SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes중환자 COVID-19 환자의 폐실에서 SARS-CoV-2 바이러스 부하가 바이러스 혈청 부하 및 치명적인 결과와 상관관계Article Published on 2022-06-142022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] association BAL Blood bronchoalveolar Bronchoalveolar lavage clinical Clinical data Clinical outcome clinical outcomes compartment contribute copy number correlation COVID-19 COVID-19 disease COVID-19 disease severity Critical Critical care Critically ill Critically ill patient critically ill patients Croatia diagnostic disease elevated highest hospital ICU admission Ill intensive care intensive care unit load Lower respiratory tract lung Lungs mechanical ventilation support outcome outcomes pandemic parameter Predictive Prognostic value pulmonary qPCR quantification quantified SARS-CoV-2 SARS-CoV-2 detection serum sample serum samples sputum survival Swab swabs upper respiratory tract Viral load viral load analysis viral loads Virus quantification virus titers while [DOI] 10.3390/v14061292 PMC 바로가기 [Article Type] Article
Identification of bronchoalveolar and blood immune-inflammatory biomarker signature associated with poor 28-day outcome in critically ill COVID-19 patients중환자 COVID-19 환자에서 좋지 않은 28일 결과와 관련된 기관지 폐포 및 혈액 면역 염증 바이오마커 식별Article Published on 2022-06-092022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission assays BAL BAL fluid BALF Biological biological profile biomarker signature Blood blood concentration bronchoalveolar Bronchoalveolar lavage Characteristics clinical Clinical outcome Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients cytokine defined described eicosanoid Eicosanoids elicited ELISA endothelial injury exhibited fiberoptic bronchoscopy Health Organization identification IFN-γ IL-10 IL-22 IL-5 IL-6 Infection Inflammatory response intensive care intensive care unit interferon Local metabolomic analysis neutrophil outcome Patient performed phenotype respiratory SARS-CoV-2 scale severe acute respiratory syndrome Coronavirus type I interferon Vascular Vasoactive VEGF WHO-CPS World Health Organization [DOI] 10.1038/s41598-022-13179-0 PMC 바로가기 [Article Type] Article
Pulmonary bacterial infections in adult patients hospitalized for COVID-19 in standard wardsObservational Study Published on 2022-06-012022-10-05 Journal: Infectious diseases now [Category] COVID19(2023년), SARS, 임상, [키워드] antibiotic use Antigen Bacteria Bacterial Bacterial infection bacteriological Blood Bordetella pertussis Bronchoalveolar lavage Characteristics Clinical data Co-infection collected conducted coronavirus cough COVID-19 COVID-19 pandemic CT-scan cultures diagnosed Enterococcus Fever France hospital hospitalized patients Infection Klebsiella Laboratory Legionella management median medical records Modification Mycoplasma nasopharyngeal occurred Oxygen requirement Patient patients hospitalized PCR PCR test pneumococcal Pneumonia positive Pseudomonas aeruginosa pulmonary retrospective SARS-CoV-2 screened Secondary infection sputum sputum samples Staphylococcus aureus Streptococcus pneumoniae with COVID-19 [DOI] 10.1016/j.idnow.2021.12.001 PMC 바로가기 [Article Type] Observational Study
Lung targeted liposomes for treating ARDSARDS 치료를 위한 폐 표적 리포솜Article Published on 2022-06-012022-09-11 Journal: Journal of controlled release : official journal o [Category] 치료제, [키워드] accumulate accumulation acute respiratory distress acute respiratory distress syndrome Administered administration alveolar approach ARDS BAL Bronchoalveolar lavage C57BL/6 characterized combined treatment COPD COVID-19 COVID-19 infections cysteine cytokine secretion distal DPPC drug Efficiency encapsulation endotracheal exhibited Gas exchange Hypoxemia IL-1β IL-6 impair infections Inflammation Inflammatory marker inflammatory markers intravenous intravenously lipid composition Lipid nanoparticles lipopolysaccharide Liposome lung lung damage Lung diseases lung disorders lung endothelial lung epithelial Lung inflammation Lungs Macrophage macrophages marker medication Methylprednisolone mice mortality rate mortality rates MPS mucolytic agent Mucus N-acetyl cysteine NAC nanoparticle Nanotechnology nitric oxide outcome Patient penetration provided pulmonary reached reduce reducing Region respiratory respiratory distress Respiratory distress syndrome secretion steroid syndrome therapeutic therapeutic effect therapeutic efficacy TNFα Treatment Treatment outcome were assessed [DOI] 10.1016/j.jconrel.2022.03.028 PMC 바로가기 [Article Type] Article
Investigation of the value of precipitins in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients with a positive marker for Aspergillus speciesAspergillus 종에 대한 양성 마커를 가진 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 환자에서 침전물의 값 조사Article Published on 2022-05-282022-09-11 Journal: Medical mycology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, 치료제, [키워드] A. fumigatus acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 Antigen antigens Aspergillus Aspergillus fumigatus assays Biomarker Biomarkers Bronchoalveolar lavage Characteristics Clinical data Co-infection collected colonization coronavirus Culture electrosyneresis ELISA galactomannan Hospitalized house hypersensitivity pneumonitis ICU ICU patient ICU Patients Infection intensive care intensive care unit investigation male management marker median microbial Patient patients performed positive precipitins Prevalence pulmonary aspergillosis purified qPCR reported respiratory respiratory sample Respiratory samples SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 patients screened serology assays Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly higher similarities similarity somatic antigen study population suggested survival rate t-test tracheal Tracheal aspirates tracheal aspirates. [DOI] 10.1093/mmy/myac031 PMC 바로가기 [Article Type] Article
Diagnostic concordance between BioFire® FilmArray® Pneumonia Panel and culture in patients with COVID-19 pneumonia admitted to intensive care units: the experience of the third wave in eight hospitals in ColombiaBioFire® FilmArray® Pneumonia 패널과 중환자실에 입원한 COVID-19 폐렴 환자의 배양 사이의 진단 일치: 콜롬비아의 8개 병원에서 3차 유행의 경험Article Published on 2022-05-092022-09-11 Journal: Critical Care [Category] COVID19(2023년), SARS, 치료기술, [키워드] analyzed antibiotic Antibiotics Antimicrobial therapy Bacteria Bacterial coinfection bacterial coinfections bacterial pneumonia Bronchoalveolar lavage C-reactive protein Care changes in Coinfection Concordance COVID-19 Culture cultures defined diagnostic diagnostic testing dose eight Enterobacter FilmArray greater hospital Hospitalized ICU identify infected with SARS-CoV-2 Inflammatory response intensive care intensive care units intubation Klebsiella pneumoniae leukocytes management mechanical ventilation Medellín, Colombia microorganism microorganisms Negative predictive value no significant difference no significant differences NPV on mechanical ventilation overall concordance Panel pathogen Pathogens Patient patients with COVID-19 patients with SARS-CoV-2 Pneumonia pneumoniae positive Positive predictive value PPV Predictive value procalcitonin processed Prospective Study respiratory pathogen serum sample serum samples specificity Staphylococcus aureus stratified Streptococcus Streptococcus agalactiae [DOI] 10.1186/s13054-022-04006-z PMC 바로가기 [Article Type] Article
Clinical impact of Candida respiratory tract colonization and acute lung infections in critically ill patients with COVID-19 pneumoniaArticle Published on 2022-05-012023-07-08 Journal: Microbial pathogenesis [Category] COVID19(2023년), [키워드] antifungal agents Bronchoalveolar lavage Candida COVID-19 mechanical ventilation SARS-CoV-2 [DOI] 10.1016/j.micpath.2022.105520 PMC 바로가기
Vaccine protection against the SARS-CoV-2 Omicron variant in macaques원숭이의 SARS-CoV-2 오미크론 변종에 대한 백신 보호Article Published on 2022-04-282022-09-11 Journal: Cell [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Ad26 Ad26.COV2.S Ad26.COV2.S vaccine Adenovirus antibody Antibody titer Antibody titers B.1.1.529 BNT162b2 BNT162b2 vaccine Bronchoalveolar lavage CD8+ T cell Cellular immune response contribute correlated cynomolgus macaques demonstrated Efficacy heterologous prime-boost High-dose homologous humoral immune responses macaque macaque. moderate mRNA mRNA-based mutated nasal swabs neutralizing antibody titers omicron populations question raised regimen respiratory response robust SARS-CoV-2 SARS-CoV-2 variant Spread T cell T cell responses the SARS-CoV-2 These data undetectable upper respiratory tract Vaccine Vaccines variant virus [DOI] 10.1016/j.cell.2022.03.024 PMC 바로가기 [Article Type] Article
Cascade Immune Mechanisms of Protection against Mycobacterium tuberculosis (IMPAc-TB): study protocol for the Household Contact Study in the Western Cape, South AfricaStudy Protocol Published on 2022-04-152023-07-02 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, [키워드] Bronchoalveolar lavage household contacts immune response interferon-gamma release assay PET-CT imaging SARS-CoV-2 Tuberculosis [DOI] 10.1186/s12879-022-07349-8 PMC 바로가기 [Article Type] Study Protocol
A case of primary COVID-19 pneumonia: plausible airborne transmission of SARS-CoV-2원발성 COVID-19 폐렴 사례: SARS-CoV-2의 그럴듯한 공기 전파Case Reports Published on 2022-04-042022-09-11 Journal: European Journal of Medical Research [Category] COVID19(2023년), SARS, 치료기술, [키워드] absence addition Admission aerosol Aerosols Airborne transmission airway alveolar anatomical Bioaerosols Bronchoalveolar lavage bronchoscopy Cholecystitis clearance contagious COVID-19 COVID-19 pneumonia CT scan detect Diagnosis diagnosis of COVID-19 different clinical manifestations Efficacy Evidence Ground glass opacity highlight increase in Infection limitation lower lobe lower respiratory system lung infiltrate nasal Patient Pneumonia positive qPCR right lower lobe RT-qPCR Saliva salivary SARS-CoV-2 Spread Swab Test tested Transmission transmission of SARS-CoV-2 upper airway upper respiratory upper respiratory tract Variability Viral load viral replication virus zone [DOI] 10.1186/s40001-022-00668-1 PMC 바로가기 [Article Type] Case Reports