Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9SARS-CoV-2 비구조 단백질 9에 대한 피리미딘 RNA 염기 모방체의 결합Article Published on 2021-09-012022-09-11 Journal: The Journal of Biological Chemistry [Category] Coronavirus, SARS, 치료법, [키워드] association complex component Compound contribute Coronaviral domain engage form fragment screen homodimer induce Interaction mechanism motif Nsp9 oligomerization oligonucleotide binding probe Protein recruit replicase replicase. RNA SARS-CoV-2 SARS-CoV-2 replication seeking small molecule Stage starting point Transcription viral replication Viral RNA [DOI] 10.1016/j.jbc.2021.101018 PMC 바로가기 [Article Type] Article
The Molecular Interplay between Human Coronaviruses and AutophagyReview Published on 2021-08-072022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome aggregates autolysosome autophagosome autophagy caused Complete conserved Coronaviral coronavirus Coronavirus disease 2019 COVID-19 degrade Diseases example HCoV-NL63 HCoV-OC43 Host Human human coronavirus Interaction life-threatening lysosome membrane MERS-CoV Mild molecular molecular mechanisms MOST multiple coronaviruses neutralize other coronavirus Pathogens pathway Protein SARS-CoV SARS-CoV-2 Symptoms therapy Vesicle virus viruses worldwide pandemic [DOI] 10.3390/cells10082022 PMC 바로가기 [Article Type] Review
CoViTris2020 and ChloViD2020: a striking new hope in COVID-19 therapyCovitris2020 및 Chlovid2020 : Covid-19 치료에서 놀라운 새로운 희망Article Published on 2021-08-012022-08-31 Journal: Molecular diversity [Category] 신약개발, 치료제, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-COVID-19 drug anti-SARS-CoV-2 antioxidant binding affinities binding affinity binding energy biological assay blocker ChloViD2020 Clinical studies Compound Coronaviral Coronaviral-2 coronavirus COVID-19 COVID-19 therapy CoViTris2020 derivative disease docked docking drug Drug discovery effective enzyme exhibited Favipiravir in vitro inhibit inhibit SARS-CoV-2 inhibitory Ivermectin lead life cycle Ligand lower binding energy medication molecular docking oxadiazole Papain Papain-like protease Papain-like protease (PLpro) PLPro Polyphenolic 2,5-disubstituted-1,3,4-oxadiazole protease Protein RdRP Remdesivir repurposing required Research respiratory RNA polymerase RNA-dependent RNA polymerase RNA-dependent RNA polymerase (RdRp) robust SARS-CoV-2 SARS-CoV-2 life cycle SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus significantly the SARS-CoV-2 therapy [DOI] 10.1007/s11030-020-10169-0 PMC 바로가기 [Article Type] Article
A functional assay for serum detection of antibodies against SARS‐CoV‐2 nucleoproteinSARS-CoV-2 핵단백질에 대한 항체의 혈청 검출을 위한 기능적 분석Resource Published on 2021-07-292022-09-10 Journal: The EMBO Journal [Category] SARS, 진단, 치료기술, [키워드] antibodies antibody Antigen presentation antiviral activities antiviral activity convalescent Coronaviral cytosolic functional highlight humoral immune response individuals induce measure Microbiology, Virology & Host Pathogen Interaction N protein neutralization Neutralization assay neutralize Neutralizing neutralizing activities Neutralizing activity nucleoprotein Patient potential benefit potential benefits PROTECT Protein provide Quantitative receptor SARS‐CoV‐2 SARS‐CoV‐2 serum T‐cell tested the antibody titre TRIM21 Vaccine [DOI] 10.15252/embj.2021108588 PMC 바로가기 [Article Type] Resource
SARS-CoV-2 Spike Protein Extrapolation for COVID Diagnosis and Vaccine DevelopmentMolecular Biosciences Published on 2021-07-282022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] acute respiratory syndrome affecting alleviate antibody antigenic target antiviral therapeutics approach can be used cell lines clinical development conserved Coronaviral coronavirus coronavirus disease Coronavirus pandemic Coronavirus-2 COVID COVID-19 COVID-19 pandemic cross-react demonstrated detect development Diagnosis diagnosis of COVID-19 diagnostic diagnostics domain effective ELISA extrapolation facilitate host cell receptor Human IgM and IgG in vitro study Infection inhibiting interact Lateral flow immunoassays mAb mAbs molecular monoclonal antibody Mortality N-terminal domain neutralize Neutralizing neutralizing antibody pandemic platform polyclonal antibody Prevent Prophylaxis RBD Receptor binding domain Region researcher S-protein S1 and S2 S1 domain S2 domain SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection selection pressure sequence similarity Serological assay spike spike gene spike glycoprotein the RBD Treatment trimer Vaccine Vaccines Viral protein virus virus-cell membrane fusion [DOI] 10.3389/fmolb.2021.607886 PMC 바로가기 [Article Type] Molecular Biosciences
Three epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutantsArticle Published on 2021-07-202022-10-04 Journal: Cell Discovery [Category] 변종, [키워드] acute respiratory syndrome antibody antibody cocktail caused Coronaviral coronavirus Coronavirus disease 2019 COVID-19 Cryo-electron microscopy Cryoelectron microscopy death effective eliminated epitope epitope mapping evade experiment group involved Measures mice mutant Mutation neutralize Neutralizing Neutralizing antibodies neutralizing antibody pandemic disease Pattern recognition receptors performed provide RBD residue SARS-CoV-2 strain the receptor-binding domain therapeutic Threats variant [DOI] 10.1038/s41421-021-00292-z PMC 바로가기 [Article Type] Article
Natural Transmission of Bat-like Severe Acute Respiratory Syndrome Coronavirus 2 Without Proline-Arginine-Arginine-Alanine Variants in Coronavirus Disease 2019 Patients코로나바이러스 질병 2019 환자에서 프롤린-아르기닌-아르기닌-알라닌 변이체가 없는 박쥐 유사 중증 급성 호흡기 증후군 코로나바이러스 2의 자연 전염Article Published on 2021-07-152022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Alanine arginine Chain Reaction cleavage Cluster Coronaviral coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Coronaviruses COVID-19 COVID-19 patients ENhance Evolution of SARS-CoV-2 Frequency furin furin cleavage PRRA motif hamster hamsters Human humans implication isolates motif Mutation natural natural infection organoids patients polymerase chain polymerase chain reaction Prevalence prevalence rate proline PRRA Quasispecies quasispecy respiratory S1/S2 SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Transmission transmitted upstream variant variants Vero VERO-E6 viral pathogenicity Viral variants virus wild-type zoonotic origin [DOI] 10.1093/cid/ciaa953 PMC 바로가기 [Article Type] Article
Multi-omic profiling of plasma reveals molecular alterations in children with COVID-19혈장의 다중 생물 프로파일 링Research Paper Published on 2021-07-062022-09-10 Journal: Theranostics [Category] MERS, SARS, 유전자 메커니즘, [키워드] Adults alteration Analysis Anti-inflammatory antioxidant AUC blood sample Blood samples children children with COVID-19 Cohort Combination conducted Coronaviral coronavirus disease Coronavirus disease 2019 Coronavirus infection COVID-19 demonstrated develop enrolled exhibiting experiment expression finding healthy children Hospital admission Hospital admissions identify immune Inference inhibited less machine learning mannitol mechanism metabolite metabolites metabolomic profiling methylmalonic acid Mild symptom mild symptoms molecular molecules outpatients Pathogenesis pathogenesis of COVID-19 performed plasma potential therapeutic agent potential therapeutic agents pro-inflammatory factors Protective protective effect Protective effects protective role Protein proteomic provided Replication reveal severe symptom statistical analyses suppressed therapeutic agents up-regulated [DOI] 10.7150/thno.61832 PMC 바로가기 [Article Type] Research Paper
The SARS-CoV-2 RNA interactomeSARS-CoV-2 RNA 상호작용체Article Published on 2021-07-012022-09-11 Journal: Molecular Cell [Category] SARS, 유전자 메커니즘, [키워드] Analysis Antiviral Applying conserved Coronaviral coronavirus COVID-19 CSDE1 develop downstream EIF3D evade experiment Factor HCoV HCoV-OC43 Host host proteins identify interact Interaction knockdown LARP1 life cycle mass spectrometry mRNA mTOR mTOR signaling OC43 PARP12 pathogen pathway Protein protocol provide Replication responsible ribonucleoprotein RNA RNA interactome capture RNA virus RNA-binding proteins RNAs robust SARS-CoV-2 SARS-CoV-2 RNA SHFL the SARS-CoV-2 therapeutic interventions Transcriptome TRIM25 virus ZC3HAV1 [DOI] 10.1016/j.molcel.2021.04.022 PMC 바로가기 [Article Type] Article
SARS-CoV-2 can recruit a heme metabolite to evade antibody immunitySARS-CoV-2는 항체 면역을 피하기 위해 헴 대사 산물을 모집할 수 있습니다Research Article Published on 2021-05-282022-09-12 Journal: Science Advances [Category] SARS, 진단, [키워드] access Antibody binding antibody immunity Bilirubin Biliverdin bind binding cleft concentrations conformational change Coronaviral distal dominant dominant epitope epitope evade flexible heme heme metabolism immune inhibited Interaction linear mapped mechanism metabolism metabolite Microscopy modulated N-terminal domain nanomolar affinity Neutralizing antibodies NTD physiological reactivity recruit recruitment regulated Relocation SARS-CoV-2 SARS-CoV-2 spike sera significantly subset target tetrapyrrole Viral antigen X-ray crystallography [DOI] 10.1126/sciadv.abg7607 PMC 바로가기 [Article Type] Research Article