Molecular mechanisms involved in anosmia induced by SARS-CoV-2, with a focus on the transmembrane serine protease TMPRSS2막횡단 세린 프로테아제 TMPRSS2를 중심으로 SARS-CoV-2에 의해 유도된 후각장애와 관련된 분자 기전Review Published on 2022-10-012022-09-11 Journal: Archives of Virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Anosmia Apoptosis blockade camostat caused cell entry cellular and molecular chromosome chromosome 21 cleaving Delta dependent on disease disorder dysfunction entry of SARS-CoV-2 event ExoN exons facilitate functional gene encoding Genetic variations help host cell Inflammation involved mechanism nafamostat neuronal number of symptoms olfactory dysfunction olfactory neuroepithelium omicron overcome pandemic virus receptor receptors risk SARS-CoV-2 Serine serine protease serine protease inhibitor serine protease inhibitors shown strain Strains Symptoms therapeutic TMPRSS2 transmembrane serine protease viral S protein virus [DOI] 10.1007/s00705-022-05545-0 PMC 바로가기 [Article Type] Review
The nervous system during COVID-19: Caught in the crossfireReview Published on 2022-10-012023-07-09 Journal: Immunological reviews [Category] COVID19(2023년), [키워드] Anosmia COVID-19 NeuroCOVID Neuroimmunology Neuroinflammation olfactory system. SARS-CoV-2 [DOI] 10.1111/imr.13114 PMC 바로가기 [Article Type] Review
Randomized clinical trial of BCG vaccine in patients with convalescent COVID-19: Clinical evolution, adverse events, and humoral immune responseArticle Published on 2022-10-012022-11-15 Journal: Journal of internal medicine [Category] 진단, [키워드] acute respiratory syndrome Adults adverse effect adverse event adverse events Ageusia angiotensin-converting enzyme 2 Anosmia Bacillus BCG center clinical clinical evolution clinical trial convalescence convalescent coronavirus coronavirus disease COVID-19 cross-protection double-blind evaluated Evolution expected Follow-up humoral humoral immune response IgG Immunoglobulin immunomodulation induce lesions Local modulation multicenter N protein neutralization neutralize NNT offer Other outcome Outpatient Patient Placebo placebo-controlled placebos prevented Primary outcome proportion Randomized receptor recipient Safe Safety. SARS-CoV-2 serum Seven severely ill patient significantly higher South America statistically significant systemic adverse effects treat university Vaccine viral disease virus [DOI] 10.1111/joim.13523 PMC 바로가기
Negative correlation between ACE2 gene expression levels and loss of taste in a cohort of COVID-19 hospitalized patients: New clues to long-term cognitive disordersArticle Published on 2022-09-292022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, [키워드] ACE1 ACE2 ACE2 expression ACE2 gene addition Ageusia Alu Analysis Angiotensin-converting enzyme Anosmia association Brain Cell cells cognitive Cognitive dysfunction Cohort consequence correlation COVID-19 disorder Effect evaluated expression expression level Factors gene expression level Genetic genetic association Health Hospitalized hospitalized patients human cell initial symptoms long-COVID long-COVID syndrome Loss of Smell loss of taste molecular nasopharyngeal negative New obligatory occur Olfactory epithelium outcomes penetration polymorphism prevalent priming protease Quantitative quantitative trait receptor Regression model Research Respiratory system RT-qPCR SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe COVID-19. Spread Symptom Symptoms tissue TMPRSS2 variable virus [DOI] 10.3389/fcimb.2022.905757 PMC 바로가기
COVID-19 symptom relationship to antibody response and ACE2 neutralization in recovered health systems employees before and after mRNA BNT162b2 COVID-19 vaccineArticle Published on 2022-09-092022-11-15 Journal: PLoS ONE [Category] SARS, 변종, 진단, [키워드] ACE2 Ageusia angiotensin-converting enzyme 2 Anosmia Antibody Response Antibody titer blood sample Clinical characteristics Cook County Health cough COVID-19 immunity COVID-19 symptom COVID-19 vaccine D614G demographics dependent on evaluated Fever health system humoral IC50 immune response Immunity Infection less magnitude mRNA BNT162b2 mutant N-terminal domain neutralization NTD participant PCR-confirmed positive Post-infection Prevent Primary infection Protein provided RBD Receptor binding domain Reinfection reported symptoms SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 test severity significantly significantly higher spike subsequent Symptom Symptoms the antibody response the spike protein these symptoms vaccination [DOI] 10.1371/journal.pone.0273323 PMC 바로가기
Impact of hypertension on long-term humoral and cellular response to SARS-CoV-2 infectionArticle Published on 2022-09-022022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, 치료제, [키워드] age airway analyzed Anosmia association Asthma Blood blood collection BMI cellular Cellular immune response cellular response clinical factor confounding factor confounding factors COPD COVID COVID - 19 determine develop diabetes exacerbate HCW HCWs Health care Hospitalized humoral humoral and cellular response hyperinflammation hypertension hypertensive identify immune response immune response. Impact independent Infection less median multivariate regression analysis myalgia Neutralizing antibodies normotensive outbreak PCR positivity regression analysis respiratory tract response Risk factors S1 IgG SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection Sex shown significantly smoking T cell Test transformation viral clearance was done [DOI] 10.3389/fimmu.2022.915001 PMC 바로가기
ORAL NEUROPATHIC PAIN POST-COVID-19 IN A YOUNG BRAZILIAN PATIENTConference abstract Published on 2022-09-012022-10-05 Journal: Oral surgery, oral medicine, oral pathology and or [Category] 변종, [키워드] Anosmia complication of COVID-19 complications Concentration concerning cough COVID-19 cytidine develop disease fatigue information knowledge Medicine memory myalgia nasal congestion neurologic neuropathic neuropathic pain oral oral examination osseous Pain patients with COVID-19 positive presenting reported service sore throat Treatment uridine vitamin B12 worsening [DOI] 10.1016/j.oooo.2022.01.079 [Article Type] Conference abstract
Effect of intra-nasal nitrilotriacetic acid trisodium salt in lowering elevated calcium cations and improving olfactory dysfunction in COVID-19 patientsRandomized Controlled Trial Published on 2022-09-012022-10-05 Journal: European archives of oto-rhino-laryngology : offic [Category] 임상, [키워드] Analysis Anosmia association Concentration COVID-19 COVID-19 adult patient COVID-19 patient Effect elevated enrolled functional healthy increase in intracellular calcium intranasal nasal olfactory olfactory disorders olfactory dysfunction patients worldwide Randomized controlled trial Research SARS-CoV-2 secretion selective significant decrease Smell Smell. Sodium chloride Symptom Treatment was performed [DOI] 10.1007/s00405-022-07424-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
Sociodemographic Characteristics and Comorbidities of Patients With Long COVID and Persistent Olfactory DysfunctionArticle Published on 2022-09-012022-11-16 Journal: JAMA Network Open [Category] SARS, 치료기술, [키워드] activities Adults affected age Ageusia analysis Anosmia association Brazil case report form center Characteristics clinical Clinical data clinical feature Clinical research conducted Connecticut COVID cross-sectional Determining develop Diagnosis dysfunction evaluated had more headache highest hygiene Hyposmia impairment Logistic regression Long neurologic Occurrence Odds ratio olfactory dysfunction onset of symptoms outcome outpatients Patient patients persistent Potential treatment Prevalence Prognosis questionnaire rehabilitation sense of smell severity significantly sleep disorder Sociodemographic Symptom Symptoms symptoms of COVID-19 the study group was recorded women [DOI] 10.1001/jamanetworkopen.2022.30637 PMC 바로가기
Effect of Ultra-Micronized Palmitoylethanolamide and Luteolin on Olfaction and Memory in Patients with Long COVID: Results of a Longitudinal StudyRandomized Controlled Trial Published on 2022-08-172022-10-05 Journal: Cells [Category] 임상, [키워드] absence affected age ameliorated Anosmia average baseline Biomarkers Brain brain fog Combination COVID COVID-19 disorders Effect group Hyposmia interval investigated Long long-haul COVID syndrome longitudinal lutein Luteolin measure mechanisms memory men Mental mental clouding Neuroinflammation Olfaction olfactory olfactory dysfunction olfactory threshold olfactory training outcomes palmitoylethanolamide parosmia Patient patients PEA-LUT Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) Prevalence qualitative smell disorders Quantitative Randomized receive recruited reduction in regimen remaining group Result SARS-COV-2 infection self-report measure severity smell disorders. subjects subsequent therapy thresholds Treatment were assessed women [DOI] 10.3390/cells11162552 PMC 바로가기 [Article Type] Randomized Controlled Trial