Autoimmune hemolytic anemia: causes and consequencesArticle Published on 2022-07-012023-07-09 Journal: Expert review of clinical immunology [Category] COVID19(2023년), [키워드] Cold agglutinin disease complement system Direct antiglobulin test Infection monocyte/macrophage system rituximab thrombosis warm autoimmune hemolytic anemia [DOI] 10.1080/1744666X.2022.2089115
Editorial: Complement and COVID-19 DiseaseEditorial Published on 2022-07-012023-07-10 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] complement system COVID-19 kinin-kallikrein system SARS – CoV – 2 Thromboinflammation [DOI] 10.3389/fimmu.2022.960809 PMC 바로가기 [Article Type] Editorial
Is the Endothelium the Missing Link in the Pathophysiology and Treatment of COVID-19 Complications?Review Published on 2022-06-012023-07-06 Journal: Cardiovascular Drugs and Therapy [Category] COVID19(2023년), [키워드] Coagulopathy complement system COVID-19 covid-19 therapies Endothelial protection Endotheliopathy. [DOI] 10.1007/s10557-021-07207-w PMC 바로가기 [Article Type] Review
Complement component 3 mutations alter the longitudinal risk of pediatric malaria and severe malarial anemiaarticle Published on 2022-04-302024-09-01 Journal: Experimental Biology and Medicine [Category] 말라리아, [키워드] C3 missense mutations complement system incident risk ratio malaria P. falciparum Severe malaria anemia [Article Type] article
SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet AggregationSARS-CoV-2 스파이크 단백질 1은 미세혈관 내피 세포 및 보체 시스템을 활성화하여 혈소판 응집을 유도합니다Article Published on 2022-03-072022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] ACE2 Activation addition adhesive molecule aggregate aggregation AMPK amplified Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antibody blockade blocking antibody Blot C3a C5a circulating complement Complement activation complement inhibitors complement system complexity conditions coronavirus disease Coronavirus disease 2019 COVID-19 detection element ELISA endothelial Endothelial cell endothelial cells endothelial damage Endothelial dysfunction enzyme evaluated Exocytosis experiment expression human host immunofluorescence incubated induce infect Inflammation Inflammatory inhibitors investigated leading leukocyte lung Microvascular thrombosis microvasculature Mortality multiorgan failure P-selectin performed phenotype Platelet platelet aggregation pro-inflammatory recruitment replicate robust S1 protein SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 spike protein 1 selectin sera severe COVID-19 patient severe COVID-19 patients significant level spike Spike protein System thromboembolic thromboembolic complication thromboembolic complications thrombomodulin thrombosis thrombotic thrombotic complication Thrombotic complications viral infection von Willebrand factor were assessed western blot Western blot analysis [DOI] 10.3389/fimmu.2022.827146 PMC 바로가기 [Article Type] Article
Severe COVID-19 is associated with hyperactivation of the alternative complement pathwayArticle Published on 2022-02-012023-07-07 Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), [키워드] Alternative pathway complement system COVID-19 Hemostasis immunology SARS-CoV-2 [DOI] 10.1016/j.jaci.2021.11.004 PMC 바로가기
Compstatins: the dawn of clinical C3-targeted complement inhibitionReview article Published on 2022-01-252022-10-05 Journal: Trends in pharmacological sciences [Category] 비임상, [키워드] Activation antibody approval C3 inhibitor clinical conditions complement complement system compstatin Critical Diseases disorders Evolution highlight inhibitor Intervention multifactorial paroxysmal nocturnal hemoglobinuria (PNH) pegcetacoplan raised remained therapeutic therapy Treatment variety [DOI] 10.1016/j.tips.2022.01.004 [Article Type] Review article
C5a and C5aR1 are key drivers of microvascular platelet aggregation in clinical entities spanning from aHUS to COVID-19C5a 및 C5aR1은 aHUS에서 COVID-19에 이르는 임상 기관에서 미세혈관 혈소판 응집의 주요 동인입니다Article Published on 2022-01-082022-09-11 Journal: Blood advances [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome added aggregation Alternative pathway antithrombogenic Atypical Bacterial infection Bacterial infections binding blockade C5a C5aR1 C5b-9 caused CCX168 Cell chronic inflammatory diseases clinical entity clinical implications Comorbidities Comorbidity complement complement system coronavirus COVID-19 Critical demonstrated develop driver dysfunction dysregulation Effect endothelial endothelial cells Endothelial dysfunction Endothelium Ex vivo Exocytosis Genetic hemolytic uremic syndrome highlight human serum Hyperactivation Infection Inflammatory diseases Microvascular thrombosis normal human serum P-selectin pathogenic mechanisms Patient patients treated Platelet platelet adhesion prothrombotic RalA rare disease Registered selectin serum severe acute respiratory syndrome Coronavirus severe COVID-19 severely ill patients suffered thrombosis Thrombus thrombus formation translate Trial triggered uremic syndrome viral infections von Willebrand factor [DOI] 10.1182/bloodadvances.2021005246 PMC 바로가기 [Article Type] Article
Complement system component dysregulation is a distinctive feature of COVID-19 disease: a prospective and comparative analysis of patients admitted to the emergency department for suspected COVID-19 diseaseClinical Trial Published on 2021-12-142022-10-04 Journal: Journal of Thrombosis and Thrombolysis [Category] COVID19(2023년), MERS, SARS, 임상, [키워드] activated Activation acute respiratory syndrome Analysis Antigen automated both groups C5a calprotectin classical pathway clinical Coagulopathy Cohort complement complement components complement system component control group coronavirus Coronavirus disease 2019 correlation COVID-19 COVID-19 disease COVID-19 infection COVID-19 patient COVID-19 patients Data analysis diagnosis of COVID-19 dysregulation emergency department Laboratory lateral flow Level no difference pathophysiology Patient plasma positive Prospective trial Quantitative SARS-CoV-2 serum significantly higher supplementary material tested Vascular damage von Willebrand factor was determined were assessed were measured with COVID-19 [DOI] 10.1007/s11239-021-02617-x PMC 바로가기 [Article Type] Clinical Trial
Next-Generation Sequencing and Proteomics of Cerebrospinal Fluid From COVID-19 Patients With Neurological Manifestations신경학적 징후가 있는 COVID-19 환자의 뇌척수액의 차세대 시퀀싱 및 단백질체학Immunology Published on 2021-12-092022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] Ageusia alterations Analysis Anosmia Case series case sery cellular cerebrospinal fluid changes in CNS complement complement system conducted Control COVID-19 COVID-19 confirmed patients COVID-19 patient CSF detection rate Diagnosis differentially expressed difficulty feature headache Infection Interaction Macrophage macrophages manifestation neurological Neurological involvement neurological manifestation neurological manifestations Next-generation sequencing NGS non-COVID-19 patient outbreak patch Pathogenesis pathological mechanism pathway Patient patients PI3K PI3K-Akt signaling Protein proteomic Proteomic analysis proteomics reported SARS-CoV-2 SARS-CoV-2 RNA screened selected Sequencing serum sample serum samples variant [DOI] 10.3389/fimmu.2021.782731 PMC 바로가기 [Article Type] Immunology