A critical overview of computational approaches employed for COVID-19 drug discoveryCOVID-19 약물 발견에 사용되는 컴퓨터 접근 방식에 대한 중요한 개요Review Published on 2021-08-212022-09-11 Journal: Chemical Society reviews [Category] MERS, SARS, 신약개발, 임상, 치료제, [키워드] accelerate appear Candidates clinic clinical trials computational approach computational method computational tool COVID-19 COVID-19 pandemic COVID-19 patients Critical death develop diagnostics drug drug candidate drug combinations Drug discovery effort hypothese Infection massive novel open pandemic peer-reviewed produced reported Repurposed drug Research the disease Vaccines [DOI] 10.1039/d0cs01065k PMC 바로가기 [Article Type] Review
Virtual screening of plant-derived compounds against SARS-CoV-2 viral proteins using computational tools컴퓨터 도구를 사용한 SARS-CoV-2 바이러스 단백질에 대한 식물 유래 화합물의 가상 스크리닝Article Published on 2021-08-102022-09-11 Journal: The Science of the total environment [Category] SARS, 치료제, [키워드] 3-chymotrypsin-like protease addition amyrin antiviral activity Atazanavir AutoDock binding Chloroquine chymotrypsin Chymotrypsin-like protease Compound computational tool Control COVID-19 COVID-19 pandemic delphinidin dicumarol docking Docking studies drug evaluate evaluated explain glycoprotein Glycyrrhetinic acid glycyrrhizin highest affinity host cell host cells hydrogen Hydrogen bond hydrophobic hydrophobic interaction hydrophobic interactions Hydroxychloroquine identify in viral inhibitor Interaction involved lowest M pro molecular molecular docking molecular target nelfinavir new SARS-CoV-2 plants protease Protein Proteins public health Recognition Replication responsible S protein SARS-CoV-2 SARS-CoV-2 viral SARS-CoV2 spike spike glycoprotein taraxasterol target umifenovir Viral protein Viral proteins viral replication viral spike virus was performed were used [DOI] 10.1016/j.scitotenv.2021.146400 PMC 바로가기 [Article Type] Article
Expert-Augmented Computational Drug Repurposing Identified Baricitinib as a Treatment for COVID-19Pharmacology Published on 2021-07-282022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome administration Anti-inflammatory therapy Antiviral applied approval approved drug Baricitinib computational tool coronavirus COVID-19 disease drug Drug repurposing Effectiveness FDA hidden human computer interaction Identified identify information iterative knowledge knowledge discovery and data mining Knowledge graph Mortality pandemic phase randomised reductions in repurposing Research rheumatoid arthritis SARS-CoV-2 Standard of care the disease treat Treatment Trial Vaccines widespread [DOI] 10.3389/fphar.2021.709856 PMC 바로가기 [Article Type] Pharmacology
Next-Generation Bioinformatics Approaches and Resources for Coronavirus Vaccine Discovery and Development—A Perspective ReviewReview Published on 2021-07-222022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 3D structure acute respiratory syndrome antigenic epitope bioinformatics bioinformatics resources caused computational tool contagious coronavirus coronavirus strain coronavirus vaccine COVID-19 database death disease effective effort epitope experimental validation function Genome sequencing genomic globe immune response immunoinformatics in viral pandemic pathogen platform Protein researcher resource resources review SARS-CoV-2 Stage target the vaccine Vaccine vaccine construct valuable resource [DOI] 10.3390/vaccines9080812 PMC 바로가기 [Article Type] Review
A Validated Mathematical Model of the Cytokine Release Syndrome in Severe COVID-19Molecular Biosciences Published on 2021-07-202022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] citokine storm complex component computational immunology computational tool contagious Coronavirus disease 2019 COVID-19 cytokine deaths disease explain help Human immune system Hypothesis Immune cell immune response induce infect Inflammatory cytokines Interaction Mathematical modelling Model Non-survivors pathogen question Release researcher SARS-CoV-2 sensitivity analysis Simulation Support survivor the disease the SARS-CoV-2 [DOI] 10.3389/fmolb.2021.639423 PMC 바로가기 [Article Type] Molecular Biosciences
Viral transmission and evolution dynamics of SARS-CoV-2 in shipboard quarantine선박 보드 검역에서 SARS-COV-2의 바이러스 전염 및 진화 역학Research Published on 2021-07-012022-09-10 Journal: Bulletin of the World Health Organization [Category] 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 America analysed Analysis collected computational tool computational tools contributed coronavirus Cruise ship database de novo diamond Evolution finding FIVE Genetic genetic linkage Increased individual Influenza initiative isolates Japan linkage Mutation natural selection objective outbreak phylogenetics Positive selection Princess progeny quarantine Recombination respiratory Ribonucleic acid RNA RNA recombination SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences sequenced severe acute respiratory syndrome Coronavirus single person Spread statistically significant subgroups tested the United State Transmission United States variant Viral viral mutation virus [DOI] 10.2471/BLT.20.255752 PMC 바로가기 [Article Type] Research
Viral transmission and evolution dynamics of SARS-CoV-2 in shipboard quarantineResearch Published on 2021-07-012022-10-27 Journal: Bulletin of the World Health Organization [Category] COVID-19, [키워드] acute respiratory syndrome America analysed Analysis collected computational tool contributed coronavirus database de novo diamond Evolution finding FIVE Genetic Increased individual initiative isolates Japan linkage Mutation natural selection objective outbreak phylogenetics Positive selection Princess progeny quarantine Recombination RNA RNA recombination SARS-CoV-2 SARS-CoV-2 genome sequence sequenced Spread statistically significant subgroups tested the United State Transmission variant viral mutation virus [DOI] 10.2471/BLT.20.255752 PMC 바로가기 [Article Type] Research
Viral transmission and evolution dynamics of SARS-CoV-2 in shipboard quarantineResearch Published on 2021-07-012022-10-27 Journal: Bulletin of the World Health Organization [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] acute respiratory syndrome America analysed Analysis collected computational tool contributed coronavirus database de novo diamond Evolution finding FIVE Genetic Increased individual initiative isolates Japan linkage Mutation natural selection objective outbreak phylogenetics Positive selection Princess progeny quarantine Recombination RNA RNA recombination SARS-CoV-2 SARS-CoV-2 genome sequence sequenced Spread statistically significant subgroups tested the United State Transmission variant viral mutation virus [DOI] 10.2471/BLT.20.255752 PMC 바로가기 [Article Type] Research
In silico analysis suggests the RNAi-enhancing antibiotic enoxacin as a potential inhibitor of SARS-CoV-2 infectionIn silico 분석은 RNAi 강화 항생제 enoxacin이 SARS-CoV-2 감염의 잠재적 억제제임을 시사합니다.Article Published on 2021-05-132022-09-10 Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Analysis anti-SARS-CoV-2 antibiotic antiviral activity component components computational tool COVID-19 COVID-19 treatment Critical Cytokines Data integration Data processing database databases Dicer drug candidate Effects enoxacin Exacerbation Gene ontology Gene regulatory networks highlight host cell identify Infection inhibitor lung mechanism microRNA Molecular biology pathway pro-inflammatory cytokines Protein recent Regulatory Replication reported RNA genome RNAi pathway SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection stem cells the disease the SARS-CoV-2 the SARS-CoV-2 genome transcription factor transcription factors Treatment Viral viral entry viral infection viral replication [DOI] 10.1038/s41598-021-89605-6 PMC 바로가기 [Article Type] Article
Smartpath k : a platform for teaching glomerulopathies using machine learningSmartpath k : 기계 학습을 사용하여 사구체 병증을 가르치는 플랫폼Software Published on 2021-04-292022-09-01 Journal: BMC Medical Education [Category] MERS, SARS, 진단, [키워드] Accuracy acquisition adopted Algorithm alternatives artificial intelligence assist automatically complementary computational tool computational tools contribute coronavirus COVID-19 Decision tree decision trees digital pathology flexible histological histopathological IMPROVE information Intelligent system kidney knowledge lack machine learning machine learning algorithm Machine learning algorithms Microscopy New coronavirus offer pandemic Pathologies pathology platform professional recognizing Region renal Renal pathology Result supplementary material Support synergy Teaching universalization was performed [DOI] 10.1186/s12909-021-02680-1 PMC 바로가기 [Article Type] Software