Efficacy of convalescent plasma therapy in the patient with COVID-19: a randomised control trial (COPLA-II trial)COVID-19 환자에서 회복기 혈장 요법의 효능: 무작위 대조 시험(COPLA-II 시험)Clinical Trial Published on 2022-04-062022-09-12 Journal: BMJ Open [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] 1:1 48 hour adverse events allergic reaction Antibody titre Blood blood bank & Clinical improvement clinical outcomes collected conducted convalescent plasma Convalescent plasma therapy COVID-19 COVID-19 patient cytokine level D-dimer Efficacy Hospital admission hospitalisation in both group incidence initial IQR median median time Mortality no difference on mechanical ventilation outcome PaO participant Patient plasma proportion randomised randomised controlled trial reduction in SARS-CoV-2 antibody secondary severe COVID-19 patients study population the patient therapy TNF-α transfused Transfusion medicine Treatment treatment group Trial [DOI] 10.1136/bmjopen-2021-055189 PMC 바로가기 [Article Type] Clinical Trial
Systems on Top of Nasal Cannula Improve Oxygen Delivery in Patients with COVID-19: a Randomized Controlled TrialRandomized Controlled Trial Published on 2022-04-012022-10-05 Journal: Journal of General Internal Medicine [Category] 임상, [키워드] addition arterial blood baseline breathlessness cannula changes in collected Controlled Controlled trial coronavirus disease Coronavirus disease 2019 COVID-19 pandemic COVID-19 patients delivery determine double-trunk mask Efficacy enrolled Final Hypoxemia hypoxemic IMPROVE low-flow oxygen median nasal outcome oxygen oxygen saturation Oxygen therapy Oxygenation PaO Primary outcome pulse Randomized randomized patients receive reduce secondary surgical surgical mask System treated treating vital parameter vital parameters was recorded was reduced with COVID-19 [DOI] 10.1007/s11606-022-07419-2 PMC 바로가기 [Article Type] Randomized Controlled Trial
Low testosterone predicts hypoxemic respiratory insufficiency and mortality in patients with COVID-19 disease: another piece in the COVID puzzle낮은 테스토스테론은 COVID-19 질병 환자의 저산소성 호흡 부전 및 사망률을 예측합니다: COVID 퍼즐의 또 다른 조각Article Published on 2022-04-012022-09-11 Journal: Journal of Endocrinological Investigation [Category] 바이오마커, [키워드] 95% CI 95% confidence interval acute illness acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age association C-reactive protein clinical impact Comorbidities coronavirus coronavirus disease COVID COVID-19 described evaluate evaluated ferritin fraction Hospital stay Hospitalized hypogonadism hypoxemic in-hospital mortality Infection Inflammation inflammatory parameter inflammatory parameters interleukin-6 investigated IRCCS Italy Lactate lactate dehydrogenase male male subject male subjects Mortality mortality rate multivariable Odds ratio Older outcome oxygen P/F ratio PaO partial pressure patients with COVID-19 Pneumonia predict Prevalence Prospective Regression analyses respiratory respiratory insufficiency SARS-CoV-2 SARS-COV-2 infection serum severe acute respiratory syndrome Coronavirus significantly subject syndrome Testosterone thyroid function Ventilation [DOI] 10.1007/s40618-021-01700-7 PMC 바로가기 [Article Type] Article
Effectiveness of an adapted diving mask (Owner mask) for non-invasive ventilation in the COVID-19 pandemic scenario: study protocol for a randomized clinical trialCOVID-19 대유행 시나리오에서 비침습적 환기를 위한 적응형 잠수 마스크(소유자 마스크)의 효과: 무작위 임상 시험을 위한 연구 프로토콜Article Published on 2022-03-182022-09-11 Journal: Trials [Category] Coronavirus, SARS, 임상, [키워드] adverse effects aerosol aerosolization Anthropometric data Behavior cause causes clinical Clinical sign Clinical signs clinical trial clinical trials Comfort confirmation Contagion Controlled trial COVID COVID-19 COVID-19 pandemic Effectiveness Face mask Follow-up group Health high risk Hospital stay Hospitalization IMPROVE in-hospital mortality include indicated initial Innovation intensive care intensive care unit intubation invasive ventilation Mask Mortality NIV non-invasive ventilation orotracheal intubation oxygen Oxygen therapy PaO Patient patients Primary outcome professionals Randomized randomized clinical trial reduce registry resource respiratory Respiratory failure SARS-CoV2 Satisfaction secondary outcome Secondary outcomes shown Sociodemographic Study protocol submitted suspicion the patient tracheal tracheal intubation variable Ventilation ventilatory virus with COVID-19 [DOI] 10.1186/s13063-022-06133-y PMC 바로가기 [Article Type] Article
Circulating Levels of PD-L1, TIM-3 and MMP-7 Are Promising Biomarkers to Differentiate COVID-19 Patients That Require Invasive Mechanical VentilationPD-L1, TIM-3 및 MMP-7의 순환 수준은 침습적 기계 환기가 필요한 COVID-19 환자를 구별하는 유망한 바이오마커입니다Article Published on 2022-03-142022-09-11 Journal: Biomolecules [Category] Coronavirus, MERS, SARS, 바이오마커, [키워드] 105 patient 105 patients acute disease Acute respiratory failure acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Biomarker Biomarkers caused Clinical data Coronavirus-2 correlated COVID-19 COVID-19 patient diagnosed with COVID-19 disease disease severity eight ELISA evaluate exhibited followed by highest Hospital stay IMV Infectious disease Invasive mechanical ventilation Level lung lesion lung lesions marker Mechanical molecules NIMV PaO Patient patients PD-L1 persistence Potential biomarker potential biomarkers quantified respiratory Respiratory failure ROC analysis RT-PCR SARS-CoV-2 sensitivity Serum level serum levels Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significant decrease specificity T-cell T-cells two group two groups was increased [DOI] 10.3390/biom12030445 PMC 바로가기 [Article Type] Article
Limitations of the ARDS criteria during high-flow oxygen or non-invasive ventilation: evidence from critically ill COVID-19 patientsObservational Study Published on 2022-03-072022-10-04 Journal: Critical Care [Category] MERS, SARS, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome Analysis ARDS Berlin caused change COVID-19 patient criteria Critically ill Critically ill patient Evidence HFNC High-flow oxygen Hypothesis Hypoxemia ICU increase in increasingly indicate inspired oxygen fraction intensive care Invasive mechanical ventilation investigated limitation mechanical ventilation median Mild moderate nasal NIV Non-invasive Non-invasive respiratory support non-invasive ventilation oxygen pandemic PaO Patient prospective observational study provided pulmonary damage Respiratory failure Respiratory function Respiratory Support Result SARS-CoV2 severity single-center Steady state switching syndrome Uppsala University Variation ventilated patient was recorded with COVID-19 [DOI] 10.1186/s13054-022-03933-1 PMC 바로가기 [Article Type] Observational Study
Potential for the lung recruitment and the risk of lung overdistension during 21 days of mechanical ventilation in patients with COVID-19 after noninvasive ventilation failure: the COVID-VENT observational trialObservational Study Published on 2022-03-042022-10-04 Journal: BMC Anesthesiology [Category] MERS, SARS, 임상, [키워드] acute respiratory distress syndrome alveolar calculated Compliance Course COVID-19 Critically ill Day dead driving Gas exchange highest improvement intensive care unit lowest lung Lung recruitability lung recruitment Lung strain mechanical ventilation mechanically ventilated patient non-survivor Noninvasive ventilation occurred PaO Patient patients PEEP Positive end-expiratory pressure Potential primary endpoint prospective observational study Recruitability recruitment Registered Respiratory failure Respiratory mechanics Respiratory system Result risk significant decrease supplementary material survivor Survivors the disease Trial university ventilatory Volume Volutrauma with COVID-19 [DOI] 10.1186/s12871-022-01600-0 PMC 바로가기 [Article Type] Observational Study
Biological evaluation of a mechanical ventilator that operates by controlling an automated manual resuscitator. A descriptive study in swineResearch Article Published on 2022-03-032022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, SARS, [키워드] addition alteration anaesthesia Analysis automated Biological blood biochemistry Brain carbonate Clinical studies condition detect eight electrocardiogram evaluate Evidence health system healthy histopathological in vivo kidney Lactate liver lung mechanical ventilation mechanical ventilator organ outbreak Oxygenation PaO parameter pathological finding performed physiological level physiological response preclinical data produced reported Support tissue tissue damage ventilatory parameters Volume [DOI] 10.1371/journal.pone.0264774 PMC 바로가기 [Article Type] Research Article
Oxidative stress-induced endothelial dysfunction and decreased vascular nitric oxide in COVID-19 patientsObservational Study Published on 2022-03-012022-10-05 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 바이오마커, 임상, [키워드] adult COVID-19 patient angiotensin Angiotensin II angiotensin-converting enzyme 2 appear Bioavailability cardiovascular risk factor contrary control subject correlated correlation COVID-19 COVID-19 patient COVID-19 patients disease severity endothelial Endothelial cell Endothelial dysfunction endothelial injury exacerbated highlight hospital hospitalized COVID-19 patients ICU ICU patient induce leucocyte marker Microvascular thrombosis nitric oxide non-ICU observational study occur oxidative stress Oxygenation PaO parameter pathogenic Patient peroxide plasma Plasma level R 2 receptor redox status reduced Research Respiratory failure resulting SARS-CoV-2 SARS-COV-2 infection septic patients Septic shock Serum level target thrombosis Vascular widespread [DOI] 10.1016/j.ebiom.2022.103893 PMC 바로가기 [Article Type] Observational Study
Experience With the Use of Baricitinib and Tocilizumab Monotherapy or Combined, in Patients With Interstitial Pneumonia Secondary to Coronavirus COVID19: A Real-World Study코로나바이러스 COVID19에 따른 간질성 폐렴 환자에서 바리시티닙과 토실리주맙 단독 요법 또는 병용 요법의 사용 경험: 실제 연구Article Published on 2022-03-012022-09-12 Journal: Reumatología clinica [Category] MERS, SARS, 진단, [키워드] Admission age average Baricitinib Combined COVID-19 COVID19 died discharge English experience group ICU interstitial pneumonia males media medical record monotherapy Neumonía intersticial PaO paO2/fiO2 Patient patients patients died Quince required secondary to Side effect Side effects Spanish Symptoms TCZ Tocilizumab treated Treatment UCI. [DOI] 10.1016/j.reumae.2020.10.006 PMC 바로가기 [Article Type] Article