Metacells untangle large and complex single-cell transcriptome networksMetacells는 크고 복잡한 단일 세포 전사체 네트워크를 풉니다.Article Published on 2022-08-132022-09-11 Journal: BMC Bioinformatics [Category] 유전자 메커니즘, [키워드] accelerate Analysis build Cell cell type cell type annotation cells Clustering Coarse-graining complex Computational biology construction correlation COVID-19 patient COVID-19 patients demonstrated develop differential expression downstream analyses downstream analysis facilitate framework heterogeneous IMPROVE imputation inherent integration Interpretation less Metacells offer populations redundancy RNA RNA sequencing scRNA-seq scRNA-seq data significantly single-cell Single-cell RNA sequencing Single-cell transcriptomics SuperCell tissue Transcriptome transcriptomic unique Visualization [DOI] 10.1186/s12859-022-04861-1 PMC 바로가기 [Article Type] Article
Cell-based receptor discovery identifies host factors specifically targeted by the SARS CoV-2 spike Research Published on 2022-08-052022-10-05 Journal: Communications Biology [Category] SARS, 치료기술, [키워드] binding build Cell cellular COVID-19 COVID-19 patients develop ENhance expressed expression Factor help Host human protein identify in viral Infection information Interaction nervous system Olfactory epithelium plasma membrane platform Protein Pseudotyped virus RBD receptor Receptor binding domain Receptor-ligand interaction regulate representing SARS CoV SARS CoV-2 SARS-CoV spike protein significantly starting surface protein target therapeutic strategy upregulated [DOI] 10.1038/s42003-022-03695-0 [Article Type] Research
Independent predictors of in-hospital mortality and the need for intensive care in hospitalized non-critical COVID-19 patients: a prospective cohort studyObservational Study Published on 2022-08-012022-10-04 Journal: Internal and Emergency Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] active cancer Admission albumin albumin level Analysis baseline blood test Blood urea nitrogen build Care Characteristics classical clinical feature condition confidence interval coronavirus COVID-19 death demographic data demographics died evaluate Factor Features Hospitalized hospitalized patient ICU ICU care in-hospital mortality independent independent predictors infected with SARS-CoV-2 intensive care intensive care unit laboratory parameter Male sex Older age outcome Pandemics Patient performed predict Predictive predictor Probability prospective cohort study receiver recruited risk ROC SARS-CoV-2 significant variables single-center study sodium Sodium. Stratification stratified tested the patient underlying disease urea [DOI] 10.1007/s11739-022-02962-6 PMC 바로가기 [Article Type] Observational Study
Handling class imbalance in COVID-19 chest X-ray images classification: Using SMOTE and weighted lossResearch article Published on 2022-08-012022-10-05 Journal: Applied Soft Computing [Category] 진단, 치료기술, [키워드] Accuracy assist AUC build Chest X-ray image Chest X-ray images claimed classification classifiers clinician CNNs COVID-19 COVID-19 diagnosis COVID-19 pandemic COVID-19 samples Data imbalance dataset datasets deep learning early diagnosis Efficiency examined hospitals Infection investigated Loss multi-classification positive patient Precision reduce selected sensitivity shown significantly specificity synthetic technique transfer transfer learning Viral pneumonia [DOI] 10.1016/j.asoc.2022.109588 [Article Type] Research article
Risk Stratification Models for Stroke in Patients Hospitalized with COVID-19 InfectionResearch article Published on 2022-08-012022-10-05 Journal: Journal of stroke and cerebrovascular diseases : t [Category] 바이오마커, [키워드] 95% CI Admission adults hospitalized afebrile AHA assigned build C-statistic c-statistics cardiovascular Cerebrovascular disease coefficient Comorbidities covariates COVID-19 Cox regression cross demographics elevated Factor generate groups help high risk hypertension identify Intracerebral hemorrhage Laboratory Leukocytosis machine material medications medium Model multivariable analyses objective outcome patients hospitalized patients with COVID-19 pulmonary disease registry Result risk Risk-stratification second stratified stroke Systolic blood pressure temperature thrombosis univariable used data with COVID-19 [DOI] 10.1016/j.jstrokecerebrovasdis.2022.106589 [Article Type] Research article
Twenty years of investigation with the case of prosopagnosia PS to understand human face identity recognition. Part I: FunctionResearch article Published on 2022-08-012022-10-05 Journal: Neuropsychologia [Category] 비임상, [키워드] Brain build cause cortical diagnostic disorder Face identity recognition facial function Holistic perception identity impairment include individual information Injury mandatory memory Part performed preserved Prosopagnosia Prosopdysgnosia PS recognize Single case specificity tested to define unique Visual recognition [DOI] 10.1016/j.neuropsychologia.2022.108278 [Article Type] Research article
COVID-19 in the 47 countries of the WHO African region: a modelling analysis of past trends and future patternsWHO 아프리카 지역 47개국의 COVID-19: 과거 동향 및 미래 패턴의 모델링 분석Article Published on 2022-08-012022-09-11 Journal: The Lancet. Global health [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI affected African Analysis approach build Comorbidities country Coverage COVID-19 COVID-19 infection COVID-19 infections dead death deaths estimate Fourier series Fourier sery generate hospitalisations Immunity immunogenicity Infection infections information introduced Markov decision process New pandemic public health Public health interventions reduce reported robust SARS-CoV-2 immunity SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 testing sequenced severity Statistics Surveillance susceptible the WHO Transmissibility Transmission dynamics vaccination variant variants variants of concern WHO [DOI] 10.1016/S2214-109X(22)00233-9 PMC 바로가기 [Article Type] Article
Pasos Hacia La Salud II: study protocol for a randomized controlled trial of a theory- and technology-enhanced physical activity intervention for Latina women, compared to the original interventionPasos Hacia La Salud II: 원래 개입과 비교하여 라틴계 여성을 위한 이론 및 기술 강화 신체 활동 개입의 무작위 대조 시험을 위한 연구 프로토콜Article Published on 2022-08-012022-09-11 Journal: Trials [Category] 임상, [키워드] activity adaptation age approach ARMS assessments baseline baseline assessments benefit build change chronic disease Chronic diseases clinical Complete COVID-19 pandemic described dissemination Effect Efficacy eHealth enhanced equity exercise exploratory feature female greater Health health benefits Health promotion help helping Hispanic increased risk increases in intent-to-treat interactions Intervention intervention effect Intervention effects Latina linear long term maintain manuscript mHealth outcome participant physical activity physically Population proportion Randomized Randomized controlled trial recruited Regression model Research secondary outcome Self-efficacy Social support Study protocol Support technology treat website women [DOI] 10.1186/s13063-022-06575-4 PMC 바로가기 [Article Type] Article
A fourth dose of Omicron RBD vaccine enhances broad neutralization against SARS-CoV-2 variants including BA.1 and BA.2 in vaccinated miceOmicron RBD 백신의 네 번째 용량은 백신 접종된 마우스에서 BA.1 및 BA.2를 포함한 SARS-CoV-2 변이체에 대한 광범위한 중화를 향상시킵니다.Article Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Antibody Response booster build COVID-19 pandemic cross-reactive demonstrated dose elicited ENhance escaped evaluated immunization induce mice NAb NAbs neutralization Neutralizing activity Neutralizing antibodies neutralizing antibody omicron Omicron variant RBD RBD vaccine SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants sequential immunization. strain triggered Vaccine Vaccines variant was used [DOI] 10.1002/jmv.27811 PMC 바로가기 [Article Type] Article
The German National Pandemic Cohort Network (NAPKON): rationale, study design and baseline characteristicsArticle Published on 2022-08-012022-11-15 Journal: European Journal of Epidemiology [Category] COVID19(2023년), SARS, 진단, [키워드] activity age baseline characteristics biosampling build cardiovascular center Characteristics Cohort complementary component conducted coronavirus 2 COVID-19 creating Cross-sectoral Deceased diagnostics enrolled Epidemiology female Follow-up Germany Government hospital Hospitalized IMPROVE Infection initial initiated integration intensive care International IQR Local longitudinal longitudinal study Medicine National network outcome pandemic Patient Pediatric case Pediatric patient performed platform population-based Prospective Prospective national cohort Regulatory Research respiratory SARS-CoV-2 Study design study population the median university [DOI] 10.1007/s10654-022-00896-z PMC 바로가기