Adverse events associated with potential drugs for COVID-19: a case study from real-world dataCOVID-19에 대한 잠재적인 약물과 관련된 부작용: 실제 데이터의 사례 연구Article Published on 2021-03-222022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 치료제, [키워드] Adverse adverse event adverse events AEs age benefit clinical trial connective tissue coronavirus disease Coronavirus disease 2019 COVID-19 drug drugs Effectiveness event global pandemic group Health Organization Healthcare provider healthcare providers immune system investigated knowledge Musculoskeletal organs/systems promise provide real-world data safety profile Sex solidarity Subcutaneous tissue tissue Toxicity Treatment Trial while World Health Organization [DOI] 10.1093/bib/bbaa234 PMC 바로가기 [Article Type] Article
The impact of COVID-19 on rare and complex connective tissue diseases: the experience of ERN ReCONNET희귀 복합 결합 조직 질환에 대한 COVID-19의 영향: ERN ReCONNET의 경험Review Published on 2021-03-012022-09-12 Journal: Nature reviews. Rheumatology [Category] Fulltext, SARS, 유전자 메커니즘, 진단, 치료법, [키워드] affected Care complex conditions connective tissue connective tissue disease COVID-19 COVID-19 pandemic demonstrated diagnostics European Health health emergency health-care management network outbreak Patient patients with COVID-19 protocols reference routine care the SARS-CoV-2 [DOI] 10.1038/s41584-020-00565-z PMC 바로가기 [Article Type] Review
COVID‐19 infection in patients with connective tissue disease: A multicity study in Hubei province, ChinaOriginal Article Published on 2021-02-042022-10-30 Journal: MedComm [Category] COVID-19, [키워드] Alliance China collected Computed tomography condition conditions connective tissue connective tissue disease Coronavirus disease 2019 COVID‐19 COVID‐19 infection COVID‐19 patient COVID‐19 CTD demographic Diagnosis disease disease severity glucocorticoid Glucocorticoids Gout greater hemoglobin Hospital stay Hospitalized Hydroxychloroquine immune dysregulation immunosuppressive individual infections information Laboratory tests lymphocyte counts novel outcome Patient patients Platelet progression reduced reported rheumatic disease risk SARS‐CoV‐2 spondylitis Spread Symptom therapy Treatment [DOI] 10.1002/mco2.56 PMC 바로가기 [Article Type] Original Article
Is SARS-CoV-2 present in the periodontium? A post-mortem studySARS-CoV-2가 치주에 존재합니까? 사후 연구Comment Published on 2021-01-012022-09-11 Journal: Evidence-based dentistry [Category] 치료기술, [키워드] age Analysis applicability Autopsy blunt blunt dissection Chain Reaction Comorbidities Comorbidity connective tissue COVID-19 infection COVID-19 test criteria cross cross-sectional cross-sectional study cycle threshold Cycle threshold value Data analysis death Deceased Descriptive analysis Effect eosin exclusion criteria facial first molar FIVE General population genetic material Haematoxylin histopathological hospitalisation individual individuals individuals with COVID-19 insertion intensive care intensive care unit Invasive mechanical ventilation Medicine men molecular analysis nasopharyngeal Nasopharyngeal swab nasopharyngeal swab test nuclear nuclear pleomorphism onset of symptom periodontal tissue polymerase chain polymerase chain reaction positive Post-mortem Real-time reverse transcriptase polymerase chain reaction responsible reverse transcriptase rRT-PCR salivary Sample size SARS-CoV-2 School Seven smoking smoking status test result tooth transcriptase university virus was collected was obtained was performed was used women [DOI] 10.1038/s41432-021-0184-0 PMC 바로가기 [Article Type] Comment
COVID-19 or clinical amyopathic dermatomyositis associated rapidly progressive interstitial lung disease? A case reportCase Report Published on 2020-11-192022-10-28 Journal: BMC Pulmonary Medicine [Category] Coronavirus, Fulltext, [키워드] accompanied Anti-Ro52 antibody antibody Case report caused characteristic Chest chest CT scan Clinical amyopathic dermatomyositis connective tissue Coronavirus disease 2019 cough COVID-19 COVID-19 epidemic Critical CTD dermatomyositis diagnosed Diagnosis diagnostic died disease epidemiological history Fever Gottron’s papules Gottron’s sign HRCT ILD inefficient interstitial Interstitial lung disease lung lung damage nucleic acid test observation pandemic Pathogenesis Patient poor prognosis positive progression proportion Rapidly progressive interstitial lung disease rashe Symptom the epidemic [DOI] 10.1186/s12890-020-01335-z PMC 바로가기 [Article Type] Case Report
Clinical, Serological, and Histopathological Similarities Between Severe COVID-19 and Acute Exacerbation of Connective Tissue Disease-Associated Interstitial Lung Disease (CTD-ILD)Immunology Published on 2020-10-022022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Activation acute exacerbation acute respiratory distress Analysis ARDS autoantibodies autoantibody Autoimmune Autoimmunity clinical Clinical course collagen Computed tomography connective tissue connective tissue disease coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients detection determine died disease ENA enrolled exacerbating Exacerbation feature fibroblast FIVE heterogeneous High-resolution histopathological finding Histopathology immunoblot immunofluorescence intensive care treatment Interstitial lung disease interstitial thickening investigated Laboratory testing mechanism objective Occurrence overlapping pathophysiology Patient Pneumonia positive predict Respiratory failure Result SARS-CoV-2 SARS-COV-2 infection serological severe complication severe COVID-19 significantly similarity syndrome the disease Therapeutic strategies tissue sample understanding was performed [DOI] 10.3389/fimmu.2020.587517 PMC 바로가기 [Article Type] Immunology
A three-arm, multicenter, open-label randomized controlled trial of hydroxychloroquine and low-dose prednisone to treat recurrent pregnancy loss in women with undifferentiated connective tissue diseases: protocol for the Immunosuppressant regimens for LIving FEtuses (ILIFE) trial미분화 결합 조직 질환이 있는 여성의 반복적인 임신 상실을 치료하기 위한 하이드록시클로로퀸 및 저용량 프레드니손의 3군, 다기관, 공개 라벨 무작위 대조 시험: LIFE(LIFE) 시험을 위한 면역억제 요법에 대한 프로토콜Study Protocol Published on 2020-09-092022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] abortion Activation addition Anticoagulant anticoagulation Arm assigned connective tissue connective tissue disease Controlled trial defined disease Efficacy eligible patient evaluate Evidence HCQ Hydroxychloroquine immune Immunosuppressant include induce Inflammation live births low-dose morbidities multicenter Open-label open-label randomized controlled trial outcome Patient patients placental Prednisone Pregnancy Prevent Primary outcome Prognosis progression protocol Randomized controlled trial Randomly Recurrent pregnancy loss Recurrent spontaneous abortion regimen secondary Secondary outcomes spontaneous abortion treat Trial Trial registration Undifferentiated Undifferentiated connective tissue disease Vascular damage women [DOI] 10.1186/s13063-020-04716-1 PMC 바로가기 [Article Type] Study Protocol
Pulmonary Fibrosis in COVID-19 Survivors: Predictive Factors and Risk Reduction StrategiesReview Article Published on 2020-08-102022-10-29 Journal: Pulmonary Medicine [Category] COVID-19, MERS, SARS, [키워드] absence acute respiratory distress advanced age Autopsy clinically complicate connective tissue COVID-19 COVID-19 infection Diseases disorders effective evaluate Evidence Factor fibrosis ICU Illness severity indicated Infection inflammatory phase initial lung lung dysfunction Lung fibrosis Lung injury measure mechanical ventilation medications MERS occur Pathogenesis pathology predictor pulmonary pulmonary fibrosis Radiographic respiratory infections risk risk factor risk reduction SARS-CoV-2 severe lung injury severity smoking Strategy Support syndrome targeted therapy the disease [DOI] 10.1155/2020/6175964 PMC 바로가기 [Article Type] Review Article
SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosisResearch Published on 2020-07-142022-10-28 Journal: Respiratory Research [Category] COVID-19, SARS, [키워드] ACE2 activate acute lung injury acute respiratory syndrome ADAM17 Affect AGT angiotensin-converting enzyme 2 assist bind binding bioinformatic analysis cellular receptor change cleaved connective tissue coronavirus COVID-19 CTGF dataset disease domain driver endothelial enzyme epithelial cell FN1 growth factor host cells human epithelial cell human lung induce Lung epithelial cells Lung fibrosis lung tissue mechanism metalloproteinase mRNA pandemic disease patients promote Protein protein expression Result SARS-CoV-2 SARS-COV-2 infection specific treatment TGFB1 Tissue Inhibitor TMPRSS2 transcriptional transmembrane serine protease Vascular VEGF viral entry were expressed were measured [DOI] 10.1186/s12931-020-01445-6 PMC 바로가기 [Article Type] Research
Efficacy and safety of Anluohuaxian in the treatment of patients with severe Coronavirus disease 2019- a multicenter, open label, randomized controlled study: a structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-06-082022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 6-minute walking distance actual Alpha analyst Anluohuaxian antiviral drugs brand bronchial asthma Care change changes Chinese Chinese herbal medicines chronic obstructive Colchicine Combined completion Compliance composed computer tomography Confirmed connective tissue control group Coronavirus disease 2019 COVID-19 criteria Cyclophosphamide cytokine diagnosed dissemination distribution drug Efficacy and safety element Endocrine enrolled Estimated evaluate expected experimental group explained facilitate fibrosis glucocorticoid groups hepatic fibrosis High-resolution history Hormones HRCT Huoshenshan Hospital Imatinib include indicate interferon-γ interstitial Interstitial lung disease investigators involved IWRS Kidney disease lactating liver lobular lung maximum Mental Disorders minimum multicenter Nasopharyngeal swab Necrosis negative neurologic Nintedanib nodule not blinded nucleic acid test number objective open label outcome outcome assessors participant Participants Pathogenesis pathway Patient pharmaceutical pill professional proportion protocol provided pulmonary pulmonary disease pulmonary fibrosis random randomised randomised controlled trial randomization randomization system Randomized Randomized controlled trial randomly divided RCT recruitment Research research drug respiratory specimen Sample size Science second selected severe COVID-19 sputum statistical status Study protocol subject technology therapeutic drug Tongji Hospital treated Treatment treatment group Trial Union Hospital university variety website West Wuhan Year [DOI] 10.1186/s13063-020-04399-8 PMC 바로가기 [Article Type] Letter