Clarifying the Use of Benzylidene Protecting Group for D-(+)-Ribono-1,4-Lactone, an Essential Building Block in the Synthesis of C -NucleosidesArticle Published on 2021-10-262022-10-30 Journal: Molecules [Category] Coronavirus, MERS, SARS, [키워드] 1-C-substituted nucleosides addition analogues antiviral activity antiviral drug block building carbohydrate Clarifying Community Compound compounds condition COVID-19 cyclic acetals DMSO Essential global pandemic group molecular NMR nucleoside Protecting protecting groups reaction ribono-1,4-lactone Scientific community Spread structural rearrangement subject Support synthesis these compound [DOI] 10.3390/molecules26216447 PMC 바로가기 [Article Type] Article
Impact of Specific N -Glycan Modifications on the Use of Plant-Produced SARS-CoV-2 Antigens in Serological AssaysPlant Science Published on 2021-09-272022-10-31 Journal: Frontiers in Plant Science [Category] COVID-19, [키워드] allergen allergic antibodies antibody Antigen average carbohydrate Cell characterized comparable contribute COVID-19 cross-reactive cross-reactive carbohydrate determinant detect determinant epitope event expressed expression False positive False positives glycosylated glycosylation human cell human sera humans immune response Impact individual Interaction Modification Neutralizing antibodies Nicotiana benthamiana pandemic plant populations posttranslational modification produced RBD reactivity Receptor binding domain reduced required SARS-CoV-2 sera serological assays serological test Specific Spike protein the SARS-CoV-2 Transient variant viral antigens viral infection virus was used while wild-type [DOI] 10.3389/fpls.2021.747500 PMC 바로가기 [Article Type] Plant Science
Computational Study of Potential Galectin-3 Inhibitors in the Treatment of COVID-19Article Published on 2021-09-132022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] alveolar macrophage binding binding affinity carbohydrate compounds COVID-19 database disrupt docking domain dual inhibitors effective FIVE function galectin-3 humans identify in vitro in vivo Inflammation inhibitor inhibitors Interaction interactions Ligand Lung fibrosis Lung injury N-terminal domain Post-infection Potential Prevent Protein Proteins pulmonary fibrosis recent reduce regulate SARS-CoV-2 similarity spike Spike protein Spread the SARS-CoV-2 the Spike viral entry Virtual screening virus [DOI] 10.3390/biomedicines9091208 PMC 바로가기 [Article Type] Article
Pan-selectin inhibitors as potential therapeutics for COVID-19 treatment: in silico screening studyCOVID-19 치료를 위한 잠재적 치료제로서의 Pan-selectin 억제제: in silico 스크리닝 연구Article Published on 2021-09-092022-09-11 Journal: Glycobiology [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome anti-cytokine anti-cytokine therapy antivirals approved drugs binding Blood carbohydrate Cell Compound compounds coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 therapeutics cytokine response Cytokine storm Cytokines death described develop disease docked docking domain E-selectin early response effective Evidence globe hospitalized patient hospitalized patients in silico induce Inflammatory cytokine Inflammatory cytokines inflammatory disease Inflammatory diseases Inflammatory response inhibitor inhibitors leukocyte Ligand ligands Migration Mortality overactive overproduction pan-selectin inhibitors Pathogenesis Proinflammatory cytokine proinflammatory cytokines protease inhibitors respiratory distress Respiratory failure screened screening procedure selectin selectins Spectrum Spread syndrome therapeutic target tissue Treatment treatment of COVID-19 Vaccine Virtual screening with COVID-19 Zinc ZINC database [DOI] 10.1093/glycob/cwab021 PMC 바로가기 [Article Type] Article
Lentil lectin derived from Lens culinaris exhibit broad antiviral activities against SARS-CoV-2 variantsResearch Article Published on 2021-08-012022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome against SARS-CoV Amino acid anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity antiviral activity antiviral lectin B.1.1.7 B.1.351 binding carbohydrate carbohydrate-binding protein collected conserved coronavirus cytotoxicity Epidemic evaluated Evidence experiment GlcNAc glycan glycosylated glycosylation site Infection information inhibit inhibit SARS-CoV-2 injection Len Lentil MERS-CoV mutant mutant strain mutants mutated N-linked glycosylation neutralization Neutralization assay P.1 Protein provide pseudovirus raised S protein S trimer SARS-CoV-2 SARS-CoV-2 variant specificity the epidemic variant variants weight loss [DOI] 10.1080/22221751.2021.1957720 PMC 바로가기 [Article Type] Research Article
A metabolic modeling approach reveals promising therapeutic targets and antiviral drugs to combat COVID-19대사 모델링 접근법은 유망한 치료 표적과 항 바이러스 약물이 Covid-19와 싸우는 것을 보여줍니다.Article Published on 2021-06-072022-09-10 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] ACSL3 antiviral drug approach balance benzyl Benzyl Isothiocyanate carbohydrate carried celgosivir Cell COVID-19 Dengue docking drug Drug discovery drugs targeting effective enzyme Enzymes flux flux balance analysis hepatitis C identify Influenza inhibit inhibitor Isothiocyanate lipid metabolism Lonafarnib metabolism positive-sense single-stranded RNA positive-sense single-stranded RNA viruses predicted Propylthiouracil Protein reveal shown Systems biology target tested therapeutic intervention therapeutic target tipifarnib Tunicamycin virus viruses Zika [DOI] 10.1038/s41598-021-91526-3 PMC 바로가기 [Article Type] Article
Plant-based diets, pescatarian diets and COVID-19 severity: a population-based case–control study in six countriesOriginal Research Published on 2021-06-072022-10-28 Journal: BMJ Nutrition, Prevention & Health [Category] COVID-19, [키워드] 95% CI association carbohydrate confounders controls country COVID-19 COVID-19 case COVID-19 infection COVID-19 patient COVID-19 severity demographic characteristics dietary habit dietary patterns duration of illness evaluate France Germany greater HCWs healthcare worker hypothesised individual information investigated Italy Mild moderate-to-severe COVID-19 multivariable logistic regression outcomes participant previous study Protein provided reported Result severe COVID-19 severity severity of symptoms Spain USA [DOI] 10.1136/bmjnph-2021-000272 PMC 바로가기 [Article Type] Original Research
Viruses Like Sugars: How to Assess Glycan Involvement in Viral AttachmentReview Published on 2021-06-072022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] acute respiratory syndrome advance Antiviral approaches attachment attachment receptor carbohydrate cellular tropism coronavirus Enterovirus D68 EV-D68 Genetic glycan HBGA heparan sulfate highlighting host cell identify identifying Interaction Involvement Like limitation majority pharmacological receptor recognize SARS-CoV-2 sialic acid targets Trigger viral infection virus viruses [DOI] 10.3390/microorganisms9061238 PMC 바로가기 [Article Type] Review
The role of carbohydrate antigen 125 in COVID-19COVID-19에서 탄수화물 항원 125의 역할Article Published on 2021-06-012022-09-11 Journal: Medical Hypotheses [Category] MERS, SARS, 바이오마커, [키워드] affecting Antigen Biomarker CA-125 carbohydrate cardiac injuries cardiovascular cardiovascular disease cardiovascular diseases cardiovascular system cause Clinical course Combination complex coronavirus disease Coronavirus disease 2019 correlation Course COVID-19 disease echocardiographic parameter echocardiographic parameters Effect heart heart failure hemodynamic identify Increases increases in Infection Inflammatory biomarker inflammatory process Laboratory life life threatening marker mechanism Mortality pathophysiology poor prognosis Prognosis severity the disease Treatment [DOI] 10.1016/j.mehy.2021.110590 PMC 바로가기 [Article Type] Article
Inhibition of SARS-CoV-2 Virus Entry by the Crude Polysaccharides of Seaweeds and Abalone Viscera In Vitro해조류 및 전복 내장의 조다당류에 의한 SARS-CoV-2 바이러스 진입 억제 In VitroArticle Published on 2021-04-152022-09-10 Journal: Marine Drugs [Category] MERS, SARS, 치료제, [키워드] Abalone abalone viscera antioxidant antiviral activities antiviral activity antiviral agent Antiviral agents carbohydrate Codium COVID-19 discus except for fucoidan fucose Haliotis HEK293 IC50 indicated Infection inhibit SARS-CoV-2 inhibition inhibitory activity kDa Laminaria molecular weight MOST polysaccharide polysaccharides Porphyra Prevent pseudovirus Sargassum SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 virus screened seaweed sulfated sulfated polysaccharide the strongest Undaria pinnatifida viscera [DOI] 10.3390/md19040219 PMC 바로가기 [Article Type] Article