Brief Research Report: Anti-SARS-CoV-2 Immunity in Long Lasting Responders to Cancer Immunotherapy Through mRNA-Based COVID-19 Vaccination간략한 연구 보고서: mRNA 기반 COVID-19 백신 접종을 통한 암 면역 요법에 대한 오래 지속되는 응답자의 항 SARS-CoV-2 면역Article Published on 2022-07-052022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] analysed antibodies antibody Antibody Response antiviral immune response BNT162b2 Cancer Cancer immunotherapy Cohort Complete Control control group COVID COVID-19 COVID-19 vaccination develop ELISA generate group healthy control IFN-γ IgG titer IgGs immune Immune checkpoint inhibitor immune checkpoint inhibitors (ICIs) immune response Immunotherapy increase in independent induce Long long lasting responders long-lasting median mRNA-based COVID-19 vaccine mRNA-based vaccine mRNA-based vaccines NAb neutralizing antibody neutralizing capacity Patient patients treated prime-boost regimen receiving regimen respond Responder responders responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific IgG serum antibodies significantly increased solid tumors statistically significant T cell response T cell responses T cells the healthy the patient treated vaccination Vaccine virus [DOI] 10.3389/fimmu.2022.908108 PMC 바로가기 [Article Type] Article
Natural killer cell homing and trafficking in tissues and tumors: from biology to application Reviews Published on 2022-06-292022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 바이오마커, [키워드] Affect Allogeneic Alter blood circulation Bone marrow Cancer Cancer immunotherapy cancer treatment cancers CAR cells cellular chemokine chemokine receptors chimeric antigen receptor clinical utility cytokine Cytokines Defense develop Evidence Ex vivo expansion Factor Factors homing Immunotherapy IMPROVE infiltration Innate lymphoid cells Integrins limit lymphoid organs lymphoid tissues mechanism microenvironment natural natural killer cell NK cell peripheral tissues profile receptors solid tumors Steady state subset tissue transcriptional transfer transferred Treatment [DOI] 10.1038/s41392-022-01058-z [Article Type] Reviews
Cytokine release syndrome-like serum responses after COVID-19 vaccination are frequent and clinically inapparent under cancer immunotherapy Research Published on 2022-06-012022-10-05 Journal: Nature cancer [Category] 임상, 진단, 치료기술, 치료법, [키워드] 95% CI absence Adverse adverse event analyzed Cancer Cancer immunotherapy Cancer therapy clinically Cohort cohort study common condition COVID-19 vaccination COVID-19 vaccines CRS CXCL8 cytokine level Cytokine release syndrome Cytokines Diagnosis eight elevated event Hospitalized immune immune response immune-checkpoint inhibitor interleukin-6 modulate observé occurred Patient patients died receive response Serious Adverse Event serum serum cytokine single-center Symptoms therapy Treatment Tumor upregulated vaccination [DOI] 10.1038/s43018-022-00398-7 [Article Type] Research
Cytotoxic T-Cell-Based Vaccine against SARS-CoV-2: A Hybrid Immunoinformatic ApproachArticle Published on 2022-01-302022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 3D structure acquired immunity administration Antigen Antigen presentation binding Cancer immunotherapy canonical cellular cellular immunity characterized Coverage COVID-19 convalescent patient cytotoxic cytotoxic T lymphocytes dendritic cells epithelia epitope Epitopes highest HLA HLA class I hybrid IEDB immune protection immune response immune stimulation immunization immunogenic immunoinformatics in silico In silico methods intranasal long term immunity molecular docking Molecular docking study NetMHCpan non-allergenic non-toxic parameter peptide platform Population positive Probability protein folding provide provided robust SARS-CoV-2 T-Cell vaccine screened stimulate Structure synthetic long peptide T-cells Toll-like receptor Toxicity vaccination VaxiJen 2.0 Viral mutations virus clearance [DOI] 10.3390/vaccines10020218 PMC 바로가기 [Article Type] Article
Potential Application of Exosomes in Vaccine Development and DeliveryResearch Paper Published on 2022-01-132023-08-30 Journal: Pharmaceutical research [Category] E형 간염, [키워드] Cancer immunotherapy Exosomes immune system Infectious disease Vaccine development [DOI] 10.1007/s11095-021-03143-4 PMC 바로가기 [Article Type] Research Paper
Adenovirus Biology, Recombinant Adenovirus, and Adenovirus Usage in Gene Therapy유전자 요법에서 아데노 바이러스 생물학, 재조합 아데노 바이러스 및 아데노 바이러스 사용Review Published on 2021-12-142022-09-10 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] adenoviral vector Adenovirus adenovirus-based best Biology Cancer Cancer cells Cancer immunotherapy Cell clinical trial clinical trials conditionally replicating adenovirus COVID-19 vaccine COVID-19 vaccines cytokine ENhance Gene therapy insertion kill m-CRA methodological Modification oncolytic virus Patients with cancer platform pluripotent stem cells promoter recombinant regenerative regenerative medicine replicate replication-defective adenoviral vector stem cell subsequent survivin therapeutic therapeutic effects therapy Tumor tumors Usage Vaccine Vaccines Viral viral replication virus wild-type [DOI] 10.3390/v13122502 PMC 바로가기 [Article Type] Review
VEGFR2 activity on myeloid cells mediates immune suppression in the tumor microenvironmentResearch Article Published on 2021-12-082023-08-30 Journal: JCI Insight [Category] E형 간염, [키워드] Cancer immunotherapy immunology macrophages oncology [DOI] 10.1172/jci.insight.150735 PMC 바로가기 [Article Type] Research Article
Predictors of poor seroconversion and adverse events to SARS-CoV-2 mRNA BNT162b2 vaccine in cancer patients on active treatment활성 치료 중인 암 환자에서 SARS-CoV-2 mRNA BNT162b2 백신에 대한 불량한 혈청 전환 및 유해 사례의 예측인자Observational Study Published on 2021-12-012022-09-11 Journal: European journal of cancer (Oxford, England : 1990 [Category] MERS, SARS, 바이오마커, 임상, 진단, [키워드] 95% CI Active surveillance active treatment adverse effects adverse event adverse events Antibody Response Antibody responses Antibody responses to the BNT162b2 vaccine benefit BNT162b2 BNT162b2 vaccine Cancer Cancer biological treatment cancer chemotherapy Cancer hormone therapy Cancer immunotherapy cancer patient Cancer patients Cancer target therapy candidate Chemotherapy ClinicalTrials conducted controls COVID-19 vaccine COVID-19 vaccine in cancer patients dose enrolled Factor female greater Hormone therapy IgG IgG response immunisation immunogenicity increasing age lack lymphocyte Lymphocyte count medications Mild mRNA BNT162b2 vaccine non-responders occur of BNT162b2 Older age Patient patients Patients with cancer predict predicted primary endpoint Prospective Study recruited responders risk S1/S2 SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccine adverse effects. second dose Seroconversion Serological testing significantly subject targeted therapy Therapies therapy Treatment women younger patient younger patients younger subject younger subjects [DOI] 10.1016/j.ejca.2021.09.030 PMC 바로가기 [Article Type] Observational Study
DeepImmuno: deep learning-empowered prediction and generation of immunogenic peptides for T-cell immunityDeepimmuno : T- 세포 면역을위한 면역 원성 펩티드의 딥 러닝에 대한 예측 및 생성Problem Solving Protocol Published on 2021-11-032022-09-10 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 변종, [키워드] AdaBoost adaptive immune system addition Algorithms alleles Antigen antigen recognition antigens approach best binding Cancer Cancer immunotherapy Cell chose CNN computational method Computational methods conducted Convolutional neural network COVID-19 dataset datasets deep learning Dengue dengue virus distribution elicit FIVE foreign antigen foreign antigens forest GAN generative adversarial network human leukocyte antigen immunogenic peptide immunogenic potential immunogenicity Impact independent killing lack leukocyte life-threatening neoantigen Pathogens peptide peptides Physicochemical properties physicochemical property predict Random forest residual residue SARS-CoV-2 SARS-CoV-2 variants seeking sequence source code Support support vector machine T-cell T-cell immunity T-cell Response T-cells targeted therapy Vaccine [DOI] 10.1093/bib/bbab160 PMC 바로가기 [Article Type] Problem Solving Protocol
Combined Blockade of GARP:TGF-β1 and PD-1 Increases Infiltration of T Cells and Density of Pericyte-Covered GARP + Blood Vessels in Mouse MC38 TumorsOriginal Research Published on 2021-07-272023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] Cancer immunotherapy GARP immune checkpoint inhibition Immunosuppression TGF-β1 [DOI] 10.3389/fimmu.2021.704050 PMC 바로가기 [Article Type] Original Research