Viral mapping in COVID-19 deceased in the Augsburg autopsy series of the first wave: A multiorgan and multimethodological approachAugsburg 부검 시리즈의 첫 번째 웨이브에서 사망 한 COVID-19의 바이러스 매핑 : 다층 및 다중 방법 학적 접근Research Article Published on 2021-07-192022-09-10 Journal: PLoS ONE [Category] MERS, 진단, 치료기술, [키워드] affected alterations alveolar damage analyzed approach Autopsies Autopsy Central nervous system Chain Reaction CNS correlation COVID-19 Deceased died diffuse Diffuse alveolar damage disease distribution early phase Epidemiology Evidence exhibited fat First wave focus frequencies Germany gross examination histological change histological changes histology immunohistochemistry information internal organ internal organs inverse correlation lung Lungs mediastinal lymph node mediastinal lymph nodes Multiorgan organ organs Other other organ other organs outcome pandemic pathophysiology Patient performed polymerase polymerase chain polymerase chain reaction positive positive sample Result SARS-CoV-2 SARS-CoV-2 detection Stage the disease the stage therapy upper airway upper airways Viral viral infection Viral load virus [DOI] 10.1371/journal.pone.0254872 PMC 바로가기 [Article Type] Research Article
Characterisation of cardiac pathology in 23 autopsies of lethal COVID-19치명적인 COVID-19의 23개 부검에서 심장 병리의 특성화Article Published on 2021-07-012022-09-11 Journal: The journal of pathology. Clinical research [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Analysis Autopsies Autopsy Cardiac pathology cardiovascular system Chain Reaction change characterisation Characteristics Coagulopathy Control tissue controls Coronary artery Coronary artery disease coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients determined by diabetes Diabetes Mellitus diathesis died Factor FIBRIN haemorrhagic diathesis heart Hospital admission hospitalisation hypertension Immunological response incidence Increased interstitial cells male microangiopathy Myocardial myocarditis Myocardium Necrosis negative RT-PCR pathophysiological Patient performed polymerase chain polymerase chain reaction positive positive correlation respiratory tract retrospective reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 scored severe acute respiratory syndrome Coronavirus severity significantly tissue transcriptase vasculature Viral RNA was selected while [DOI] 10.1002/cjp2.212 PMC 바로가기 [Article Type] Article
Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 PneumoniaCOVID-19 폐렴이 있는 흡연자의 폐 조직에서 안지오텐신 전환 효소 2 수용체의 낮은 유전자 발현Article Published on 2021-05-262022-09-01 Journal: Biomolecules [Category] SARS, 진단, [키워드] ACE-2 acute respiratory syndrome age angiotensin Angiotensin converting enzyme receptor Angiotensin-converting enzyme aspect Autopsies Bayesian biological interaction case sery cell entry receptor Chain Reaction complex concerning coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 pneumonia Critical enzyme evaluated expression expressor focus Gender Gene Expression hypertension Infection less Lower lung lung tissue lung tissue sample lung tissue samples mRNA expression observational study polymerase chain polymerase chain reaction prevalent real-time polymerase chain reaction respiratory retrospective risk factor SARS-CoV-2 SARS-CoV-2 genome Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Severe COVID-19 pneumonia smoker Smokers smoking susceptibility susceptibility to infection translational Vascular injury Viral virus with COVID-19 [DOI] 10.3390/biom11060796 PMC 바로가기 [Article Type] Article
Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of COVID-19 deathResearch Article Published on 2021-05-242022-10-31 Journal: Heliyon [Category] COVID-19, [키워드] aggregation airways Angiogenesis ARDS Autopsies Autopsy B-cells Bronchial epithelium cause causes CD163 cells Coagulation Complete composed consolidation COVID-19 death dominant Endothelium epithelial event Inflammatory response intra-alveolar lung lung parenchyma Macrophage MOST occurred pathology Patient pericyte pneumocyte produced proliferation pulmonary regenerative thrombocyte Thrombocytes Treatment virus [DOI] 10.1016/j.heliyon.2021.e07134 PMC 바로가기 [Article Type] Research Article
Brainstem neuropathology in two cases of COVID-19: SARS-CoV-2 trafficking between brain and lungCOVID-19의 두 가지 사례에서 뇌간 신경병리학: 뇌와 폐 사이의 SARS-CoV-2 트래피킹Case Reports Published on 2021-05-182022-09-10 Journal: Journal of Neurology [Category] SARS, 치료기술, [키워드] abnormality Activation Anatomy Antigen Autopsies Brain Brainstem brainstem reflex cells controls COVID-19 COVID-19 negative COVID-19 patients cranial cranial nerves demonstrated died element Evidence exhibited expression feature glial cells histopathological examination immunohistochemistry include increase in lung material Medulla oblongata negative patients nervous system Neurological COVID-19 Neuron neuronal Neuropathology oblongata Other pathophysiology Patient reported respiratory centers Respiratory failure Result SARS-Co SARS-CoV-2 SARS-CoV-2 nucleoprotein Spread supplementary material the SARS-CoV-2 two COVID-19 patients two patients vagus nerve Viral widespread [DOI] 10.1007/s00415-021-10604-8 PMC 바로가기 [Article Type] Case Reports
Glycated ACE2 receptor in diabetes: open door for SARS-COV-2 entry in cardiomyocyteOriginal Investigation Published on 2021-05-072022-10-31 Journal: Cardiovascular Diabetology [Category] COVID-19, SARS, [키워드] ACE2 ACE2 expression ACE2 protein ACE2 receptor affecting alterations Autopsies Autopsy binding cardiomyocyte cellular entry coronavirus disease COVID-19 COVID-19 infection Deceased diabete diabetes diagnosed domain Effect evaluate evaluate the effect evaluated expression Glucose glycosylated glycosylated forms hACE2 heart Hospitalized human ACE2 in vitro include Infection Invasion investigated Italy lysine mechanism Modification monomeric myocardial damage objective oligomerization Patient patients patients with diabete protease Protein rationale residue SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV2 Serine spike supplementary material susceptibility tissue TMPRSS2 TMPRSS2 protein Total transmembrane upregulation viral invasion was performed [DOI] 10.1186/s12933-021-01286-7 PMC 바로가기 [Article Type] Original Investigation
Histomorphological patterns of regional lymph nodes in COVID-19 lungsCOVID-19 폐에서 국소 림프절의 조직 형태학적 패턴Main Topic: COVID-19 Published on 2021-05-052022-09-10 Journal: Der Pathologe [Category] MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] Analysis analyzed Antigen presentation Autopsies Autopsy B‐cell CD11c CD163 CD68 CD8 CD8-positive T‑lymphocytes CD8-positive T‑Lymphozyten CD8A cells Characteristics class switch COVID-19 CXCL9 cytokine Cytokine release syndrome dendritic cells described edema expression Factor follicular follicular dendritic cell follicular dendritic cells Gene expression analysis Gene expression profiling Germinal center germinal centers granzyme granzyme B heterogeneity histiocytosis hypoplasia immune response Immunity Immunoglobulin immunoglobulin class Immunohistochemie immunohistochemistry immunologic response include increased expression involved Keimzentrum lung lymph Lymph node lymph nodes material mechanism Mild mild to moderate moderate moderate to severe MZB1 objective PAK1 Patient plasmablast plasmablasts plasmacytosis qRT-PCR Region regional lymph nodes Result SARS-CoV-2 N SARS-CoV‑2 SARS-CoV‑2 severe COVID-19 Stat1 Viral Viral load was performed Zytokin-Freisetzungssyndrom [DOI] 10.1007/s00292-021-00945-6 PMC 바로가기 [Article Type] Main Topic: COVID-19
Postmortem radiologic and pathologic findings in COVID-19: The Toronto experience with pre-hospitalization deaths in the communityCOVID-19의 사후 방사선 및 병리학적 발견: 지역사회에서 입원 전 사망에 대한 토론토 경험Case Reports Published on 2021-05-012022-09-11 Journal: Forensic science international [Category] SARS, 치료기술, [키워드] Admission alveolar damage Autopsies Autopsy cellular change clinical care Community Computed tomography connection consolidation Course COVID-19 COVID-19 pandemic Critical dead death description diagnosis of COVID-19 died Diffuse alveolar damage disease Evolution fatal COVID-19 fatality feature feedback FIVE Healthcare system Healthcare systems Histopathology hospital Hospitalization in vivo individual information initial Intensive involved knowledge lung Lung histopathology lung parenchyma Medical imaging MOST over pandemic pathologic pattern performed Postmortem Postmortem CT scan Public public health radiologic SARS-CoV-2 Stage subject the disease Toronto Treatment [DOI] 10.1016/j.forsciint.2021.110755 PMC 바로가기 [Article Type] Case Reports
Liver histopathology in COVID-19 patients: A mono-Institutional series of liver biopsies and autopsy specimensCOVID-19 환자의 간 조직 병리학: 단일 기관 시리즈의 간 생검 및 부검 표본Article Published on 2021-05-012022-09-11 Journal: Pathology, research and practice [Category] SARS, 치료기술, [키워드] absence Activation adopted alteration analyzed Autopsies Autopsy biopsy changes Comorbidity COVID-19 COVID-19 patient COVID19 described ectasia Endothelial cell endothelial cells Hepatitis hepatocellular histopathological features histopathological finding Histopathology In situ hybridization infecting Kupffer cells liver Liver function test liver function tests Morphological morphological feature morphological features non-specific pathology protocols regenerative resulting SARS-CoV-2 SARS-COV-2 infection specimen steatosis therapeutic Therapies thrombosis Vascular viral infection viral particle [DOI] 10.1016/j.prp.2021.153451 PMC 바로가기 [Article Type] Article
Minimally Invasive Autopsy Practice in COVID-19 Cases: Biosafety and Findings †Article Published on 2021-04-012022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] approach Autopsies Autopsy biohazard biosafety Complete conducted COVID-19 COVID-19 cases COVID-19 infection death Deceased diagnose Diffuse alveolar damage disease Diseases evaluate feasible finding invasive lung MIA Minimally Invasive Autopsy minimally invasive tissue sampling MITS organ Patient patients PCR-confirmed COVID-19 Personal protective equipment post-mortem biopsy Postmortem Practice responsible RT-PCR Safe Sample Stage was performed [DOI] 10.3390/pathogens10040412 PMC 바로가기 [Article Type] Article