Spike protein multiorgan tropism suppressed by antibodies targeting SARS-CoV-2Article Published on 2021-11-222022-10-31 Journal: Communications Biology [Category] COVID-19, MERS, [키워드] addition anti-SP antibody antibody biodistribution blood-brain barrier Brain COVID-19 COVID-19 patients CSF determine effective Efficacy extension healthy highest highlight in vivo individuals kidney liver Lungs mice Multiorgan occur organ organ-specific outcomes Protein reduce SARS-CoV-2 spike Support suppressed the spike protein tissue analysis Vaccine development Vascular viral infection while [DOI] 10.1038/s42003-021-02856-x PMC 바로가기 [Article Type] Article
Non-clinical safety assessment and in vivo biodistribution of CoviFab, an RBD-specific F(ab′)2 fragment derived from equine polyclonal antibodiesArticle Published on 2021-11-142023-06-16 Journal: Toxicology and applied pharmacology [Category] MERS, SARS, [키워드] biodistribution COVID-19 CoviFab Good laboratory practices preclinical studies [DOI] 10.1016/j.taap.2021.115796 PMC 바로가기 [Article Type] Article
577. COVI-VAC™, a Live Attenuated COVID-19 Vaccine, Provides Single Dose Protection Against Heterologous Challenge with SARS-CoV-2 Beta (B.1.351) in the Syrian Golden Hamster ModelPoster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] affected Against age Amino acid Analysis animal B.1.351 Beta biodistribution board challenge change clinical trials conducted COVID-19 COVID-19 vaccine demonstrated Efficacy employee evaluated figure furin cleavage site hamster Heterologous heterologous challenge Histopathology in vivo Inc include intranasal intranasally key tissue Kushnir less maintain member Model Mutation neutralization neutralizing antibody non-human primate model Phase 1 PhD presenting prevented protection Protective qPCR raise reduced Result Robert SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant sequence serum Seven silent single dose spike-based vaccines Syrian Golden hamsters timepoint Vaccine variant variant of SARS-CoV-2 Viral antigen viral antigens viral evolution viral replication weighed weight weight loss wildtype [DOI] 10.1093/ofid/ofab466.775 PMC 바로가기 [Article Type] Poster Abstracts
Cyclic 68 Ga-Labeled Peptides for Specific Detection of Human Angiotensin-Converting Enzyme 2Basic Science Investigation Published on 2021-11-012022-10-30 Journal: Journal of Nuclear Medicine [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome affected angiotensin-converting enzyme 2 ARDS binding biodistribution calculated Cohort compounds Concentration coronavirus coronavirus disease COVID-19 COVID-19 patients cyclic detect detection generate glycol hACE2 half-maximal inhibitory concentration Human humanized hypothese identify identity inhibitor linear linker liver lung Lungs modulation murine murine model organ organ injury organ-specific peptide pet Pharmacologic reduction residues SARS-CoV-2 SARS-COV-2 infection small intestine Specific susceptibility transgenic transgenic model Visual was determined was used [DOI] 10.2967/jnumed.120.261768 PMC 바로가기 [Article Type] Basic Science Investigation
The evaluation of novel oral vaccines based on self-amplifying RNA lipid nanparticles (saRNA LNPs), saRNA transfected Lactobacillus plantarum LNPs, and saRNA transfected Lactobacillus plantarum to neutralize SARS-CoV-2 variants alpha and delta자가 증폭 RNA 지질 나반파 (Sarna LNP), Sarna 형질 감염된 락토 바실러스 발바닥 LNP 및 Sarna 형질 감염된 Lactobacillus plantarum에 기초한 신규 구강 백신의 평가를 위해 SARS-COV-2 변이체 알파 및 델타를 중화시킨다.Article Published on 2021-10-292022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Alpha antibody BALB/c mice biodistribution cells Concentration coronavirus evaluate Express followed by highest IgA IgG IgG1 IgG2a immunology intestine lactobacillus large intestine liver mice mRNA neutralize oral administration Oral vaccine oral vaccines protein levels recovered COVID-19 patient Recovered COVID-19 patients respiratory responses RNA RNA vaccines S-protein saRNA SARS-CoV-2 variant secreted severe acute respiratory syndrome Coronavirus small intestine study groups Vaccines variant Viral viral neutralization was done [DOI] 10.1038/s41598-021-00830-5 PMC 바로가기 [Article Type] Article
Quantifying nanodiamonds biodistribution in whole cells with correlative iono-nanoscopyArticle Published on 2021-08-022022-10-04 Journal: Nature Communications [Category] 바이오마커, [키워드] Alpha approach benefit biodistribution Cancer therapy Cell clinical study Effect Effects example experiments Fluorescence imaging fluorescent Imaging techniques Interaction ions mechanism Microscopy Nanoparticles Particle Particles probes quantification Research resulting ultrastructure unique [DOI] 10.1038/s41467-021-25004-9 PMC 바로가기 [Article Type] Article
A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity유리한 생체 분포 패턴과 유망한 면역성을 지닌 코어 쉘 구조의 COVID-19 mRNA 백신Article Published on 2021-05-312022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 비임상, 임상, 진단, 치료제, [키워드] addition administration biodistribution composed COVID-19 COVID-19 vaccine COVID-19 vaccines Critical D614G effective effective vaccine Extensive facilitate full-length SARS-CoV-2 full-length SARS-CoV-2 spike protein humans Immunity inoculation intramuscular levels of antibody liver LPP mice mRNA mRNA vaccine N501Y Neutralizing non-human primate non-human primates packaged Protein Safe SARS-CoV-2 spike Spike protein stability T cell T cell response Translational research unique Vaccine vaccine candidate Vaccines variant variants wild-type SARS-CoV-2 [DOI] 10.1038/s41392-021-00634-z PMC 바로가기 [Article Type] Article
Capturing Cytokines with Advanced Materials: A Potential Strategy to Tackle COVID-19 Cytokine Storm고급 재료로 사이토카인 캡처: COVID-19 사이토카인 폭풍에 대처하기 위한 잠재적 전략Review Published on 2021-05-012022-09-12 Journal: Advanced Materials (Deerfield Beach, Fla.) [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome antibodies antibody anticipated biodistribution biomaterials caused clinical trial coronavirus COVID-19 COVID-19 cytokine storm COVID-19 pandemic cytokine cytokine release Cytokine release syndrome Cytokine storm develop immunopathology in vivo Inflammatory cytokine Inflammatory diseases Interaction limit management mild symptoms multiple organ failure Nanoparticles neutralization offered patients with COVID-19 Potential potential mechanism recent Research SARS-CoV-2 Septic shock severe pneumonia Side effect storm Strategy target the cytokine storm therapeutic strategy [DOI] 10.1002/adma.202100012 PMC 바로가기 [Article Type] Review
Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets비강 내 융합 억제 리포펩티드는 흰 족제비에서 SARS-CoV-2 직접 접촉 전파를 방지합니다Report Published on 2021-03-262022-09-10 Journal: Science (New York, N.y.) [Category] MERS, SARS, 신약개발, 치료제, [키워드] 24 hour 24 hours acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration animal model bind biodistribution C terminus Cell complementary condition conformational change conformational changes conserved Contact Containment coronavirus COVID-19 pandemic Critical Daily dimeric disease effective Efficacy ferret ferrets fusion glycoprotein host cell host cell membrane host cell membranes host cells in vitro in vivo Infection inhibit inhibitor inhibitory initiate initiated intranasal life history lipoprotein Lipoproteins membrane fusion mutant viruses peptide Prevent prevented Prophylactic Prophylaxis reduce reducing respiratory Safe SARS-CoV-2 SARS-CoV-2 transmission Science selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sick Spike protein target tested translate Transmission transmission of SARS-CoV-2 Viral viral spike protein Viral transmission virus [DOI] 10.1126/science.abf4896 PMC 바로가기 [Article Type] Report
Proteomic Characterization, Biodistribution, and Functional Studies of Immune-Therapeutic Exosomes: Implications for Inflammatory Lung Diseases면역 치료 엑소좀의 단백질 특성, 생체 분포 및 기능 연구: 염증성 폐 질환에 대한 시사점Immunology Published on 2021-03-252022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 activated acute respiratory syndrome acute respiratory syndrome coronavirus addition analyzed binding biodistribution blocking bone disease Cell characterization circulation clinical trial clinical trials complex controls coronavirus COVID-19 DCs dendritic cell dendritic cells disease downregulate downstream Effect Efficacy Exosome Exosomes experiment expression followed by functions identify immature immune immune response immune therapy immunoblot Immunotherapy implication In-vitro Inflammatory Inflammatory diseases inflammatory disorders initial Interaction internalization Intravenous injection involved liver tissue lung Lung diseases Lungs major organ major organs mice parenchymal parenchymal cells peripheral tissues predominant presenting Protein Proteins proteomics respiratory scrutiny Signaling spleen suggested sustained target target proteins target receptor therapeutic therapy transmigration various inflammatory diseases [DOI] 10.3389/fimmu.2021.636222 PMC 바로가기 [Article Type] Immunology