Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5SARS-CoV-2 오미크론 하위 변이체 BA.2.12.1, BA.4 및 BA.5에 의한 항체 회피Article Published on 2022-08-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Analysis antibodies antibody antigenic bebtelovimab breakthrough infections Clinical use COVID-19 vaccine COVID-19 vaccines dominant Efficacy evade facilitate individual lead Lineage Mutation Neutralizing antibodies omicron raise receptor Receptor-binding domain Region residue SARS-CoV-2 sera South Africa Spike protein Spike proteins the receptor-binding domain the United State therapeutic therapeutic antibodies United States vaccine breakthrough infections Viral yielding [DOI] 10.1038/s41586-022-05053-w PMC 바로가기 [Article Type] Article
Resolving adjuvant mode of action to enhance vaccine efficacyReview article Published on 2022-08-012022-10-05 Journal: Current opinion in immunology [Category] 비임상, [키워드] adjuvant antibody B cell Bacterial breadth Cell mediated immunity Clinical use Compound contributed DAMPs Diseases Effects Efficacy ENhance facilitate Factor highlight human vaccine immune responses less magnitude mechanism of action Mechanisms of action PAMPs promote protective immunity PRRs Research sustained T cell Vaccine viral pathogens while [DOI] 10.1016/j.coi.2022.102229 [Article Type] Review article
Characterization of SARS-CoV-2 Escape Mutants to a Pair of Neutralizing Antibodies Targeting the RBD and the NTDRBD 및 NTD를 표적으로 하는 한 쌍의 중화 항체에 대한 SARS-CoV-2 탈출 돌연변이의 특성화Article Published on 2022-07-252022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] active immunization Affect antibodies antibody binding Cell culture characterization Clinical use Cluster Combination Efficacy escape escape mutant escape mutants escape mutation gene segments Genetic human immunoglobulin identify immunization immunization strategies Immunoglobulin indicate lead mice monoclonal monoclonal antibodies monoclonal antibody more difficult Mutation mutations neutralization Neutralization assay Neutralizing Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibodies neutralizing monoclonal antibody nine not affected NTD pair passage pseudotype RBD RBD mutations reduced SARS-CoV-2 SARS-CoV-2 escape mutations SARS-CoV-2 variant SARS-CoV-2 variants selected Spike protein targeting the RBD the spike protein variable region variant variants variants of concern VoC [DOI] 10.3390/ijms23158177 PMC 바로가기 [Article Type] Article
Clinical Performance of Three Commercial SARS-CoV-2 Rapid Antigen Tests for Community-Dwelling Individuals in a Tropical Setting열대 환경에서 커뮤니티 거주 개인을 위한 3가지 상용 SARS-CoV-2 신속 항원 검사의 임상 성능Multicenter Study Published on 2022-07-052022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] analytical sensitivity Antigen antigen test biosensor carried Certest clinical clinical performance. Clinical use country COVID-19 pandemic cross-reactivity detect Ecuador genomic Genomic surveillance gold gold standard IMPROVE individual individuals infectious agent International Laboratory limit of detection market multicenter Mutation Nasopharyngeal swab nasopharyngeal swabs new SARS-CoV-2 performance point of care positive prevalent Rapid RapiGEN RapiGEN® Ag test kit reduction in regulatory agencies RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 surveillance SARS-CoV-2 transmission SARS-CoV-2 variants SARS–CoV–2 SD-Biosensor sensitivity setting shown South America South Korea Spain specificity Surveillance symptomatic individuals Test tested tropical variant [DOI] 10.3389/fcimb.2022.832235 PMC 바로가기 [Article Type] Multicenter Study
Current and novel biomarkers of thrombotic risk in COVID-19: a Consensus Statement from the International COVID-19 Thrombosis Biomarkers ColloquiumCOVID-19의 혈전 위험에 대한 현재 및 신규 바이오마커: 국제 COVID-19 혈전증 바이오마커 콜로키움의 합의 성명Review Published on 2022-07-012022-09-11 Journal: Nature reviews. Cardiology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, 치료기술, 치료법, [키워드] Activation aggregation Biomarker Biomarkers Clinical use Coagulation Coagulopathy Consensus coronavirus disease Coronavirus disease 2019 COVID-19 current D-dimer disease disease severity Elevation elevations Endothelial cell excessive inflammation fibrinogen fibrinolysis hypercoagulability in-hospital mortality Injury Intervention marker pandemic Patient patients Platelet platelet activation platelet aggregation platform Post-vaccine predict Prognosis prothrombotic recommendation Research risk risk stratification syndrome thrombocytopenia thromboembolic Thromboembolic events thrombosis thrombotic thrombotic and thromboembolic events thrombotic risk with COVID-19 [DOI] 10.1038/s41569-021-00665-7 PMC 바로가기 [Article Type] Review
mRNA vaccines: Past, present, futureReview article Published on 2022-07-012022-10-05 Journal: Asian Journal of Pharmaceutical Sciences [Category] 비임상, [키워드] addition adjuvant Cancer candidate carrier Clinical use conventional vaccines COVID-19 Diseases ENhance in vitro Lipid nanoparticles mRNA mRNA stability mRNA vaccine Nanoparticles outcomes Pandemics platform provide provided RNA safety profile shown tissue transcribed Treatment vaccine platform viral disease virus widespread [DOI] 10.1016/j.ajps.2022.05.003 [Article Type] Review article
Role of Fc Core Fucosylation in the Effector Function of IgG1 AntibodiesIgG1 항체의 이펙터 기능에서 Fc 코어 푸코실화의 역할Review Published on 2022-06-302022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] ADCC ADCP antibody Antigen approved B-cell Cancer Cell cellular cytotoxicity Clinical use core decrease Dengue disease severity Effect effector Efficacy ENhance fetal fucosylation function highlighting human IgG1 Fc humoral Humoral response IgG IgG Fc IgG1 IgG1 antibody immune in vitro in vivo Infection Inflammatory diseases knowledge less mAb mAbs Macrophage mechanism Modification monoclonal antibody N-glycan natural immune response natural killer NK cells parasites phagocytosis Platelet polyclonal polymorphonuclear neutrophil pregnant women Regulation reported role SARS-CoV 2 Seven shown significantly therapeutic therapeutic antibodies treat virus virus infection [DOI] 10.3389/fimmu.2022.929895 PMC 바로가기 [Article Type] Review
Receptor-Binding-Motif-Targeted Sanger Sequencing: a Quick and Cost-Effective Strategy for Molecular Surveillance of SARS-CoV-2 Variants수용체 결합 모티브 표적 생어 시퀀싱: SARS-CoV-2 변이체의 분자 감시를 위한 빠르고 비용 효율적인 전략Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adopted aligned Alpha Alpha variant B.1.1.529 B.1.1.7 B.1.617.2 causative agent changes in CLC Clinical use coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Critical death Delta delta variant develop disease spread Genome gold gold standard Infection involved Lineage lineages modifications molecular mutate Mutation mutations nasal nasal swab nasal swabs nucleocapsid omicron Omicron variant Omicron variants pandemic prevalent Prevent public health receptor-binding motif Receptor-binding motif (RBM) resource Saliva Sanger sequencing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence sequences Sequencing severe acute respiratory syndrome Coronavirus Spike protein Spread Strategy Surveillance swab samples the disease variant variant surveillance. variants WGS whole-genome sequencing [DOI] 10.1128/spectrum.00665-22 PMC 바로가기 [Article Type] Article
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance약물 내성을 예측하고 피하기 위한 SARS-CoV-2 주요 프로테아제의 기질 외피 정의Article Published on 2022-06-212022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] antiviral therapies antiviral therapy antivirals binding cleavage Clinical use COVID-19 pandemic Critical drug resistance effective Efficacy elements enzyme Enzymes High-resolution identify inhibitor inhibitors M pro maturation morbidity and mortality Mutation nine peptide peptides polymerases predict promote protease Protease inhibitor protease inhibitors Proteases resistance mutations robust SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 variant SARS-CoV-2 variants severe disease Spread Structure susceptible to define treatment strategy Vaccine viral pathogen [DOI] 10.1038/s41467-022-31210-w PMC 바로가기 [Article Type] Article
Going Retro, Going Viral: Experiences and Lessons in Drug Discovery from COVID-19레트로화, 바이럴화: COVID-19 약물 발견의 경험과 교훈Article Published on 2022-06-142022-09-11 Journal: Molecules [Category] Coronavirus, COVID19(2023년), SARS, 신약개발, 치료제, [키워드] active site Antibiotics binding binding site Cell culture Clinical use computational studies Computational study COVID-19 COVID-19 pandemic develop docking drug Drug discovery drug target effective effort enzyme experience fidaxomicin flexible implication improvement in silico in vitro inhibit inhibitors lesson Ligand ligands Mutagenesis NiRAN nucleotide nucleotide analogs pace pathogen Pathogens predicted protein complex protein complexes RdRP researcher rifabutin rifamycins. RNA synthesis RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp severity silico studies speed Spread throughput viral replication Virtual screening [DOI] 10.3390/molecules27123815 PMC 바로가기 [Article Type] Article