Drug-induced organ injury in coronavirus disease 2019 pharmacotherapy: Mechanisms and challenges in differential diagnosis and potential protective strategies2019년 코로나바이러스 질병의 약물 유발 장기 손상 약물 요법: 감별 진단 및 잠재적 보호 전략의 메커니즘 및 과제Review Published on 2021-07-012022-09-11 Journal: Journal of biochemical and molecular toxicology [Category] 바이오마커, 치료제, [키워드] adverse effect adverse effects Adverse reaction Adverse reactions Antiviral antiviral drug Biomarker caused clinical complication clinical manifestation clinical trial clinical trials coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection differential diagnosis Diseases drug drug regimen drug-induced drug-induced organ injury Emerging infectious diseases facilitate global public health Health Organization heart highlight highly pathogenic in some increasingly Infectious diseases Inflammation information kidney liver management mechanisms organ organ injury organs outbreak outcome oxidative oxidative stress pandemic Protective SARS-CoV-2 virus Side effect Therapeutic strategies therapeutic strategy Viral viral infection World Health Organization [DOI] 10.1002/jbt.22795 PMC 바로가기 [Article Type] Review
Multisystemic Inflammatory Syndrome and Thrombotic Microangiopathy as Complications of COVID-19 in a Child: A Case ReportPediatrics Published on 2021-06-042022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] Acute kidney injury affected Asymptomatic clinical clinical complication Complication complications condition coronavirus disease COVID-19 fatal disease healthy child include Infection Inflammatory Kawasaki-like syndrome kidney lupus nephritis microangiopathy Mortality multisystemic multisystemic inflammatory syndrome nephritic syndrome Novel coronavirus Prognostic factor progressed renal dysfunction report SARS-CoV-2 SARS-COV-2 infection syndrome target thrombotic thrombotic microangiopathy [DOI] 10.3389/fped.2021.659069 PMC 바로가기 [Article Type] Pediatrics
Targeting inflammation in atherosclerosis — from experimental insights to the clinic Reviews Published on 2021-05-112022-10-05 Journal: Nature Reviews Drug Discovery [Category] 바이오마커, [키워드] adaptive Atherosclerosis atherosclerotic clinical complication clinical study complement complications Cytokines death demonstrated dominant human disease hypertension Immunity inflammasomes Inflammation inflammatory pathway inhibiting Lipid management Measures mechanisms modulation pharmacological intervention Prevent review risk targeting targets treat [DOI] 10.1038/s41573-021-00198-1 [Article Type] Reviews
SARS-CoV-2 testing strategy: A comparison of restricted and extended strategies in a Swiss outpatient cohort from the community and hospital employeesResearch Article Published on 2021-04-222022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome applied clinical complication clinical complications clinical symptom Cohort cohort study collected Community coronavirus effective epidemiological link Fever finding First wave help highest hospital hospitalisation individual Infection number of symptom occurred participant Patient positive respiratory symptom risk factor Risk factors SARS-CoV-2 SARS-CoV-2 testing selected Spread symptom onset Symptoms Testing Transmission used data Viral load widespread [DOI] 10.1371/journal.pone.0250021 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 M pro : A Potential Target for Peptidomimetics and Small-Molecule InhibitorsSARS-CoV-2 M pro : 펩티드모방체 및 소분자 억제제의 잠재적 표적Review Published on 2021-04-192022-09-10 Journal: Biomolecules [Category] MERS, SARS, 변종, 신약개발, 치료제, [키워드] Administered Analysis approved Candidates catalytic activity caused clinical complication compounds coronavirus COVID-19 COVID-19 pandemic cysteine cysteine protease debate drug drugs Ebola effective vaccine Efficacy and safety evaluated event FDA HCV Health Impact Infection inhibitor inhibitors interactions interruption Intervention limitation M pro mutate New coronavirus new coronavirus SARS-CoV-2 offer parasite peptidomimetics Potential Prevent priority protease protease inhibitors recommendation Remdesivir Replication Repurposed drug Repurposed drugs repurposing responsible SARS-CoV-2 SARS-CoV-2 Mpro SARS-CoV-2 variant SARS-CoV-2 variants social distancing Spread target Treatment treatment of COVID-19 treatment of HIV Viral viral infection viral replication while WHO’ world population [DOI] 10.3390/biom11040607 PMC 바로가기 [Article Type] Review
The risk of clinical complications and death among pregnant women with COVID-19 in the Cerner COVID-19 cohort: a retrospective analysisResearch Article Published on 2021-04-162022-10-28 Journal: BMC Pregnancy and Childbirth [Category] COVID-19, MERS, [키워드] 95% CI age association Cerner clinical complication Clustering Cohort Comorbidity confounding variables COVID-19 death diabete disease evaluate female patient groups high-risk population higher odd hospital Hospitalization Immune suppression Inconclusive index infectious disease outbreak invasive ventilation Logistic LOS management medication moderate morbidity morbidity and mortality Mortality no difference no significant difference nonpregnant Pregnancy pregnant pregnant women recommendation regions Regression model Result retrospective Retrospective analysis risk supplementary material Variability Ventilation with COVID-19 women [DOI] 10.1186/s12884-021-03772-y PMC 바로가기 [Article Type] Research Article
Sex differences in clinical characteristics and risk factors for disease severity of hospitalized patients with COVID‐19Original Article Published on 2021-04-082022-10-30 Journal: MedComm [Category] COVID-19, [키워드] 95% confidence interval Admission Affect Beijing BMI body mass index CHD Clinical characteristics clinical complication Clinical efficacy Clinical symptoms Comorbidities Coronary heart disease coronavirus COVID‐19 COVID‐19 diagnosed disease disease severity Factor female female group Female patients females groups Hospitalization hospitalized patient Laboratory less male male group median age NAFLD no significant difference nonalcoholic fatty liver obesity Odds ratio Older outcome Patient Pneumonia proportion recent regression analysis reported risk factor Risk factors Sankey diagram SARS‐CoV‐2 SARS‐CoV‐2 Sex difference sex differences smoking two groups [DOI] 10.1002/mco2.66 PMC 바로가기 [Article Type] Original Article
[Impact of COVID-19 on the presentation and course of acute appendicitis in paediatrics]Observational Study Published on 2021-04-012022-10-05 Journal: Anales de pediatria [Category] 임상, [키워드] Acute appendicitis age Apendicitis aguda Apendicitis complicada Appendicitis Care children clinical complication Complicaciones postoperatorias Complicated appendicitis complications Course COVID-19 COVID-19 pandemic decrease diagnosed Diagnosis English Health Hospitalization increase in intraoperative material Observational cohort study Pandemia pandemic Pathologies Patient Perforación Perforation postoperative Postoperative Complications severity significant difference Spanish surgical pathology the disease [DOI] 10.1016/j.anpedi.2020.12.003 PMC 바로가기 [Article Type] Observational Study
The Weight of Obesity in Immunity from Influenza to COVID-19인플루엔자에서 COVID-19까지의 면역에서 비만의 무게Review Published on 2021-03-172022-09-12 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 진단, [키워드] acute respiratory syndrome addressed amplify cardiovascular disease cardiovascular risk clinical complication Comorbidity Complication complications condition coronavirus coronavirus disease COVID-19 COVID-19 hospitalization death develop diabetes Endocrine Factor favor greater Health hemodynamic instability highlight hypertension immune Immunity immunopathological immunopathology Increased individual Influenza influenza infection influenza pneumonia involved low-grade inflammation mechanism metabolic dysfunction Mortality obesity pathophysiology persistence Pneumonia poor prognosis respiratory manifestations response risk risk factor SARS-CoV-2 severe COVID-19 severe influenza susceptibility Symptom Virological weight [DOI] 10.3389/fcimb.2021.638852 PMC 바로가기 [Article Type] Review
The Potential Therapeutic Effect of RNA Interference and Natural Products on COVID-19: A Review of the Coronaviruses InfectionPharmacology Published on 2021-02-232022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome anticancer antioxidant antiviral activity cause China clinical complication Compound coronavirus Coronavirus infection coughing death determine drugs Effect expression Fever Genes Genetic immune system include Infection inhibiting Interference miRNA miRNAs Morphological natural natural products organ pandemic phytochemicals Pneumonia Potential product Replication reported respiratory infection review RNA RNA interference SARS-CoV-2 SARS-CoV-2 virus Shortness of breath shown siRNA siRNAs virus Wuhan [DOI] 10.3389/fphar.2021.616993 PMC 바로가기 [Article Type] Pharmacology