Dysautonomia Following Tetanus, Diphtheria, and Pertussis Vaccine (Tdap): The First Case of Extreme Cachexia Caused by Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA Syndrome) in a Human파상풍, 디프테리아, 백일해 백신(Tdap)에 따른 자율신경실조: 인간에서 보조제에 의해 유발된 자가면역/염증 증후군(ASIA 증후군)으로 인한 극심한 악액질의 첫 번째 사례Case Report Published on 2021-12-062024-07-28 Journal: Medicina [Category] 백일해, 파상풍, [키워드] aluminum autoantibodies autoimmune/inflammatory syndrome induced by adjuvants Autoimmunity Cachexia molecular mimicry Tdap Vaccine [DOI] 10.3390/medicina57121333 PMC 바로가기 [Article Type] Case Report
Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy children and adolescents: a double-blind, randomised, controlled, phase 1/2 clinical trial건강한 소아 및 청소년을 대상으로 한 불활성화 SARS-CoV-2 백신(CoronaVac)의 안전성, 내약성 및 면역원성: 이중 맹검, 무작위, 대조, 1/2상 임상 시험Clinical Trial Published on 2021-12-012022-09-12 Journal: The Lancet. Infectious Diseases [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] 95% CI Adverse reaction age All participants aluminum Antibody Response Antibody titre assigned Beijing block Block randomisation center children China Chinese clinical trial Control CoronaVac COVID-19 pandemic COVID-19 vaccine detectable development dose dose-escalation double-blind Endpoint enrolled geometric mean titre groups healthy children Humoral response hydroxide inactivated individual Infection injection injection site Intramuscular injection investigators Laboratory live SARS-CoV-2 Mild moderate MOST neutralising antibody occurred Pain participant Participants per-protocol population phase 1 trial Pneumonia prevention primary immunogenicity Program randomised Randomly receive Registered reported Safe Safety safety population safety profile SARS-CoV-2 SARS-CoV-2 vaccine Science second dose Serious Adverse Event Seroconversion seroconversion rate severity significant difference Support technology three group Tolerability vaccination Vaccine were excluded [DOI] 10.1016/S1473-3099(21)00319-4 PMC 바로가기 [Article Type] Clinical Trial
Monitoring of SARS-CoV-2 RNA in wastewater as an epidemiological surveillance tool in Mendoza, Argentina아르헨티나 멘도사에서 역학 감시 도구로서의 폐수 내 SARS-CoV-2 RNA 모니터링Article Published on 2021-11-202022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, 치료법, [키워드] advance aluminum Analysis applied Concentration COVID-19 COVID-19 case COVID-19 cases diagnosed Epidemiologic surveillance epidemiological epidemiological surveillance Epidemiology exponential growth genetic marker Genetic markers glycol growth Health status increase in individual infections marker MONITOR monitoring N1 and N2 nucleocapsid pandemic plant plateau Polyethylene glycol populations positive correlation quantification RNA isolation RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 RNA spatial information Surveillance Treatment Viral load Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2021.148887 PMC 바로가기 [Article Type] Article
Development of the Inactivated QazCovid-in Vaccine: Protective Efficacy of the Vaccine in Syrian HamstersMicrobiology Published on 2021-09-272022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] aluminum antibody Antigen body temperature buffer candidate vaccine clinical symptom coronavirus disease COVID-19 Culture develop development dose Effectiveness filtration formaldehyde gel hamster hamsters homologous hydroxide inactivated Inactivated vaccine indicated Infection Kazakhstan log lung observation period Particles patients Pneumonia Protective protective efficacy purified QazCovid-in Registered replicative retained saline solution SARS-CoV-2 Stress survival Syrian hamsters TCID the SARS-CoV-2 virus the vaccine trials Vaccine Vero Cell viral replication virion virulent virus virus-neutralizing antibody was used were used [DOI] 10.3389/fmicb.2021.720437 PMC 바로가기 [Article Type] Microbiology
Assessment of adjuvantation strategy of lipid squalene nanoparticles for enhancing the immunogenicity of a SARS-CoV-2 spike subunit protein against COVID-19코로나19에 대한 SARS-CoV-2 스파이크 소단위 단백질의 면역원성을 향상시키기 위한 지질 스쿠알렌 나노입자의 면역보강 전략 평가Article Published on 2021-09-252022-09-12 Journal: International journal of pharmaceutics [Category] MERS, SARS, 진단, [키워드] Administered aluminum assessment comparable coronavirus disease COVID-19 COVID-19 vaccine cytokine dose effective intervention Efficacy ELISA enhancing the immunogenicity group histological examination IgG IL-10 immune response immunomodulation induce information injection interferon intramuscularly investigated Lipid Lipid squalene nanoparticles mice modulating Neutralizing pandemic Protective antibody Protein S-protein SARS-CoV-2 spike secretion serum sample significantly Single injection splenocytes subunit the SARS-CoV-2 the vaccine Vaccine vaccine adjuvant vaccine injection virus [DOI] 10.1016/j.ijpharm.2021.121024 PMC 바로가기 [Article Type] Article
RBD-homodimer, a COVID-19 subunit vaccine candidate, elicits immunogenicity and protection in rodents and nonhuman primatesArticle Published on 2021-09-072022-10-04 Journal: Cell Discovery [Category] 변종, 치료기술, [키워드] addition aluminum antibody approach Biological techniques biosafety caused COVID-19 cross-neutralization activity domain effective elicit elicited expression homodimer Immunity immunology Injury lung lung damage majority mice non-human primates pandemic pandemic of COVID-19 Prevent provided raised RBD RBD dimer reduce reducing respiratory tract rodent Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV-2 variants significantly Spread strong immune response subunit the vaccine Transport Vaccine vaccine candidate Viral load [DOI] 10.1038/s41421-021-00320-y PMC 바로가기 [Article Type] Article
An enveloped virus-like particle vaccine expressing a stabilized prefusion form of the SARS-CoV-2 spike protein elicits highly potent immunitySARS-CoV-2 스파이크 단백질의 안정화된 예비융합 형태를 발현하는 외피 바이러스 유사 입자 백신은 매우 강력한 면역을 유도합니다Article Published on 2021-08-162022-09-12 Journal: Vaccine [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome adjuvant aluminum Antibody binding clinical evaluation Coronavirus disease 2019 Coronavirus-2 COVID-19 effort elicit evaluated expressing form Formulation identify IgG1 IgG2 Immunity immunization immunogenicity injection isotype mice neutralization titer Neutralizing activity Neutralizing antibodies phosphate prefusion SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 spike protein selected single dose Spike protein Support Syrian golden hamster the SARS-CoV-2 Vaccine vaccine candidate Virus-like particle virus-like particle vaccine Virus-like-particles. [DOI] 10.1016/j.vaccine.2021.07.034 PMC 바로가기 [Article Type] Article
Effect of 2 Inactivated SARS-CoV-2 Vaccines on Symptomatic COVID-19 Infection in Adults: A Randomized Clinical TrialClinical Trial Published on 2021-07-062022-10-05 Journal: JAMA [Category] 임상, [키워드] 95% CI adverse event Adverse reaction age aluminum Analysis Bahrain Chinese clinical contributed COVID-19 COVID-19 vaccines Data collection data set dose doses double-blind Effect effective vaccine Efficacy efficacy analysis Enrollment evaluate Evidence Final Follow-up group groups had no hydroxide inactivated Inactivated vaccine injection interim analysis Intramuscular injection laboratory-confirmed median men occurred Older outcome participant per 1000 person-years phase 3 trial Primary outcome randomization Randomized randomized clinical trial reaction receive reduced resulting risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine second dose secondary outcome Serious Adverse Event Severe case severe COVID-19 significantly strain symptomatic the vaccine Treatment United Arab Emirate Vaccine vaccine dose was collected [DOI] 10.1001/jama.2021.8565 PMC 바로가기 [Article Type] Clinical Trial
Immunogenicity Studies of Plant-Produced SARS-CoV-2 Receptor Binding Domain-Based Subunit Vaccine Candidate with Different Adjuvant FormulationsArticle Published on 2021-07-052022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] addition adjuvant adjuvants aluminum Antibody Response candidate Cell Cellular immune response clinical trials coronavirus disease COVID-19 demonstrated domain effective vaccine Efficacy and safety elicited evaluated Formulation Frequency fused gel groups Head-to-head comparison hydroxide IgG IgG1 IgG2a Immune profile immune response immunogenicity MF59 mice Neutralizing antibodies neutralizing antibody no significant difference performed plant-based vaccine problem public health RBD RBD-Fc Receptor-binding domain Research responses Salmonella SARS-CoV-2 significantly increased subtype Subunit vaccine subunit vaccines tested Transmission vaccination Vaccine virus spread [DOI] 10.3390/vaccines9070744 PMC 바로가기 [Article Type] Article
Review: Vaccine Myth-Buster – Cleaning Up With Prejudices and Dangerous MisinformationImmunology Published on 2021-06-102022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] adjuvants aluminum Anxiety cleaning concerning correlation distribution FIVE formaldehyde Genetic genetic vaccines Health immunization inactivation include information medication misinformation parent Patient prejudice raised Research researcher selected Side effect Side effects Support target threat vaccination Vaccine Vaccine hesitancy vaccine safety Vaccines WHO World Health Organization [DOI] 10.3389/fimmu.2021.663280 PMC 바로가기 [Article Type] Immunology