Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells
인간 PSC 유래 심근세포 및 1차 내피 세포에서 항고혈압 약물 치료 및 SARS-CoV-2 감염에 대한 감수성
Article
[키워드] ACE2
ACEi
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus-2
Alter
angiotensin
angiotensin receptor blocker
angiotensin-converting enzyme 2
angiotensin-converting enzyme inhibitor
Antihypertensive drug
antihypertensive medication
ARB
Cell
cell type
Coronavirus-2
COVID-19
drug treatment
endothelial
Endothelial cell
endothelial cells
Enzyme inhibitor
heart
hPSC-derived cardiomyocytes
Immunity
interferon
involved
Lisinopril
losartan
MAPK
medications
membrane-bound
mitogen
mitogen-activated protein kinase
modulate
multicenter trials
Necrosis
NF-κB
not affect
nuclear
pathogenicity
Pathways
Protein
protein coding gene
protein coding genes
protein kinase
receptor
receptor blocker
RNA
RNA sequencing
SARS-CoV-2
SARS-COV-2 infection
Severe acute respiratory syndrome
severe acute respiratory syndrome Coronavirus
severe acute respiratory syndrome coronavirus-2
signaling pathways
significant difference
significant differences
stem cells
susceptibility
therapy
TNF
toxic effect
toxic effects
Transcriptome
transcriptome change
transcriptome changes
Treatment
Tumor
tumor necrosis
tumor necrosis factor
[DOI] 10.1016/j.stemcr.2021.08.018 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.stemcr.2021.08.018 PMC 바로가기 [Article Type] Article