The Effects of ATIR Blocker on the Severity of COVID-19 in Hypertensive Inpatients and Virulence of SARS-CoV-2 in Hypertensive hACE2 Transgenic MiceOriginal Article Published on 2022-01-012022-10-29 Journal: Journal of Cardiovascular Translational Research [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] ACE2 ACE2 expression acute respiratory syndrome angiotensin converting enzyme 2 antihypertensive drugs AT1 AT1 receptor blocker AT1R ATIR Biomarker blocker cellular entry coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient CRP determine Effect enzyme hACE2 had no Heart injury higher risk hospitalized COVID-19 patient hypertension hypertensive hypertensive COVID-19 patient hypertensive patient IL-1 IL-6 inflammation marker Inpatient kidney outcome Post-infection receptor renin-angiotensin system required SARS-CoV-2 SARS-COV-2 infection serum severity supplementary material transgenic mice treated Treatment [DOI] 10.1007/s12265-021-10147-3 PMC 바로가기 [Article Type] Original Article
Clinical outcomes of COVID-19 following the use of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers among patients with hypertension in Korea: a nationwide studyCOVID-19 Published on 2021-12-292022-10-31 Journal: Epidemiology and Health [Category] COVID-19, MERS, [키워드] 95% CI 95% confidence interval ACEi ACEIs Admission all-cause mortality Analysis angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors Angiotensin-receptor blockers ARB ARBs association blocker CIs clinical clinical evidence Clinical outcome clinical outcomes Cohort coronavirus disease COVID-19 COVID-19 cohort COVID-19 diagnosis COVID-19 patient event Evidence hypertension intensive care Interaction Korean mechanical ventilation men mitigate outcome outcomes Patient Poisson regression model primary endpoint Probability protective role recent Respiratory disease risk RRs Selection bias Sepsis shown Support Treatment Weighting [DOI] 10.4178/epih.e2021004 PMC 바로가기 [Article Type] COVID-19
Cardiac Arrhythmias and COVID-19: Correlation With Disease SeverityCardiology Published on 2021-12-182022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 95% CI ACE-I African American age Analysis angiotensin-converting enzyme inhibitor arrhythmia Arrhythmias association Atrial fibrillation baseline characteristics blocker cardiac Cardiac arrhythmia cardiac arrhythmias cardiovascular complication CCI Comorbidity coronavirus disease correlation COVID-19 death demographic characteristics diagnoses disease severity electrical evaluate had more HFNC hospitalized COVID-19 patient incidence Invasive mechanical ventilation Laboratory life-threatening male nasal New Older Oxygen requirement Patient patients hospitalized patients who survived patients with arrhythmia Poisson regression positive airway pressure positively correlated receptor recruited reported Result retrospective risk significantly higher the patient therapy USA Ventilation was used with COVID-19 [DOI] 10.7759/cureus.20507 PMC 바로가기 [Article Type] Cardiology
Interactions amongst inflammation, renin-angiotensin-aldosterone and kallikrein-kinin systems: suggestive approaches for COVID-19 therapyReview Published on 2021-12-062022-10-30 Journal: The Journal of Venomous Animals and Toxins Including Tropical Diseases [Category] COVID-19, [키워드] approach blocker caused chronic disease component consequence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disorders Effect infected patients Infectious disease Inflammation Interaction interactions kallikrein-kinin Kallikrein-kinin system potential therapy RAAS renin-angiotensin-aldosterone system Research SARS-associated coronavirus SARS-COV-2 infection the SARS-CoV-2 virus therapy Treatment triggered virulence [DOI] 10.1590/1678-9199-JVATITD-2020-0181 PMC 바로가기 [Article Type] Review
Predictors at Admission of Mechanical Ventilation and Death in an Observational Cohort of Adults Hospitalized With Coronavirus Disease 2019Observational Study Published on 2021-12-062022-10-05 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, [키워드] 95% confidence interval Abnormalities adjusted odds ratio Admission age angiotensin receptor antagonists angiotensin receptor blocker antihypertensive medication association blocker calculate CIs Clinical characteristics Cohort collected collected data Community Comorbidities conducted Coronary artery disease COVID-19 death demographics disease End-stage renal disease hospital Hospital admission Hospitalization hospitalized patient hypertension Immunocompromise IMV Invasive mechanical ventilation Laboratory Lung disease Mechanical Medical conditions medications Mortality neurologic disorders Older age outcome Patient predictor prehospital public health pulmonary disease Radiographic random receptor recorded retrospective SARS-CoV-2 Symptoms United States vital signs [DOI] 10.1093/cid/ciaa1459 PMC 바로가기 [Article Type] Observational Study
FDA approved L-type channel blocker Nifedipine reduces cell death in hypoxic A549 cells through modulation of mitochondrial calcium and superoxide generationArticle Published on 2021-12-012022-10-04 Journal: Free radical biology & medicine [Category] SARS, 신약개발, [키워드] A549 cell A549 cells alveolar Analysis approved blocker calcium channel Calcium channel blocker can be used CCB CCBs Cell cell damage cell death cellular cellular and molecular confocal microscopy COVID-19 cytosolic evaluated examined FDA hypoxia hypoxic ImageJ individual cell inducer L-type lung epithelial cell mitochondrial Mitochondrial calcium modulation molecular morphology Nifedipine nuclear oxygen pathophysiology platform Protective protective effect Quantitative analysis reactive oxygen species (ROS) reduce reduction required ROS ROS production SARS-CoV-2 significant increase suggested targets therapeutic trials viability was used [DOI] 10.1016/j.freeradbiomed.2021.08.245 PMC 바로가기 [Article Type] Article
“The possible implication of endothelin in the pathology of COVID-19-induced pulmonary hypertension”Review article Published on 2021-12-012022-10-05 Journal: Pulmonary pharmacology & therapeutics [Category] 바이오마커, [키워드] Affect blocker changed China chronic disease COVID-19 COVID-19 pandemic COVID-19 pathology develop disease Endothelin Evidence fibrosis hypertension Hypoxemia Infection Inflammation outcome pathology Patient Post COVID syndrome Precaution proinflammatory proliferative prothrombotic pulmonary pulmonary hypertension reported Respiratory failure Respiratory illness restrict survivor thrombosis variety Wuhan [DOI] 10.1016/j.pupt.2021.102082 [Article Type] Review article
Cardiovascular drugs and COVID-19 clinical outcomes: A living systematic review and meta-analysis심혈관계 약물과 코로나19 임상 결과: 살아있는 체계적인 검토 및 메타 분석Review Published on 2021-12-012022-09-12 Journal: British Journal of Clinical Pharmacology [Category] SARS, 진단, [키워드] 95% CI adjusted analyses all-cause mortality Analysis angiotensin-converting enzyme inhibitor ARBs association blocker cardiovascular cardiovascular drugs Clinical outcome Confirmed COVID-19 infection COVID-19 COVID-19 patients database disease severity drug drugs estimate evaluate heterogeneity Hospitalization hypertensive patient Infection Living systematic review mean difference Meta-analysis outcome Patient Quantitative receptor risk Risk of bias screened susceptibility systematic review Validity [DOI] 10.1111/bcp.14927 PMC 바로가기 [Article Type] Review
Patterns of pharmaceuticals use during the first wave of COVID-19 pandemic in Athens, Greece as revealed by wastewater-based epidemiology제약의 패턴은 폐수 기반 역학에 의해 밝혀진 그리스 아테네에서 Covid-19 Pandemic의 첫 번째 물결 동안 사용됩니다.Article Published on 2021-12-012022-08-31 Journal: The Science of the total environment [Category] SARS, 치료제, [키워드] acute respiratory syndrome coronavirus analgesics Analysis Angiotensin II Antibiotics anticancer drugs antiviral drug antiviral drugs antivirals applied Asymptomatic blocker changes in chronic lung disease Comorbidity condition coronavirus coronavirus 2 correlated COVID-19 COVID-19 infection COVID-19 pandemic decrease demonstrated disease diuretics drug Drug consumption changes drugs effective Epidemiology First wave Greece healthy individuals heart disease hydrochlorothiazide Hydroxychloroquine hypertension in healthy individual Infection lack lockdown Lung disease MONITOR morbidity and mortality Non-invasive NSAID NSAIDS occur pandemic Paracetamol pattern public health receptor Receptor Blockers reduced respiratory SARS-CoV-2 screening methods severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease Treatment Vaccine valsartan various treatment various treatments was used wastewater Wastewater-based epidemiology Wide-scope screening methods. with COVID-19 [DOI] 10.1016/j.scitotenv.2021.149014 PMC 바로가기 [Article Type] Article
Risk of Covid-19-Related Hospitalization and More Severe Outcomes in Medicare Beneficiaries Treated with Renin-Angiotensin-Aldosterone System Inhibitors for HypertensionObservational Study Published on 2021-12-012022-10-05 Journal: Journal of General Internal Medicine [Category] SARS, 임상, [키워드] 95% CI 95% confidence interval ACEi ACEIs Admission Analysis angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors ARB ARBs beneficiary blocker case-control study CCB CCBs Control COVID-19 death determine diuretics duration of hospitalization female Hospitalization Hospitalized hypertension ICU ICU admission increased risk Intensive intensive care interquartile range Invasive mechanical ventilation mechanical ventilation median age Medicare monotherapy Odds ratio outcome receptor reduction in residual confounding risk System the median treated Treatment [DOI] 10.1007/s11606-021-07155-z PMC 바로가기 [Article Type] Observational Study