소시키고 COVID-19의 임상 적 심각성을 개선시킨다.Article Published on 2022-01-252022-09-10 Journal: Scientific Reports [Category] [DOI] 10.1038/s41598-022-05424-3 PMC 바로가기 [Article Type] Article
A Computer-Aided Approach for the Discovery of D-Peptides as Inhibitors of SARS-CoV-2 Main ProteaseMolecular Biosciences Published on 2022-01-242022-10-31 Journal: Frontiers in Molecular Biosciences [Category] [DOI] 10.3389/fmolb.2021.816166 PMC 바로가기 [Article Type] Molecular Biosciences
Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CL pro inhibitors for treating COVID-19COVID-19 치료를 위한 SARS-CoV-2 3CL pro 억제제로서의 9,10-디히드로페난트렌 유도체 발견Article Published on 2022-01-152022-09-11 Journal: European journal of medicinal chemistry [Category] [DOI] 10.1016/j.ejmech.2021.114030 PMC 바로가기 [Article Type] Article
Drug Repurposing for the Identification of Compounds with Anti-SARS-CoV-2 Capability via Multiple TargetsArticle Published on 2022-01-122022-10-28 Journal: Pharmaceutics [Category] [DOI] 10.3390/pharmaceutics14010176 PMC 바로가기 [Article Type] Article
Repurposing of Drugs for SARS-CoV-2 Using Inverse Docking FingerprintsChemistry Published on 2021-12-282022-10-31 Journal: Frontiers in Chemistry [Category] [DOI] 10.3389/fchem.2021.757826 PMC 바로가기 [Article Type] Chemistry
Exploration of SARS-CoV-2 3CL pro Inhibitors by Virtual Screening Methods, FRET Detection, and CPE Assay가상 스크리닝 방법, FRET 감지 및 CPE 분석에 의한 SARS-CoV-2 3CL pro 억제제 탐색Article Published on 2021-12-272022-09-11 Journal: Journal of Chemical Information and Modeling [Category] [DOI] 10.1021/acs.jcim.1c01089 PMC 바로가기 [Article Type] Article
Molecular Docking and Dynamics Investigations for Identifying Potential Inhibitors of the 3-Chymotrypsin-like Protease of SARS-CoV-2: Repurposing of Approved Pyrimidonic Pharmaceuticals for COVID-19 TreatmentSARS-COV-2의 3- chymotrypsin- 유사 프로테아제의 잠재적 억제제를 식별하기위한 분자 도킹 및 역학 조사 : Covid-19 치료를위한 승인 된 피리 미도 론적 제약의 재구성Article Published on 2021-12-092022-08-31 Journal: Molecules [Category] [DOI] 10.3390/molecules26247458 PMC 바로가기 [Article Type] Article
Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitroScutellaria baicalensis 추출물 및 Baicalein은 SARS-COV-2 및 그의 3C- 유사 프로테아제의 복제를 시험관 내에서 억제합니다.Article Published on 2021-12-012022-08-31 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] [DOI] 10.1080/14756366.2021.1873977 PMC 바로가기 [Article Type] Article
Thermodynamic and structural insights into the repurposing of drugs that bind to SARS-CoV-2 main proteaseChemistry Published on 2021-11-182022-10-29 Journal: Molecular Systems Design & Engineering [Category] [DOI] 10.1039/d1me00124h PMC 바로가기 [Article Type] Chemistry