both viruses – Page 3 – Communicable Diseases Research

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV

Research

Published on 2021-04-122022-10-05
Journal: Nature [Category] SARS, 신약개발, 치료제,

Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2

편자박쥐 ACE2 orthologs에서 파생된 돌연변이는 SARS-CoV-2의 ACE2-Fc 중화를 향상시킵니다

Research Article

Published on 2021-04-092022-09-10
Journal: PLoS Pathogens [Category] MERS, SARS, 변종,

[키워드] ACE2 ACE2 binding ACE2 ortholog ACE2 orthologs ACE2 proteins ACE2 residue ACE2-Fc acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 bat bat ACE2 bats binding binding affinity both viruses Cell cellular receptor Combination Consensus coronavirus described domain ENhance expressing FIVE hACE2 heterogeneity horseshoe bat horseshoe bats Human human ACE2 Hypothesis identify impacted inactive infect Infection Infectious virus Interaction intermediate introduced investigated Mutation neutralization neutralize neutralized Neutralizing ortholog orthologs pangolin pangolins potency Protein pseudovirus pseudoviruses RaTG13 RBD RBDs receptor receptor ACE2 Receptor-binding domain Region regions residue respiratory S-protein SARS-CoV SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 pseudoviruses SARS-CoV-2 RBD SARS-like coronavirus SARS-like viruses selection pressure severe acute respiratory syndrome Coronavirus soluble ACE2 species susceptibility the binding affinity the RBD the SARS-CoV-2 These data Variability variant Viral viral spike virus wild-type
[DOI] 10.1371/journal.ppat.1009501 PMC 바로가기 [Article Type] Research Article

Disparate temperature-dependent virus–host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

인간 호흡기 상피에서 SARS-CoV-2 및 SARS-CoV에 대한 서로 다른 온도 의존성 바이러스-숙주 역학

Research Article

Published on 2021-03-292022-08-13
Journal: PLoS Biology [Category] Biochemistry, COVID-19, SARS,

[키워드] acute respiratory syndrome coronavirus Affect both virus both viruses Cell culture characteristic clinical feature coronavirus coronavirus 2 CoV infection epithelial epithelial cell exhibit Host host cell host cell response host innate immune response dynamics human respiratory epithelium human-to-human transmission dynamics infected individuals Infection influence innate immune response interferon investigated Lower respiratory tract performed Phylogenetic relationship primary human airway primary human airway epithelial cell culture model pro-inflammatory response pro-inflammatory responses public health replicated Replication replication efficiency replication kinetics respiratory respiratory viruses SARS-CoV SARS-CoV infection SARS-CoV-2 SARS-CoV-2 and SARS-CoV infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown Spread temperature temperature-dependent interferon These data time-resolved transcriptome analysis Transcriptome transcriptome analysis transmission efficiencies type I type III interferon upper respiratory epithelium upper respiratory tract Viral viral replication viral replication kinetics virus–host dynamics virus–host interaction dynamics viruses
[DOI] 10.1371/journal.pbio.3001158 PMC 바로가기 [Article Type] Research Article

Recovering coronavirus from large volumes of water

대량의 물에서 코로나바이러스 복구

Article

Published on 2021-03-252022-09-11
Journal: The Science of the total environment [Category] SARS, 치료기술,

Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signatures

SARS-CoV-2 및 H1N1 폐 손상의 공간 매핑은 차등 전사 서명을 식별합니다

Report

Published on 2021-03-232022-09-10
Journal: Cell Reports Medicine [Category] MERS, SARS, 신종인플루엔자, 유전자 메커니즘, 진단,

[키워드] Abstract acute respiratory distress acute respiratory distress syndrome alveolar epithelium anti-viral response anti-viral responses antiviral response ARDS Autopsy both viruses cellular change Coagulopathy COVID-19 demonstrated double infection dual enhanced Extracellular gene signature H1N1 H1N1 influenza identify induced genes infected individual Influenza Injury leads lung Lung injury lung tissue Macrophage macrophage activation macrophages pathway patients with SARS-CoV-2 phenotype platform Post-mortem Region remodeling respiratory distress response SARS-CoV-2 SARS-CoV-2 ARDS SARS-COV-2 infection SARS-CoV-2 infections severe SARS skewed spatial transcriptomics squamous metaplasia syndrome therapeutic target therapeutic targets tissue tissue remodeling transcriptional transcriptional change Transcriptome transcriptomic Type II pneumocyte type II pneumocytes unique Vascular injury vascular tissue Viral viral infections
[DOI] 10.1016/j.xcrm.2021.100242 PMC 바로가기 [Article Type] Report

ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species

Research

Published on 2021-03-012022-10-05
Journal: Nature Ecology & Evolution [Category] SARS, 변종, 유전자 메커니즘,

Interactions of Influenza and SARS-CoV-2 with the Lung Endothelium: Similarities, Differences, and Implications for Therapy

Review

Published on 2021-01-222022-10-28
Journal: Viruses [Category] COVID-19,

Dispersal history of Miniopterus fuliginosus bats and their associated viruses in east Asia

Research Article

Published on 2021-01-142022-10-28
Journal: PLoS ONE [Category] Coronavirus,

[키워드] Adenovirus Asia bat both viruses cave China D-loop DNA examined fecal FIVE Host Japan Jeju Island Korean Peninsula Miniopterus mitochondrial occurred Phylogeny significantly Taiwan virus
[DOI] 10.1371/journal.pone.0244006 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

SARS-CoV-2 D614G 변이체는 생체 외에서 효율적인 복제 및 생체 내 전달을 나타냅니다.

Report

Published on 2020-12-182022-09-10
Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter angiotensin animal models Antisera appear both virus both viruses change Changing Characteristics China coronavirus D614G D614G substitution D614G variant dominant Effect Efficacy ENhance enzyme epithelial cell epithelial cells Ex vivo exhibit experiment faster glycine greater greater transmissibility hamster hamsters Human human Angiotensin-converting enzyme human cell human cells in vitro in vivo indicate infecting Infection maintain morphology Mutation neutralization Neutralizing new virus pandemic spread Pathogenesis pathogenicity Population prevalent primary human airway Primary human airway epithelial cells primary human cell primary human cells pulmonary disease replaced REPLACED BY replicate Replication respiratory respiratory tissue respiratory tissues SARS-CoV-2 SARS-CoV-2 D614G SARS-CoV-2 variant Science severe acute respiratory syndrome Coronavirus significantly Spike protein strain Strains susceptible the times These data transgenic mice Transmissibility Transmission vaccine candidate vaccine candidates variant variant of SARS-CoV-2 Viral viral pathogenesis viral spike protein viral titer virulence virus viruses wild-type virus
[DOI] 10.1126/science.abe8499 PMC 바로가기 [Article Type] Report

The Second Wave of COVID-19 Pandemic Strikes during the Flu Season: An Awareness Perspective

Opinion

Published on 2020-12-182022-10-30
Journal: Medicina [Category] COVID-19, MERS, SARS,