Licorice ( Glycyrrhiza glabra ) Extracts-Suitable Pharmacological Interventions for COVID-19? A ReviewReview Published on 2021-11-262022-10-28 Journal: Plants [Category] COVID-19, [키워드] acute respiratory distress addition Anti-inflammatory anti-inflammatory drug anti-inflammatory properties Antiviral antiviral drug ARDS clinical trial component contribute coronavirus COVID-19 COVID-19 patients COVID-19 symptoms database develop Glycyrrhetinic acid glycyrrhiza glycyrrhizic acid in vitro in vivo inhibit Intervention licorice mechanism medication medicinal plants Mortality Previous studies Replication review SARS-CoV-2 pandemic shown suggested syndrome the SARS-CoV-2 the vaccine Treatment vaccination was selected Web of Science [DOI] 10.3390/plants10122600 PMC 바로가기 [Article Type] Review
Colchicine Is Safe Though Ineffective in the Treatment of Severe COVID-19: a Randomized Clinical Trial (COLCHIVID)Randomized Controlled Trial Published on 2021-11-092022-10-04 Journal: Journal of General Internal Medicine [Category] SARS, 임상, [키워드] 95% CI 95%CI Adverse anti-inflammatory drug baseline clinical Colchicine colchicine treatment Complete conducted COVID-19 Critical disease death demonstrated Disease progression effective Efficacy evaluated event feature group had no hospital Hospitalized hospitalized patient ICU IL-12p70 IL-17A IL-8 immunological Ineffective interim analysis measure objective outcome participant Patient patients Placebo placebo-controlled clinical trial Primary outcome progression Randomized receive recruited recruitment Registration Result Safe Serum level severe COVID-19 severe COVID-19 patient suggested Treatment triple-blind [DOI] 10.1007/s11606-021-07203-8 PMC 바로가기 [Article Type] Randomized Controlled Trial
Occurrence, Fate, Effects, and Risks of Dexamethasone: Ecological Implications Post-COVID-19Review Published on 2021-10-272022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Administered anti-inflammatory drug Aquatic ecosystems cause concentrations contaminant coronavirus disease COVID-19 crustacean Deleterious demonstrated Dexa Dexamethasone downstream drinking water drug ecological ecological implication Effect Effects fish glucocorticoid hospitalizations hospitalized COVID-19 patients implication IMPROVE infections management molecular Occurrence organism outbreak outcome plants raised reduction released SARS-CoV-2 Surface water susceptible transformation treat Treatment wastewater whole organism widespread [DOI] 10.3390/ijerph182111291 PMC 바로가기 [Article Type] Review
Current Understanding of the Innate Control of Toll-like Receptors in Response to SARS-CoV-2 InfectionReview Published on 2021-10-222022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] affected anti-inflammatory drug approved caused component Control coronavirus disease COVID-19 current Cytokine storm drug Effectiveness healthcare hyperinflammation Hyperinflammatory immune response Infection inflammatory immune response Innate innate response invading pathogens involved knowledge microbial pandemic patients with COVID-19 phenotype recognize response responsible SARS-CoV-2 SARS-COV-2 infection severity of COVID-19 therapeutic TLR TLRs Toll-like receptor Toll-like receptor (TLR) understanding [DOI] 10.3390/v13112132 PMC 바로가기 [Article Type] Review
Pragmatic clinic randomized trial to improve chronic kidney disease care: Design and adaptation due to COVID disruptionsRandomized Controlled Trial Published on 2021-10-012022-10-05 Journal: Contemporary clinical trials [Category] SARS, 임상, [키워드] ACEi age Analysis angiotensin receptor blocker anti-inflammatory drug ARB blood pressure Care caused CDS changes chronic Chronic kidney disease CKD clinical Clinical decision support clinician clinics Complete COVID COVID care disruption COVID-19 COVID-19 pandemic criteria displaying enzyme Glucose Health IMPROVE inhibitor initial Intervention kidney Laboratory Modification Patient Pragmatic pragmatic clinical trial primary care provided Randomized randomized trial Support Treatment Trial usual care [DOI] 10.1016/j.cct.2021.106501 PMC 바로가기 [Article Type] Randomized Controlled Trial
IgM-enriched immunoglobulin in COVID-19: Case series of 15 severely ill SARS-CoV-2-infected patientsCOVID-19의 IgM 강화 면역글로불린: 중증 SARS-CoV-2 감염 환자 15명의 사례 시리즈Case Reports Published on 2021-10-012022-09-12 Journal: International immunopharmacology [Category] MERS, 임상, 진단, [키워드] acute respiratory syndrome anti-inflammatory drug appear clinical study Computed tomography coronavirus COVID-19 Cytokine storm Dexamethasone hallmark Healthcare system hospitalised hyperinflammation IgM-enriched immunoglobulin Immunoglobulin improvement in-hospital mortality Infection intensive care Intravenous immunoglobulin (IVIG) Iran management nine outcome Patient patient with COVID-19 patients Radiographic reduce mortality reported rising SARS-CoV SARS-CoV-2 SARS-CoV-2-infected patient Sepsis Severe case severe COVID-19 shown the disease treated Treatment with COVID-19 [DOI] 10.1016/j.intimp.2021.107998 PMC 바로가기 [Article Type] Case Reports
Functionalized Dendrimer Platforms as a New Forefront Arsenal Targeting SARS-CoV-2: An OpportunityReview Published on 2021-09-182022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] acute respiratory syndrome anti-inflammatory drug antiviral drug approach approved approved drug arsenal candidate caused clinical trial coronavirus coronavirus disease coronavirus SARS-CoV-2 COVID-19 COVID-19 disease COVID-19 infection COVID-19 pandemic decrease dendrimer dendrimers develop drug FDA food IMPROVE Nanotechnology New opportunity pandemic pro-inflammatory cytokines repurposing strategy SARS-CoV-2 targeting the cytokine storm the patient transmission of SARS-CoV-2 Vaccine [DOI] 10.3390/pharmaceutics13091513 PMC 바로가기 [Article Type] Review
Ventilatory support and corticosteroid therapy in SARS-CoV-2SARS-CoV-2의 환기 지원 및 코르티코스테로이드 요법Review Published on 2021-09-012022-09-11 Journal: Revista española de quimioterapia : publicación [Category] SARS, 치료제, [키워드] anti-inflammatory drug Anti-inflammatory drugs Antiviral caused clinical trial Community Corticosteroid corticosteroid therapy Corticosteroids COVID-19 disease Health Organization Hospital admission New coronavirus pandemic Patient Respiratory failure SARS-CoV-2 Support tested therapeutic therapeutic strategy ventilatory support World Health Organization [DOI] 10.37201/req/s01.16.2021 PMC 바로가기 [Article Type] Review
Potential inhibitors of the main protease of SARS-CoV-2 and modulators of arachidonic acid pathway: Non-steroidal anti-inflammatory drugs against COVID-19SARS-CoV-2의 주요 프로테아제 및 아라키돈산 경로 조절제의 잠재적 억제제: COVID-19에 대한 비스테로이드성 항염증제Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 신약개발, 치료제, [키워드] 3CLpro anti-inflammatory drug anti-viral drug Anti-viral drugs antiviral drugs arachidonic acid Arachidonic acid pathway attenuate AutoDock AutoDock vina binding affinities binding affinity Candidates chymotrypsin Chymotrypsin-like protease Compound conducted COVID-19 Cytokine storm dataset develop Disturbed docking docking result docking results downregulation evaluated Final Gene expression profiling hepatotoxicity highlight inflammatory mediator Inflammatory mediators inhibitor inhibitor N3 Interaction investigated Ligand lower binding energy metabolic molecular molecular docking Molecular simulation NCBI GEO non-steroidal anti-inflammatory drug Non-steroidal anti-inflammatory drugs NSAID NSAIDS pathway performed perturbations Potential predicted protease Repository SARS-CoV-2 SARS-CoV2 selected Systems biology Talniflumate target the cytokine storm the SARS-CoV-2 Z-score [DOI] 10.1016/j.compbiomed.2021.104686 PMC 바로가기 [Article Type] Article
The Role of the PFNA Operon of Bifidobacteria in the Recognition of Host’s Immune Signals: Prospects for the Use of the FN3 Protein in the Treatment of COVID-19숙주의 면역 신호 인식에서 비피도박테리아의 PFNA 오페론의 역할: COVID-19 치료에서 FN3 단백질의 사용에 대한 전망Review Published on 2021-08-262022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 유전자 메커니즘, [키워드] addressed anti-inflammatory drug Anti-inflammatory drugs Bacteria bifidobacteria binding Cluster consequence core genes COVID-19 creation cytokine cytokine receptor Cytokine storms domain domains Evolution FIVE host immune system host-microbe interaction humans immune system immunomodulatory properties immunomodulatory property implicated implication Interaction mechanism microbial motif motifs operon over PFNA operon Protein protein kinase question Recognition resulting role SARS-COV-2 infection Serine species threonine TNF-α transmembrane region [DOI] 10.3390/ijms22179219 PMC 바로가기 [Article Type] Review