Avidity of IgG to SARS-CoV-2 RBD as a Prognostic Factor for the Severity of COVID-19 ReinfectionCOVID-19 재감염의 중증도에 대한 예후 인자로서 SARS-CoV-2 RBD에 대한 IgG의 결합도Article Published on 2022-03-162022-09-11 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, [키워드] antibody avidity avidity index Course COVID-19 COVID-19 reinfection disease Factor hospital IgG IgG avidity median Mild not significant Outpatient outpatients Patient Primary infection Probability Prognostic factor RBD Reinfection repeated risk SARS-CoV-2 SARS-CoV-2 RBD severity shown significantly higher significantly increased the RBD was determined [DOI] 10.3390/v14030617 PMC 바로가기 [Article Type] Article
Evolution of Anti-RBD IgG Avidity following SARS-CoV-2 InfectionSARS-CoV-2 감염에 따른 항-RBD IgG 결합력의 진화Article Published on 2022-03-042022-09-12 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] anti-RBD Anti-RBD IgG anti-viral antibody antibodies antibody antibody affinity antibody-secreting cell avidity B cell binding domain blood sample clone cognate antigen Cohort collected convalescent convalescent plasma COVID-19 Decline determine domain Donor elicit elicited Evolution functional Germinal center higher affinity Humoral response IgG immune response increase increase in Infection maturation memory B cells mRNA vaccination natural infection plasma produced RBD Receptor-binding domain resolution of symptoms SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection secreting short-lived vaccination [DOI] 10.3390/v14030532 PMC 바로가기 [Article Type] Article
Spike-based COVID-19 immunization increases antibodies to nucleocapsid antigen스파이크 기반 COVID-19 면역은 뉴클레오캡시드 항원에 대한 항체를 증가시킵니다Article Published on 2022-02-012022-09-11 Journal: Translational research : the journal of laboratory [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] antibody Antibody Response Antibody responses Antigen avidity BNT162b2 C-terminus COVID-19 COVID-19 vaccination cross-reactive antibodies cross-reactive antibody detect full length Health care health care workers IgA IgG level IgG levels immunization immunoassay immunogenicity increase increase in individuals Infection MONITOR mRNA mRNA-1273 multiplex N antigen nucleocapsid nucleocapsid antigen Protein S-based vaccines SARS-CoV-2 S Seropositivity Subunit vaccine subunit vaccines suggested the SARS-CoV-2 vaccination Vaccine [DOI] 10.1016/j.trsl.2021.10.004 PMC 바로가기 [Article Type] Article
Formation and Expansion of Memory B Cells against Coronavirus in Acutely Infected COVID-19 IndividualsArticle Published on 2022-01-292022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Activation analyzed antibodies antibody production Antibody Response avidity B cell B cells breadth circulating antibodies conserved coronavirus Coronaviruses COVID-19 cross-reactive Endemic expansion feature Formation generate IgG IgG antibody IgG response individual Infection investigated MBC memory memory B cell Mild naïve nucleocapsid plasmablasts Population Protein Proteins reactive reactivity Receptor binding domain Region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein Severe infection subject the antibody response the N protein the S protein viral spike α-coronavirus β-coronavirus β-Coronaviruses [DOI] 10.3390/pathogens11020186 PMC 바로가기 [Article Type] Article
Humoral immune response after different SARS-CoV-2 vaccination regimens상이한 SARS-COV-2 백신 접종 요법 후 체액 면역 반응Research Article Published on 2022-01-212022-09-01 Journal: BMC Medicine [Category] SARS, 변종, 진단, 치료기술, [키워드] age Alpha anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibody Antibody Response Antigen AstraZeneca avidity AZD1222 B.1.1.7 B.1.1.7 variant B.1.617.2 binding BNT162b2 boost booster vaccination ChAdOx1 ChAdOx1 nCoV-19 comparable Concentration correlation COVID-19 cVNT delta variant examined first vaccination followed by Heterologous homologous humoral immune response Humoral immunity IgG IgG antibodies IgG antibody immune response immunoblot Immunoglobulin Immunoglobulin G individual investigation leads Maturity process Moderna mRNA mRNA vaccine neutralisation test Neutralising Antibodies Occurrence Pfizer/BioNTech Prevalence RBD Receptor binding domain recipient reduction in regimen Result robust S-protein SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 nucleoprotein SARS-CoV-2 spike SARS-CoV-2 vaccination sera Seroconversion significantly higher significantly lower strength subunit supplementary material sVNT tested the antibody response the RBD the SARS-CoV-2 the vaccine titre titres trimeric vaccination Vaccination schemes Vaccine vaccine dose vaccinee variant Virus neutralisation Virus variants of concern VoC was done was measured was used were measured [DOI] 10.1186/s12916-021-02231-x PMC 바로가기 [Article Type] Research Article
High-titer neutralization of Mu and C.1.2 SARS-CoV-2 variants by vaccine-elicited antibodies of previously infected individuals이전에 감염된 개인의 백신 유도 항체에 의한 Mu 및 C.1.2 SARS-CoV-2 변이체의 고역가 중화Article Published on 2022-01-112022-09-11 Journal: Cell Reports [Category] SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Ad26 Ad26.COV2.S angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies antibody Antibody titers avidity BNT162b2 C.1.2 convalescent individual convalescent individuals coronavirus COV2.S COVID-19 decrease disease fitness high affinity humoral Humoral response individual infected individual Infection less Moderna Moderna mRNA-1273 mRNA Mu mutated Mutation neutralization neutralize Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Pfizer Pfizer BNT162b2 rationale respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sera severe acute respiratory syndrome Coronavirus Spike protein Spike proteins the spike protein titers vaccinated individual vaccinated individuals vaccination Vaccine variant variants virus viruses [DOI] 10.1016/j.celrep.2021.110237 PMC 바로가기 [Article Type] Article
Immune Maturation Effects on Viral Neutralization and Avidity of Hyperimmunized Equine Anti-SARS-CoV-2 SeraCommunication Published on 2022-01-022022-10-27 Journal: Antibodies [Category] COVID-19, [키워드] analyzed anti-SARS-CoV-2 Antigen avidity biological activity country COVID-19 develop domain Effect hyperimmune hyperimmune equine hyperimmunization immune maturation immunization immunochemical increase in initial neutralize polyclonal producing SARS-COV-2 infection sera Spike protein the RBD the SARS-CoV-2 therapeutic Therapeutics viral neutralization [DOI] 10.3390/antib11010003 PMC 바로가기 [Article Type] Communication
Determinants of early antibody responses to COVID-19 mRNA vaccines in a cohort of exposed and naïve healthcare workers노출되고 순진한 의료 종사자 집단에서 COVID-19 mRNA 백신에 대한 초기 항체 반응의 결정 요인Clinical Trial Published on 2022-01-012022-09-11 Journal: EBioMedicine [Category] 변종, 임상, 진단, 치료기술, 치료법, [키워드] 95% CI Adults adverse events Affect allergy Alpha Analysis analyzed antibody Antibody avidity antibody levels Antibody Response Antigen antigens avidity Barcelona Beta BNT162b2 brand center Cohort Comorbidities Comorbidity COVID-19 COVID-19 mRNA vaccine Daniel Data collection days post-infection decision determinant development dose Effectiveness Efficacy European evaluated expected Factor Gamma had no Health care Health care worker health care workers healthcare worker healthy individual heterogeneity IgA IgG IgG and IgM IgG level IgG levels Immunity indicate Infectious disease Infectious diseases Influenza Innovation maintenance manuscript Moderna mRNA mRNA vaccination mRNA vaccines mRNA-1273 naïve neutralization neutralization capacity neutralizing capacity nucleocapsid omicron Pfizer/BioNTech preparation Program reagent receiving recommendation respond response responsiveness robust SARS-CoV-2 SARS-CoV-2 spike Science second dose seropositive Severo Ochoa shown Single-dose smoking Spanish state Study design Support supported symptomatic systemic adverse effect systemic adverse effects technology the preparation union vaccination vaccine doses vaccinees variant variants variants of concern wild-type [DOI] 10.1016/j.ebiom.2021.103805 PMC 바로가기 [Article Type] Clinical Trial
David versus goliath: ACE2-Fc receptor traps as potential SARS-CoV-2 inhibitors데이비드 대 골리앗: 잠재적인 SARS-CoV-2 억제제로서의 ACE2-Fc 수용체 트랩Review Published on 2022-01-012022-09-11 Journal: mAbs [Category] SARS, 변종, [키워드] ACE2 ACE2-Fc administration affinity Affinity maturation angiotensin angiotensin-converting enzyme 2 antiviral activity avidity boost catalytic activity catalytic site COVID-19 DAVID Efficacy eliminated ENhance Evolution fusion Hospitalization immunoadhesins IMPROVE inhibitor intrinsic limit monoclonal antibodies monoclonal antibody mutations Neutralizing neutralizing antibody outbreak pandemic pharmacokinetics platform Point mutation point mutations receptor receptor traps. SARS Coronavirus SARS coronavirus 2 SARS-associated betacoronaviruses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants shown Spike protein suggested therapeutic therapeutic agent TRAP Vaccine viral burden viral escape virus spike protein [DOI] 10.1080/19420862.2022.2057832 PMC 바로가기 [Article Type] Review
A Dual-Antigen SARS-CoV-2 Serological Assay Reflects Antibody Avidity이중 항원 SARS-CoV-2 혈청학적 분석은 항체 결합력을 반영합니다Letter to the Editor Published on 2021-12-012022-09-12 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] avidity avidity maturation COVID-19 SARS-CoV-2 Serological assay [DOI] 10.1128/jcm.02262-21 PMC 바로가기 [Article Type] Letter to the Editor