Identification of COVID-19-Associated DNA Methylation Variations by Integrating Methylation Array and scRNA-Seq Data at Cell-Type Resolution세포 유형 분해능에서 메틸화 어레이 및 scRNA-Seq 데이터를 통합하여 COVID-19 관련 DNA 메틸화 변이 식별Article Published on 2022-06-212022-09-11 Journal: Genes [Category] MERS, 바이오마커, [키워드] AHNAK antiviral activity biological processe Biomarker cell type cell types COVID-19 COVID-19 patient COVID-19 patients CX3CR1 Cytokines DNA DNA methylation DNAm variation gene Epigenetic FIVE identification immune immune dysfunction immune response immune responses Inflammatory response knowledge LFNG low expression lymphopenia Methylation methylation array phenomenon play roles pro-inflammatory cytokines regulated Regulation reported Resolution S100A9 scRNA-seq scRNA-seq. signaling pathways single-cell single-cell level specificity T cell T cells TRAF3IP3 Transcriptome Variation Whole blood [DOI] 10.3390/genes13071109 PMC 바로가기 [Article Type] Article
Synergistic Antiviral Activity of Pamapimod and Pioglitazone against SARS-CoV-2 and Its Variants of ConcernSARS-CoV-2 및 우려 변종에 대한 파마피모드 및 피오글리타존의 상승적 항바이러스 활성Article Published on 2022-06-202022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acting activity agonist Alpha Anti-inflammatory antiviral activity antiviral potency approved Arthritis assumption Beta cell type cellular cellular pathway cellular targets clinical study clinically evaluated Combination components concern coronavirus COVID-19 COVID-19 patients Delta described diabetes drug effective evaluated Gamma in vitro inhibit SARS-CoV-2 inhibitor kinase mitogen mitogen-activated protein kinase molnupiravir omicron p38-inhibitor pamapimod pathway Paxlovid pioglitazone polymerase potential therapy PPRy-agonist Protease inhibitor protein kinase public health threat reduce Replication replication of SARS-CoV-2 rheumatoid arthritis SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 replication selective Severity of disease small molecule Small molecules Support synergistic These data transmitted treat Treatment type 2 diabetes Vaccine-induced immunity variant variants variants of concern viral replication virulent virus variants virus variants. VOCs Wuhan [DOI] 10.3390/ijms23126830 PMC 바로가기 [Article Type] Article
Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vapingCOVID-19의 신경 전달 및 흡연 및 전자담배에 의한 신경염증 상태에서 성상교세포 안지오텐신 전환 효소 2의 잠재적 역할Article Published on 2022-06-072022-09-11 Journal: Fluids and Barriers of the CNS [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 ACE2 expression affecting Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Astrocyte astrocytes Brain Cell cell type cells characterized Choroid plexus conducted COVID-19 COVID-19 patients COVID-19 severity cultured cells cytokine distribution domain endothelial cells entry receptor enzyme epithelial cell epithelial cells evaluate the effect exacerbate exacerbated expressed expression glial cell help highlight hypothalamus IL-5 IL-6 Immunocompromised immunohistochemistry immunomodulatory Inflammation manifestation marker Medulla oblongata meninges neural transmission Neurogenesis Neuron neurons Nicotine oblongata Pathogenesis pathogenesis of COVID-19 pericytes Post-infection Potential proinflammatory Real-time PCR responsible risk factor SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection shown significantly Smokers smoking smoking. stroma systemically third ventricle Transmission understanding ventricular were used western blot zone [DOI] 10.1186/s12987-022-00339-7 PMC 바로가기 [Article Type] Article
Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patientsResearch article Published on 2022-06-072022-10-05 Journal: Immunity [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] accompanied Admission analyzed baseline basophils blood sample cell type changes changes in conserved courses COVID-19 COVID-19 patient Cytometry discharge disease disease resolution element elevated Frequency healthy individual heterogeneous hospital discharge hospitalized COVID-19 patient immune Immune cell immune cell signaling immune response immunological immunological change increases in Infection longitudinal analysis mass outcome pathophysiological Patient patients hospitalized phosphorylated Pneumonia recovery reduced reduction in Regulatory T cell Respiratory failure reveal Sepsis severe SARS-CoV-2 Signaling single-cell T cell trajectory while with COVID-19 [DOI] 10.1016/j.immuni.2022.06.004 [Article Type] Research article
Extracellular vesicles in kidney disease Reviews Published on 2022-05-312022-10-05 Journal: Nature reviews. Nephrology [Category] 바이오마커, [키워드] addition administration Alter amplification body fluids candidate Cell cell type cell-to-cell communication chronic kidney diseases circulating diagnostic Efficacy Evidence extracellular vesicle fibrosis gene expression profile glomerular Increasing Inflammation investigated involved kidney kidney damage Kidney disease majority mechanism modulate molecular organ pathology pathophysiological preclinical data prognostic promote reduce reflect regenerative released robust Standardization stem cell target cells thought tubular cell urinary Vesicle [DOI] 10.1038/s41581-022-00586-9 [Article Type] Reviews
Genetic Landscape of the ACE2 Coronavirus ReceptorACE2 코로나바이러스 수용체의 유전적 지형Meta-Analysis Published on 2022-05-032022-09-11 Journal: Circulation [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] ACE2 ACE2 protein Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biological systems blood immune cells cardiometabolic cardiovascular disease cardiovascular diseases cardiovascular diseases. Cell cell type circulating Clinical studies clinical study Combined complex complex disease conducted coronavirus correlated correlation COVID-19 COVID-19 severity cross-sectional Diseases DNA methylation elevated epidemiological epigenomic expressed functional gastrointestinal tracts Genetic genetic architecture Genome genome-wide association Genome-wide association study heart heritability Hospitalization Human human cell human cells immune cells in silico individual Infection landscape likelihood loci mapped medications mendelian randomization Meta-analysis Odds ratio outcome Phenotypes plasma Protein Quantitative randomization receptor Regulatory related diseases resource respiratory SARS-CoV-2 severe COVID-19 soluble ACE2 suggested tissue transcriptomic Treatment variant Vascular vascular disease vascular diseases [DOI] 10.1161/CIRCULATIONAHA.121.057888 PMC 바로가기 [Article Type] Meta-Analysis
Angiotensin-converting enzyme 2 (ACE2): Two decades of revelations and re-evaluation안지오텐신 전환 효소 2(ACE2): 20년 간의 폭로와 재평가Review Published on 2022-05-012022-09-11 Journal: Peptides [Category] Coronavirus, COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE ACE2 acting Amino acid amyloid angiotensin Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme-2 binding cardiovascular caused cell membrane cell type conversion coronavirus counterbalance COVID COVID-19 pandemic driving ectoenzyme enzyme event expressed Factor homology implicated Inflammatory mechanisms membrane protein neprilysin pathological conditions Pathologies pathology Pathways peptide peptides physiological producing Protective provide provided receptor regulate Renin renin-angiotensin system sACE2 SARS SARS virus SARS-CoV2 specificity susceptibility therapeutic target Transport Treatment Vascular Vasoactive Vasopeptidase. virus Zinc [DOI] 10.1016/j.peptides.2022.170766 PMC 바로가기 [Article Type] Review
Recognition of Immune Cell Markers of COVID-19 Severity with Machine Learning Methods기계 학습 방법을 통한 COVID-19 심각도의 면역 세포 마커 인식Article Published on 2022-04-282022-09-11 Journal: BioMed Research International [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, [키워드] Algorithms analyzed B cell best Biomarker Biomarkers CD4 CD8 Cell cell type classifiers COVID-19 COVID-19 disease COVID-19 disease severity CX3CR1 Decision tree determine disease Disease progression disease severity feature filtered Gene expression analysis gene expression profile Host IL1B Immune cell immune cells immune response Immunological response immunological responses Inflammatory involved ITK KEGG pathway machine learning molecular mechanism molecular mechanisms monocyte Mortality NK cell Numerous PRDM1 random Random forest Recognition Regulation resulting SARS-COV-2 infection single-cell these cell These cells TLR2 [DOI] 10.1155/2022/6089242 PMC 바로가기 [Article Type] Article
Analyzing single cell transcriptome data from severe COVID-19 patients중증 코로나19 환자의 단세포 전사체 데이터 분석Article Published on 2022-04-212022-09-11 Journal: STAR protocols [Category] MERS, 바이오마커, 유전자 메커니즘, 진단, [키워드] bioinformatics Cell cell type cell types cellular Complete COVID-19 COVID-19 severity database detect disease-associated enrichment analysis Gene Expression Genomics Health Sciences identify immunology in silico in vitro in vivo marker gene Molecular biology protocol Regulatory resources RNAseq RNAseq. severe COVID-19 severe COVID-19 patient Single Cell single-cell Transcriptome transcriptomics upregulated upregulation [DOI] 10.1016/j.xpro.2022.101379 PMC 바로가기 [Article Type] Article
Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model인간 만능 줄기 세포 유래 모델에서 SARS-CoV-2 감염에 대한 대식세포 아형의 차등 효과Article Published on 2022-04-192022-09-12 Journal: Nature Communications [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] ACE2 antibody Apoptosis cell type cells co-culture contribute coronavirus disease-2019 COVID-19 COVID-19 disease severity Effect effective ENhance growth host-pathogen interaction immune response Inflammatory factor inhibition inhibitory effect Interaction involved lung lung cells M2 macrophages Macrophage macrophage phenotypes macrophages pluripotent stem cell progression SARS-COV-2 infection significantly subtype suppress the SARS-CoV-2 virus Therapeutic strategies up-regulate viral entry viral infection [DOI] 10.1038/s41467-022-29731-5 PMC 바로가기 [Article Type] Article