Structural analysis of SARS-Cov-2 nonstructural protein 1 polymorphisms found in the Brazilian Amazon브라질 아마존에서 발견된 SARS-Cov-2 비구조 단백질 1 다형성의 구조 분석Article Published on 2021-11-012022-09-11 Journal: Experimental Biology and Medicine [Category] SARS, 변종, 치료기술, [키워드] 3D structure 3D structure modeling Affect affected Alpha Amino acid amino acids Analysis analyzed approved B.1.1.28 B.1.1.33 backbone beta-CoVs Brazil C-terminal carried change changes in circulating city coronavirus coronavirus disease coronavirus disease COVID-19 COVID-19 death Deletion Evolution genomic Infection intermediate variable Lineage modify mutants Mutation N-terminal New non-structural protein nonstructural protein 1 nsp1 pathogenicity polymorphism Protein Proteins residue residues SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 proteins Structure substitutions Surveillance tertiary structure the SARS-CoV-2 Therapies Vaccine variable region viral mutation Viral mutations virus Virus evolution virus infection Wuhan [DOI] 10.1177/15353702211021348 PMC 바로가기 [Article Type] Article
Recent Advances of COVID-19 Modeling Based on Regenerative MedicineCell and Developmental Biology Published on 2021-10-252022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] 3D structure advance angiotensin-converting enzyme 2 animal models catch caused cell line cell population COVID-19 deficiency drug drugs Endocrine future therapeutic Health Health Organization host cell induced pluripotent stem cells Infection introduced involved liver main receptor mechanism Medicine mice Model modeling neurologic offer Organoid organoids other organ pandemic pathogenicity pathophysiology pluripotent stem cell recent receptors regenerative regenerative medicine renal systems respiratory respiratory infection responsible SARS-CoV-2 SARS-COV-2 infection stem cell subjects suggested treat Vaccine virus Wuhan, China [DOI] 10.3389/fcell.2021.683619 PMC 바로가기 [Article Type] Cell and Developmental Biology
Computational Analysis of Missense Variants in the Human Transmembrane Protease Serine 2 ( TMPRSS2 ) and SARS-CoV-2Research Article Published on 2021-10-192022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, [키워드] 3D structure activating acute respiratory syndrome ADP-ribosylation association cleaving conserved ConSurf coronavirus decrease Deleterious deleterious effect Effect evaluated facilitate Human identify missense variant mutant posttranslational modification progression Prostate cancer protease Protein proteolytic cleavage PROVEAN Ramachandran plot SARS-CoV-2 serine 2 SIFT stability susceptibility target cell tested the S protein TMPRSS2 transmembrane variant viral entry [DOI] 10.1155/2021/9982729 PMC 바로가기 [Article Type] Research Article
Computational Analysis of Missense Variants in the Human Transmembrane Protease Serine 2 ( TMPRSS2 ) and SARS-CoV-2인간 막 횡단 프로테아제 세린 2 (TMPRSS2) 및 SARS-COV-2에서의 미스 센스 변이체의 계산 분석Research Article Published on 2021-10-192022-09-10 Journal: BioMed Research International [Category] 변종, [키워드] 3D structure activating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADP-ribosylation association cleaving conserved ConSurf coronavirus decrease Deleterious deleterious effect deleterious effects Effect evaluated facilitate Human identify missense variant mutant posttranslational modification PROCHECK progression Prostate cancer protease Protein proteolytic cleavage PROVEAN PTMs Ramachandran plot respiratory S protein SARS-CoV-2 Serine serine 2 severe acute respiratory syndrome Coronavirus SIFT stability susceptibility target cell target cells Template tested the S protein TMPRSS2 transmembrane variant Viral viral entry [DOI] 10.1155/2021/9982729 PMC 바로가기 [Article Type] Research Article
Spread of Mink SARS-CoV-2 Variants in Humans: A Model of Sarbecovirus Interspecies EvolutionMicrobiology Published on 2021-09-202022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] 3D structure ACE2 Antibody neutralization circulation consequence COVID-19 COVID-19 vaccines Denmark enzyme epitope Evolution exhibited Human human ACE2 humans immune response linear mink mink coronavirus Model monoclonal antibody Mutation neutralization Neutralizing antibodies NRP-1 predicted Prevalence sarbecovirus SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 vaccines SARS-CoV-2 variant Spread susceptibility target unlikely Vaccine variant variant viruses [DOI] 10.3389/fmicb.2021.675528 PMC 바로가기 [Article Type] Microbiology
SARS‐CoV‐2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanismsArticle Published on 2021-09-142022-10-31 Journal: Molecular Systems Biology [Category] COVID-19, SARS, [키워드] 3D model 3D structure bioinformatics can be used complex Coronavirus infection Coverage COVID‐19 Data visualization forms help Host human proteins implicated knowledge mechanism Methods & Resources Microbiology, Virology & Host Pathogen Interaction modifications proteome provide provided resource resulting reveal SARS‐CoV‐2 SARS‐CoV‐2 proteins SARS‐CoV‐2 structural biology structures translation Viral protein viral replication [DOI] 10.15252/msb.202010079 PMC 바로가기 [Article Type] Article
Characterization of the NiRAN domain from RNA-dependent RNA polymerase provides insights into a potential therapeutic target against SARS-CoV-2Research Article Published on 2021-09-132022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, SARS, [키워드] 3D structure acute respiratory syndrome affecting anti-SARS-CoV-2 approved bind binding biochemical bioinformatics canonical caused cell lines Characteristics characterization characterized Combination Compound coronavirus disease Coronavirus-2 COVID-19 COVID-19 pandemic COVID-19 therapeutics death domain domains drug drug target exhibit exhibited FDA FIVE functional Health in silico inhibiting inhibitor Kinase inhibitor molecular docking Nidovirale pandemic potential therapeutic target predict predicted provide provided RdRP reduce reported resulting RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 infected cells significantly significantly higher small molecule inhibitor strain the SARS-CoV-2 thumb urgency viral life cycle Viral load [DOI] 10.1371/journal.pcbi.1009384 PMC 바로가기 [Article Type] Research Article
Identification of novel transmembrane Protease Serine Type 2 drug candidates for COVID-19 using computational studiesResearch article Published on 2021-09-072022-10-05 Journal: Informatics in Medicine Unlocked [Category] 신약개발, [키워드] 3D structure acute respiratory syndrome Amikacin binding affinities build computational method Computational study conducted Coronavirus-2 COVID-19 docking docking score drug drug candidate Drug repurposing effective therapy enzyme exhibited functional Health homology homology modeling host cell identification identify in silico inhibit SARS-CoV-2 inhibition molecular dynamics outcomes pandemic SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection screened severity Spread TMPRSS2 transmembrane Type was performed [DOI] 10.1016/j.imu.2021.100725 [Article Type] Research article
Molecular Dynamics Studies on the Structural Characteristics for the Stability Prediction of SARS-CoV-2SARS-CoV-2의 안정성 예측을 위한 구조적 특성에 관한 분자 역학 연구Review Published on 2021-08-132022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, [키워드] 3D structure ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Affect Analysis bind binding free energy binding free energy calculation conformational coronavirus COVID-19 pandemic D614G domain Dynamics fluctuation form forms free energy global pandemic human ACE2 human cell human cells Interaction investigated involved Korean L455F MD simulation mutant mutants patients performed prediction prevalent Protein RBD RBD region released respiratory Respiratory system S2 domain SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein stability the RBD variant wild type [DOI] 10.3390/ijms22168714 PMC 바로가기 [Article Type] Review
Next-Generation Bioinformatics Approaches and Resources for Coronavirus Vaccine Discovery and Development—A Perspective ReviewReview Published on 2021-07-222022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 3D structure acute respiratory syndrome antigenic epitope bioinformatics bioinformatics resources caused computational tool contagious coronavirus coronavirus strain coronavirus vaccine COVID-19 database death disease effective effort epitope experimental validation function Genome sequencing genomic globe immune response immunoinformatics in viral pandemic pathogen platform Protein researcher resource resources review SARS-CoV-2 Stage target the vaccine Vaccine vaccine construct valuable resource [DOI] 10.3390/vaccines9080812 PMC 바로가기 [Article Type] Review