In silico drug repurposing against SARS-CoV-2 using an integrative transcriptomic profiling approach: Hydrocortisone and Benzhydrocodone as potential drug candidates against COVID-19통합 전사체 프로파일링 접근법을 사용하여 SARS-CoV-2에 대한 인실리코 약물 용도 변경: COVID-19에 대한 잠재적 약물 후보로서 히드로코르티손 및 벤즈히드로코돈Article Published on 2022-09-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] ADAR alveolar cell Analysis Anti-viral antiviral immune response Benzhydrocodone binding affinity CASP1 cellular response Cellular responses Clinical studies clinical study complementary COVID-19 COVID-19 pathogenesis determine drug drug candidate Drug repurposing dysregulated enrichment enrichment analysis evaluated FDA-approved drug FOS hallmark HBEGF Host Hydrocortisone ICAM1 identify IFI35 immune system in silico in silico approaches in viral in vitro in vivo experiment infected with SARS-CoV-2 Infectious disease involved IRF2 JUN management MMP9 molecular molecular docking Pathogenesis pathway Pathways promise Protein protein-protein interaction Proteins Repurposed drug Repurposed drugs SARS-CoV-2 SARS-COV-2 infection Signal transduction STAT3 subject suggested transcriptomic transcriptomic profile transcriptomics up-regulated USP18 viral infectious disease [DOI] 10.1016/j.meegid.2022.105318 PMC 바로가기 [Article Type] Article
A novel logical model of COVID-19 intracellular infection to support therapies developmentArticle Published on 2022-08-292022-11-15 Journal: PLoS Computational Biology [Category] SARS, 치료제, [키워드] Analysis Anti-inflammatory Anti-viral benefit cellular pathway Combination Corticosteroid counterproductive COVID-19 COVID-19 infection drug drug treatment Effect Efficacy Infection involved mathematical mechanism molecular Pathways performed sensitivity analysis Support therapy triple combination [DOI] 10.1371/journal.pcbi.1010443 PMC 바로가기
Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapyArticle Published on 2022-08-152022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 치료제, [키워드] ACE2 ACE2 receptors acute respiratory syndrome Analysis Anti-viral antiviral activity article Ashwagandha build Clinical management Compound coronavirus Coronavirus disease 2019 COVID-19 Critical disease drug Drug discovery flu help Immune homeostasis implicated Infection Inflammation information inhibit knowledge management MPro multiple organs organs other compounds pandemic parameter Patient patients Population pro-inflammatory cytokine protease provided Regulation SARS-CoV-2 SARS-COV-2 infection secure Side effect Standardization targeted therapy the patient Treatment Vaccine virus was performed Withania somnifera [DOI] 10.3389/fcimb.2022.933824 PMC 바로가기
The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate강력한 항바이러스 약물 후보로서 SARS-CoV-2 3C 유사 프로테아제에 대한 펩티도미메틱 억제제의 구조 기반 설계Article Published on 2022-08-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 3C Like protease 3CL 3CL pro acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 Anti-viral anti-viral drug applied complexes Compound coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 deficiency described develop drug candidates effective inhibit inhibitor inhibitors inhibitory activity Like Medicine pathogen Peptidomimetic inhibitors potent Prevent Pro protease Protease inhibitor protein-ligand respiratory SARS-CoV-2 screened Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus structure-based design targeting the SARS-CoV-2 Transcription treat viral replication X-ray [DOI] 10.1016/j.ejmech.2022.114458 PMC 바로가기 [Article Type] Article
Propolis efficacy on SARS-COV viruses: a review on antimicrobial activities and molecular simulationsSARS-COV 바이러스에 대한 프로폴리스 효능: 항균 활성 및 분자 시뮬레이션에 대한 검토Review Published on 2022-08-012022-09-11 Journal: Environmental science and pollution research inter [Category] COVID19(2023년), SARS, 치료제, [키워드] activities activity addition adjuvants Anti-inflammatory Anti-viral antimicrobial Antimicrobial activities appear biological properties combating Comorbidities Compound COVID-19 COVID-19 patient COVID-19 symptoms COVID-19 treatment COVID-19 vaccine discharge Efficacy evaluated flavonoids highlight hospitals immunomodulatory include investigated Molecular simulation molecular simulations mortality rate nutraceutical nutraceuticals patients Pharmacological properties Propolis provide receiving reduce viral replication reduced Research SARS-CoV viruses SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2-infected patients Symptom the SARS-CoV-2 virus Treatment Vaccine viral clearance viral replication while [DOI] 10.1007/s11356-022-21652-6 PMC 바로가기 [Article Type] Review
SOLVx therapeutics vaccine – Activate T-cell immunity using broad surveillance epitope strategy against mutant strains SARS-COV2SOLVx 치료제 백신 - 돌연변이 균주 SARS-COV2에 대한 광범위한 감시 에피토프 전략을 사용하여 T 세포 면역 활성화Article Published on 2022-08-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha Analysis Anti-viral B cell B cells BALB/c mice biochemical biological samples cellular coronavirus cytokine levels Cytokine storm decrease Defense develop dose Effect Efficacy and safety elevated epitope eradication euthanized Evolution functional Genome HCoV HCoV-229E hematological humoral IFN-γ IL-10 IL-6 immune response Immunoglobulin Immunoglobulin G increase in interferon gamma Laboratory lung tissue Lungs mice mRNA mutable mutant mutant strain NK cell parameter PBMC PBMCs peptide peptides Prophylactic qPCR reduced SARS-COV2 mutant significantly SOLVx statistically significant suggested Surveillance T cell T-cell immunity therapeutic TNF-alpha TNF-α treated Treatment treatment group treatment groups Vaccine virus Virus evolution virus infectivity were assessed were used [DOI] 10.1016/j.biopha.2022.113212 PMC 바로가기 [Article Type] Article
Remdesivir reduced upper respiratory tract SARS-CoV-2 viral RNA concentration in COVID-19 patients who developed pneumonitisCorrespondence Published on 2022-08-012022-10-05 Journal: The Journal of Infection [Category] COVID19(2023년), SARS, 치료제, [키워드] Anti-viral clinical Concentration COVID-19 COVID-19 patient reduced Remdesivir SARS-CoV-2 SARS-CoV-2 viral RNA Treatment upper respiratory tract viral kinetics Viral load Virological [DOI] 10.1016/j.jinf.2022.08.031 [Article Type] Correspondence
Asia Pacific perspectives on the second year of the COVID-19 pandemic: A follow-up surveyCOVID-19 대유행 2년차에 대한 아시아 태평양 전망: 후속 조사Article Published on 2022-08-012022-09-12 Journal: Clinical and experimental allergy : journal of the [Category] Coronavirus, 진단, [키워드] Adverse reaction anaphylaxis Anti-viral anticipated Asia Baricitinib Care changes in cilgavimab clinical complement contributed Coronavirus disease 2019 country COVID-19 COVID-19 disease COVID-19 vaccination programme Dexamethasone Endemic endemic diseases Epidemiology Follow-up force incidence males mild-to-moderate disease morbidity and mortality mRNA neutralizing antibody novel Pacific Association pandemic Perspective preventive measures Prophylaxis public health public health measure question Remdesivir response Ritonavir severe disease Severe infection survey Therapeutics Tixagevimab vaccination Vaccine [DOI] 10.1111/cea.14191 PMC 바로가기 [Article Type] Article
Theaflavin 3-gallate inhibits the main protease (M pro) of SARS-CoV-2 and reduces its count in vitroTheaflavin 3-gallate는 SARS-CoV-2의 주요 프로테아제(M pro)를 억제하고 시험관 내에서 그 수를 감소시킵니다.Article Published on 2022-07-302022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] active site Analysis Anti-viral Atazanavir darunavir demonstrated docking score drug target exhibited flavin gallate in viral in vitro inhibit inhibited inhibitor Interaction isolate Lopinavir M pro Molecular docking study Particle protease Protein reduce reduced reduction Replication Repurposed drug Repurposed drugs residue SARS-CoV-2 SARS-CoV-2 virus target the SARS-CoV-2 virus theaflavin Vero Cell Vero cells Viral particles viral replication viral transcript viral transcripts [DOI] 10.1038/s41598-022-17558-5 PMC 바로가기 [Article Type] Article
Human surfactant protein D facilitates SARS-CoV-2 pseudotype binding and entry in DC-SIGN expressing cells, and downregulates spike protein induced inflammation인간 계면활성제 단백질 D는 DC-SIGN 발현 세포에서 SARS-CoV-2 유사형 결합 및 진입을 촉진하고 스파이크 단백질 유도 염증을 하향 조절합니다Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 Analysis Anti-viral binding carbohydrate cause Cell cell interaction cell line cell surface receptor cells chemokine chemokines collectins controls COVID-19 cytokine cytokine response Cytokines DC-SIGN dendritic cell domain downregulate downregulated eight epithelial expressing facilitate fragment of HEK 293T HEK293T cell HEK293T cells help Human IFN-α IL- 6 IL-1β IL-8 immune function immune response immunomodulatory effect increase independent independent of infection assay infection assays Inflammation inhibit SARS-CoV-2 innate immune innate immune system Interaction intercellular involved Macrophage macrophages MHC class MHC class II modulating mRNA expression mRNA level mRNA levels N-terminal naïve T cell naïve T cells NF-κB pathogen Pathogens pro-inflammatory cytokine pro-inflammatory cytokines Protein pseudotype RANTES receptors Replication rfhSP-D. RNA virus RT-qPCR SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 spike protein shown SIGN spike Spike protein surface receptor T cells the Spike THP-1 TNF-α treated Treatment Vero Cell Vero cells viral entry viruses [DOI] 10.3389/fimmu.2022.960733 PMC 바로가기 [Article Type] Article