Chapter Two: Biological underpinnings of sex differences in neurological disordersBook chapter Published on 2022-07-302022-10-05 Journal: International Review of Neurobiology [Category] 비임상, [키워드] addressed Biological Brain Brain-body communication complex contribute diagnostics Efficacy epigenetic mechanisms genetics heterogeneity increasingly mechanism molecular Neurological disease Neurological diseases Neurological disorder Prognosis remained Research response to treatments severity of symptoms sex chromosomes Sex difference sex differences Sex hormones Signaling susceptibility women [DOI] 10.1016/bs.irn.2022.06.009 [Article Type] Book chapter
[Change in serum IgG antibody during the recovery stage of Omicron variant infection in children: an analysis of 110 cases][소아 오미크론 변이체 감염 회복기 혈청 IgG 항체 변화 : 110건 분석]Article Published on 2022-07-152022-09-11 Journal: Zhongguo dang dai er ke za zhi = Chinese journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis antibody BBIBP-CorV Beijing Biological Biological products booster vaccination caused Child children China Chinese citation Clinical data Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 diagnosed Diagnosis disease dose doses English four group four groups groups IgG IgG antibody inactivated Inactivated vaccine Infection journal no significant difference no significant differences Nucleic acid detection omicron pediatrics protective effect RBD IgG Recovery stage reduction in respiratory Retrospective analysis route SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-CoV-2 nucleic acid SARS-CoV-2 vaccination SARS-CoV-2 vaccine serum IgG Serum level severe acute respiratory syndrome Coronavirus Sex significant difference significant differences significantly higher significantly lower Sinopharm status the vaccine Tianjin Transmission two group two groups vaccination Vaccine variant was performed [DOI] 10.7499/j.issn.1008-8830.2204074 PMC 바로가기 [Article Type] Article
Immune response and safety to inactivated COVID-19 vaccine: a comparison between people living with HIV and HIV-naive individuals비활성화된 COVID-19 백신에 대한 면역 반응 및 안전성: HIV 감염자와 HIV 감염 경험이 없는 개인 간의 비교Article Published on 2022-07-052022-09-12 Journal: AIDS Research and Therapy [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI Adults Adverse reaction Antibody neutralization Antiretroviral therapy baseline binding antibody unit Biological CD4 chemiluminescence colloidal gold COVID-19 COVID-19 vaccine COVID-19 vaccines effective Efficacy ELISA enrolled Follow-up Frequency geometric geometric mean concentration GMC humoral immune response IgG IgG antibody IgG response immune immune response inactivated Inactivated COVID-19 vaccine individual injection NAb not different observation outcome peaked PLWH PLWH population PLWH. primary immunogenicity product remained response SARS-CoV-2 neutralizing antibody second dose Serious Adverse Events seroconversion rate shown Sinopharm specific IgM with HIV Wuhan [DOI] 10.1186/s12981-022-00459-y PMC 바로가기 [Article Type] Article
COH04S1 and beta sequence-modified vaccine protect hamsters from SARS-CoV-2 variantsArticle Published on 2022-06-172022-10-06 Journal: iScience [Category] 진단, [키워드] Beta Biological Biological sciences Candidates clinical investigation contagious COVID-19 COVID-19 vaccine cross-protective immunity cross-reactive antibody delta variant Efficacy elicit evade hamster healthy volunteers immunization immunogenic immunology Infection intramuscular Lower respiratory tract Lung pathology neutralizing antibody responses non-human primate nucleocapsid antigen PROTECT Protective response Safe SARS-CoV-2 SARS-CoV-2 variant Vaccine vaccine candidate Virology VoC weight loss Wuhan-Hu-1 [DOI] 10.1016/j.isci.2022.104457 PMC 바로가기 [Article Type] Article
Identification of bronchoalveolar and blood immune-inflammatory biomarker signature associated with poor 28-day outcome in critically ill COVID-19 patients중환자 COVID-19 환자에서 좋지 않은 28일 결과와 관련된 기관지 폐포 및 혈액 면역 염증 바이오마커 식별Article Published on 2022-06-092022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission assays BAL BAL fluid BALF Biological biological profile biomarker signature Blood blood concentration bronchoalveolar Bronchoalveolar lavage Characteristics clinical Clinical outcome Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients cytokine defined described eicosanoid Eicosanoids elicited ELISA endothelial injury exhibited fiberoptic bronchoscopy Health Organization identification IFN-γ IL-10 IL-22 IL-5 IL-6 Infection Inflammatory response intensive care intensive care unit interferon Local metabolomic analysis neutrophil outcome Patient performed phenotype respiratory SARS-CoV-2 scale severe acute respiratory syndrome Coronavirus type I interferon Vascular Vasoactive VEGF WHO-CPS World Health Organization [DOI] 10.1038/s41598-022-13179-0 PMC 바로가기 [Article Type] Article
The Biological Functions and Clinical Significance of SARS-CoV-2 Variants of CorcernReview Published on 2022-05-202022-10-06 Journal: Front Med (Lausanne) [Category] 진단, [키워드] ACE2 acute respiratory syndrome Affect Alpha variant Angiotensin-converting enzyme antigenic B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Biological blunt Brazil Characteristics clinical Combination convalescent individuals coronavirus country COVID-19 COVID-19 vaccines Deleterious Deletion Delta delta variant E484K E484K mutation Efficacy ENhance evade FIVE function Gamma Genetic immune evasion India Infection influence immune response insertion K417 Mutation mutations N501Y Neutral Neutralizing antibodies neutralizing antibody omicron optimism other variant P.1 pathogenicity phenotype promote raise RBD Receptor binding domain Region Reinfection risk SARS-CoV-2 SARS-CoV-2 variant sensitivity severe disease Significance South Africa Spike protein Spread spread to Strains the Alpha variant the Beta variant the Delta variant the Gamma variant the Omicron variant the RBD the SARS-CoV-2 the SARS-CoV-2 genome the spike protein the United State The United States Transmissibility triggered United Kingdom vaccination Vaccine-induced immunity Vaccines variant variant of concern variants of concern viral cell viral replication Virological virus VoC VOCs [DOI] 10.3389/fmed.2022.849217 PMC 바로가기 [Article Type] Review
Effectiveness and Durability of mRNA Vaccine-Induced SARS-CoV-2-Specific Humoral and Cellular Immunity in Severe Asthma Patients on Biological Therapy생물학적 치료에 대한 중증 천식 환자에서 mRNA 백신 유도 SARS-CoV-2-특이적 체액 및 세포 면역의 효과 및 지속성Article Published on 2022-05-202022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome age Asthma asthma patient Biological BNT162b2 mRNA vaccine cellular cellular immunity coronavirus Coronavirus disease 2019 COVID-19 COVID-19 vaccination declined decrease dose doses Effectiveness Efficacy elicit elicited evaluated healthy humoral Humoral immunity Immunity impacted mRNA not affect Patient populations regimen SARS-CoV-2 second dose severe asthma patients on biological therapy. significantly the vaccine therapy treated Treatment vaccination Vaccine Vaccine-induced immunity [DOI] 10.3389/fimmu.2022.892277 PMC 바로가기 [Article Type] Article
Biological and Immune Responses to Current Anti-SARS-CoV-2 mRNA Vaccines beyond Anti-Spike Antibody ProductionAnti-Spike 항체 생산을 넘어 현재의 Anti-SARS-CoV-2 mRNA 백신에 대한 생물학적 및 면역 반응Review Published on 2022-05-142022-09-11 Journal: Journal of Immunology Research [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] administration anti-SARS-CoV-2 vaccines anti-spike antibodies antibodies antibody waning antiviral antibodies appear Biological booster carried Cell clinical observation coding current disease distribution effective Efficiency emergence encapsulation Express Factor help immune system Infection injected intramuscularly lack mass vaccination memory B cell memory B cells mRNA not limited oral mucosa pandemic plasma membrane Production PROTECT Protein response RNA molecules RNA virus SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2 spike protein spike Spike protein the SARS-CoV-2 the Spike tissue vaccination Vaccine Viral viral variant Viral variants virtue [DOI] 10.1155/2022/4028577 PMC 바로가기 [Article Type] Review
Weighted Gene Co-Expression Network Analysis to Identify Potential Biological Processes and Key Genes in COVID-19-Related StrokeCOVID-19 관련 뇌졸중의 잠재적 생물학적 과정 및 주요 유전자를 식별하기 위한 가중 유전자 공동 발현 네트워크 분석Article Published on 2022-05-092022-09-11 Journal: Oxidative Medicine and Cellular Longevity [Category] 유전자 메커니즘, [키워드] Analysis Biological biological processe Cell coronavirus disease COVID-19 Critical Cytoscape Cytoscape software cytosolic database dataset datasets elevated enrichment analysis Extracellular matrix FIVE Functional enrichment analysis gene co-expression network Gene Expression Omnibus Gene ontology Genes GEO hub genes identify indicated integrin integrin signaling Interaction Intervention involved ITGA2B ITGB3 KEGG Kyoto Lineage network pathway Pathways PI3K PI3K-Akt signaling Platelet platelet activation Potential receptor Research screened stroke target was used [DOI] 10.1155/2022/4526022 PMC 바로가기 [Article Type] Article
Therapeutic antibodies – natural and pathological barriers and strategies to overcome them치료 항체 - 자연 및 병리학적 장벽 및 이를 극복하기 위한 전략Review Published on 2022-05-012022-09-12 Journal: Pharmacology & therapeutics [Category] COVID19(2023년), SARS, 진단, [키워드] administration antibodies antibody Antigen approved Biological Biological barriers cellular Efficacy expected Extracellular IMPROVE intravenously less overcome pandemic pathological Pathological barriers Patient SARS-CoV2 systemic side effect therapeutic Therapeutic antibody Therapeutic strategies therapy Treatment [DOI] 10.1016/j.pharmthera.2021.108022 PMC 바로가기 [Article Type] Review