Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial Research Published on 2022-08-012022-10-05 Journal: Nature Medicine [Category] 바이오마커, 변종, 임상, [키워드] antibodies approved biopsy blockade Blood BRAF carried circulating clinical trial Colorectal cancer disease DNA Efficacy EGFR eight Endpoint enrolled EudraCT growth factor monoclonal antibody mutant alleles Mutation Open-label Patient patients primary endpoint randomized trial RAS receptor regimen responses restrict secondary single-arm phase 2 Standard-of-care subsequent survival therapy Tolerability Treatment Trial Tumor were excluded wild-type Withdrawal [DOI] 10.1038/s41591-022-01886-0 [Article Type] Research
Circulating tumour DNA — looking beyond the blood Reviews Published on 2022-08-012022-10-05 Journal: Nature Reviews Clinical Oncology [Category] 바이오마커, 변종, [키워드] Analysis Biomarkers biopsy Blood cerebrospinal fluid circulating Clinical use complementary DNA majority offer over plasma Research review tissue tissue sample unique Urine [DOI] 10.1038/s41571-022-00660-y [Article Type] Reviews
Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial Research Published on 2022-07-212022-10-05 Journal: Nature Medicine [Category] 변종, 임상, 치료제, [키워드] 95% confidence interval Administered administration adverse event approval benefit biopsy cells characteristic clinical disease doses Efficacy Fever Glioblastoma herpes simplex initial investigator-initiated Japan leukopenia lymphocyte lymphocytopenia magnetic resonance imaging nausea occurred Patient patients phase 2 trial prespecified endpoint primary endpoint radiation therapy registry safety profile Secondary endpoints single-arm trial survival survival rate the median therapy Trial virus vomiting [DOI] 10.1038/s41591-022-01897-x [Article Type] Research
Eosinophilic esophagitis auxiliary diagnosis based on a peptide ligand to eosinophil cationic protein in esophageal mucus of pediatric patients Research Published on 2022-07-182022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] allergic Analysis association atopic auxiliary biopsy cationic characterized Clinical practice clone demonstrated develop Diagnosis disease disorder Dysphagia eosinophil Eosinophilic eosinophils esophagitis evaluated fibrosis Gastroesophageal reflux histopathological individual individuals inflammatory condition Ligand mass spectrometry Patient patients Pediatric patient Pediatric patients peptide performed Protein proteomic reactive reactivity responses selected sensitivity specificity tissue up-regulated was used [DOI] 10.1038/s41598-022-16293-1 [Article Type] Research
Promising Strategies for Preserving Adult Endothelium Health and Reversing Its Dysfunction: From Liquid Biopsy to New Omics Technologies and Noninvasive Circulating Biomarkers성인 내피의 건강을 유지하고 그 기능 장애를 되돌리기 위한 유망한 전략: 액체 생검에서 새로운 Omics 기술 및 비침습적 순환 바이오마커까지Review Published on 2022-07-072022-09-11 Journal: International Journal of Molecular Sciences [Category] MERS, 바이오마커, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome Biomarker Biomarkers biomarkers and therapeutic targets biopsy cardiovascular system Clinical studies condition COVID-19 disease distress dysfunction endothelial Endothelial dysfunction Endothelium endothelium dysfunction Evidence functions human body Inflammation liquid network medicine New newer omics technologies. nutrition omics technologies oxygen Pathogenesis Potential biomarker potential biomarkers Preserving respiratory distress resulting Sepsis Strategy syndrome technology therapeutic therapeutic target therapeutic targets tissue tissues vascular homeostasis [DOI] 10.3390/ijms23147548 PMC 바로가기 [Article Type] Review
Assessing ROSE for adequacy of EBUS-TBNA compared with a direct-to-cell block approach as a response to the COVID-19 pandemicResearch article Published on 2022-07-012022-10-05 Journal: Journal of the American Society of Cytopathology [Category] 진단, [키워드] analyzed approach Assessing average biopsy calculated cancer patient Care Cell block collected coronavirus disease COVID-19 COVID-19 pandemic cytopathology determine diagnostic Discontinuing Effect Endobronchial ultrasound-guided transbronchial needle aspiration Generalized linear model group had no less malignancy material pandemic Patient patients proportion Rapid Rapid on-site evaluation reported SAS significant effect significantly social distancing statistically significant transbronchial Treatment version 9.4 [DOI] 10.1016/j.jasc.2022.07.165 [Article Type] Research article
Atypical Unilateral SARS-CoV-2 Pneumonia in a Single Lung Re-Transplanted Patient: A Case ReportArticle Published on 2022-07-012022-11-15 Journal: Transplantation proceedings [Category] COVID19(2023년), SARS, 진단, [키워드] affecting airway epithelial cells Allograft Angiotensin converting enzyme-2 anti-SARS-CoV-2 anticoagulation Atypical bilateral pneumonia binding biopsy Case report caused Clinical characteristics clinical condition collected Community decrease diffusion discharged Donor first symptom flu-like syndrome highlight hospital identify immunohistochemistry impacted infected with SARS-CoV-2 lung Lungs monoclonal antibody occurred Oxygen therapy pandemic Patient performed Pneumonia receptor report Respiratory failure SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pneumonia significantly staining Steroids syndrome the patient the SARS-CoV-2 Unilateral Ventilation virus worsened [DOI] 10.1016/j.transproceed.2022.05.007 PMC 바로가기
The effect of COVID-19 on prostate cancer testing in Australia호주의 전립선암 검사에 대한 COVID-19의 영향Article Published on 2022-06-212022-09-11 Journal: BMC urology [Category] 바이오마커, [키워드] 95% prediction interval analysed Australia average average values biopsy Cancer cancers COVID 19 COVID 19 trends COVID-19 COVID-19 pandemic decrease Department determine DHS diagnostic diagnostic testing Effect healthcare Human interval lockdown Medicare Migration National not significant occurred pandemic performed predicted prediction Prostate Prostate cancer PSA testing. remained schedule service statistically significant territory Victoria website widespread [DOI] 10.1186/s12894-022-01043-2 PMC 바로가기 [Article Type] Article
A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells당뇨병 환경은 인간 신장 오르가노이드 및 환자 세포에서 SARS-CoV-2 감염에 대한 ACE2 발현 및 세포 감수성을 증가시킵니다Article Published on 2022-06-072022-09-11 Journal: Cell Metabolism [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 ACE2 expression aerobic aerobic glycolysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biopsy Cell cells cellular condition COVID-19 COVID-19 pathogenesis Critical develop diabete diabetes diabetes 2 Diabetic diabetic kidney diabetic patient diabetic patients dichloroacetate door energy metabolism enzyme exhibited Glycolysis hallmark human kidney human kidney organoids. increase individual inhibitor Intervention kidney Kidney disease kidney organoid kidney organoids metabolism mitochondrial Organoid organoids Patient prevented programming reduced resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe COVID-19 susceptibility Viral detection Viral load [DOI] 10.1016/j.cmet.2022.04.009 PMC 바로가기 [Article Type] Article
Evolution of pathological findings in surveillance biopsies of lung transplant recipients infected with SARS-CoV-2SARS-CoV-2에 감염된 폐 이식 수혜자의 감시 생검에서 병리학적 소견의 진화Article Published on 2022-06-012022-09-11 Journal: Transplant infectious disease : an official journa [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] Admission alteration biopsy Bronchiolitis bronchiolitis obliterans case sery coronavirus disease Coronavirus disease 2019 COVID-19 described determine Diagnosis died Evolution Follow-up GRADE heart histology Hospitalized ICU immunofluorescence inclusion criteria infected with SARS-CoV-2 intensive care intensive care unit large cohort lung Lung injury lung transplant lung transplantation non-transplant patient non-transplant patients one patient Organizing pneumonia outcome outcomes pathologic pathological finding pathology Patient positive Prognosis Protein recipient recipients rejection respiratory pathogen SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid Society specimen subset Surveillance Symptomatic patients tested transbronchial Transplant Two patient two patients was performed [DOI] 10.1111/tid.13823 PMC 바로가기 [Article Type] Article