biosynthetic – Page 3 – Communicable Diseases Research

Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators

지질 방울은 SARS-CoV-2 복제 및 염증 매개체 생성을 촉진합니다

Research Article

Published on 2020-12-162022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, MERS, SARS, 치료법,

[키워드] addition Analysis Antiviral biosynthetic CD36 Cell cell death cellular metabolism complex component contribute COVID-19 COVID-19 pandemic COVID-19 patient demonstrated described develop disease donors double-stranded droplet effort electron microscopy energy homeostasis ENhance enzyme expression function homeostasis Host host cell host cells host immunity human cell lines infected cells Infection Inflammation inflammatory mediator inhibited LDs Lipid lipid droplet lipid droplets lipid metabolism mechanism mediator mediators metabolism modulate modulation monocyte Monocytes organelle parasite Pathogenesis pathway Pathways Perspective pharmacological platform PPARγ pro-inflammatory response Protein recruit recruited reduce reduced Regulation Replication RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 replication SARS-CoV2 SARS-CoV2 infection significantly Support target therapeutic intervention Therapeutic strategies therapeutic strategy Transport triggered Vero Cell Vero cells Viral viral particle Viral particles viral replication virus virus replication viruses
[DOI] 10.1371/journal.ppat.1009127 PMC 바로가기 [Article Type] Research Article

The continued advance of vaccine adjuvants – ‘we can work it out’

Review article

Published on 2020-08-012022-10-05
Journal: Seminars in Immunology
[Category] 비임상,

In Silico Discovery of Candidate Drugs against Covid-19

Article

Published on 2020-04-062022-10-28
Journal: Viruses
[Category] COVID-19, SARS,

Genetic determinants of genus-level glycan diversity in a bacterial protein glycosylation system

박테리아 단백질 글리코실화 시스템에서 속 수준 글리칸 다양성의 유전적 결정인자

Research Article

Published on 2019-12-232022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] acquisition Bacteria Bacterial bacterial pathogen bacterial species bacterial specy biosynthetic biosynthetic pathway biosynthetic pathways Comparative genomics component components conjunction conservation core genome determine driven by effort event Evolution Express expressed functional gene networks Genes Genetic genetic determinant genetic difference genetic interactions genus glycosylation Host Human human disease human pathogen identify independent influence instance instances Interaction involved isolate isolates loss-of-function Neisseria gonorrhoeae Neisseria meningitidis oligosaccharide oligosaccharides Pathogens pathway Pathways Perspective phylogenetically polymorphism post-translational modification Protein Recombination required robust selective status subset sugar sugars unique
[DOI] 10.1371/journal.pgen.1008532 PMC 바로가기 [Article Type] Research Article

East-Asian Helicobacter pylori strains synthesize heptan-deficient lipopolysaccharide

동아시아 헬리코박터 파일로리 균주는 헵탄 결핍 지방 다당류를 합성합니다

Research Article

Published on 2019-11-202022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

Article

Published on 2019-01-102022-10-29
Journal: Nature Communications
[Category] Coronavirus,

Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of α-ketoglutarate

α-케토글루타레이트의 항상성 조절을 통한 Caulobacter crescentus의 트리카르복실산 회로와 펩티도글리칸 합성 간의 누화

Research Article

Published on 2017-08-212022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] accumulation addition Alter Antibiotics approach approaches Bacteria bacterial cell bacterial cells biosynthetic block blocks building by-product Caulobacter crescentus caused Cell cell wall cell wall synthesis cellular cellular metabolism cellular processe cellular processes central metabolism characterized classical conserved CRISPRi Crosstalk deletion mutant Disruption drug design energy generate genetics growth highlight homeostasis homeostatic inhibit interfere Interference master regulator metabolism metabolite metabolomics Morphological morphology mutant peptidoglycan phenotype precursors property Replication required resulting reveal robust susceptibility susceptible synthesis TCA cycle the cell transcriptomics tricarboxylic acid while
[DOI] 10.1371/journal.pgen.1006978 PMC 바로가기 [Article Type] Research Article

The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6 , a Gene Identified through Mining the DPH1 – DPH5 Interaction Network

효모에서 디프타마이드 생합성의 아미드화 단계에는 DPH1 - DPH5 상호작용 네트워크 마이닝을 통해 확인된 유전자인 DPH6이 필요합니다

Research Article

Published on 2013-02-282022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] accumulate Accuracy adenine adenine nucleotide ADP Affect agent amidase Amino acid approach association ATP Author bind Biosynthesis biosynthetic biosynthetic pathway candidate candidate gene Cell cell growth characterized check Complete completion component components Corynebacterium diphtheriae defined Diphthamide dissociation domain DPH1 Dph5 Dph6 Dph7 eEF2 elongation factor embryogenesis enzyme evade expected failure Final form found generate Genes Genetic genetic interaction genomic growth histidine Identified identify inactivation indicated inhibitor inhibitors initial Interaction involved Like maintain mass spectrometry mice molecular mutant name network nucleotide observation pathogen pathway produced promote Protein protein synthesis Proteins Regulatory required residue response Saccharomyces cerevisiae step target trait translation translational upregulated
[DOI] 10.1371/journal.pgen.1003334 PMC 바로가기 [Article Type] Research Article

Tetraspanin Is Required for Generation of Reactive Oxygen Species by the Dual Oxidase System in Caenorhabditis elegans

Tetraspanin은 Caenorhabditis elegans의 이중 산화 효소 시스템에 의한 반응성 산소 종의 생성에 필요합니다

Research Article

Published on 2012-09-202022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Activation addition aerobic aerobic metabolism aging Analysis association Author biosynthetic biosynthetic pathway Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans cause Cell cell surface cellular cellular component cellular components co-expression collagen Combination complex complexes conjunction conserved Defense deficiency demonstrated dependent on disease DOXA dual elegan enzyme Enzymes Evidence experiment exposure to Extracellular matrix failure functions Generation Genetic genetic mutation genetics Host host defense hydrogen hydrogen peroxide Imbalance Immunity in vitro in vivo inhibit isozyme less lipids mammalian cells mammals maturation mechanism member metabolism modifications mucosal mutant mutants Mutation NADPH NADPH oxidase nucleic acids Oxidase oxidative stress oxygen pathway peroxidase physiological produced Protein provide Radiation reactive reactive oxygen species redox state regulated Regulatory required responsible restored ROS Signaling signaling pathway Specy suggested System tetraspanin the cell Thyroid thyroid hormone toxic tyrosine unique UV light
[DOI] 10.1371/journal.pgen.1002957 PMC 바로가기 [Article Type] Research Article