Effectiveness of Booster Doses of the SARS-CoV-2 Inactivated Vaccine KCONVAC against the Mutant StrainsArticle Published on 2022-09-122022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, 치료기술, [키워드] addition B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta boost booster CD8 T cell CD8 T-cell cellular Cellular immune response cellular immune responses cellular immunity convalescent COVID-19 epidemic Delta Effectiveness Efficiency High-dose humoral immune inactivated Inactivated vaccine inactivated vaccine KCONVAC injection neutralizing antibody omicron reached recognize SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variants several variants strain the SARS-CoV-2 vaccination variant variants was selected [DOI] 10.3390/v14092016 PMC 바로가기
Durable antibody and effector memory T cell responses in breastmilk from women with SARS-CoV-2Article Published on 2022-09-122022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] antibody asked B.1.1.7 B.1.351 Beta binding Blood breast milk breast permeability breastmilk CCR7 CD4 CD45RO CD8 T cell Cell complex COVID-19 COVID-19 vaccine D614G domain dried blood spot effector memory elect enrolled expressed first COVID-19 symptom flow cytometry Gamma IgA IgA response IgG IgM Immunity Immunoglobulin indicated Infant lactating memory memory T memory T cells milk mother mucosal mucosal immunity neutralize neutralized Neutralizing P.1 participant passive immunity permeability positive potassium ion pregnant women Protective reactivity receive robust SARS-CoV-2 SARS-COV-2 infection second set significantly higher sodium Stool T cell T cell response tested the spike protein timepoint was collected were assessed women [DOI] 10.3389/fimmu.2022.985226 PMC 바로가기
Tracing the trajectories of SARS-CoV-2 variants of concern between December 2020 and September 2021 in the Canary Islands (Spain)Article Published on 2022-09-092022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, [키워드] acute respiratory syndrome B.1.1.7 B.1.351 B.1.617.2 Beta Canary Canary Island Canary Islands collected coronavirus COVID-19 Delta dissect distribution effort epidemic wave Europe explain Gamma genomic Genomic surveillance helping heterogeneous Outbreaks pandemic public health respiratory sample responsible SARS-CoV-2 SARS-CoV-2 variant sequenced Spain Spread Surveillance the SARS-CoV-2 tracing trajectory variants of concern variants of concern tracking. viral genome VoC VOCs [DOI] 10.3389/fcimb.2022.919346 PMC 바로가기
A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through T cell-mediated immunityArticle Published on 2022-09-072022-11-15 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition amplified Antibody Response antigen expression attenuate B.1.351 B.1.617.2 Beta caused CD3 CD4 CD8 cell-mediated immune Cell-mediated immunity Cellular immune response Convalescent patients COVID-19 COVID-19 vaccine cytokine response Delta disease severity displaying dual-antigen saRNA vaccine elicit hamsters humoral immune response induce lower dose mice mRNA vaccine mutated N antigen Neutralizing antibody response Neutralizing antibody titer PROTECT Proteins RNA RNA vaccine S-RBD SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants self-amplifying RNA spike T cell Th1 vaccination variant variants of concern Viral load [DOI] 10.1016/j.ymthe.2022.04.014 PMC 바로가기
Impaired immunity and high attack rates caused by SARS-CoV-2 variants among vaccinated long-term care facility residentsArticle Published on 2022-09-012022-11-15 Journal: Immunity, Inflammation and Disease [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome addressed Alpha variant antibody attack rate B.1.1.7 B.1.351 Beta Breakthrough infection Care caused cell-mediated immune response Cell-mediated immunity concentrations coronavirus COVID-19 COVID-19 outbreak COVID-19 vaccination elderly HCWs healthcare worker high risk IgG Immunity Immunoglobulin Impaired investigated Long-term care Long-term care facility marker NAb titer Neutralizing antibodies neutralizing antibody outbreak protocols SARS-CoV-2 variant second dose severe coronavirus disease spike glycoprotein susceptible vaccination vaccine doses vaccine response Vaccine-induced immunity variant variants [DOI] 10.1002/iid3.679 PMC 바로가기
Integrated bioinformatics-cheminformatics approach toward locating pseudo-potential antiviral marine alkaloids against SARS-CoV-2-MproSARS-CoV-2-Mpro에 대한 유사 잠재적 항바이러스 해양 알칼로이드를 찾기 위한 통합 생물정보학-화학정보학 접근Article Published on 2022-09-012022-09-11 Journal: Proteins [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 added Alpha analyzed Antiviral antiviral marine alkaloids approach ATB AutoDock B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta binding energy candidate carried complex complexes contagious Coronavirus-2 darunavir docking docking study drug drug-likeness drug-likeness profiles prediction Entropy enzyme exhibit free energy H-bond highest Initially investigated Ligand literature review Lopinavir lowest MD simulation MM/PBSA molecular molecular docking molecular docking simulation molecular dynamics Molecular mechanics Molecular Orbital morbidity morbidity and mortality MPro omicron pharmacokinetics pharmacological physicochemical predicted profile profiles protease Protein Protein Data Bank retrieved RMSD RMSF SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease selected Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2-Mpro. surface area thermodynamic Topology Toxicity variants Virtual screening were assessed were recorded [DOI] 10.1002/prot.26341 PMC 바로가기 [Article Type] Article
Whole-genome sequencing of SARS-CoV-2 reveals diverse mutations in circulating Alpha and Delta variants during the first, second, and third waves of COVID-19 in South Kivu, east of the Democratic Republic of the CongoResearch article Published on 2022-09-012022-10-05 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] A.23.1 Analysis B.1.351 B.1.617.2 circulating circulation coding sequence consensus genome COVID-19 D614G Delta delta variant Diagnosis disease severity dominant Genes Genetic evolution Genetic variation genome coverage genomic global pandemic highlight identify include information isolate Lineage management mapped molecular MOST Mutation nucleocapsid protein objective ORF1ab ORF3 outbreak Oxford P.1 pandemic pangolin Phylogenetic analysis Point mutation processed reference genome responsible Result reveal SARS-CoV-2 SARS-CoV-2 isolate sequence sequenced Sequencing Seven South South Kivu subsequent Surveillance synonymous the SARS-CoV-2 genome Treatment variant variants were used whole-genome sequencing Wuhan [DOI] 10.1016/j.ijid.2022.05.041 [Article Type] Research article
Second round of an interlaboratory comparison of SARS-CoV2 molecular detection assays used by 45 veterinary diagnostic laboratories in the United StatesArticle Published on 2022-09-012022-11-15 Journal: Journal of veterinary diagnostic investigation : o [Category] SARS, 변종, 치료기술, [키워드] addition analyst analytical sensitivity Analytical specificity analyzed assays B.1.1.7 B.1.351 buffer COVID-19 COVID-19 pandemic Critical detect diagnosis of COVID-19 diagnostic evaluate evaluated FDA help humans identify interlaboratory comparison investigation Laboratory limitations marker medium molecular N1 and N2 network nucleocapsid pandemic public health real-time RT-PCR recognize response RNA RT-rtPCR SARS-CoV2 second specificity Support the United State Transport variant variants Viral RNA [DOI] 10.1177/10406387221115702 PMC 바로가기
In silico evaluation of food-derived carotenoids against SARS-CoV-2 drug targets: Crocin is a promising dietary supplement candidate for COVID-19Article Published on 2022-09-012022-11-16 Journal: Journal of food biochemistry [Category] COVID19(2023년), SARS, 변종, [키워드] ADP-ribose antioxidant B.1.351 binding affinity binding energy carotenoid carotenoids clinical trial complex component COVID-19 COVID-19 pandemic crocin dietary supplement dietary supplement candidates docking experiment docking result drug target effective exhibited Favipiravir food-derived carotenoids globe Healthcare system Helicase in silico inhibitors inhibitory effect Inhibitory effects Ivermectin Lineage molecular molecular docking Molecular dynamics simulation multitarget inhibitors. mutant mutant spike protein performed phosphatase Preliminary data Prophylaxis protease provide receptor receptors Remdesivir Replication SARS-CoV-2 SARS-CoV-2 drug Spike protein stability suggested target target protein tested therapy Treatment variants of concern [DOI] 10.1111/jfbc.14219 PMC 바로가기
Genomic epidemiology and emergence of SARS-CoV-2 variants of concern in the United Arab Emirates Research Published on 2022-08-292022-10-05 Journal: Scientific Reports [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] A.23.1 adopted Analysis B.1 B.1.1 B.1.1.7 B.1.351 clade collected contribute demonstrated epidemiological Epidemiology Frequency highest Hospitalization Hospitalized International Local measure Measures Mutation occur ORF1a outbreak pandemic positive proportion provide public health authority reduce RT-PCR SARS-CoV-2 SARS-CoV-2 variant sequenced Seven significantly Spread Surveillance Transmission transmission of SARS-CoV-2 United Arab Emirate variants variants of concern variants of interest viral sequence VoC VOCs VOI VOIs [DOI] 10.1038/s41598-022-16967-w [Article Type] Research