Dynamics of antibody titers and cellular immunity among Japanese healthcare workers during the 6 months after receiving two doses of BNT162b2 mRNA vaccineBNT162b2 mRNA 백신 2회 접종 후 6개월 동안 일본 의료 종사자의 항체 역가 및 세포 면역의 역학Article Published on 2022-07-302022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] All participant All participants Analysis antibody Antibody titer Antibody titers Asymptomatic BNT162b2 BNT162b2 mRNA BNT162b2 vaccine Breakthrough infection breakthrough infections Cellular immune response cellular immune responses cellular immunity clinical trial collected conducted COVID-19 determinant determinants determine dose Dynamics elevated follow-up period healthcare healthcare worker Healthcare workers humoral IgG immune response immune responses incidence Japanese knowledge medical condition Medical conditions mRNA vaccine mRNA vaccines mRNA vaccines. Nucleocapsid proteins of BNT162b2 participant Pfizer Pfizer-BioNTech positive prospective cohort study receiving SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine seroconverted serum sample serum samples study period T-cell immune response T-cell immune responses timepoint vaccination Vaccine waned were measured within 6 months [DOI] 10.1016/j.vaccine.2022.06.016 PMC 바로가기 [Article Type] Article
The generation of stem cell-like memory cells early after BNT162b2 vaccination is associated with durability of memory CD8 + T cell responsesBNT162b2 백신 접종 후 초기에 줄기 세포 유사 기억 세포의 생성은 기억 CD8 + T 세포 반응의 내구성과 관련이 있습니다Article Published on 2022-07-262022-09-12 Journal: Cell Reports [Category] MERS, 진단, [키워드] activated Activation average BNT162b2 CD8 CD8(+) T cell Cell cells cellular immune responses correlation COVID-19 CP: Immunology decrease determine dose effector cell elicit Frequency healthcare worker Host humoral immunized memory memory cell Memory cells memory T MHC class I MHC class I multimer MHC-I of BNT162b2 phenotype required SARS-CoV-2 significantly T cell T cell response T cell responses T cells vaccination Vaccine Vaccine-induced immunity vaccine. [DOI] 10.1016/j.celrep.2022.111138 PMC 바로가기 [Article Type] Article
Humoral and Cellular Immune Responses of COVID-19 vaccines against SARS-Cov-2 Omicron variant: a systemic reviewSARS-Cov-2 오미크론 변이체에 대한 COVID-19 백신의 체액 및 세포 면역 반응: 전신 검토Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed B.1.1.529 booster booster dose cellular Cellular immune response cellular immune responses center contagious coronavirus 2 country COVID-19 vaccine Critical current dominant variant dose Effectiveness elicit elicited Future Genome Health Organization Heterologous homogenous homologous or heterologous humoral Humoral and cellular immune responses humoral immune response humoral immune response, cellular immune response immune Immune escape immune responses induce molecular basis multiple mutation multiple mutations mutated Mutation Neutralizing antibody response neutralizing antibody responses omicron Omicron variant PROTECT Protective public health question regimen regimens reported respiratory response robust S-protein SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 virus Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Systemic review systemically T cell T cell response the SARS-CoV-2 virus vaccination Vaccination strategy Vaccine vaccine. variant VoC WHO World Health Organization [DOI] 10.7150/ijbs.73583 PMC 바로가기 [Article Type] Review
Recent advances on smart glycoconjugate vaccines in infections and cancerArticle Published on 2022-07-012022-11-15 Journal: The Febs Journal [Category] COVID19(2023년), SARS, 진단, [키워드] antigenic antigens approaches Biomedical research Cancer carbohydrate cellular cellular immune responses characterized death develop effective vaccine Efficacy effort epitope glycan glycosylation Human immunodeficiency virus humoral immune immune response immune system immunogenic immunoglobulin G response Immunological memory IMPROVE induce Infection Infectious disease joint morbidity outbreak pathogen pathogen-specific profile Protective provoke public health recent SARS-CoV-2 selective significantly T-cell immunity therapeutic vaccination vaccination. Vaccine Vaccine development virus [DOI] 10.1111/febs.15909 PMC 바로가기
T-cell proliferation assay for the detection of SARS-CoV-2-specific T-cellsSARS-CoV-2-특이적 T-세포 검출을 위한 T-세포 증식 분석Article Published on 2022-07-012022-09-11 Journal: Clinica chimica acta; international journal of cli [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] an area Analysis antibody approved AUC B-cell B-cell response blood sample Blood samples carried cellular cellular immune responses clinical setting clinical settings complex Control control group controls ELISA assay False positive False positives Health care Health care worker health care workers humoral Humoral and cellular immune responses IgG immune immune responses Immunoglobulin Immunoglobulin G Infection less lymphocyte lymphocyte transformation Lymphocyte transformation test majority membrane N and M non-infected nucleocapsid peptide peptide pool peptide pools proliferation Protein representing resulting ROC analysis S protein S1 subunit SARS-CoV-2 SARS-CoV-2 spike protein Spike protein Stimulation T-cell T-cell Response T-cell response. T-cell responses the S protein the S1 subunit the SARS-CoV-2 thymidine Trigger vaccinated individual vaccination Vaccines were recorded [DOI] 10.1016/j.cca.2022.05.025 PMC 바로가기 [Article Type] Article
Prevalence of COVID-19-associated symptoms during acute infection in relation to SARS-CoV-2-directed humoral and cellular immune responses in a mild-diseased convalescent cohort경증 회복기 코호트에서 SARS-CoV-2 유도 체액 및 세포 면역 반응과 관련하여 급성 감염 중 COVID-19 관련 증상의 유병률Article Published on 2022-07-012022-09-12 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute infection antibody antiviral immunity association Cellular immune response cellular immune responses Cohort convalescent convalescent individual correlation cough COVID-19 COVID-19 symptom COVID-19 symptoms disease severity effective eight evaluated humoral humoral immune response humoral immune responses IgG immune immune response intensities intensity Loss of Smell majority no difference polymerase chain positive Prevalence Prevent questionnaire recent reduced SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2-specific T cell Serum level severe symptom severity shown Symptom symptom severity Symptoms Symptoms. T cell response T cells virus clearance were assessed [DOI] 10.1016/j.ijid.2022.04.019 PMC 바로가기 [Article Type] Article
Immunity to SARS-CoV-2: What Do We Know and Should We Be Testing for It?SARS-CoV-2에 대한 면역: 우리는 무엇을 알고 있으며 이에 대해 테스트해야 합니까?Review Published on 2022-06-152022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome adaptive antibodies Care cellular immune responses Characteristics Combination Correlate of protection COVID-19 Diseases global pandemic humans immune immune responses Immunity lack Multiple Multiple studies Neutralizing antibodies new SARS-CoV-2 pathogen Pathogens Preexisting immunity public health respiratory robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant serologic assays serologic testing serology Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus-2 shown Standardization Testing the patient threshold transmission rate utility vaccination Vaccine Vaccines Vaccines. variant [DOI] 10.1128/jcm.00482-21 PMC 바로가기 [Article Type] Review
Kinetics and Persistence of the Cellular and Humoral Immune Responses to BNT162b2 mRNA Vaccine in SARS-CoV-2-Naive and -Experienced Subjects: Impact of Booster Dose and Breakthrough InfectionsSARS-CoV-2-나이브 및 -경험 대상자에서 BNT162b2 mRNA 백신에 대한 세포 및 체액 면역 반응의 동역학 및 지속성: 추가 용량 및 돌발 감염의 영향Article Published on 2022-05-312022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] administration age analyzed Anti-nucleocapsid antibodies anti-SARS-CoV-2 anti-spike antibodies anti-spike antibody antibodies antibody association Belgium benefit blood sample Blood samples blood sampling BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine booster booster dose booster doses breakthrough infections cell-mediated immune response cellular cellular and humoral immune response Cellular immune response cellular immune responses collected COVID-19 COVID-19 vaccine DiaSorin dose Elecsy enrolled evaluated greater HCW HCWs Healthcare system healthcare worker Healthcare workers help Human humoral Humoral and cellular immune responses humoral immune response Humoral response IFN-γ IgG immune protection immune response immune responses immunization immunogenicity Impact implication increase in individual level individuals Infection initial Kinetics LIAISON Lymphocytes management mandatory mRNA vaccination mRNA vaccine naïve naïve individuals natural infection Neutralization assay neutralization capacity Neutralizing antibodies neutralizing antibodies. pandemic participant Participants Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes persistence Prevent Prospective Study Qiagen QuantiFERON quantified reduce regimen response SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination second dose secretion severe COVID-19 significantly higher tested the SARS-CoV-2 triggering understanding university vaccination vaccine dose variant Vero E6 was performed [DOI] 10.3389/fimmu.2022.863554 PMC 바로가기 [Article Type] Article
Long-Lived Immunity in SARS-CoV-2-Recovered Children and Its Neutralizing Capacity Against OmicronSARS-CoV-2 회복 아동의 장기 면역 및 오미크론에 대한 중화 능력Article Published on 2022-05-172022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] activity Against antibody Antibody Response Antigen Asymptomatic Capacity CD4 T cell CD8 T cell CD8 T cells cellular immune responses children Cohort COVID-19 cross-neutralization D614G declined effectively controlled fold humoral Humoral and cellular immune responses immune immune memory immune responses Immunity IMPROVE induce Infection lack memory T cell memory T cells Mild neutralization neutralize Neutralizing activity Neutralizing antibodies neutralizing antibody omicron pre-existing immunity pre-immune recall remained response robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific T cells seronegative T cell T cells vaccination Vaccine vaccine response vaccine. variant variants variants of concern [DOI] 10.3389/fimmu.2022.882456 PMC 바로가기 [Article Type] Article
Bacteria-enabled oral delivery of a replicon-based mRNA vaccine candidate protects against ancestral and delta variant SARS-CoV-2레플리콘 기반 mRNA 백신 후보의 박테리아 지원 경구 전달은 조상 및 델타 변이형 SARS-CoV-2로부터 보호Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alphaviruses antibody antigenic diversity B.1.617.2 Bacteria Cellular immune response cellular immune responses clade contributed contributing to Coronavirus-2 COVID-19 cross-protective domain Efficacy epitope Epitopes Evolution feasible forest gene delivery hamster hamsters heptad repeat immune responses immunization immunized immunized mice Immunoglobulin lung Lungs mass vaccination membrane protein mRNA mRNA vaccine mucosal mucosal vaccine NAbs nasal Nasal cavity Neutralizing antibodies neutralizing antibody non-structural protein nsp13 offer oral Oral Immunization oral route Pneumonia principle PROTECT provide RBD Receptor binding domain recorded replicon-based respiratory Salmonella Salmonella-mediated SARS-CoV-2 secretory IgA SIgA the vaccine vaccination Vaccine vaccine efficacy variant variants variants. Viral viral replication virus [DOI] 10.1016/j.ymthe.2022.01.042 PMC 바로가기 [Article Type] Article