ACE inhibitors – Page 3 – Communicable Diseases Research

Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?

Endocrinology

Published on 2021-06-232022-10-31
Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, SARS,

Exploring the Mystery of Angiotensin-Converting Enzyme II (ACE2) in the Battle against SARS-CoV-2

Review Article

Published on 2021-06-042022-10-31
Journal: Journal of the Renin-Angiotensin-Aldosterone Syste [Category] COVID-19, MERS, SARS,

[키워드] ACE inhibitors ACE2 ACE2 expression ACE2 receptor age Angiotensin receptor blockers Angiotensin-converting enzyme battle Betacoronavirus caused Cell cellular entry Cerebrovascular disease chronic obstructive clinical Colon Comorbidity COPD Coronary heart disease COVID-19 COVID-19 patient COVID-19 therapeutics diabetes Enterocyte expression Factor hypertension infect Infection inflammatory signaling knowledge management master regulator outcome pandemic pneumocyte positive primary site pulmonary disease regulated Regulation respiratory tract SARS-CoV-2 SARS-CoV-2 infections smoking the SARS-CoV-2 virus Trial Tuberculosis
[DOI] 10.1155/2021/9939929 PMC 바로가기 [Article Type] Review Article

Comparison of infection risks and clinical outcomes in patients with and without SARS-CoV-2 lung infection under renin-angiotensin-aldosterone system blockade: Systematic review and meta-analysis

Review

Published on 2021-06-012023-07-13
Journal: British Journal of Clinical Pharmacology [Category] SARS,

[키워드] ACE inhibitors ACE2 angiotensin II receptor blockers SARS-CoV-2
[DOI] 10.1111/bcp.14660 PMC 바로가기 [Article Type] Review

Dysregulation of COVID-19 related gene expression in the COPD lung

COPD 폐에서 COVID-19 관련 유전자 발현의 조절 장애

Research

Published on 2021-05-292022-09-10
Journal: Respiratory Research [Category] 유전자 메커니즘,

[키워드] ACE inhibitor ACE inhibitors ACE2 ACE2 gene ACEi aetiology angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin II Basigin biopsies biopsy cardiovascular disease cathepsin cathepsin B Characteristics chronic chronic obstructive pulmonary disease Clinical course Control control subjects controls COPD coronavirus coronavirus 2 coronavirus disease correlated Corticosteroid COVID-19 determine disease disease phenotype downstream elevated enzyme epithelial expression expression of gene Gene Expression hypertension identify increased risk Infection Inflammation inhaled corticosteroid log2FC lung Lung function Obstructive obstructive pulmonary disease outcome Patient protease Proteases pulmonary disease quantified RAS RAS gene receptor regulated Regulation Renin renin-angiotensin system required respiratory Result RNA sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 receptors Serine severe acute respiratory syndrome coronavirus 2 subject supplementary material susceptibility TMPRSS4 upregulated was increased
[DOI] 10.1186/s12931-021-01755-3 PMC 바로가기 [Article Type] Research

Developing new drugs that activate the protective arm of the renin-angiotensin system as a potential treatment for respiratory failure in COVID-19 patients

코로나19 환자의 호흡부전 치료제로 레닌-안지오텐신계 보호팔을 활성화하는 신약 개발

Review

Published on 2021-05-012022-09-11
Journal: Drug discovery today [Category] SARS, 신약개발, 치료법,

[키워드] 20-hydroxyecdysone ACE inhibitors ACE2 activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 agonist agonists angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin receptor blockers Anti-inflammatory caused clinical picture coronavirus COVID-19 COVID-19 patient Developing drug enzyme global health Health Imbalance Impact IMPROVE induce pandemic Potential treatment proportion Protective RAS reached Rebalance receptor Renin renin-angiotensin system Respiratory failure SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe pneumonia
[DOI] 10.1016/j.drudis.2021.02.010 PMC 바로가기 [Article Type] Review

Mortality in Patients with COVID-19 on Renin Angiotensin System Inhibitor Long-Term Treatment: An Observational Study Showing that Things Are Not Always as They Seem

Observational Study

Published on 2021-05-012022-10-05
Journal: Advances in therapy [Category] SARS, 임상,

[키워드] ACE ACE inhibitor ACE inhibitors Admission age angiotensin Angiotensin receptor blockers Angiotensin-converting enzyme ARB ARBs blocker concerning condition conducted consecutive patient coronavirus disease COVID-19 death defined determinant diabete died disease drug First wave had no high mortality rate hospital hypertension increased mortality increased risk inhibitor Italy Laboratory long-term treatment Mild moderate Mortality Multivariate analysis multivariate model no significant difference pandemic patients with COVID-19 physician receiving receptor Renin reported System the patient treated was used with COVID-19
[DOI] 10.1007/s12325-021-01704-y PMC 바로가기 [Article Type] Observational Study

Dipeptidyl peptidase-4 (DPP-4) inhibitor and mortality in coronavirus disease 2019 (COVID-19) – A systematic review, meta-analysis, and meta-regression

Review article

Published on 2021-05-012022-10-05
Journal: Diabetes & metabolic syndrome [Category] SARS, 신약개발,

Influence of renin-angiotensin-aldosterone system inhibitors on plasma levels of angiotensin-converting enzyme 2

안지오텐신 전환 효소 2의 혈장 수준에 대한 레닌-안지오텐신-알도스테론계 억제제의 영향

Article

Published on 2021-04-012022-09-11
Journal: ESC heart failure [Category] SARS, 유전자 메커니즘,

[키워드] 95% confidence interval ACE ACE inhibitor ACE inhibitors ACE2 Analysis angiotensin angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors ARB association body mass body mass index cardiovascular disease cardiovascular risk factor cardiovascular risk factors circulating comparable Concentration concentrations concern COVID‐19 death entry receptor enzyme expression heart failure in vivo increased risk influence inhibitor lack large cohort median age Patient plasma plasma concentration Plasma levels platform positive proteomic RAAS raised Regression model SARS-CoV-2 SARS‐CoV‐2 Treatment USA was measured women
[DOI] 10.1002/ehf2.13249 PMC 바로가기 [Article Type] Article

Accelerated Repurposing and Drug Development of Pulmonary Hypertension Therapies for COVID-19 Treatment Using an AI-Integrated Biosimulation Platform

AI 통합 바이오시뮬레이션 플랫폼을 사용한 코로나19 치료를 위한 폐 고혈압 치료제 용도 변경 및 약물 개발 가속화

Article

Published on 2021-03-292022-08-31
Journal: Molecules [Category] 신약개발, 치료제,

[키워드] accelerated ACE ACE inhibitor ACE inhibitors ACEi angiotensin Angiotensin-converting enzyme approach artificial intelligence blocker calcium calcium channel calcium channel blockers CCB CCBs cellular entry Combination Compound conducted COVID-19 COVID-19 pandemic COVID-19 pathogenesis Critical dataset development drug Drug repurposing drug therapy Effect enzyme hypertension implicated in silico in vitro in vivo investigated pathway Pathways penetration platform pulmonary pulmonary hypertension RAS reached Renin renin-angiotensin system Replication repurposing SARS-CoV-2 shown systemic therapy target therapeutic therapy tissue tissues virus
[DOI] 10.3390/molecules26071912 PMC 바로가기 [Article Type] Article

SARS-COV-2 comorbidity network and outcome in hospitalized patients in Crema, Italy

SARS-COV-2 동반이환 네트워크 및 이탈리아 크레마 입원 환자의 결과

Research Article

Published on 2021-03-252022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS,

[키워드] Accuracy ACE ACE inhibitor ACE inhibitors Admission angiotensin angiotensin converting enzyme antagonist C-reactive protein caused Chain Reaction Charlson Comorbidity Index Chest CT chest X-ray Comorbidities Comorbidity Computed tomography correlated correlation Course death Deceased diagnostic Diagnostic accuracy disease distribution drug enzyme Fatality rate Follow-up gold gold standard high mortality homogenous hospital hospitalized patient ICU admission impairment individual inhibitor interstitial pneumonia Italy Laboratory males median age Multiorgan Nasopharyngeal swab negative patients network analysis Non-invasive respiratory support occurred outcome outcomes Patient patients patients older pharmacological treatments polymerase chain reaction positive respiratory Respiratory Support reverse transcriptase SARS-CoV-2 significantly study population survived Swab was performed were recorded
[DOI] 10.1371/journal.pone.0248498 PMC 바로가기 [Article Type] Research Article