Methylene blue for intractable pain from oral mucositis related to cancer treatment: a randomized phase 2 clinical trialarticle Published on 2022-11-032024-09-02 Journal: BMC Medicine [Category] 대상포진, [키워드] Cancer therapy Methylene blue Oral Rinse Oral mucositis [DOI] 10.1186/s12916-022-02579-8 PMC 바로가기 [Article Type] article
IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spikeArticle Published on 2022-09-052022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] Adaptive immune response bind binding Cancer Cancer therapy cells cleavage cleave enzyme expressed expression facilitate homology identify IL4I1 immune immunosuppressive immunosuppressive enzymes Immunotherapy involved Lymphocytes mechanism of action monocyte Monocyte-derived macrophages moonlighting protein negative control Protease activity Protein Pseudotyped virus Region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein secreted spike surface protein survival the spike protein TMPRSS13 TMPRSS2 transmembrane serine protease virus [DOI] 10.3389/fimmu.2022.982839 PMC 바로가기
Cytokine release syndrome-like serum responses after COVID-19 vaccination are frequent and clinically inapparent under cancer immunotherapy Research Published on 2022-06-012022-10-05 Journal: Nature cancer [Category] 임상, 진단, 치료기술, 치료법, [키워드] 95% CI absence Adverse adverse event analyzed Cancer Cancer immunotherapy Cancer therapy clinically Cohort cohort study common condition COVID-19 vaccination COVID-19 vaccines CRS CXCL8 cytokine level Cytokine release syndrome Cytokines Diagnosis eight elevated event Hospitalized immune immune response immune-checkpoint inhibitor interleukin-6 modulate observé occurred Patient patients died receive response Serious Adverse Event serum serum cytokine single-center Symptoms therapy Treatment Tumor upregulated vaccination [DOI] 10.1038/s43018-022-00398-7 [Article Type] Research
Outcomes of COVID-19 and risk factors in patients with cancer Research Published on 2022-04-042022-10-05 Journal: Nature cancer [Category] COVID19(2023년), SARS, 치료법, [키워드] acute respiratory syndrome Advancing age Cancer Cancer center Cancer therapy Comorbidity coronavirus coronavirus disease COVID-19 COVID-19 pandemic death diagnosed higher risk India management Mild Most patient outcomes palliative intent Patients with cancer provide risk factor severe COVID-19 smoking Treatment [DOI] 10.1038/s43018-022-00363-4 [Article Type] Research
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells Research Published on 2022-03-172022-10-05 Journal: Nature Immunology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] acute SARS-CoV-2 infection Analysis Autoimmunity Cancer Cancer therapy expression feature Genes IFN-I IFN-I response Immunotherapy in vitro Infectious disease inhibiting interferon LAG-3 mechanism mRNA Perturbation receptor regulate regulatory network SP140 T cell T cells target TFS TIGIT transcription factor transcriptional Type type 1 interferon unique [DOI] 10.1038/s41590-022-01152-y [Article Type] Research
Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapyResearch article Published on 2022-03-012022-10-05 Journal: Bioactive Materials [Category] Coronavirus, 비임상, [키워드] accumulated addition adverse effect Cancer therapy cancer treatment Cas9 cells CRISPR/Cas DNA Efficiency element encapsulate expressing Factor gene editing in vitro in vivo Intravenous injection kidneys lack Lipid nanoparticle liver Neutral nucleic acid organ Plasmid PLK1 Protein provide regimen RNA robust Safe sgRNA significantly siRNA triggered tumor growth [DOI] 10.1016/j.bioactmat.2021.05.051 [Article Type] Research article
SARS-CoV-2 Antibody Seroprevalence in Patients With Cancer on Systemic Antineoplastic Treatment in the First Wave of the COVID-19 Pandemic in PortugalInfectious Disease Published on 2022-02-212022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute SARS-CoV-2 infection anti-SARS-CoV-2 antibody Antineoplastic assays baseline Cancer Cancer therapy cohort of patient Contact COVID-19 COVID-19 pandemic COVID-19 patient cross-sectional determine diagnosis of COVID-19 early phase First wave General population high risk hospital IgG IgM Immunoglobulin Inconclusive maintain negative RT-PCR no evidence of nucleocapsid oncology pandemic Patient Patients with cancer Portugal positive preventive measures recruited recruitment reported risk RT-PCR Safe SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 protein serological test serology Seroprevalence seroprevalence study serum serum IgG serum sample single-center study visit subject systemic tested Treatment Two patient Wave [DOI] 10.7759/cureus.22428 PMC 바로가기 [Article Type] Infectious Disease
The antibody response of haematological malignancies to COVID-19 infection and vaccinationComment Published on 2022-01-112022-10-28 Journal: British Journal of Cancer [Category] COVID-19, MERS, [키워드] Antibody Response Cancer patients Cancer therapy COVID-19 infection develop fatal disease General population guideline Haematological cancer haematological malignancy help Immunocompromised immunosuppressive therapies infected with COVID-19 less malignancies malignancy measure oncology patients patients with COVID-19 patients with haematological Protective raise rate of seroconversion receiving reduced seroconversion rate survival vaccination vaccination schedule while [DOI] 10.1038/s41416-021-01682-6 PMC 바로가기 [Article Type] Comment
Use of the ONCO-TreC electronic diary compared with a standard paper diary to improve adherence to oral cancer therapy in patients with solid and haematological tumours: protocol for a randomised controlled trial고형 및 혈액 종양 환자의 구강암 치료 순응도를 향상시키기 위해 표준 종이 일기와 비교한 ONCO-TreC 전자 일기의 사용: 무작위 대조 시험을 위한 프로토콜Article Published on 2022-01-112022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] 1:1 absolute difference adherence All study participants ARMS both group both groups Cancer therapy conducted conferences Controlled trial dropout rate drug dose Effectiveness enrolled Ethical approval Ethics ethics committee evaluation period finding Fisher greater healthcare Healthcare professional healthcare professionals identify IMPROVE information information management Informed consent intention-to-treat population Italian less oncology open label oral cancer Oral medicine oral medicine. paper Patient peer-reviewed performed platform primary analysis proportion protocol randomised randomised controlled trial reduction in registration number responsible Satisfaction secondary significance level Study participants therapy Tumours Version was obtained [DOI] 10.1136/bmjopen-2021-055814 PMC 바로가기 [Article Type] Article
Hybrid transthoracic oesophagectomy due to carcinoma with complications after COVID-19 pneumonia – A case reportCase report Published on 2022-01-012022-10-05 Journal: International Journal of Surgery Case Reports [Category] 변종, [키워드] affected Antibiotics arise ATBAntibiotics Cancer cancer patient Cancer therapy Case report Cell ChemoRadiotherapy for Oesophageal cancer followed by Surgery Study PR - partial response clinical Complication complications Computed tomography COVID pneumonia COVID-19 COVID-19 pandemic CROSSChemoRadiotherapy for Oesophageal cancer followed by Surgery Study PR - partial response CTComputed Tomography develop diagnosed disease ECCGEsophagectomy Complications Concensus Group – ECCG Endosonography Esophagectomy Complications Concensus Group – ECCG EUSEndosonography Factor hybrid indicated male malignancy oesophagus organs Patient PET/CT PETPositron Emission Tomography Pneumonia Positron emission tomography postoperative Postoperative complication Predictive protocol question required Respiratory failure risk Septic shock similar study standardized uptake values subsequent SUVstandardized uptake values Symptom syndrome therapy was performed X-ray examination X-rayX-ray examination [DOI] 10.1016/j.ijscr.2021.106749 [Article Type] Case report