The efficacy of combined therapy of qingfeiPaidu capsule and lianhuaqingwen capsule nursing interventions for hospitalized patients with COVID-19: A retrospective study of medical recordsRandomized Controlled Trial Published on 2022-08-122022-10-04 Journal: Medicine [Category] 임상, [키워드] affecting alleviate anti-inflammatory effect baseline Blood Blood urea nitrogen C-reactive protein caused Chinese circulating Clinical characteristics clinical symptom Clinical symptoms Combined Combined therapy COVID-19 COVID-19 patient criteria demonstrated discharge Efficacy enrolled global pandemic group groups Hospitalization hospitalized patient immune function individuals Inflammation Intervention Laboratory lactate dehydrogenase life-threatening lung Lymphocyte count medical record Medicine Mild Moderate COVID-19 outcome outcomes Patient patients with COVID-19 Prognosis pulmonary inflammation Randomly Retrospective study severity scores therapy Traditional Treatment were recorded White blood cells [DOI] 10.1097/MD.0000000000029964 PMC 바로가기 [Article Type] Randomized Controlled Trial
Cellular senescence and senolytics: the path to the clinic Reviews Published on 2022-08-112022-10-05 Journal: Nature Medicine [Category] 바이오마커, 임상, 진단, 치료제, [키워드] alleviate Cell cell cycle arrest cellular senescence Clinical use condition deleterious effect disease Diseases disorder disorders drug humans Intervention Prevent Protein review secrete senescent cell shown therapeutic target tissue tissue damage [DOI] 10.1038/s41591-022-01923-y [Article Type] Reviews
Exploring the mechanism of action of Xuanfei Baidu granule (XFBD) in the treatment of COVID-19 based on molecular docking and molecular dynamicsArticle Published on 2022-08-102022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, [키워드] acting Activation alleviate Analysis analyzed Anti-inflammatory effects Apoptosis Baidu binding binding energy binding free energy bioinformatics Bioinformatics analysis carried chemotaxis clinical symptom Clinical symptoms Combination component Corona COVID-19 CSF2 database disease docking effective gene target GeneCard hydrogen bonds immune response Immunity IMPROVE Inflammation inflammatory cell Inflammatory factor Inflammatory response ingredient inhibiting Intersection KEGG Lymphocytes mechanism mechanism of action molecular molecular docking molecular dynamics monomer NLRP3 Pachypodol pandemic Patient platform Protein protein targets radius of gyration reduce Research residue SARS-COV-2 infection screened signaling pathway significantly solvent stability targets TCMSP database therapeutic treating COVID-19 Treatment was used White blood cell Xuanfei Baidu granule [DOI] 10.3389/fcimb.2022.965273 PMC 바로가기
Performance and application evaluation of SARS-CoV-2 antigen assaySARS-CoV-2 항원 분석의 성능 및 응용 평가Review Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Accessibility accumulated acute respiratory syndrome acute respiratory syndrome coronavirus addition alleviate Antigen antigen detection approved Asymptomatic can not Clinical data coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis COVID-19 vaccines diagnoses Diagnosis False positive False positives gold gold standard hospitals increase in Interpretation Laboratory laboratory diagnosis mutant mutant strain Mutant strains Negative predictive value nucleic acid Nucleic acid detection offer performance positive result Practitioner Predictive value Prevalence Probability promote reagent SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 nucleic acid sensitivity Sensitivity and specificity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specificity speed the SARS-CoV-2 the WHO trade-off WHO [DOI] 10.1002/jmv.27798 PMC 바로가기 [Article Type] Review
Interferon induction, evasion, and paradoxical roles during SARS-CoV-2 infectionSARS-CoV-2 감염 시 인터페론 유도, 회피 및 역설적 역할Review Published on 2022-08-012022-09-11 Journal: Immunological reviews [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus alleviate antiviral immunity causative agent caused cell type cell types coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death deficiency disease disease severity effort evade function IFN IFN response IFNs immune immune evasion interferon interferons interferons (IFNs location mechanism outcome paradoxical pathway Pathways Protective Research responses SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly supported Therapeutics Treatment treatment of COVID-19 Type type I Type I and III IFN virus while [DOI] 10.1111/imr.13113 PMC 바로가기 [Article Type] Review
COVID-19 personal health mention detection from tweets using dual convolutional neural networkResearch article Published on 2022-08-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 치료기술, [키워드] addition alleviate approach automated auxiliary CNN condition COVID-19 dataset deep learning detect experiment expressions health condition health monitoring identify identifying information media MONITOR offer pandemic personal health provide public health real time social media spread of COVID-19 Surveillance text mining [DOI] 10.1016/j.eswa.2022.117139 [Article Type] Research article
GMI, a protein from Ganoderma microsporum, induces ACE2 degradation to alleviate infection of SARS-CoV-2 Spike-pseudotyped virusGanoderma microsporum의 단백질인 GMI는 SARS-CoV-2 Spike-pseudotyped 바이러스의 감염을 완화하기 위해 ACE2 분해를 유도합니다Article Published on 2022-08-012022-09-11 Journal: Phytomedicine : international journal of phytother [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression activating addition alleviate bafilomycin blocking Cell cell viability cells cloned Cytometry deaths Degradation determined by downregulated dynamin Effect Efficacy examined exhibit expressing flow cytometry fluorescence microscopy fluorescent function Fungal immunomodulatory proteins fungal protein GFP GMI green fluorescent protein HEK293T host cells Human immunomodulatory immunomodulatory functions in vitro induce infecting Infection inhibited inhibiting Interaction lentiviral lung epithelial lung tissue lysosome macrophages mechanism MG132 mice MTT nebulizer not affect overexpressing pandemic Prevent prevention proteasome Protein protein level pseudovirus reduced rescued respiratory responsible S2 domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection Severe acute respiratory syndrome spike Spike protein Therapeutic strategies triggered Type Vaccine viability viral infection virus was determined western blot [DOI] 10.1016/j.phymed.2022.154215 PMC 바로가기 [Article Type] Article
Spatially Patterned Neutralizing Icosahedral DNA Nanocage for Efficient SARS-CoV-2 Blocking효율적인 SARS-CoV-2 차단을 위한 공간적으로 패턴화된 중화 정이십면체 DNA 나노케이지Article Published on 2022-07-272022-09-11 Journal: Journal of the American Chemical Society [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] aggregation alleviate anti-SARS-CoV-2 assembly binding binding site blocking composed conformational disease-causing DNA efficient ENhance exhibit form global public health Host induce Infection inhibit inhibitory effect limit moderate multidimensional mutant strain Mutant strains neutralization Neutralizing omicron positioned Prevent provide pseudovirus reagent SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike trimer spike trimer steric the SARS-CoV-2 threat triangular Viral viral infection virus viruses wild-type [DOI] 10.1021/jacs.2c02764 PMC 바로가기 [Article Type] Article
Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection Research Published on 2022-07-252022-10-05 Journal: Nature chemical biology [Category] COVID19(2023년), SARS, 변종, 치료법, 치료제, [키워드] alleviate approach can be used cathepsin L Cell CRISPR decrease expression Host host protease in vivo infected with SARS-CoV-2 inhibitor interstitial inflammation knockdown Lower lung Messenger RNA mice mRNA pathological changes Potential treatment Prevent proinflammatory protease reduced reported SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pathogenesis severity survival treat Treatment unique virus [DOI] 10.1038/s41589-022-01094-4 [Article Type] Research
The prevalence of psychological stress in student populations during the COVID-19 epidemic: a systematic review and meta-analysis Research Published on 2022-07-152022-10-05 Journal: Scientific Reports [Category] 치료법, [키워드] 95% CI alleviate Anxiety anxiety symptom assessment checklist China Chinese Cochrane Library COVID-19 COVID-19 epidemic COVID-19 outbreak cross-sectional study database Depression depressive symptom employment English Epidemic Factors Gender group Home isolation identify incidence Infrastructure literature management mental health service Meta-analysis moderate outbreak Periodicals Population Prevalence Psychological Quality random-effects model reaction researcher retrieved screened searched Stress stress symptom Symptom systematic review the epidemic VIP was used Web of Science [DOI] 10.1038/s41598-022-16328-7 [Article Type] Research