An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primatesAAV 기반 실온 안정 단일 용량 COVID-19 백신은 인간이 아닌 영장류에서 내구성 있는 면역원성과 보호 기능을 제공합니다Article Published on 2021-09-082022-09-12 Journal: Cell Host & Microbe [Category] MERS, SARS, 비임상, 진단, [키워드] AAV Abstract adeno-associated virus affected antibody Antigen Complete COVID-19 COVID-19 vaccine cross-reactivity deaths dose Durability effective elicit expression functional Gene therapy Genome Human immunization injection low-dose macaques memory Neutralizing antibody titer NHPs non-human primate pandemic pathogen peak persistence pre-existing immunity produced provide responses Result resulting room-temperature stable Safe SARS-CoV-2 SARS-CoV-2 pandemic single dose stability Support sustained temperature the SARS-CoV-2 Vaccine vaccine candidate vaccine for COVID-19 variants vector viral challenge [DOI] 10.1016/j.chom.2021.08.002 PMC 바로가기 [Article Type] Article
Rapid generation of mouse model for emerging infectious disease with the case of severe COVID-19중증 COVID-19의 경우 신종 감염병에 대한 마우스 모델의 신속한 생성Research Article Published on 2021-08-112022-09-12 Journal: PLoS Pathogens [Category] MERS, 진단, [키워드] adeno-associated virus animal model antibody cocktail applied approach COVID-19 demonstrated disease Drug development Efficacy expressing expression hACE2 Infectious disease Infectious diseases mechanism mice mimicking mouse model multi pandemic of COVID-19 pathogen pathophysiology patients Rapid receptor receptor hACE2 Research SARS-CoV-2 SARS-COV-2 infection severe COVID-19 the disease the patient therapeutic Therapeutics utility vector vectors virus was tested wild-type [DOI] 10.1371/journal.ppat.1009758 PMC 바로가기 [Article Type] Research Article
A novel mouse AAV6 hACE2 transduction model of wild-type SARS-CoV-2 infection studied using synDNA immunogensResearch article Published on 2021-06-092022-10-05 Journal: iScience [Category] 비임상, [키워드] ACE-2 acute respiratory syndrome adeno-associated virus cellular common Coronavirus-2 described DNA vaccine effective interventions euthanized expressing expression hACE2 humoral responses immunization immunogen immunology Infection INO-4800 intranasal instillation Laboratory mice Plasmid Protective respiratory tract robust SARS-CoV-2 SARS-COV-2 infection susceptible TCID50 Viral load Virology wild-type SARS-CoV-2 [DOI] 10.1016/j.isci.2021.102699 [Article Type] Research article
The current landscape of nucleic acid therapeutics Reviews Published on 2021-05-312022-10-05 Journal: Nature nanotechnology [Category] 변종, 유전자 메커니즘, [키워드] addition adeno-associated virus Antisense oligonucleotides approaches approved causes clinically Conjugates Conventional curative disease drugs Effect example explain facilitate facilitated Genetic highlight IMPROVE in vivo induce Lipid nanoparticle long-lasting Messenger RNA nucleic acid platform RNA stability target protein therapeutic effect translation treat Treatment vectors [DOI] 10.1038/s41565-021-00898-0 [Article Type] Reviews
Vectored Immunotherapeutics for Infectious Diseases: Can rAAVs Be The Game Changers for Fighting Transmissible Pathogens?Immunology Published on 2021-05-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] adeno-associated virus antibody antigens Can Clinical efficacy Clinical studies Conventional de novo synthesis Diseases Efficacy Efficiency expression Fighting foreign protein game Gene therapy genomic variation HIV Host Immunity immunomodulatory immunotherapies Immunotherapy in vivo Infection Infectious disease Influenza inherent lentivirus malaria mechanism neutralizing antibody offer passive transfer Pathogens pre-existing immunity profiles Prophylactic reduce repeated Severity of disease single dose tested therapeutic strategy Topology transgene Treatment vaccination Vaccines vectors viral vectors virus [DOI] 10.3389/fimmu.2021.673699 PMC 바로가기 [Article Type] Immunology
Are Viral Vectors Any Good for RNAi Antiviral Therapy? †Editorial Published on 2020-10-202022-10-28 Journal: Viruses [Category] Coronavirus, MERS, SARS, [키워드] adeno-associated virus animal models antiviral drug antiviral drugs antiviral therapy approach cassettes COVID-19 demonstrated expressed gene silencing Good HBV Hepatitis B virus hepatitis C inhibit lentivirus miRNA Protein Replication RNA RNA interference RNA molecule RNAi RNAi pathway rotavirus shRNA siRNA stability therapeutic therapeutic efficacy vector vectors viral disease viral replication Viral vector virus replication [DOI] 10.3390/v12101189 PMC 바로가기 [Article Type] Editorial
Immunomodulatory Effects of Hydroxychloroquine and Chloroquine in Viral Infections and Their Potential Application in Retinal Gene TherapyReview Published on 2020-07-142022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] AAV acute respiratory syndrome adeno-associated virus anti-malarial drug application Autoimmune diseases cells cGAS Chloroquine concentrations Coronavirus-2 dependent on dose-dependent effect doses drug Effect Efficacy and safety ENhance Gene therapy Human immunodeficiency virus Hydroxychloroquine immune responses immunomodulatory activity immunomodulatory effect IMPROVE inflammatory reaction inhibiting Innate immunity lysosomal mechanism of action nucleic acid observation outcome Potential potential benefit practicality proportion reducing Replication Retina Retinal Retinal disease SARS-CoV-2 Support therapeutic TLR9 Toll-like receptor transduced Treatment viral infection viral infections [DOI] 10.3390/ijms21144972 PMC 바로가기 [Article Type] Review
A Viral-Vectored Multi-Stage Malaria Vaccine Regimen With Protective and Transmission-Blocking Efficacies바이러스 벡터 다단계 말라리아 백신 요법: 보호 및 전파 차단 효능Original Research Published on 2019-10-152024-08-11 Journal: Frontiers in immunology [Category] 말라리아, [키워드] adeno-associated virus human adenovirus serotype 5 multi-stage malaria vaccine Pfs25 Plasmodium falciparum circumsporozoite protein transmission-blocking [DOI] 10.3389/fimmu.2019.02412 PMC 바로가기 [Article Type] Original Research
Adeno-Associated Virus as an Effective Malaria Booster Vaccine Following Adenovirus Priming아데노바이러스 프라이밍 후 효과적인 말라리아 부스터 백신으로서의 아데노연관바이러스Original Research Published on 2019-04-052024-08-11 Journal: Frontiers in immunology [Category] 말라리아, [키워드] adeno-associated virus human adenovirus serotype 5 Malaria vaccine Pfs25 Plasmodium falciparum circumsporozoite protein transmission-blocking [DOI] 10.3389/fimmu.2019.00730 PMC 바로가기 [Article Type] Original Research
Adeno-associated virus vectored immunoprophylaxis to prevent HIV in healthy adults: a phase 1 randomised controlled trial건강한 성인에서 HIV를 예방하기 위한 아데노 관련 바이러스 매개 면역 예방: 1상 무작위 대조 시험Article Published on 2019-03-152022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] adeno-associated virus adverse event adverse events AIDS alternative analyses anti-drug antibody antibody assigned cassettes Clinical research Cohort Complete Consent detect development dose dose-escalation double-blind eligibility eligible ELISA expression finding Follow-up foundation funding Future gene delivery Gene Expression generally mild genomes groups healthy HIV HIV antibodies HIV infection immunisation induce initiative Intervention Intramuscular injection Melinda Gate Melinda Gates men moderate muscle biopsy neutralisation neutralisation activity neutralising Neutralising Antibodies neutralising antibody Phase 1 Placebo placebo-controlled Prevent provided public health quadricep quadriceps randomised randomised controlled trial Randomly reactogenicity receive Registered Research resolved RT-PCR screened Serious Adverse Event Serious Adverse Events serotype serum sustained T-cell Response T-cell responses Tolerability Trial United State United States Vaccine virus Volunteer volunteers was done were recorded [DOI] 10.1016/S2352-3018(19)30003-7 PMC 바로가기 [Article Type] Article